Cited by 596Stroke Rehabilitation and RecoveryNeurogenesis and neuroplasticity mechanismsAcute Ischemic Stroke Management

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Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

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Zhang, Zheng Gang, Chopp, Michael·2009·The Lancet Neurology

DOI 10.1016/s1474-4422(09)70061-4PMC PMC2727708

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Abstract

Restorative cell-based and pharmacological therapies for experimental stroke substantially improve functional outcome. These therapies target several types of parenchymal cells (including neural stem cells, cerebral endothelial cells, astrocytes, oligodendrocytes, and neurons), leading to enhancement of endogenous neurogenesis, angiogenesis, axonal sprouting, and synaptogenesis in the ischaemic brain. Interaction between these restorative events probably underpins the improvement in functional outcome. This Review provides examples of cell-based and pharmacological restorative treatments for stroke that stimulate brain plasticity and functional recovery. The molecular pathways activated by these therapies, which induce remodelling of the injured brain via angiogenesis, neurogenesis, and axonal and dendritic plasticity, are discussed. The ease of treating intact brain tissue to stimulate functional benefit in restorative therapy compared with treating injured brain tissue in neuroprotective therapy might more readily help with translation of restorative therapy from the laboratory to the clinic.

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Tratamento com minociclina e transplante intraestriatal de células mononucleares da medula óssea após acidente vascular experimental encefálico
da Silva, M. C. (2011) · Americanae (AECID Library)

Authors: Zhang, Z. G., & Chopp, M.
Affiliations: Henry Ford Health (US)
Oakland University (US)
Corresponding author: Chopp, Michael
ORCID: Zhang, Zheng Gang
Chopp, Michael
Venue: The Lancet Neurology
Publisher: Elsevier BV
Published: 2009-05
Volume: 8
Issue: 5
Pages: 491-500
ISSN: 1474-4422 (ISSN-L)
DOI: 10.1016/s1474-4422(09)70061-4
PMC: PMC2727708
OpenAlex: W2121567769
Cited by: 596
References: 152
Citations by year: 2026: 8 · 2025: 16 · 2024: 19 · 2023: 26 · 2022: 20 · 2021: 26 · 2020: 35 · 2019: 32 · 2018: 43 · 2017: 34 · 2016: 41 · 2015: 49 · 2014: 50 · 2013: 63 · 2012: 53
FWCI: 5.86
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL064766, R01HL64766)
National Institute of Neurological Disorders and Stroke (P01 NS23392, P01NS42345, P50NS023393, P01NS042345)
Topics: Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords: stroke, cell therapy, pharmacotherapy, neurogenesis, angiogenesis, axonal sprouting, synaptogenesis, neuroplasticity, functional recovery, neural stem cells, brain endothelial cells, astrocytes, oligodendrocytes, neuroprotection
MeSH terms: Animals, Astrocytes, Axons, Brain, Clinical Trials as Topic, Humans, Neuronal Plasticity, Oligodendroglia, Neuroprotective Agents, Neovascularization, Physiologic, Recovery of Function, Stroke, Neurogenesis

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Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

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