Cited by 860Folate and B Vitamins ResearchPorphyrin Metabolism and DisordersAlcoholism and Thiamine Deficiency

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Vitamin B12, folic acid, and the nervous system

Reynolds, Edward·2006·The Lancet Neurology

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Abstract

There are many reasons for reviewing the neurology of vitamin-B12 and folic-acid deficiencies together, including the intimate relation between the metabolism of the two vitamins, their morphologically indistinguishable megaloblastic anaemias, and their overlapping neuropsychiatric syndromes and neuropathology, including their related inborn errors of metabolism. Folates and vitamin B12 have fundamental roles in CNS function at all ages, especially the methionine-synthase mediated conversion of homocysteine to methionine, which is essential for nucleotide synthesis and genomic and non-genomic methylation. Folic acid and vitamin B12 may have roles in the prevention of disorders of CNS development, mood disorders, and dementias, including Alzheimer's disease and vascular dementia in elderly people.

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Authors: Reynolds, E.
Affiliations: King's College London (GB)
Corresponding author: Reynolds, Edward
ORCID: Reynolds, Edward
Venue: The Lancet Neurology
Publisher: Elsevier BV
Published: 2006-11
Volume: 5
Issue: 11
Pages: 949-960
ISSN: 1474-4422 (ISSN-L)
DOI: 10.1016/s1474-4422(06)70598-1
OpenAlex: W2167574472
Cited by: 860
References: 153
Citations by year: 2026: 42 · 2025: 43 · 2024: 70 · 2023: 50 · 2022: 49 · 2021: 52 · 2020: 46 · 2019: 52 · 2018: 43 · 2017: 48 · 2016: 55 · 2015: 47 · 2014: 30 · 2013: 43 · 2012: 49
FWCI: 3.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Keywords: vitamin B12, folic acid, folate deficiency, megaloblastic anemia, neuropsychiatric syndromes, inborn errors of metabolism, methionine synthase, homocysteine, DNA methylation, nucleotide synthesis, central nervous system development, mood disorders, dementia, Alzheimer's disease, vascular dementia
MeSH terms: Animals, Folic Acid, Humans, Metabolic Diseases, Models, Biological, Multiple Sclerosis, Nervous System, Vitamin B 12, Vitamin B 12 Deficiency

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Vitamin B12, folic acid, and the nervous system

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