Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

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Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline

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Intracellular amyloid-β in Alzheimer's disease

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Tissue inhibitors of metalloproteinases: evolution, structure and function

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Mechanisms, challenges and opportunities in stroke

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Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

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The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

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Strategies for MMP inhibition in cancer: innovations for the post-trial era

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Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease

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VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain

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Metalloproteinase inhibitors: biological actions and therapeutic opportunities

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Processing of tumour necrosis factor-α precursor by metalloproteinases

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Activation mechanisms of matrix metalloproteinases.

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Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia

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Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

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S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death

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Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

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Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases

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Matrix Metalloproteinase Expression Increases After Cerebral Focal Ischemia in Rats

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White Matter Lesions in an Unselected Cohort of the Elderly: Molecular Pathology Suggests Origin From Chronic Hypoperfusion Injury

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Metalloproteinases: Mediators of Pathology and Regeneration in the CNS

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Matrix Metalloproteinases Increase Very Early during Experimental Focal Cerebral Ischemia

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Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

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Increased blood-brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging

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The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis

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A Highly Specific Inhibitor of Matrix Metalloproteinase-9 Rescues Laminin from Proteolysis and Neurons from Apoptosis in Transient Focal Cerebral Ischemia

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Multiple roles for MMPs and TIMPs in cerebral ischemia

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The Biochemical, Biological, and Pathological Kaleidoscope of Cell Surface Substrates Processed by Matrix Metalloproteinases

Cauwe, B., den Steen, P. E. V., & Opdenakker, G. (2007) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230701340019 · Cited by 389

Matrix Metalloproteinase Inhibition Prevents Oxidative Stress-Associated Blood–Brain Barrier Disruption after Transient Focal Cerebral Ischemia

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Matrix Metalloproteinases Expressed by Astrocytes Mediate Extracellular Amyloid-β Peptide Catabolism

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Matrix Metalloproteinase-9 Degrades Amyloid-β Fibrils in Vitro and Compact Plaques in Situ

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Microvascular Basal Lamina Antigens Disappear During Cerebral Ischemia and Reperfusion

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Vascular Matrix Metalloproteinase-2 Cleaves Big Endothelin-1 Yielding a Novel Vasoconstrictor

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Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

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Metalloproteinase Inhibition Reduces Thrombolytic (Tissue Plasminogen Activator)–Induced Hemorrhage After Thromboembolic Stroke

Lapchak, P. A., Chapman, D. F., & Zivin, J. A. (2000) · Stroke · doi:10.1161/01.str.31.12.3034 · Cited by 336

Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-β peptide (1–40).

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Plasminogen Activators and Matrix Metalloproteinases in Angiogenesis

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Vasculogenesis, angiogenesis, and arteriogenesis: Mechanisms of blood vessel formation and remodeling

Semenza, G. L. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21523 · Cited by 329

Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration

Wang, L., Zhang, Z. G., Zhang, R. L., Gregg, S. R., Hozeska-Solgot, A., LeTourneau, Y., Wang, Y., & Chopp, M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5380-05.2006 · Cited by 316

Matrix metalloproteinases degrade myelin basic protein

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Glial activation and white matter changes in the rat brain induced by chronic cerebral hypoperfusion: an immunohistochemical study

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Involvement of Matrix Metalloproteinase in Neuroblast Cell Migration from the Subventricular Zone after Stroke

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Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: a possible mechanism of inflammatory demyelination.

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Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders

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Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis

Rosenberg, G. A., Dencoff, J. E., Correa, N., Reiners, M., & Ford, C. C. (1996) · Neurology · doi:10.1212/wnl.46.6.1626 · Cited by 278

Closure of the Blood-Brain Barrier by Matrix Metalloproteinase Inhibition Reduces rtPA-Mediated Mortality in Cerebral Ischemia With Delayed Reperfusion

Pfefferkorn, T., & Rosenberg, G. A. (2003) · Stroke · doi:10.1161/01.str.0000083051.93319.28 · Cited by 272

Matrix Metalloproteinase-9 Facilitates Remyelination in Part by Processing the Inhibitory NG2 Proteoglycan

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Matrix Metalloproteinase-3: A Novel Signaling Proteinase from Apoptotic Neuronal Cells That Activates Microglia

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Matrix metalloproteinases: multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis

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Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer’s disease.

