Cited by 2,187Dementia and Cognitive Impairment ResearchDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and Management

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Risk of dementia in diabetes mellitus: a systematic review

Biessels, Geert Jan, Staekenborg, Salka, Brunner, Eric, Brayne, Carol, Scheltens, Philip·2006·The Lancet Neurology

DOI 10.1016/s1474-4422(05)70284-2

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Abstract

The relation between diabetes and major types of dementia is controversial. This systematic review examines the incidence of dementia in people with diabetes mellitus. We identified 14 eligible longitudinal population-based studies of variable methodological quality. The incidence of "any dementia" was higher in individuals with diabetes than in those without diabetes in seven of ten studies reporting this aggregate outcome. This high risk included both Alzheimer's disease and vascular dementia (eight of 13 studies and six of nine studies respectively). Detailed data on modulating and mediating effects of glycaemic control, microvascular complications, and comorbidity (eg, hypertension and stroke) were generally absent. The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology, but which of these mechanisms are clinically relevant is unclear. Further high quality studies need to be initiated, with objective diabetes assessment, together with reliable methods to establish the contribution of vascular disease and other comorbidity to dementia.

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Authors: Biessels, G. J., Staekenborg, S., Brunner, E., Brayne, C., & Scheltens, P.
Affiliations: University Medical Center Utrecht (NL)
The Royal Free Hospital (GB)
University of Cambridge (GB)
Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Corresponding author: Biessels, Geert Jan
ORCID: Biessels, Geert Jan
Brunner, Eric
Brayne, Carol
Scheltens, Philip
Venue: The Lancet Neurology
Publisher: Elsevier BV
Published: 2006-01
Volume: 5
Issue: 1
Pages: 64-74
ISSN: 1474-4422 (ISSN-L)
DOI: 10.1016/s1474-4422(05)70284-2
OpenAlex: W2102528806
Semantic Scholar: e31a373bc94c4485f348ff98d71acb0db0ade3fc
Cited by: 2,187
References: 98
Citations by year: 2026: 67 · 2025: 110 · 2024: 126 · 2023: 118 · 2022: 132 · 2021: 149 · 2020: 143 · 2019: 143 · 2018: 127 · 2017: 114 · 2016: 129 · 2015: 131 · 2014: 137 · 2013: 114 · 2012: 94
FWCI: 4.86
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Neurology (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: diabetes mellitus, dementia, Alzheimer's disease, vascular dementia, dementia incidence, glycemic control, microvascular complications, hypertension, stroke, amyloid metabolism, insulin, vascular disease
MeSH terms: Dementia, Diabetes Mellitus, Humans, Longitudinal Studies, Models, Biological, Risk, Outcome Assessment, Health Care, Community Health Planning, Diabetes Complications

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