Vitamin B12, folic acid, and the nervous system

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Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation

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Prevention of neural tube defects: Results of the Medical Research Council vitamin study

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Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer Disease

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Neuropsychiatric Disorders Caused by Cobalamin Deficiency in the Absence of Anemia or Macrocytosis

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Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders

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Oxidative stress and antioxidant defenses in mild cognitive impairment: A systematic review and meta-analysis

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B vitamins and n-3 fatty acids for brain development and function: review of human studies

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Cognitive impact after short-term exposure to different proton pump inhibitors: assessment using CANTAB software

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Elevated homocysteine levels in levodopa-treated idiopathic Parkinson's disease: a meta-analysis

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Lifestyle and genetic determinants of folate and vitamin B12 levels in a general adult population

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Role of vitamin B12 deficiency in ischemic stroke risk and outcome

Yahn, G. B., Abato, J. E., & Jadavji, N. M. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.291381 · Cited by 68

Spinal Cord Injury Changes the Structure and Functional Potential of Gut Bacterial and Viral Communities

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Mechanism of photooxidation of folic acid sensitized by unconjugated pterins

Dántola, M. L., Denofrio, M. P., Zurbano, B. N., Giménez, C. S., Ogilby, P. R., Lorente, C., & Thomas, A. H. (2010) · Photochemical & Photobiological Sciences · doi:10.1039/c0pp00210k · Cited by 68

Prevalence of MR imaging abnormalities in vitamin B12 deficiency patients presenting with clinical features of subacute combined degeneration of the spinal cord

Jain, K. K., Malhotra, H. S., Garg, R. K., Gupta, P. K., Roy, B., & Gupta, R. K. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.05.020 · Cited by 68

Vitamins and Cognition: What is the Evidence?

Kennedy, D. O., & Haskell, C. F. (2011) · Drugs · doi:10.2165/11594130-000000000-00000 · Cited by 67

Pharmacology of epigenetics in brain disorders

Narayan, P. J., & Dragunow, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00526.x · Cited by 67

Reversible encephalopathy and axonal neuropathy in Parkinson's disease during duodopa therapy

Manca, D., Cossu, G., Murgia, D., Molari, A., Ferrigno, P., Marcia, E., & Melis, M. (2009) · Movement Disorders · doi:10.1002/mds.22807 · Cited by 67

BluB/CobT2 fusion enzyme activity reveals mechanisms responsible for production of active form of vitamin B12 by Propionibacterium freudenreichii

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Serum vitamin B12 is inversely associated with periodontal progression and risk of tooth loss: A prospective cohort study

Zong, G., Holtfreter, B., Scott, A. E., Völzke, H., Petersmann, A., Dietrich, T., Newson, R. S., & Kocher, T. (2016) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12483 · Cited by 64

Perinatal folate supply: relevance in health outcome parameters

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Antivitamins B12—A Structure‐ and Reactivity‐Based Concept

Kräutler, B. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201502072 · Cited by 66

Neural tube defects and disturbed maternal folate- and homocysteine-mediated one-carbon metabolism

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Vitamin B12 deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse

Fernàndez-Roig, S., Lai, S., Murphy, M. M., Fernandez-Ballart, J. D., & Quadros, E. V. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-41 · Cited by 63

Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population

Sukla, K. K., & Raman, R. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.152 · Cited by 61

Proton pump inhibitors, adverse events and increased risk of mortality

Lanas-Gimeno, A., Hijos, G., & Lanas, Á. (2019) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2019.1664470 · Cited by 60

Proton pump inhibitors and risk of dementia

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A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policy

Tighe, P., Ward, M., McNulty, H., Finnegan, O., Dunne, A., Strain, J., Molloy, A. M., Duffy, M. E., Pentieva, K. D., & Scott, J. M. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29427 · Cited by 59

Serum homocysteine levels in relation to clinical progression in multiple sclerosis

Teunissen, C. E., Killestein, J., Kragt, J. J., Polman, C. H., Dijkstra, C. D., & Blom, H. J. (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.151555 · Cited by 60