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Interleukin-10, interleukin-4, and transforming growth factor-? differentially regulate lipopolysaccharide-induced production of pro-inflammatory cytokines and nitric oxide in co-cultures of rat astroglial and microglial cells

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Blood–brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation

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Remarkable roles of proteolysis on and beyond the cell surface

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Binswanger's disease--revisited

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Long-Term Doxycycline Is More Effective Than Atenolol to Prevent Thoracic Aortic Aneurysm in Marfan Syndrome Through the Inhibition of Matrix Metalloproteinase-2 and -9

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Recent advances in MMP inhibitor design

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Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke

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White matter damage is associated with matrix metalloproteinases in vascular dementia

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Alterations of the blood-brain barrier and glial cells in white-matter lesions in cerebrovascular and Alzheimer’s disease patients

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Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-α in the Rat

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Leukocyte Gelatinase B Cleavage Releases Encephalitogens from Human Myelin Basic Protein

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Angiopoietin 2 Induces Glioma Cell Invasion by Stimulating Matrix Metalloprotease 2 Expression through the αvβ1 Integrin and Focal Adhesion Kinase Signaling Pathway

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Minocycline reduces gadolinium‐enhancing magnetic resonance imaging lesions in multiple sclerosis

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Hypoxia-enhanced Expression of the Proprotein Convertase Furin Is Mediated by Hypoxia-inducible Factor-1

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Pathogenesis of Binswanger chronic progressive subcortical encephalopathy

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Increased Production of Matrix Metalloproteinases in Enriched Astrocyte and Mixed Hippocampal Cultures Treated with β‐Amyloid Peptides

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Abnormal Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Brain Arteriovenous Malformations

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Matrix Metalloproteinase-2 Plays a Critical Role in the Pathogenesis of White Matter Lesions After Chronic Cerebral Hypoperfusion in Rodents

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The APP family of proteins: similarities and differences

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Measurement of Gelatinase B (MMP-9) in the Cerebrospinal Fluid of Patients With Vascular Dementia and Alzheimer Disease

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Silencing hypoxia-inducible factor-1α inhibits cell migration and invasion under hypoxic environment in malignant gliomas

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Modern concept of vascular cognitive impairment

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Angiogenic Recruitment of Pericytes from Bone Marrow after Stroke

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Tissue Inhibitor of Metalloproteinase-3 Induces a Fas-associated Death Domain-dependent Type II Apoptotic Pathway

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Biochemistry and Molecular Biology of Amyloid β‐Protein and the Mechanism of Alzheimer's Disease

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Transcriptional responses to intermittent hypoxia

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Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer’s disease brain

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Cerebral metabolic impairment in patients with obstructive sleep apnoea: an independent association of obstructive sleep apnoea with white matter change

Kamba, M. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.71.3.334 · Cited by 127

A novel intracellular role of matrix metalloproteinase‐3 during apoptosis of dopaminergic cells

Choi, D. H., Kim, E., Son, H. J., JOH, T. H., Kim, Y. S., Kim, D., Beal, M. F., & Hwang, O. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05399.x · Cited by 124

Doxycycline Suppresses Cerebral Matrix Metalloproteinase-9 and Angiogenesis Induced by Focal Hyperstimulation of Vascular Endothelial Growth Factor in a Mouse Model

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Chronic cerebral hypoperfusion induces MMP-2 but not MMP-9 expression in the microglia and vascular endothelium of white matter

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Angiopoietin-2 Facilitates Vascular Endothelial Growth Factor-Induced Angiogenesis in the Mature Mouse Brain

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Early Beneficial Effect of Matrix Metalloproteinase Inhibition on Blood—Brain Barrier Permeability as Measured by Magnetic Resonance Imaging Countered by Impaired Long-Term Recovery after Stroke in Rat Brain

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The 5A/6A polymorphism in the promoter of the stromelysin-1 (MMP-3) gene predicts progression of angiographically determined coronary artery disease in men in the LOCAT gemfibrozil study. Lopid Coronary Angiography Trial.

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Matrix Metalloproteinase-1 and Matrix Metalloproteinase-3 Gene Promoter Polymorphisms Are Associated With Carotid Artery Stenosis

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Intrathecal synthesis of matrix metalloproteinase-9 in patients with multiple sclerosis: implication for pathogenesis

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Stromelysin-1 (MMP-3) in synovial fluid of patients with rheumatoid arthritis has potential to cleave membrane bound Fas ligand.

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Doxycycline reduces mortality and injury to the brain and cochlea in experimental pneumococcal meningitis

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Tissue inhibitor of metalloproteinases‐3 and matrix metalloproteinase‐3 regulate neuronal sensitivity to doxorubicin‐induced apoptosis

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Matrix metalloproteinase expression during experimental autoimmune neuritis

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Tissue inhibitor of metalloproteinases-3 facilitates Fas-mediated neuronal cell death following mild ischemia

Wetzel, M. K., Li, L., Harms, K., Roitbak, T., Ventura, P. B., Rosenberg, G. A., Khokha, R., & Cunningham, L. A. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402246 · Cited by 76

Effective combination of minocycline and interferon-β in a model of multiple sclerosis

Giuliani, F., Fu, S. A., Metz, L. M., & Yong, V. W. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.04.020 · Cited by 71

Endothelin-1-Mediated Signaling in the Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Astrocytes

