Cited by 596Stroke Rehabilitation and RecoveryNeurogenesis and neuroplasticity mechanismsAcute Ischemic Stroke Management

The DOI matches its Crossref record; 149 of the 152 references it cites were found in a registry or an index.

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

Open access

Zhang, Zheng Gang, Chopp, Michael·2009·The Lancet Neurology

DOI 10.1016/s1474-4422(09)70061-4PMC PMC2727708

Open this paper in CoChat — free account

Abstract

Restorative cell-based and pharmacological therapies for experimental stroke substantially improve functional outcome. These therapies target several types of parenchymal cells (including neural stem cells, cerebral endothelial cells, astrocytes, oligodendrocytes, and neurons), leading to enhancement of endogenous neurogenesis, angiogenesis, axonal sprouting, and synaptogenesis in the ischaemic brain. Interaction between these restorative events probably underpins the improvement in functional outcome. This Review provides examples of cell-based and pharmacological restorative treatments for stroke that stimulate brain plasticity and functional recovery. The molecular pathways activated by these therapies, which induce remodelling of the injured brain via angiogenesis, neurogenesis, and axonal and dendritic plasticity, are discussed. The ease of treating intact brain tissue to stimulate functional benefit in restorative therapy compared with treating injured brain tissue in neuroprotective therapy might more readily help with translation of restorative therapy from the laboratory to the clinic.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/s1474-4422(09)70061-4

Cites

149 of 149 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Tissue Plasminogen Activator for Acute Ischemic Stroke
(1995) · New England Journal of Medicine · doi:10.1056/nejm199512143332401 · Cited by 11,654
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
Hacke, W., Kaste, M., Bluhmki, E., Brozman, M., Dávalos, A., Guidetti, D., Larrue, V., Lees, K. R., Medeghri, Z., Machnig, T., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0804656 · Cited by 6,684
Mechanisms of angiogenesis
Risau, W. (1997) · Nature · doi:10.1038/386671a0 · Cited by 5,727
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,628
Mechanism of activation of protein kinase B by insulin and IGF‐1.
Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 3,014
Neuronal replacement from endogenous precursors in the adult brain after stroke
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799
Endovascular Stroke Therapy Results Improve over Time: The ‘Learning Curve' at a New Comprehensive Stoke Center
Benardete, E. A., & Nair, A. K. (2015) · Cerebrovascular Diseases Extra · doi:10.1159/000370060 · Cited by 2,559
The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130
Fiber tracking: principles and strategies – a technical review
Mori, S., & van Zijl, P. C. M. (2002) · NMR in Biomedicine · doi:10.1002/nbm.781 · Cited by 2,019

Show all 152 references

Research works printed but not linked: 1

Ding, 2008, Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats, J Cereb Blood Flow Metab, 28, 1440, 10.1038/jcbfm.2008.33 · DOI · Paper page