Lower ADD1 Gene Promoter DNA Methylation Increases the Risk of Essential Hypertension

Zhang, L., Liu, P., Wang, L., Yuan, F., Xu, L., Xin, Y., Fei, L.-J., Zhong, Q., Huang, Y., Xu, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063455 · Cited by 60

Comparison of standardised dietary folate intake across ten countries participating in the European Prospective Investigation into Cancer and Nutrition

Park, J. Y., Nicolas, G., Freisling, H., Biessy, C., Scalbert, A., Romieu, I., Chajès, V., Chuang, S.-C., Ericson, U., Wallström, P., et al. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511005733 · Cited by 60

Effect of folic acid supplementation on preterm delivery and small for gestational age births: A systematic review and meta-analysis

Zhang, Q., Wang, Y., Xin, X., Zhang, Y., Liu, D., Peng, Z., He, Y., Xu, J., & Ma, X. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.11.012 · Cited by 62

Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus

Obeid, R., Andrès, E., Češka, R., Hooshmand, B., Guéant‐Rodriguez, R., Prada, G. I., Sławek, J. W., Traykov, L. D., Van, B. T., Várkonyi, T. T., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13082176 · Cited by 70

Antiepileptic drugs, hyperhomocysteinemia and B-vitamins supplementation in patients with epilepsy

Belcastro, V., & Striano, P. (2012) · Epilepsy Research · doi:10.1016/j.eplepsyres.2012.07.003 · Cited by 60

Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet

Bagnyukova, T., Powell, C. L., Pavliv, O., Tryndyak, V., & Pogribny, I. P. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.073 · Cited by 59

A Common Polymorphism in HIBCH Influences Methylmalonic Acid Concentrations in Blood Independently of Cobalamin

Molloy, A. M., Pangilinan, F., Mills, J. L., Shane, B., O’Neill, M. B., McGaughey, D. M., Velkova, A., Abaan, H. Ö., Ueland, P. M., McNulty, H., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.03.005 · Cited by 59

Valproate and folate: Congenital and developmental risks

Reynolds, E. H., & Green, R. (2020) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2020.107068 · Cited by 59

Cognitive Impairment in Adult Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Hopkins, C. W. P., Powell, N., Norton, C., Dumbrill, J. L., Hayee, B., & Moulton, C. D. (2021) · Journal of the Academy of Consultation-Liaison Psychiatry · doi:10.1016/j.psym.2020.10.002 · Cited by 57

A review on potential roles of vitamins in incidence, progression, and improvement of multiple sclerosis

Khosravi-Largani, M., Pourvali‐Talatappeh, P., Rousta, A., Karimi-Kivi, M., Noroozi, E., Mahjoob, A., Asaadi, Y., Shahmohammadi, A., Sadeghi, S., Shakeri, S., et al. (2018) · eNeurologicalSci · doi:10.1016/j.ensci.2018.01.007 · Cited by 59

Maternal micronutrients and brain global methylation patterns in the offspring

Sable, P., Randhir, K., Kale, A. A., Chavan, P., & Joshi, S. (2013) · Nutritional Neuroscience · doi:10.1179/1476830513y.0000000097 · Cited by 58

Brain Hemodynamic Intermediate Phenotype Links Vitamin B12 to Cognitive Profile of Healthy and Mild Cognitive Impaired Subjects

Cecchetti, L., Lettieri, G., Handjaras, G., Leo, A., Ricciardi, E., Pietrini, P., & Pellegrini, S. (2019) · Journal of Neural Transplantation and Plasticity · doi:10.1155/2019/6874805 · Cited by 10

Hormone disorder and vitamin deficiency in attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASDs)

Bala, K. A., Doğan, M., Kaba, S., Mutluer, T., Aslan, O., & Doğan, Ş. Z. (2016) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2015-0473 · Cited by 55

A review of vitamin B12

Rizzo, G., & Laganà, A. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811907-5.00005-1 · Cited by 60