He, S., Prasanna, G., & Yorio, T. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-1138 · Cited by 68

In pneumococcal meningitis a novel water-soluble inhibitor of matrix metalloproteinases and TNF-α converting enzyme attenuates seizures and injury of the cerebral cortex

Meli, D. N., Loeffler, J. M., Baumann, P., Neumann, U., Buhl, T., Leppert, D., & Leib, S. L. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.01.026 · Cited by 67

Stromelysin-1 and gelatinase A are upregulated before TNF-α in LPS-stimulated neuroinflammation

Mun-Bryce, S., Lukes, A., Wallace, J. A., Lukes-Marx, M., & Rosenberg, G. A. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02303-x · Cited by 67

Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood–brain barrier opening in rodents: Differences in response based on strains and solvents

Rosenberg, G. A., Estrada, E. Y., & Mobashery, S. (2006) · Brain Research · doi:10.1016/j.brainres.2006.11.041 · Cited by 59

Association of matrix metalloproteinase 3 promoter genotype with disease outcome in rheumatoid arthritis

Mattey, D. L., Nixon, N. B., Dawes, P. T., Ollier, W., & Hajeer, A. H. (2004) · Genes and Immunity · doi:10.1038/sj.gene.6364050 · Cited by 48

Tissue Inhibitor of Metalloproteinase-3 Is Associated With Neuronal Death in Reperfusion Injury

Wallace, J. A., Alexander, S. M., Estrada, E. Y., Hines, C., Cunningham, L. A., & Rosenberg, G. A. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000040943.89393.c1 · Cited by 47

Structural and Vasoactive Factors Influencing Intracerebral Arterioles in Cases of Vascular Dementia and Other Cerebrovascular Disease: A Review

Zhang, W. W., Badonic, T., Höög, A., Jiang, M. H., Ma, K. C., Nie, J. X., Olsson, Y., & Sourander, P. (1994) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106714 · Cited by 30

Differential expression of tissue inhibitor of metalloproteinases‐3 in cultured astrocytes and neurons regulates the activation of matrix metalloproteinase‐2

Liu, W., Furuichi, T., Miyake, M., Rosenberg, G. A., & Liu, K. J. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21179 · Cited by 29

Impact of the matrix metalloproteinase MMP-3 on dementia

Helbecque, N., Cottel, D., Hermant, X., & Amouyel, P. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.030 · Cited by 23

Matrix metalloproteinase 3 haplotypes and dementia and Alzheimer's disease

Reitz, C., van Rooij, F. J. A., de Maat, M. P. M., den Heijer, T., Albert Hofman, D., Witteman, J. C. M., & Breteler, M. M. B. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.01.001 · Cited by 11

A? peptides and calcium influence secretion of the amyloid protein precursor from chick sympathetic neurons in culture

Mok, S. S., Clippingdale, A. B., Beyreuther, K. T., Masters, C. L., Barrow, C. J., & Small, D. H. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000815)61:4 · Cited by 10

Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders

Zlokovic, B. V. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3114 · Cited by 2,969

The Science of Stroke: Mechanisms in Search of Treatments

Moskowitz, M. A., Lo, E. H., & Iadecola, C. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.002 · Cited by 1,930

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

Iturria-Medina, Y., Sotero, R. C., Toussaint, P. J., Mateos-Pérez, J. M., Evans, A. C., Initiative, T. A. D. N., Weiner, M. W., Aisen, P., Petersen, R., Jack, C. R., et al. (2016) · Nature Communications · doi:10.1038/ncomms11934 · Cited by 1,202

The yak genome and adaptation to life at high altitude

Qiu, Q., Zhang, G., Ma, T., Qian, W., Wang, J., Ye, Z., Cao, C., Hu, Q., Kim, J., Larkin, D. M., et al. (2012) · Nature Genetics · doi:10.1038/ng.2343 · Cited by 983

The role of macrophage phenotype in vascularization of tissue engineering scaffolds

Spiller, K. L., Anfang, R. R., Spiller, K. J., Ng, J., Nakazawa, K. R., Daulton, J. W., & Vunjak-Novakovic, G. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.02.012 · Cited by 948

Review Matrix

(2009)

Multiple Roles of Metalloproteinases in Neurological Disorders

Yang, Y. R., Hill, J. W., & Rosenberg, G. A. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385504-6.00006-3 · Cited by 62

Implication of matrix metalloproteinases in regulating neuronal disorder

Mukherjee, A. K., & Swarnakar, S. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3752-y · Cited by 27

The Role of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in the Pathophysiology of Neurodegeneration: A Literature Study

Mroczko, B., Groblewska, M., & Barcikowska, M. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130647 · Cited by 61

Matrix Metalloproteinases, New Insights into the Understanding of Neurodegenerative Disorders

Kim, Y.-S., & Joh, T. H. (2012) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.20.2.133 · Cited by 103