Sorted by citations

The Science of Stroke: Mechanisms in Search of Treatments
Moskowitz, M. A., Lo, E. H., & Iadecola, C. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.002 · Cited by 1,930
Animal models of traumatic brain injury
Xiong, Y., Mahmood, A., & Chopp, M. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3407 · Cited by 1,456
Self-citation
Astrocyte reactivity and reactive astrogliosis: costs and benefits
Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934
Ischemia/Reperfusion
Kalogeris, T. J., Baines, C. P., Krenz, M., & Korthuis, R. J. (2016) · Comprehensive physiology · doi:10.1002/cphy.c160006 · Cited by 856
Stem cells in human neurodegenerative disorders — time for clinical translation?
Lindvall, O., & Kokaia, Z. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40543 · Cited by 629
Glial Cells: Role of the Immune Response in Ischemic Stroke
Xu, S., Lü, J., Shao, A., Zhang, J. H., & Zhang, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00294 · Cited by 626
Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke
Liu, Z., & Chopp, M. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.008 · Cited by 610
Self-citation
Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury
Zhang, Z. G., Buller, B., & Chopp, M. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0126-4 · Cited by 503
Self-citation
Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke
Kang, L., Yu, H., Yang, X., Zhu, Y., Bai, X., Wang, R., Cao, Y., Xu, H., Luo, H., Lu, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16191-y · Cited by 554
Blood–brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke
Khatri, R., McKinney, A. M., Swenson, B., & Janardhan, V. (2012) · Neurology · doi:10.1212/wnl.0b013e3182697e70 · Cited by 478
Pathophysiology of Blood–Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery
Bernardo-Castro, S., Sousa, J. A., Brás, A., Cecília, C., Rodrigues, B., Almendra, L., Machado, C., Santo, G., da Silva, F. A. D. A., Ferreira, L., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.594672 · Cited by 395
Astrocytes: Role and Functions in Brain Pathologies
Siracusa, R., Fusco, R., & Cuzzocrea, S. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01114 · Cited by 361
Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation
Hermann, D. M., & Chopp, M. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70039-x · Cited by 333
Self-citation
Coupling of neurogenesis and angiogenesis after ischemic stroke
Ruan, L., Wang, B. Z., Zhuge, Q., & Jin, K. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.042 · Cited by 307
Exosomes Derived from Mesenchymal Stromal Cells Promote Axonal Growth of Cortical Neurons
Zhang, Y., Chopp, M., Liu, X., Katakowski, M., Wang, X., Tian, X., Wu, D., & Zhang, Z. G. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9851-0 · Cited by 308
Self-citation
Exosomes/miRNAs as mediating cell-based therapy of stroke
Xin, H., Li, Y., & Chopp, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00377 · Cited by 307
Self-citation
Angiogenesis, neurogenesis and brain recovery of function following injury.
Xiong, Y., Mahmood, A., & Chopp, M. (2010) · PubMed · Cited by 297
Self-citation
Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: Applications for natural compounds from medicinal herbs
Zhu, T., Wang, L., Wang, L.-P., & Wan, Q. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112719 · Cited by 302
Reactive gliosis in the pathogenesis of CNS diseases
Pekny, M., & Pekna, M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.014 · Cited by 289
Cell cycle control of mammalian neural stem cells: putting a speed limit on G1
Salomoni, P., & Calegari, F. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.01.006 · Cited by 286
The Role of Astrocytes in Multiple Sclerosis Progression
Correale, J. D., & Farez, M. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00180 · Cited by 270
Ageing and neurodegenerative diseases
