Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

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Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline

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Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease

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Immune Response and Pathogen Invasion at the Choroid Plexus in the Onset of Cerebral ToxoplasmosisPreprint

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The Skin and Lewy Body Disease

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Point-of-Injury Treatment with Hydrogel Containing Dexamethasone Improves Cognitive Function and Reduces Secondary Injury Response After TBI

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Blood–Brain Barrier Dysfunction in Neuroinflammation and Autophagy

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Ferula ammoniacum gum aqueous extract exerts anti-inflammatory and antioxidant mechanisms to combat aluminum chloride-induced Alzheimer’s disease in rats: possible involvement of opioid pathways

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Differences in blood levels of neuroligin-derived peptides in a cohort for early detection of Alzheimer’s disease

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Anti-Inflammatory and Antioxidant Effects of ω-3 Polyunsaturated Fatty Acids on Astrocytes and Their Implications for the Blood–Brain Barrier’s Integrity and Function

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Pathogenesis and therapeutic strategies for neuropsychiatric lupus centered on innate immune activation

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Red Complex Pathogens, Periodontal Dysbiosis and Periodontal Therapy in Alzheimer’s Disease and Dementia

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Mitochondrial dysfunction in intracerebral hemorrhage: molecular mechanisms and pathological consequences

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Pericytes as key mediators of microenvironmental signaling crosstalk: implications in vascular diseases and cancer

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Immunopathogenesis of Bacterial Meningitis

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Human immunoglobulin G suppresses the production of matrix metalloproteinase‐9 in peripheral blood mononuclear cells of patients with multiple sclerosis

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Engineering Vascular Niche for Bone Tissue Regeneration

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Neuroinflammation

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Serum levels of matrix metalloproteinase 2 and its inhibitor after tonic-clonic seizures

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Enhanced Age-Dependent Motor Impairment in Males of Drosophila melanogaster Modeling Spinocerebellar Ataxia Type 1 Is Linked to Dysregulation of a Matrix Metalloproteinase

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Gelatinase-Mediated Impairment of Microvascular Beds in Cerebral Ischemia and Reperfusion Injury

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Perivascular Inflammation and Extracellular Matrix Alterations in Blood-Brain Barrier Dysfunction and Epilepsy

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Comparative Investigation of Expression of Glutamatergic and GABAergic Genes in the Rat Hippocampus after Focal Brain Ischemia and Central LPS Administration

Kalinina, T. S., Shishkina, G. T., Lanshakov, D. A., Sukhareva, E. V., Onufriev, M. V., Moiseeva, Y. V., Gulyaeva, N. V., & Дыгало, Н. Н. (2023) · Biochemistry (Moscow) · doi:10.1134/s0006297923040090 · Cited by 1

Collagen XVII in the human brain

Seppänen, A. (2011) · UEF eRepo (University of Eastern Finland) · Cited by 1

Neuroprotective Properties of Carvacrol Against Cadmium-induced Neurotoxicity in Male RatsPreprint

Yıldız, M. O., Çelik, H., Çağlayan, C., Genç, A., Doğan, T., & Satıcı, E. (2021) · Research Square · doi:10.21203/rs.3.rs-1127978/v1 · Cited by 1

Using the natural resistance of motor neuron subpopulations to identify therapeutic targets in amyotrophic lateral sclerosis

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Role of MMPs and TIMP-3 in neuronal death and white matter injury following transient global ischemia.

Walker, E. J. (2009) · UNM’s Digital Repository (University of New Mexico)

Src Family Kinases in Intracerebral Hemorrhage

Liu, D. (2014) · InTech eBooks · doi:10.5772/58488 · Cited by 1

Cerebrospinal fluid biomarkers for differentiating between Alzheimer’s disease and Vascular dementia

Bjerke, M. (2011) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Identifying Vascular Targets to Treat Hemorrhagic Stroke

Lapchak, P. A. (2012) · Springer eBooks · doi:10.1007/978-1-4419-9530-8_2

Workflow for automated quantification of cerebromicrovascular gelatinase activity

Mattila, O. S., Rantanen, V., Saksi, J., Strbian, D., Pikkarainen, T. O., Hautaniemi, S., & Lindsberg, P. J. (2014) · Microvascular Research · doi:10.1016/j.mvr.2014.08.009

Gene Expression Profiling in Human Acute Ischemic Stroke

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Blood-based Biomarkers for Personalised Medicine Applications in Schizophrenia

