The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
The promise of minocycline in neurology
Abstract
The capacity of minocycline to alleviate disease for several neurological disorders in animals is increasingly being recognised. Indeed, that one drug alone can attenuate the severity of disease in stroke, multiple sclerosis, spinal-cord injury, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis is astounding. In this review, we describe the evidence for the efficacy of minocycline in several animal models of neurological disease, discuss the mechanisms by which minocycline affects a range of neurological diseases with diverse causes, and introduce the emerging investigation of minocycline in clinical neurology. The encouraging results of minocycline in experimental neurology bode well for its therapeutic use in human neurological diseases.
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“Thanks to the ability to efficiently cross the BBB, minocycline is considered neuroprotective for a variety of neurological conditions, including PD [251,252,253,254,255,256,257].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [253]
In the citing paper
“Thanks to the ability to efficiently cross the BBB, minocycline is considered neuroprotective for a variety of neurological conditions, including PD [251,252,253,254,255,256,257].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [253]
Citations
Cites
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Research works printed but not linked: 1
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Minocycline: Far beyond an Antibiotic
Garrido‐Mesa, N., Zarzuelo, A., & Gálvez, J. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12139 · Cited by 935
Vandooren, J., den Steen, P. E. V., & Opdenakker, G. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.770819 · Cited by 790
Activated Microglia Contribute to the Maintenance of Chronic Pain after Spinal Cord Injury
Hains, B. C., & Waxman, S. G. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0003-06.2006 · Cited by 641
Preclinical and clinical research on inflammation after intracerebral hemorrhage
Wang, J. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.08.001 · Cited by 609
Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition
Wong, M.-L., Inserra, A., Lewis, M. D., Mastronardi, C. A., Leong, L., Choo, J., Kentish, S., Xie, P., Morrison, M., Wesselingh, S. L., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.46 · Cited by 568
Metadata
- Authors
- Yong, V. W., Wells, J., Giuliani, F., Casha, S., Power, C., & Metz, L. M.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Yong, V Wee
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2004-12
- Volume
- 3
- Issue
- 12
- Pages
- 744-751
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2063885093
- Cited by
- 518
- References
- 64
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 17 · 2023: 19 · 2022: 20 · 2021: 19 · 2020: 24 · 2019: 14 · 2018: 27 · 2017: 19 · 2016: 17 · 2015: 28 · 2014: 33 · 2013: 32 · 2012: 35
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Teva Pharmaceutical Industries
- Multiple Sclerosis Society of Canada
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- minocycline, neuroprotection, stroke, multiple sclerosis, spinal cord injury, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, animal models of neurological disease, clinical trials
- MeSH terms
- Animals, Humans, Minocycline, Nervous System Diseases
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