Hung, C.-W., Chen, Y., Hsieh, W.-L., Chiou, S., & Kao, C.-L. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.006 · Cited by 257
Amine-modified single-walled carbon nanotubes protect neurons from injury in a rat stroke model
Lee, H. J., Park, J., Yoon, O. J., Kim, H., Lee, D., Kim, D. H., Lee, W. B., Lee, N., Bonventre, J. V., & Kim, S. S. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.281 · Cited by 226
Intra-Arterial Bone Marrow Mononuclear Cells in Ischemic Stroke
Moniche, F., González, A., González-Marcos, J. R., Carmona, M., Piñero, P., Espigado, I., García-Solís, D., Cayuela, A., Montaner, J., Boada, C., et al. (2012) · Stroke · doi:10.1161/strokeaha.112.659409 · Cited by 225
Exosomes in stroke pathogenesis and therapy
Zhang, Z. G., & Chopp, M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81133 · Cited by 228
Self-citation
Angiogenesis, Neurogenesis and Neuroplasticity in Ischemic Stroke
Font, M. À., Arboix, A., & Krupiński, J. (2010) · Current Cardiology Reviews · doi:10.2174/157340310791658802 · Cited by 222
The Size of Mesenchymal Stem Cells is a Significant Cause of Vascular Obstructions and Stroke
Ge, J., Guo, L., Wang, S., Zhang, Y., Cai, T., Zhao, R. C. H., & Wu, Y. (2014) · Stem Cell Reviews and Reports · doi:10.1007/s12015-013-9492-x · Cited by 218
Mesenchymal Stem Cell Transplantation Attenuates Brain Injury After Neonatal Stroke
van Velthoven, C. T. J., Sheldon, R. A., Kavelaars, A., Derugin, N., Vexler, Z. S., Willemen, H. L. D. M., Maas, M., Heijnen, C. J., & Ferriero, D. M. (2013) · Stroke · doi:10.1161/strokeaha.111.000326 · Cited by 203
Cerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome after stroke
Zhang, C., Chopp, M., Cui, Y., Wang, L., Zhang, R., Zhang, L., Lü, M., Szalad, A., Doppler, E., Hitzl, M., et al. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22495 · Cited by 194
Self-citation
Neuroprotection in stroke: the importance of collaboration and reproducibility
Neuhaus, A. A., Couch, Y., Hadley, G., & Buchan, A. M. (2017) · Brain · doi:10.1093/brain/awx126 · Cited by 200
Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery
Hayakawa, K., Pham, L.-D. D., Katušić, Z. S., Arai, K., & Lo, E. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121146109 · Cited by 190
In Vivo Inhibition of miR-155 Promotes Recovery after Experimental Mouse Stroke
Caballero‐Garrido, E., Peña-Philippides, J. C., Lordkipanidze, T. G., Bragin, D. E., Yang, Y., Erhardt, E. B., & Roitbak, T. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1641-15.2015 · Cited by 182
Repeated Mesenchymal Stem Cell Treatment after Neonatal Hypoxia-Ischemia Has Distinct Effects on Formation and Maturation of New Neurons and Oligodendrocytes Leading to Restoration of Damage, Corticospinal Motor Tract Activity, and Sensorimotor Function
van Velthoven, C. T. J., Kavelaars, A., van Bel, F., & Heijnen, C. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1835-10.2010 · Cited by 182
Cell based therapies for ischemic stroke: From basic science to bedside
Liu, X., Ye, R., Yan, T., Yu, S. P., Wei, L., Xu, G., Fan, X., Jiang, Y., Stetler, R. A., Liu, C., et al. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.007 · Cited by 179
Stem Cell Research in Stroke
Lindvall, O., & Kokaia, Z. (2011) · Stroke · doi:10.1161/strokeaha.110.599654 · Cited by 178
Human Adult Dental Pulp Stem Cells Enhance Poststroke Functional Recovery Through Non-Neural Replacement Mechanisms
Leong, W. K., Henshall, T. L., Arthur, A., Kremer, K. L., Lewis, M. D., Helps, S. C., Field, J., Hamilton‐Bruce, M. A., Warming, S., Manavis, J., et al. (2012) · Stem Cells Translational Medicine · doi:10.5966/sctm.2011-0039 · Cited by 173
Neurorestorative Therapy for Stroke
Chen, J., Venkat, P., Zacharek, A., & Chopp, M. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00382 · Cited by 169
Self-citation
Neuronal Production of Lipocalin-2 as a Help-Me Signal for Glial Activation