The Effects of Bariatric Surgery on Vitamin B Status and Mental Health

Mansoori, A. A., Shakoor, H. I., Ali, H. I., Feehan, J., Dhaheri, A. S. A., Ismail, L. C., Bosevski, M., Apostolopoulos, V., & Stojanovska, L. (2021) · Nutrients · doi:10.3390/nu13041383 · Cited by 56

TFOS Lifestyle: Impact of nutrition on the ocular surface

Markoulli, M. P., Ahmad, S., Arcot, J., Arita, R., Benitez-del-Castillo, J., Caffery, B. E., Downie, L. E., Edwards, K. P., Flanagan, J., Labétoulle, M., et al. (2023) · The Ocular Surface · doi:10.1016/j.jtos.2023.04.003 · Cited by 61

Serum folate and homocysteine and depressive symptoms among Japanese men and women

Nanri, A., Mizoue, T., Matsushita, Y., Sasaki, S., Ohta, M., Sato, M., & Mishima, N. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2009.143 · Cited by 53

Adherence to a Mediterranean diet and plasma fatty acids: data from the Bordeaux sample of the Three-City study

Féart, C., Torres, M. J., Samieri, C., Jutand, M., Peuchant, E., Simopoulos, A. P., & Barberger‐Gateau, P. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114510005805 · Cited by 61

The excessive caloric intake and micronutrient deficiencies related to obesity after a long-term interdisciplinary therapy

Poli, V. F. S., Sanches, R. B., Moraes, A. D. S., Fidalgo, J. P. N., Nascimento, M. A., Bresciani, P., Andrade-Silva, S. G., Cipullo, M. A. T., Clemente, J. C., & Caranti, D. A. (2017) · Nutrition · doi:10.1016/j.nut.2017.01.012 · Cited by 52

Structural basis of transcobalamin recognition by human CD320 receptor

Alam, A., Woo, J., Schmitz, J., Prinz, B., Root, K., Chen, F., Bloch, J. S., Zenobi, R., & Locher, K. P. (2016) · Nature Communications · doi:10.1038/ncomms12100 · Cited by 57

Congenital B12 deficiency following maternal gastric bypass

Celiker, M., & Chawla, A. (2009) · Journal of Perinatology · doi:10.1038/jp.2009.16 · Cited by 51

Homocysteine, vitamin B12 and folate levels in Iranian patients with Multiple Sclerosis: A case control study

Moghaddasi, M., Mamarabadi, M., Mohebi, N., Razjouyan, H., & Aghaei, M. (2013) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2013.05.007 · Cited by 51

Comparison of four automated serum vitamin B12 assays

İspir, E., Serdar, M. A., Özgürtaş, T., Gülbahar, Ö., Akın, K. O., Yeşildal, F., & Kurt, İ. (2015) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2014-0843 · Cited by 50

Folic acid administration prevents ouabain‐induced hyperlocomotion and alterations in oxidative stress markers in the rat brain

Brocardo, P. S., Budni, J., Pavesi, E., Franco, J. L., Uliano‐Silva, M., Trevisan, R., Terenzi, M. G., Dafré, A. L., & Rodrigues, A. L. S. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00827.x · Cited by 49

Neurodegeneration in multiple sclerosis involves multiple pathogenic mechanisms

Levin, M. C., Gardner, L. A., Douglas, J. N., Meyers, L., Lee, S., & Shin, Y. (2014) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s54391 · Cited by 52

Subacute combined degeneration caused by nitrous oxide intoxication: case reports.

Lin, R.-J., Chen, H.-F., Chang, Y., & Su, J.-J. (2011) · PubMed · Cited by 48

Dietary B Vitamins and a 10-Year Risk of Dementia in Older Persons

Lefèvre‐Arbogast, S., Féart, C., Dartigues, J., Helmer, C., Letenneur, L., & Samieri, C. (2016) · Nutrients · doi:10.3390/nu8120761 · Cited by 48

Antiepileptic Drugs and MTHFR Polymorphisms Influence Hyper‐Homocysteinemia Recurrence in Epileptic Patients

Belcastro, V., Gaetano, G., Italiano, D., Oteri, G., Caccamo, D., Pisani, L. R., Striano, P., Striano, S., Ientile, R., & Pisani, F. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01164.x · Cited by 48

Evaluation of vitamin B12 effects on DNA damage induced by pioglitazone.

