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Vitamin B12, folic acid, and the nervous system
Abstract
There are many reasons for reviewing the neurology of vitamin-B12 and folic-acid deficiencies together, including the intimate relation between the metabolism of the two vitamins, their morphologically indistinguishable megaloblastic anaemias, and their overlapping neuropsychiatric syndromes and neuropathology, including their related inborn errors of metabolism. Folates and vitamin B12 have fundamental roles in CNS function at all ages, especially the methionine-synthase mediated conversion of homocysteine to methionine, which is essential for nucleotide synthesis and genomic and non-genomic methylation. Folic acid and vitamin B12 may have roles in the prevention of disorders of CNS development, mood disorders, and dementias, including Alzheimer's disease and vascular dementia in elderly people.
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“Deficiency or lack of homeostasis of important micronutrients is another form of malnutrition that has major impacts on everyday performance, intellectual and emotional condition, as well as physical health (11, 12).”
From Evolution of the diagnosis of malnutrition in adults: a primer for clinicians (2024) · cites this paper as [11]
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Metadata
- Authors
- Reynolds, E.
- Affiliations
- King's College London (GB)
- Corresponding author
- Reynolds, Edward
- ORCID
- Reynolds, Edward
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 5
- Issue
- 11
- Pages
- 949-960
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2167574472
- Cited by
- 860
- References
- 153
- Citations by year
- 2026: 42 · 2025: 43 · 2024: 70 · 2023: 50 · 2022: 49 · 2021: 52 · 2020: 46 · 2019: 52 · 2018: 43 · 2017: 48 · 2016: 55 · 2015: 47 · 2014: 30 · 2013: 43 · 2012: 49
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- vitamin B12, folic acid, folate deficiency, megaloblastic anemia, neuropsychiatric syndromes, inborn errors of metabolism, methionine synthase, homocysteine, DNA methylation, nucleotide synthesis, central nervous system development, mood disorders, dementia, Alzheimer's disease, vascular dementia
- MeSH terms
- Animals, Folic Acid, Humans, Metabolic Diseases, Models, Biological, Multiple Sclerosis, Nervous System, Vitamin B 12, Vitamin B 12 Deficiency
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