Xing, C., Wang, X., Cheng, C., Montaner, J., Mandeville, E. T., Leung, W., van Leyen, K., Lok, J. M., Wang, X., & Lo, E. H. (2014) · Stroke · doi:10.1161/strokeaha.114.005733 · Cited by 162
Exosomes and stem cells in degenerative disease diagnosis and therapy
Chang, Y.-H., Wu, K.-C., Harn, H.-J., Lin, S.-Z., & Ding, D.-C. (2018) · Cell Transplantation · doi:10.1177/0963689717723636 · Cited by 159
Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke
Xia, Y., Ling, X., Hu, G., Zhu, Q., Zhang, J., Li, Q., Zhao, B., Wang, Y., & Deng, Z. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01834-0 · Cited by 157
Mesenchymal stem cells as a treatment for neonatal ischemic brain damage
van Velthoven, C. T. J., Kavelaars, A., & Heijnen, C. J. (2012) · Pediatric Research · doi:10.1038/pr.2011.64 · Cited by 157
Stem Cells as an Emerging Paradigm in Stroke 3
Savitz, S. I., Cramer, S. C., Wechsler, L. R., Aronowski, J. A., Boltze, J., Borlongan, C. V., Case, C., Chase, T. N., Chopp, M., Carmichael, S. T., et al. (2013) · Stroke · doi:10.1161/strokeaha.113.003379 · Cited by 157
Self-citation
Transplanted Late Outgrowth Endothelial Progenitor Cells as Cell Therapy Product for Stroke
Moubarik, C., Guillet, B. A., Bennis, Y., Codaccioni, J.-L., Piercecchi‐Marti, M., Sabatier, F., Pellegrini, L., Dou, L., Foucault‐Bertaud, A., Velly, L. J., et al. (2010) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9157-y · Cited by 151
Angiogenesis-regulating microRNAs and Ischemic Stroke
Yin, K., Hamblin, M., & Chen, Y. (2015) · Current Vascular Pharmacology · doi:10.2174/15701611113119990016 · Cited by 153
Oligodendrogenesis after cerebral ischemia
Zhang, R., Chopp, M., & Zhang, Z. G. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00201 · Cited by 159
Self-citation
Endothelium-Targeted Deletion of microRNA-15a/16-1 Promotes Poststroke Angiogenesis and Improves Long-Term Neurological Recovery
Sun, P., Zhang, K., Hassan, S., Zhang, X., Tang, X., Pu, H., Stetler, R. A., Chen, J., & Yin, K. (2020) · Circulation Research · doi:10.1161/circresaha.119.315886 · Cited by 149
Effects of vascular endothelial growth factor in ischemic stroke
Ma, Y., Zechariah, A., Qu, Y., & Hermann, D. M. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23088 · Cited by 147
Reactive astrogliosis in stroke: Contributions of astrocytes to recovery of neurological function
Sims, N. R., & Yew, W. P. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2016.12.016 · Cited by 149
Potential of Stem Cell-Based Therapy for Ischemic Stroke
Marei, H. E. S., Hasan, A., Rizzi, R., Althani, A., Afifi, N. M., Cenciarelli, C., Caceci, T., & Shuaib, A. M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00034 · Cited by 140
Toward Cell Therapy Using Placenta-Derived Cells: Disease Mechanisms, Cell Biology, Preclinical Studies, and Regulatory Aspects at the Round Table
Parolini, O., Alviano, F., Bergwerf, I., Boraschi, D., Bari, C. D., Waele, P. D., Dominici, M., Evangelista, M., Falk, W., Hennerbichler, S., et al. (2009) · Stem Cells and Development · doi:10.1089/scd.2009.0404 · Cited by 135
Vascular Endothelial Cell-specific MicroRNA-15a Inhibits Angiogenesis in Hindlimb Ischemia
Yin, K., Olsen, K. F., Hamblin, M., Zhang, J., Schwendeman, S. P., & Chen, Y. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.364414 · Cited by 136
Motor System Reorganization After Stroke: Stimulating and Training Toward Perfection
Jones, T. A., & Adkins, D. L. (2015) · Physiology · doi:10.1152/physiol.00014.2015 · Cited by 142
Cellular Mechanisms of Neurovascular Damage and Repair After Stroke
Arai, K., Lok, J. M., Guo, S., Hayakawa, K., Xing, C., & Lo, E. H. (2011) · Journal of Child Neurology · doi:10.1177/0883073811408610 · Cited by 127
Local Hemodynamics Dictate Long-Term Dendritic Plasticity in Peri-Infarct Cortex
Mostany, R., Chowdhury, T. G., Johnston, D. G., Portonovo, S. A., Carmichael, S. T., & Portera‐Cailliau, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3908-10.2010 · Cited by 127
