The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Risk of dementia in diabetes mellitus: a systematic review
Abstract
The relation between diabetes and major types of dementia is controversial. This systematic review examines the incidence of dementia in people with diabetes mellitus. We identified 14 eligible longitudinal population-based studies of variable methodological quality. The incidence of "any dementia" was higher in individuals with diabetes than in those without diabetes in seven of ten studies reporting this aggregate outcome. This high risk included both Alzheimer's disease and vascular dementia (eight of 13 studies and six of nine studies respectively). Detailed data on modulating and mediating effects of glycaemic control, microvascular complications, and comorbidity (eg, hypertension and stroke) were generally absent. The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology, but which of these mechanisms are clinically relevant is unclear. Further high quality studies need to be initiated, with objective diabetes assessment, together with reliable methods to establish the contribution of vascular disease and other comorbidity to dementia.
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In the citing paper
“Importantly, epidemiological studies indicate that T2DM is associated to an increased risk to develop AD in comparison to normal people (Biessels et al., 2006).”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Biessels et al., 2006
In the citing paper
“Type 2 diabetes (T2D) has been demonstrated to be related to accelerated cognitive decline (3) and increased risk of dementia (4)”
From Type 2 Diabetes and Antidiabetic Medications in Relation to Dementia Diagnosis (2014) · cites this paper as [4]
In the citing paper
“However, many studies have shown that patients tend to develop dementia in a relatively shorter period of time relative to patients without diabetes.”
From Type 2 Diabetes and Antidiabetic Medications in Relation to Dementia Diagnosis (2014) · cites this paper as [4]
Citations
Cites
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Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
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Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Global and societal implications of the diabetes epidemic
Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883
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Items 101–103 of 103
Carmichael, O. T., Neiberg, R. H., Dutton, G. R., Hayden, K. M., Horton, E., Pi-Sunyer, F. X., Johnson, K. C., Rapp, S. R., Spira, A. P., & Espeland, M. A. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa591 · Cited by 24
The effect of diabetes on the cognitive trajectory of older adults in Mexico and the United States
Avila, J. C., Mejia-Arangom, S., Jupiter, D., Downer, B., & Wong, R. (2021) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbaa094 · Cited by 18
Zhou, M., Tang, A. S., Zhang, H., Xu, Z., Ke, A. M. C., Su, C., Huang, Y., Mantyh, W. G., Jaffee, M. S., Rankin, K. P., et al. (2025) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2025.104820 · Cited by 9
Metadata
- Authors
- Biessels, G. J., Staekenborg, S., Brunner, E., Brayne, C., & Scheltens, P.
- Affiliations
- University Medical Center Utrecht (NL)
- The Royal Free Hospital (GB)
- University of Cambridge (GB)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Biessels, Geert Jan
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 5
- Issue
- 1
- Pages
- 64-74
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2102528806
- Semantic Scholar
- e31a373bc94c4485f348ff98d71acb0db0ade3fc
- Cited by
- 2,187
- References
- 98
- Citations by year
- 2026: 67 · 2025: 110 · 2024: 126 · 2023: 118 · 2022: 132 · 2021: 149 · 2020: 143 · 2019: 143 · 2018: 127 · 2017: 114 · 2016: 129 · 2015: 131 · 2014: 137 · 2013: 114 · 2012: 94
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- diabetes mellitus, dementia, Alzheimer's disease, vascular dementia, dementia incidence, glycemic control, microvascular complications, hypertension, stroke, amyloid metabolism, insulin, vascular disease
- MeSH terms
- Dementia, Diabetes Mellitus, Humans, Longitudinal Studies, Models, Biological, Risk, Outcome Assessment, Health Care, Community Health Planning, Diabetes Complications
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