Alzoubi, K., Khabour, O., Hussain, N., Al-azzam, S., & Mhaidat, N. (2012) · Mutation research · doi:10.1016/j.mrgentox.2012.06.009 · Cited by 43

Micronutrient supplementation in pregnancy: Who, what and how much?

Parisi, F., di Bartolo, I., Savasi, V. M., & Cetin, I. (2018) · Obstetric Medicine · doi:10.1177/1753495x18769213 · Cited by 56

Concentrations of unmetabolized folic acid and primary folate forms in plasma after folic acid treatment in older adults

Obeid, R., Kirsch, S. H., Kasoha, M., Eckert, R., & Herrmann, W. (2010) · Metabolism · doi:10.1016/j.metabol.2010.06.020 · Cited by 47

Utility of measuring vitamin B12 and its active fraction, holotranscobalamin, in neurological vitamin B12 deficiency syndromes

Schrempf, W., Eulitz, M., Neumeister, V., Siegert, G., Koch, R., Reichmann, H., & Storch, A. (2010) · Journal of Neurology · doi:10.1007/s00415-010-5764-4 · Cited by 46

Determination of 13 Vitamin B and the Related Compounds Using HPLC with UV Detection and Application to Food Supplements

Sasaki, K., Hatate, H., & Tanaka, R. (2020) · Chromatographia · doi:10.1007/s10337-020-03902-2 · Cited by 46

Folate- and vitamin B12–deficient diet during gestation and lactation alters cerebellar synapsin expressionviaimpaired influence of estrogen nuclear receptor α

Pourié, G., Martin, N., Bossenmeyer‐Pourié, C., Akchiche, N., Guéant‐Rodriguez, R., Geoffroy, A., Jeannesson, É., Chehadeh, S. E. H., Mimoun, K., Brachet, P., et al. (2015) · The FASEB Journal · doi:10.1096/fj.14-264267 · Cited by 51

Homeostasis and Dynamic Stability of the Phenotype Link Robustness and Plasticity

Nijhout, H. F., & Reed, M. C. (2014) · Integrative and Comparative Biology · doi:10.1093/icb/icu010 · Cited by 45

Thiamine Deficiency Promotes T Cell Infiltration in Experimental Autoimmune Encephalomyelitis: The Involvement of CCL2

Ji, Z., Fan, Z., Zhang, Y., Yu, R., Yang, H., Zhou, C., Luo, J., & Ke, Z. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302702 · Cited by 45

Dorsal column myelopathy after intrathecal chemotherapy for leukemia

Pinnix, C. C., Chi, L., Jabbour, E. J., Milgrom, S. A., Smith, G. L., Daver, N. G., Garg, N., Cykowski, M. D., Fuller, G. N., Cachia, D., et al. (2016) · American Journal of Hematology · doi:10.1002/ajh.24611 · Cited by 45

The critical chemical and mechanical regulation of folic acid on neural engineering

Kim, G. B., Chen, Y., Kang, W., Guo, J., Payne, R. A., Li, H., Wei, Q., Baker, J., Dong, C., Zhang, S., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.03.059 · Cited by 45

Clinical, Electrophysiological and Radiological Features of Nitrous Oxide-Induced Neurological Disorders

Bao, L., Li, Q., Li, Q., Chen, H., Zhang, R., Shi, H., & Cui, G. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s236939 · Cited by 45

Association of folate intake with the occurrence of depressive episodes in middle-aged French men and women

Astorg, P., Couthouis, A., de Courcy, G. P., Bertrais, S., Arnault, N., Meneton, P., Galan, P., & Herçberg, S. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507873612 · Cited by 44

No Association Linking Short-Term Proton Pump Inhibitor Use to Dementia: Systematic Review and Meta-analysis of Observational Studies

Khan, M. A., Yuan, Y., Iqbal, U., Kamal, S., Khan, M. U., Khan, Z. H., Lee‐Smith, W., & Howden, C. W. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000500 · Cited by 45