Acupuncture for neurogenesis in experimental ischemic stroke: a systematic review and meta-analysis
Lü, L., Zhang, X., Zhong, L. L. D., Chen, Z., Li, Y., Zheng, G., & Bian, Z. (2016) · Scientific Reports · doi:10.1038/srep19521 · Cited by 122
Non-Coding RNA in Acute Ischemic Stroke: Mechanisms, Biomarkers and Therapeutic Targets
Wang, S., Liu, Z., & Shi, Z. (2018) · Cell Transplantation · doi:10.1177/0963689718806818 · Cited by 123
Memantine Enhances Recovery From Stroke
López-Valdés, H. E., Clarkson, A. N., Ao, Y., Charles, A. C., Carmichael, S. T., Sofroniew, M. V., & Brennan, K. C. (2014) · Stroke · doi:10.1161/strokeaha.113.004476 · Cited by 124
Electroacupuncture Promotes Post-Stroke Functional Recovery via Enhancing Endogenous Neurogenesis in Mouse Focal Cerebral Ischemia
Kim, Y. R., Kim, H. N., Ahn, S., Choi, Y. H., Shin, H. K., & Choi, B. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090000 · Cited by 120
Treatments to Promote Neural Repair after Stroke
Cramer, S. C. (2018) · Journal of Stroke · doi:10.5853/jos.2017.02796 · Cited by 133
Sleep Disturbance Impairs Stroke Recovery in the Rat
Zunzunegui, C., Gao, B., Cam, E., Hodor, A., & Bassetti, C. L. (2011) · SLEEP · doi:10.5665/sleep.1252 · Cited by 119
Vascularization Pattern After Ischemic Stroke is Different in Control Versus Diabetic Rats
Prakash, R., Li, W., Qu, Z. X., Johnson, M., Fagan, S. C., & Ergul, A. (2013) · Stroke · doi:10.1161/strokeaha.113.001660 · Cited by 118
Delayed Administration of Human Umbilical Tissue-Derived Cells Improved Neurological Functional Recovery in a Rodent Model of Focal Ischemia
Zhang, L., Li, Y., Zhang, C., Chopp, M., Gosiewska, A., & Hong, K. (2011) · Stroke · doi:10.1161/strokeaha.110.593129 · Cited by 118
Self-citation
Finding an optimal rehabilitation paradigm after stroke: enhancing fiber growth and training of the brain at the right moment
Wahl, A.-S., & Schwab, M. E. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00381 · Cited by 122
RETRACTED: ADAMTS13 controls vascular remodeling by modifying VWF reactivity during stroke recovery
Xu, H., Cao, Y., Yang, X., Cai, P., Kang, L., Zhu, X., Luo, H., Lu, L., Wei, L., Bai, X., et al. (2017) · Blood · doi:10.1182/blood-2016-10-747089 · Cited by 112
Retracted
Delayed administration of erythropoietin reducing hippocampal cell loss, enhancing angiogenesis and neurogenesis, and improving functional outcome following traumatic brain injury in rats: comparison of treatment with single and triple dose
Xiong, Y., Mahmood, A., Meng, Y., Zhang, Y., Qu, C., Schallert, T. J., & Chopp, M. (2009) · Journal of neurosurgery · doi:10.3171/2009.9.jns09844 · Cited by 111
Self-citation
Growth factors in ischemic stroke
Lanfranconi, S., Locatelli, F., Corti, S. P., Candelise, L., Comi, G. P., Baron, P., Strazzer, S., Bresolin, N., & Bersano, A. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00987.x · Cited by 111
Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury
Pham, L. D., Hayakawa, K., Seo, J. H., Nguyen, M., Som, A. T., Lee, B. J., Guo, S., Kim, K., Lo, E. H., & Arai, K. (2012) · Glia · doi:10.1002/glia.22320 · Cited by 108
Intra-arterial Cell Transplantation Provides Timing-Dependent Cell Distribution and Functional Recovery After Stroke
Ishizaka, S., Horie, N., Satoh, K., Fukuda, Y., Nishida, N., & Nagata, I. (2013) · Stroke · doi:10.1161/strokeaha.112.677328 · Cited by 106
Non-coding RNAs in cerebral endothelial pathophysiology: Emerging roles in stroke
Yin, K., Hamblin, M., & Chen, Y. E. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.03.013 · Cited by 106
Intraarterial route increases the risk of cerebral lesions after mesenchymal cell administration in animal model of ischemia
Argibay, B., Trekker, J., Himmelreich, U., Beiras, A., Topete, A., Taboada, P., Pérez‐Mato, M., Prado, A. V., Iglesias‐Rey, R., Rivas, J. M., et al. (2017) · Scientific Reports · doi:10.1038/srep40758 · Cited by 105
