Cited by 125Neuroinflammation and Neurodegeneration MechanismsNeurological Disorders and TreatmentsNeurological Disease Mechanisms and Treatments

The Potential of Minocycline for Neuroprotection in Human Neurologic Disease

Zemke, Daniel, Majid, Arshad·2004·Clinical Neuropharmacology

Abstract

Minocycline is a member of the tetracycline class of molecules with broad-spectrum antibiotic activity. The unique properties of minocycline result in increased tissue distribution when compared with the other tetracyclines. Of particular interest is the ability of minocycline to diffuse into the central nervous system at clinically effective levels. Aside from its antimicrobial properties, minocycline has been found to have beneficial effects on inflammation, microglial activation, matrix metalloproteinases, nitric oxide production, and apoptotic cell death. Concordantly, minocycline has been found to have neuroprotective effects in animal models of a number of diseases including stroke, multiple sclerosis, and Parkinson disease. The proven safety of minocycline over decades of use as an antibiotic suggests that it may have potential for development into an effective treatment of multiple neurologic conditions in humans.

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Crossref · 10.1097/01.wnf.0000150867.98887.3e

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65 of 65 references verified0 citation errors · 0 not checkable

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Authors
Zemke, D., & Majid, A.
Affiliations
Michigan State University (US)
Venue
Clinical Neuropharmacology
Published
2004-11
Volume
27
Issue
6
Pages
293-298
ISSN
0362-5664 (ISSN-L)
OpenAlex
W2047780499
Cited by
125
References
64
Citations by year
2026: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 10
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
minocycline, neuroprotection, tetracycline, CNS penetration, neuroinflammation, microglial activation, matrix metalloproteinases, nitric oxide, apoptosis, stroke, multiple sclerosis, Parkinson's disease, neurological disorders
MeSH terms
Animals, Humans, Minocycline, Nervous System Diseases, Cell Death, Microglia, Neuroprotective Agents, Matrix Metalloproteinases

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