Cyanocobalamin, vitamin B12, depresses glutamate release through inhibition of voltage-dependent Ca2+ influx in rat cerebrocortical nerve terminals (synaptosomes)

Hung, K.-L., Wang, C., Huang, C.-Y., & Wang, S. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.11.059 · Cited by 44

The effect of vitamin B supplementation on homocysteine metabolism and clinical state of patients with chronic epilepsy treated with carbamazepine and valproic acid

Bochyńska, A., Lipczyńska-Łojkowska, W., Gugała-Iwaniuk, M., Lechowicz, W., Restel, M., Graban, A., Lipska-Ziętkiewicz, B. S., & Ryglewicz, D. (2012) · Seizure · doi:10.1016/j.seizure.2012.01.013 · Cited by 42

Status of Vitamin B12 and Folate among the Urban Adult Population in South India

Sivaprasad, M., Shalini, T., Balakrishna, N., Sudarshan, M., Lopamudra, P., Suryanarayana, P., Arlappa, N., Ravikumar, B. P., Radhika, M. S., & Reddy, G. B. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000442677 · Cited by 43

Do the benefits of folic acid fortification outweigh the risk of masking vitamin B12deficiency?

Mills, J. L., Molloy, A. M., & Reynolds, E. H. (2018) · BMJ · doi:10.1136/bmj.k724 · Cited by 43

The status of vitamins B6, B12, folate, and of homocysteine in geriatric home residents receiving laxatives or dietary fiber

Sturtzel, B., Dietrich, A., Wagner, K., Gisinger, C., & Elmadfa, I. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0053-6 · Cited by 43

The basis for folinic acid treatment in neuro-psychiatric disorders

Ramaekers, V. T., Sequeira, J. M., & Quadros, E. V. (2016) · Biochimie · doi:10.1016/j.biochi.2016.04.005 · Cited by 43

PPAR signaling pathway is a key modulator of liver proteome in pups born to vitamin B12 deficient rats

Ahmad, S., Kumar, K. A., Basak, T., Bhardwaj, G., Yadav, D. K., Lalitha, A., Chandak, G. R., Raghunath, M., & Sengupta, S. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.07.027 · Cited by 42

What is the safe upper intake level of folic acid for the nervous system? Implications for folic acid fortification policies

Reynolds, E. H. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.231 · Cited by 42

Dietary Supplement for Core Symptoms of Autism Spectrum Disorder: Where Are We Now and Where Should We Go?

Li, Y., Ou, J., Li, Y., & Xiang, D.-X. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00155 · Cited by 44

Reuniting overnutrition and undernutrition, macronutrients, and micronutrients

Kim, M., Basharat, A., Santosh, R., Mehdi, S. F., Razvi, Z., Yoo, S. K., Lowell, B., Kumar, A., Brima, W., Danoff, A., et al. (2018) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3072 · Cited by 48

Diet and medical foods in Parkinson’s disease

Lange, K. W., NAKAMURA, Y., Chen, N., Guo, J., Kanaya, S., Lange, K. M., & Li, S. (2019) · Food Science and Human Wellness · doi:10.1016/j.fshw.2019.03.006 · Cited by 43

Role of shortwave and microwave diathermy in peripheral neuropathy

Fu, T., Lineaweaver, W. C., Zhang, F., & Zhang, J. (2019) · Journal of International Medical Research · doi:10.1177/0300060519854905 · Cited by 42

Identification of Natural Compounds of the Apple as Inhibitors against Cholinesterase for the Treatment of Alzheimer’s Disease: An In Silico Molecular Docking Simulation and ADMET Study

Jamal, Q. M. S., Khan, M. I., Alharbi, A. H., Ahmad, V., & Yadav, B. S. (2023) · Nutrients · doi:10.3390/nu15071579 · Cited by 42

Evaluation of oxidized buckypaper as material for the solid phase extraction of cobalamins from milk: Its efficacy as individual and support sorbent of a hydrophilic–lipophilic balance copolymer

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