Tomasik, J. (2014) · EUR Research Repository (Erasmus University Rotterdam)

Proteomic analysis of TRIF interactome and functional characterisation of novel TRIF interacting proteins

Ahmed, S. (2012) · Arrow@dit (Dublin Institute of Technology)

Perinatal Nicotine Exposure and Programming of HIE Sensitive Phenotype in Neonatal Rat Brains

Li, Y. (2013) · The Scholars Repository - LLU (Loma Linda University)

Effect of Maternal Hypoxia on Fetal Development: Programming of HIE Phenotype in Neonatal Rat Brain

Gonzalez‐Rodriguez, P. J. (2014) · The Scholars Repository - LLU (Loma Linda University)

Neuroimaging of White Matter Injury: A Multimodal Approach to Vascular Disease

Rosenberg, G. A., Huisa, B. N., Jalal, F. Y., & Yang, Y. R. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9123-1_4

Cases for 3D Cultures in Drug Discovery

Kisaalita, W. (2010) · CRC Press eBooks · doi:10.1201/ebk1420073492-c12

Chemical Microenvironmental Factors

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Small Vessel Disease of the Brain and Stroke: Association with Clinic and Ambulatory Blood Pressure

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Smart, Injury-Triggered Therapy for Ocular Trauma

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Serum Proteome Changes Following HIV Infection

Haarburger, D. (2010) · Open University of Cape Town (University of Cape Town)

Development and Preclinical Evaulation of Novel Enzyme-targeting Radiotracers for Positron Emission Tomography

Hicks, J. W. (2015) · TSpace (University of Toronto)

Biochemical Characterization of Human Matrix Metalloproteinases and Their Newly Designed Inhibitors Related to Stroke

Cao, Q. (2010)

Identifisering av PAX- og MMP-uttrykk i tre prostatakreft-cellelinjer

Weibust, E. (2009) · NORA - Norwegian Open Research Archives

Blood–Brain Barrier

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Novel role for Gas6 as a positive regulator of myelination

Goudarzi, S. (2016)

Quantification of allosteric communications in matrix metalloprotease-1 on alpha-synuclein aggregates and substrate-dependent virtual screeningPreprint

Kamboj, S., Harms, C., Wright, D., Nash, A., Kumar, L., Klein‐Seetharaman, J., & Sarkar, S. K. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.11.426304

Metalloproteinases genes and their relationship with depression

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Análise do perfil de expressão metaloproteinases (MMPs) e seus inibidores, Timp e Reck, em modelo animal de Doença de Parkinson

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Metaloproteinases de matriz e depressão: influência genética e impacto clínico

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Efeitos de polimorfismos genéticos sobre as concentrações circulantes de metaloproteinases da matriz extracelular em mulheres com migrânea

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Hiperlipidémia okozta neurodegeneratív és vér-agy gát-elváltozások ApoB-100 transzgenikus egerekben

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Animal models for vascular cognitive impairment

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FN1, Collagen, MMP-2, and Lumican Associated with ECM Organization with Multiple Signaling Pathways Dysfunction in Schizophrenia Pathogenesis by Network Biology ApproachesPreprint

Bhuiyan, P., Khan, M. A., Sun, Z., & Qian, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-2070137/v1

Bioresponsive Nanomaterials for CNS Disease

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Data from Hepatitis B–Induced IL8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation

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Expression of matrix metalloproteinase in patients with Alzheimer and mechanism of huangqi granule (astragalus saponins) intervention

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Changes in the Midbrain Neurobiological Responses to Lithium Chloride under Inflammatory Conditions

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Hyperoside Alleviates Macrophage-mediated Neuroinflammation And Oxidative Stress Through Activating PI3K/AKT And Nrf2/HO-1 Signaling Pathway Post Spinal Cord InjuryPreprint

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Comparative investigation of glutamate and GABA gene expression in the hippocampus after focal brain ischemia and central lps administration

Kalinina, T. S., Shishkina, G. T., Lanshakov, D. A., Sukhareva, E. V., Onufriev, M. V., Moiseeva, Y. V., Gulyaeva, N. V., & Дыгало, Н. Н. (2023) · Biochemistry (Moscow) · doi:10.31857/s0320972523040097

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Investigating the Mechanisms involved in Traffic-Generated Air Pollution: Mediated Disruption of the Blood-Brain Barrier in a Wild Type Mouse Model using a Pharmaceutical Intervention Approach