Biphasic Mechanisms of Neurovascular Unit Injury and Protection in CNS Diseases
Maki, T., Hayakawa, K., Pham, L. D., Xing, C., Lo, E. H., & Arai, K. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311312030004 · Cited by 103
Perturbed cellular response to brain injury during aging
Popa‐Wagner, A., Buga, A.-M., & Kokaia, Z. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.10.008 · Cited by 100
Endothelial Progenitor Cells: Therapeutic Perspective for Ischemic Stroke
Zhao, Y., Yuan, B., Chen, J., Feng, D., Zhao, B., Qin, C., & Chen, Y. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12040 · Cited by 100
The lncRNA Malat1 functions as a ceRNA to contribute to berberine-mediated inhibition of HMGB1 by sponging miR-181c-5p in poststroke inflammation
Cao, D.-W., Liu, M., Duan, R., Tao, Y.-F., Zhou, J., Fang, W., Zhu, J., Niu, L., & Sun, J. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0284-y · Cited by 102
Microneedle-mediated vascular endothelial growth factor delivery promotes angiogenesis and functional recovery after stroke
Liu, Y., Long, L., Zhang, F., Hu, X., Zhang, J., Hu, C., Wang, Y., & Xu, J. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.08.057 · Cited by 102
Omega-3 polyunsaturated fatty acids enhance cerebral angiogenesis and provide long-term protection after stroke
Wang, J., Shi, Y., Zhang, L., Zhang, F., Hu, X., Zhang, W., Leak, R. K., Gao, Y., Chen, L., & Chen, J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.04.014 · Cited by 101
Transplantation of human neural stem cells restores cognition in an immunodeficient rodent model of traumatic brain injury
Haus, D. L., López-Velázquez, L., Gold, E. M., Cunningham, K. M., Perez, H. D., Anderson, A. J., & Cummings, B. J. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.04.008 · Cited by 99
Testosterone enhances functional recovery after stroke through promotion of antioxidant defenses, BDNF levels and neurogenesis in male rats
Fanaei, H., Karimian, S. M., Sadeghipour, H. R., Hassanzade, G., Kasaeian, A., Attari, F., Khayat, S., Ramezani, V., & Javadimehr, M. (2014) · Brain Research · doi:10.1016/j.brainres.2014.02.028 · Cited by 100
The rodent endovascular puncture model of subarachnoid hemorrhage: mechanisms of brain damage and therapeutic strategies
Kooijman, E., Nijboer, C. H. A., van Velthoven, C. T. J., Kavelaars, A., Kesecioğlu, J., & Heijnen, C. J. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-2 · Cited by 99
Diabetes Mellitus Impairs Cognitive Function in Middle-Aged Rats and Neurological Recovery in Middle-Aged Rats After Stroke
Zhang, L., Chopp, M., Zhang, Y., Xiong, Y., Li, C., Sadry, N., Rhaleb, I. A., Lü, M., & Zhang, Z. G. (2016) · Stroke · doi:10.1161/strokeaha.115.012578 · Cited by 98
Self-citation
Role of neural precursor cells in promoting repair following stroke
Dibajnia, P., & Morshead, C. M. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.107 · Cited by 98
Diabetes Impairs Cortical Plasticity and Functional Recovery Following Ischemic Stroke
Sweetnam, D., Holmes, A. S., Tennant, K. A., Zamani, A., Walle, M., Jones, P., Wong, C., & Brown, C. E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5075-11.2012 · Cited by 91
Ascl1 lineage cells contribute to ischemia-induced neurogenesis and oligodendrogenesis
Zhang, R. L., Chopp, M., Roberts, C., Jia, L., Wei, M., Lu, M., Wang, X., Pourabdollah, S., & Zhang, Z. G. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.134 · Cited by 91
Self-citation
Experimental Models of Brain Ischemia: A Review of Techniques, Magnetic Resonance Imaging, and Investigational Cell-Based Therapies
Canazza, A., Minati, L., Boffano, C., Parati, E. A., & Binks, S. N. M. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00019 · Cited by 92
Adult Human Neurogenesis: From Microscopy to Magnetic Resonance Imaging
