The promise of minocycline in neurology

Inflammation is detrimental for neurogenesis in adult brain

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Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

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Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

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A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

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Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia

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Minocycline Prevents Nigrostriatal Dopaminergic Neurodegeneration in the MPTP Model of Parkinson’s Disease

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Minocycline Provides Neuroprotection Against N -Methyl- d -aspartate Neurotoxicity by Inhibiting Microglia

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Minocycline Treatment Reduces Delayed Oligodendrocyte Death, Attenuates Axonal Dieback, and Improves Functional Outcome after Spinal Cord Injury

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A novel mechanism of action of tetracyclines: Effects on nitric oxide synthases

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Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice.

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Targeting leukocyte MMPs and transmigration

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Animal model pharmacokinetics and pharmacodynamics: a critical review

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Minocycline Slows Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

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Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease

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Minocycline Reduces Traumatic Brain Injury-mediated Caspase-1 Activation, Tissue Damage, and Neurological Dysfunction

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Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases

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Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum

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Clinical Pharmacokinetics of Doxycycline and Minocycline

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Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury

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Minocycline markedly protects the neonatal brain against hypoxic‐ischemic injury

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Tetracyclines inhibit tissue collagenase activity

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Minocycline Reduces Cell Death and Improves Functional Recovery after Traumatic Spinal Cord Injury in the Rat

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Minocycline delays disease onset and mortality in a transgenic model of ALS

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Inhibition of autoimmune encephalomyelitis by a tetracycline

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Minocycline Up-regulates Bcl-2 and Protects against Cell Death in Mitochondria

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Pharmacokinetic studies on minocycline in man

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Minocycline Reduces the Lipopolysaccharide-Induced Inflammatory Reaction, Peroxynitrite-Mediated Nitration of Proteins, Disruption of the Blood–Brain Barrier, and Damage in the Nigral Dopaminergic System

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Deleterious Effects of Minocycline in Animal Models of Parkinson’s Disease and Huntington’s Disease

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Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS

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Minocycline worsens hypoxic-ischemic brain injury in a neonatal mouse model

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Minocycline and doxycycline are not beneficial in a model of Huntington's disease

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Minocycline-induced autoimmune syndromes: An overview

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Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats

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Minocycline reduces gadolinium‐enhancing magnetic resonance imaging lesions in multiple sclerosis

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Minocycline Reduces Traumatic Brain Injury-mediated Caspase-1 Activation, Tissue Damage, and Neurological Dysfunction

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Minocycline Enhances MPTP Toxicity to Dopaminergic Neurons

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Placebo-controlled phase I/II studies of minocycline in amyotrophic lateral sclerosis

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Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease

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Liquid chromatographic determination of minocycline in brain-to-plasma distribution studies in the rat

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Efficient three‐drug cocktail for disease induced by mutant superoxide dismutase

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Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO

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Minocycline blocks nitric oxide-induced neurotoxicity by inhibition p38 MAP kinase in rat cerebellar granule neurons

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Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection

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The influence of tetracyclines on T cell activation

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The tetracycline derivative minocycline differentially affects cytokine production by monocytes and T lymphocytes

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Minocycline in Huntington's disease: A pilot study

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The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors

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Gelatinase B/matrix metalloproteinase‐9 cleaves interferon‐β and is a target for immunotherapy

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Excessive Matrix Metalloproteinase Activity in Diabetes: Inhibition by Tetracycline Analogues with Zinc Reactivity

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Minocycline for Huntington’s disease: An open label study

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Inhibitory action of minocycline on lipopolysaccharide-lnduced release of nitric oxide and prostaglandin E2 in BV2 microglial cells

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Minocycline safety and tolerability in Huntington disease

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Suppression of activated microglia promotes survival and function of transplanted oligodendroglial progenitors

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Delayed minocycline but not delayed mild hypothermia protects against embolic stroke

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Effect of minocycline in experimental autoimmune encephalomyelitis

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Comparison of doxycycline and a chemically modified tetracycline inhibition of leukocyte functions.

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Minocycline is protective in a mouse model of Huntington's disease

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MINOCYCLINE EXCRETION AND DISTRIBUTION IN RELATION TO RENAL FUNCTION IN MAN

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Benefit-risk assessment of acne therapies

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Reply

Hockly, E., Beunard, J., Lowden, P. A. S., & Bates, G. P. (2003) · Annals of Neurology · doi:10.1002/ana.21893 · Cited by 2

Minocycline: Far beyond an Antibiotic

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Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade

Vandooren, J., den Steen, P. E. V., & Opdenakker, G. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.770819 · Cited by 790

Activated Microglia Contribute to the Maintenance of Chronic Pain after Spinal Cord Injury

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Preclinical and clinical research on inflammation after intracerebral hemorrhage

Wang, J. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.08.001 · Cited by 609

Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition

Wong, M.-L., Inserra, A., Lewis, M. D., Mastronardi, C. A., Leong, L., Choo, J., Kentish, S., Xie, P., Morrison, M., Wesselingh, S. L., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.46 · Cited by 568

NEUROLOGICAL REVIEW ONLINE FIRST Prospects for

Neuroprotection, M., Plane, J. M., Shen, P. Y., David, P., Pleasure, E., & Deng, M. W. (2014)

The Potential of Minocycline for Neuroprotection in Human Neurologic Disease

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Minocycline in neurological diseases

Bandini, F. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)00998-1 · Cited by 7

Minocycline in neurological diseases ? Authors' reply

METZ, L., & YONG, V. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70005-3

The Disease Ameliorating Effects of Minocycline in Neurologic Disorders

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