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Morphologic aspects of ethanol-induced changes in the glymphatic system and their effect on nervous system func-tion

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Exploring the Intracellular Functions of Matrix Metalloproteinases in Neuronal and Glial Cells

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Brain large artery dilatation increases the risk for Alzheimer’s disease pathologyPreprint

Simpson, D., Morrone, C. D., Wear, D., Khani, A., Liu, F., Gutierrez, J., & Yu, W. H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.29.672901

Differential effects of aging and Alzheimer’s disease on microemboli clearance in a mouse model of microinfarctionPreprint

Haugen, F. O., & Silasi, G. (2025) · bioRxiv · doi:10.1101/2025.09.30.679680

A Specific Haplotype of the MMP2 Gene Promoter May Increase the Risk of Developing Cerebral Palsy

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Assessment of the change over time of serum matrix metalloproteinases and vascular endothelial growth factor in the acute period of ischemic stroke

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Investigating gender differences in Alzheimer's disease

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Predictive value of matrix metalloproteinase-9 combined with magnetic resonance spectroscopy for delayed cerebral edema after spontaneous intracerebral hemorrhage

Sun, J., & Chen, L. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2025.1681290

Neurovascular large artery dilatation increases the risk for Alzheimer's disease pathology

Simpson, D., Morrone, C. D., Wear, D., Khani, A., Liu, F., Gutierrez, J., & Yu, W. H. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107368

Rôle des ADAM dans le processus physiopathologique de la maladie d'Alzheimer

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In vivo peptide biomarker screening for molecular imaging in eae neuroinflammation

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Métalloprotéases matricielles et maladie d'Alzheimer : étude du rôle de MT1-MMP dans le métabolisme de l'APP/Aß

Py, N. A. (2014) · theses.fr (ABES) · doi:10.70675/76e6e222zc088z470cza0c6za5a23187870c

Etudes de trois métalloprotéases matricielles, MT1-MMP, MT5-MMP et MMP-12 dans l'amyloïdogenèse et les atteintes inflammatoires et vasculaires associées à la maladie d'Alzheimer

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Exploitation d'une biobanque de patients atteints de Trypanosomose Humaine Africaine à Trypanosoma brucei gambiense : recherche et validation de biomarqueurs

Bonnet, J. (2017) · theses.fr (ABES) · doi:10.70675/3064bc89zacb1z4dfez8fe7z289a7fc067d5

Caractérisation d’une famille de protéines intrinsèquement désordonnées, les syndécans

Gondelaud, F. (2020) · theses.fr (ABES) · doi:10.70675/a43fb43bzced0z479cz9a50z4fc7530e838d

Conception, synthèse et évaluation biologique d'inhibiteurs de MT5-MMP : nouvelle cible d'intéret thérapeutique potentiel dans le traitement de la maladie d'Alzheimer

Zipfel, P. (2020) · theses.fr (ABES) · doi:10.70675/a2a691b7zbde1z435ezac62ze79e3310bff0

Pathogenesis and treatment approaches for oxidative stress and neuroinflammation in traumatic brain injury and Alzheimer’s disease

Mishra, T., Sharma, S., Joshi, S., Prajapati, S. K., & Tejaswi (2025) · Neurophysiology · doi:10.1007/s11062-026-10002-8

Machine-Learning Approach to Identify Tissue Inhibitors of Metalloproteinases (TIMP) and Clinical Variables Predicting Executive Phenotypes in HIV-infected Adults

Weng, Y.-W., Tsai, H., Lee, S. S., Hsu, C.-H., & Lin, S.-H. (2026) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofag335

Melatonin as a Pleiotropic Modulator of Mitochondrial Function and Cellular Signaling in Ischemic Brain Injury

Ortiz-Martinez, G., Ortega‐Varela, L. F., Olvera‐Cortés, M. E., Russi-Hernández, M., Anzures-Gutiérrez, S. A., Ramírez-Medina, S., Rosas-Ponce, L. M., & Cervantes-Alfaro, J. M. (2026) · Cells · doi:10.3390/cells15121084

How do pro-inflammatory cytokines alter miRNA profiles in brain endothelial cells? Mechanisms, consequences, and therapeutic strategies for blood-brain barrier protection

Metwally, N. G., Mohamad, S., & Bruchhaus, I. (2026) · Frontiers in Malaria · doi:10.3389/fmala.2026.1849845 · Cited by 1

