Insulin and neurodegenerative disease: shared and specific mechanisms

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Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988–1994

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Diabetes mellitus and the risk of dementia: The Rotterdam Study

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Parkinson's Disease

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Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

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The Endocrine Regulation of Aging by Insulin-like Signals

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Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function

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Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies

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Insulin receptors are widely distributed in the central nervous system of the rat

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Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes

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Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

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Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease

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The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

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Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study

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Association of diabetes mellitus and dementia, the Rotterdam study

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Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

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Identification of insulin in rat brain.

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Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E genotype

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Memory improvement following induced hyperinsulinemia in Alzheimer’s disease

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Brain Insulin Receptors and Spatial Memory

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Is Type II Diabetes Associated With an Increased Risk of Cognitive Dysfunction?: A critical review of published studies

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Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus

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The role of cerebral ischemia in Alzheimer’s disease

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Insulin and Insulin-like Growth Factor-1 Regulate Tau Phosphorylation in Cultured Human Neurons

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Is Diabetes Associated With Cognitive Impairment and Cognitive Decline Among Older Women?

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Evidence for Genetic Linkage of Alzheimer's Disease to Chromosome 10q

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Insulin/Insulin-like Growth Factor I Hybrid Receptors Have Different Biological Characteristics Depending on the Insulin Receptor Isoform Involved

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Role of insulin and insulin receptor in learning and memory

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Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling

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Insulin receptors and insulin action in the brain: review and clinical implications

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Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain.

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Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation

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Inflammation, autotoxicity and Alzheimer disease

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Serum insulin-like growth factor I regulates brain amyloid-β levels

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Serum insulin-like growth factor I regulates brain amyloid-β levels

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Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study

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Prevalence of Dementia in Older Latinos: The Influence of Type 2 Diabetes Mellitus, Stroke and Genetic Factors

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Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects

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Susceptibility Locus for Alzheimer's Disease on Chromosome 10

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Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees

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NIDDM and Blood Pressure as Risk Factors for Poor Cognitive Performance: The Framingham Study

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Insulin In The Brain

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Intracerebroventricular insulin enhances memory in a passive-avoidance task

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Alzheimer's β‐amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

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Insulin gene expression and insulin synthesis in mammalian neuronal cells.

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Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-ε4 Allele

Cook, D. G., Leverenz, J. B., McMillan, P. J., Kulstad, J. J., Ericksen, S., Roth, R. A., Schellenberg, G. D., Jin, L., Kovacina, K. S., & Craft, S. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63822-9 · Cited by 329

The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses

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Transport of Insulin Across the Blood-Brain Barrier: Saturability at Euglycemic Doses of Insulin

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Pathophysiological implications of insulin resistance on vascular endothelial function

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Enhancement of Memory in Alzheimer Disease With Insulin and Somatostatin, but Not Glucose

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Improving influence of insulin on cognitive functions in humans

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Insulin promotes rapid delivery of N -methyl- d - aspartate receptors to the cell surface by exocytosis

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Decreased cognitive function in aging non-insulin-dependent diabetic patients

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The Role of Insulin in Human Brain Glucose Metabolism

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Insulin resistance and risk for stroke

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Potential roles of insulin and IGF-1 in Alzheimer's disease

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Insulin increases CSF Aβ42 levels in normal older adults

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Cerebrospinal Fluid Insulin Levels Increase During Intravenous Insulin Infusions in Man*

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Clinical Criteria for the Diagnosis of Vascular Dementia

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The Relationship Between Diabetes Mellitus and Parkinson'S Disease

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Degradation of Soluble Amyloid β-Peptides 1–40, 1–42, and the Dutch Variant 1–40Q by Insulin Degrading Enzyme from Alzheimer Disease and Control Brains

Pérez, A., Morelli, L., Cresto, J. C., & Castaño, E. M. (2000) · Neurochemical Research · doi:10.1023/a:1007527721160 · Cited by 240

Longitudinal association of vascular and Alzheimer’s dementias, diabetes, and glucose tolerance

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The impact of comorbid disease and injuries on resource use and expenditures in parkinsonism

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GLUTX1, a Novel Mammalian Glucose Transporter Expressed in the Central Nervous System and Insulin-sensitive Tissues

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Insulin and Insulin-Like Growth Factor I Receptors: Similarities and Differences in Signal Transduction

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Selective, Physiological Transport of Insulin Across the Blood-Brain Barrier: Novel Demonstration by Species-Specific Radioimmunoassays

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Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes.

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Insulin-degrading Enzyme Rapidly Removes the β-Amyloid Precursor Protein Intracellular Domain (AICD)

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β-Amyloid-(1–42) Impairs Activity-dependent cAMP-response Element-binding Protein Signaling in Neurons at Concentrations in Which Cell Survival Is Not Compromised

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Cognitive Function in an Elderly Population With Persistent Impaired Glucose Tolerance

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Degradation of Alzheimer's ß-Amyloid Protein by Human and Rat Brain Peptidases: Involvement of Insulin-Degrading Enzyme

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Diabetes Mellitus Is a Risk Factor for Vascular Dementia, but Not for Alzheimer’s Disease: A Population-Based Study of the Oldest Old

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No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans.

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Intraventricular insulin increases dopamine transporter mRNA in rat VTA/substantia nigra

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Diabetes mellitus in Huntington disease

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Insulin-degrading enzyme.

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Signalling through IGF-I and insulin receptors: where is the specificity?

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The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review

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Vascular Risks and Incident Dementia: Results from a Cohort Study of the Very Old

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Insulin metabolism in Alzheimer’s disease differs according to apolipoprotein E genotype and gender

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Characterization of risk factors for vascular dementia

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Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease

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Immunological Analysis of Glucose Transporters Expressed in Different Regions of the Rat Brain and Central Nervous System

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Vascular parkinsonism: a distinct, heterogeneous clinical entity

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The influence of diabetes mellitus and hyperglycaemia on stroke incidence and outcome

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Hyperinsulinemia: the missing link among oxidative stress and age-related diseases?

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Prevalence of cerebrovascular lesions in Parkinson's disease. A postmortem study

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Insulin: new roles for an ancient hormone

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Insulin receptor mRNA in the substantia nigra in Parkinson's disease.

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