Cited by 598Protease and Inhibitor MechanismsNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

Rosenberg, Gary A·2009·The Lancet Neurology

DOI 10.1016/s1474-4422(09)70016-x

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Abstract

Matrix metalloproteinases (MMPs) and proteins containing a disintegrin and metalloproteinase domain (ADAM) are important in neuroinflammation, and recent studies have linked their actions to neurodegenerative disorders. MMPs act as cell-surface sheddases and can affect cell signalling initiated by growth factors or death receptors. Four tissue inhibitors of metalloproteinases (TIMPs) regulate metalloproteinase activity. These proteases increase the permeability of the blood-brain barrier, which can cause oedema, haemorrhage, and cell death. MMPs also participate in tissue repair by promoting angiogenesis and neurogenesis. In vascular cognitive impairment, MMPs change permeability of the blood-brain barrier and might contribute to white matter damage. MMPs and ADAMs might contribute to the formation and degradation of amyloid proteins in Alzheimer's disease and cause death of dopaminergic neurons in Parkinson's disease. In this Review, by examining the effects of neuroinflammation, we try to understand the role that MMPs might have in neurodegenerative diseases. Therapeutic strategies that use inhibitors of MMPs could represent potential novel treatments for neurological diseases.

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Authors: Rosenberg, G. A.
Affiliations: University of New Mexico (US)
Corresponding author: Rosenberg, Gary A
ORCID: Rosenberg, Gary A
Venue: The Lancet Neurology
Publisher: Elsevier BV
Published: 2009-02
Volume: 8
Issue: 2
Pages: 205-216
ISSN: 1474-4422 (ISSN-L)
DOI: 10.1016/s1474-4422(09)70016-x
OpenAlex: W2124054487
Cited by: 594
References: 107
Citations by year: 2026: 27 · 2025: 23 · 2024: 18 · 2023: 34 · 2022: 33 · 2021: 35 · 2020: 29 · 2019: 28 · 2018: 22 · 2017: 34 · 2016: 33 · 2015: 52 · 2014: 54 · 2013: 47 · 2012: 37
FWCI: 2.62
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS045847, R01NS052305)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: matrix metalloproteinases, ADAMS, neuroinflammation, neurodegenerative diseases, blood-brain barrier permeability, tissue inhibitors of metalloproteinases, matrix metalloproteinase inhibitors, Alzheimer's disease, amyloid, Parkinson's disease, dopaminergic neurons, vascular cognitive impairment, white matter injury, angiogenesis, neurogenesis, signal transduction
MeSH terms: Humans, Inflammation, Protease Inhibitors, Neurodegenerative Diseases, Matrix Metalloproteinases

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Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

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