The role and mechanism of lysyl hydroxylase 1 (LH1) in vascular lesions in hypertensive intracerebral hemorrhage

Xu, H., Guo, Y., Wen, H., Sun, Y., Li, H., & Chen, J. (2026) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x261468909

Blood-Based Biomarkers for Post-Stroke Cognitive Impairment

Pu, J., Guo, W., Li, H., Wang, Z., Mu, T., Xie, F., Chen, J., Cao, J., Zhong, C., Li, H., et al. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48070702

Neuroendocrine-immune perturbations in metabolic disease: pathophysiological mechanisms underlying cognitive impairment

Fraer, A., Saleh, S., Tasabehji, D., Sharma, D. S., & Mokadem, M. (2026) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2026.1857087 · Cited by 1

Unwinding the Neurovascular Unit: The Vascular Extracellular Matrix and Mechanochemical Collagen Functionalization in Vascular Dementia

Ellingson, A., Kalyanasundaram, A., & Orgel, J. P. R. O. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146521 · Cited by 1

Parkinson’s Disease, Microglia, and Extracellular Matrix Remodeling

Serrano‐García, N., Ponce-Juárez, A., Ganado, M., Pérez-Villavicencio, J., & Rubio‐Osornio, M. (2026) · Neuroglia · doi:10.3390/neuroglia7030027

Theranostic Innovative Strategies for Brain Diseases: New Insights on Neurovascular Unit-Associated Pathological Changes in Neurodegenerative Disorders and Aging

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Higher erythrocyte sedimentation rate is associated with accelerated white matter lesion progression

Patel, A. A., Mautong, H., Vallamchetla, S. K., Demirer, M., Middlebrooks, E. H., & Lin, M. (2026) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2026.108725

Aberrant signals in vascular dementia: Pleiotrophin/laminin pathway and glutamate metabolic dysregulation

Zhang, X., Gao, L., Zhang, Q., Sun, K., Qiao, Y., Cheng, R., Li, X., Wang, Q., Bi, H., & Ding, Y. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150508

Mechanisms of Acupuncture on the Neurovascular Unit in Migraine: A Narrative Review

Wang, Y., Zhang, C., Shen, L., Wang, Y., Wang, X., Song, L., Wang, L., Zhang, N., Ma, D., & Xiong, T. (2026) · European Journal of Neurology · doi:10.1111/ene.70730

Oxidative Stress, Neuroinflammation, and Neuroprotection

Jain, V. (2026) · Royal Society of Chemistry eBooks · doi:10.1039/9781837071395-00137

BindingDB Entry 50011295: Matrix Metalloproteinases as New Targets in Alzheimer's Disease: Opportunities and Challenges.

BindingDB (2022) · UC San Diego · doi:10.7270/q2bv7m7k

BindingDB Entry 50047101: Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.

BindingDB (2017) · UC San Diego · doi:10.7270/q25m67mm

BindingDB Entry 50002420: Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease.

BindingDB (2020) · UC San Diego · doi:10.7270/q2sj1p72

BindingDB Entry 50013093: Discovery of 7-aminophenanthridin-6-one as a new scaffold for matrix metalloproteinase inhibitors with multitarget neuroprotective activity.

BindingDB (2022) · UC San Diego · doi:10.7270/q2fx7f6p

Sonic hedgehog-matrix metalloproteinase crosstalk in neurovascular ageing and stroke: a potential mechanistic link

Bindal, P., Kasher, P. R., & Ogawa, S. (2026) · GeroScience · doi:10.1007/s11357-026-02619-8

Dissecting cross-talk between microglia and motoneurons in ALS: signaling events and soluble factors

Barbosa, M. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Review Matrix

(2009)

Multiple Roles of Metalloproteinases in Neurological Disorders

Yang, Y. R., Hill, J. W., & Rosenberg, G. A. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385504-6.00006-3 · Cited by 62

Implication of matrix metalloproteinases in regulating neuronal disorder

Mukherjee, A. K., & Swarnakar, S. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3752-y · Cited by 27

The Role of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in the Pathophysiology of Neurodegeneration: A Literature Study

Mroczko, B., Groblewska, M., & Barcikowska, M. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130647 · Cited by 61

Matrix Metalloproteinases, New Insights into the Understanding of Neurodegenerative Disorders

Kim, Y.-S., & Joh, T. H. (2012) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.20.2.133 · Cited by 103