Sierra, A., Encinas, J. M., & Maletić‐Savatić, M. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00047 · Cited by 95
NAMPT as a Therapeutic Target against Stroke
Wang, P., & Miao, C. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.08.012 · Cited by 87
Progesterone Increases Circulating Endothelial Progenitor Cells and Induces Neural Regeneration after Traumatic Brain Injury in Aged Rats
Li, Z., Wang, B., Kan, Z., Zhang, B., Yang, Z. R., Chen, J., Wang, D., Wei, H., Zhang, J.-N., & Jiang, R. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2011.1807 · Cited by 88
Multiparametric, Longitudinal Optical Coherence Tomography Imaging Reveals Acute Injury and Chronic Recovery in Experimental Ischemic Stroke
Srinivasan, V. J., Mandeville, E. T., Can, A., Blasi, F., Climov, M., Daneshmand, A., Lee, J. H., Yu, E. S., Radhakrishnan, H., Lo, E. H., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071478 · Cited by 87
Poststroke Sonic Hedgehog Agonist Treatment Improves Functional Recovery by Enhancing Neurogenesis and Angiogenesis
Jin, Y., Barnett, A., Zhang, Y., Yu, X., & Luo, Y. (2017) · Stroke · doi:10.1161/strokeaha.117.016650 · Cited by 86
Dual-Modal Imaging-Guided Precise Tracking of Bioorthogonally Labeled Mesenchymal Stem Cells in Mouse Brain Stroke
Lim, S., Yoon, H. Y., Jang, H. J., Song, S., Kim, W., Park, J., Lee, K. E., Jeon, S., Lee, S., Lim, D., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b02173 · Cited by 85
Pretreatment with statins improves early outcome in patients with first-ever ischaemic stroke: a pleiotropic effect of statins or a beneficial effect of hypercholesterolemia?
Arboix, A., García‐Eroles, L., Oliveres, M., Targa, C., Balcells, M., & Massons, J. (2010) · BMC Neurology · doi:10.1186/1471-2377-10-47 · Cited by 83
Exosomes derived from bone marrow mesenchymal stem cells overexpressing microRNA-25 protect spinal cords against transient ischemia
Zhao, L., Jiang, X., Shi, J., Gao, S., Zhu, Y., Gu, T., & Shi, E. (2018) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2018.07.095 · Cited by 86
Remodeling of Cerebral Microcirculation after Ischemia-Reperfusion
Lapi, D., & Colantuoni, A. (2015) · Journal of Vascular Research · doi:10.1159/000381096 · Cited by 82
Lentivirus‐Mediated Overexpression of MicroRNA‐210 Improves Long‐Term Outcomes after Focal Cerebral Ischemia in Mice
Zeng, L., He, X., Liu, J., Zheng, C., Wang, Y., & Yang, G. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12589 · Cited by 82
CDP-choline treatment induces brain plasticity markers expression in experimental animal stroke
Gutiérrez‐Fernández, M., Rodríguez‐Frutos, B., Fuentes, B., Vallejo‐Cremades, M. T., Álvarez-Grech, J., Expósito-Alcaide, M., & Díez‐Tejedor, E. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.12.015 · Cited by 80
Endogenous CNTF mediates stroke-induced adult CNS neurogenesis in mice
Kang, S. S., Keasey, M. P., Arnold, S. A., Reid, R., Geralds, J., & Hagg, T. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.08.020 · Cited by 83
Dendritic structural plasticity
Tavosanis, G. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20951 · Cited by 89
Stem cell transplantation for ischemic stroke
Boncoraglio, G. B., Bersano, A., Candelise, L., Reynolds, B. A., & Parati, E. A. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007231.pub2 · Cited by 81
Therapeutic Potential of Human Induced Pluripotent Stem Cells in Experimental Stroke
Chang, D.-J., Lee, N., Park, I., Choi, C., Jeon, I., Kwon, J., Oh, S.-H., Shin, D. A., Tae, J., Lee, D. R., et al. (2013) · Cell Transplantation · doi:10.3727/096368912x657314 · Cited by 80
Transduction of Neural Precursor Cells with TAT-Heat Shock Protein 70 Chaperone: Therapeutic Potential Against Ischemic Stroke after Intrastriatal and Systemic Transplantation
Doeppner, T. R., Ewert, T. A. S., Tönges, L., Herz, J., Zechariah, A., ElAli, A., Ludwig, A., Giebel, B., Nagel, F., Dietz, G. P. H., et al. (2012) · Stem Cells · doi:10.1002/stem.1098 · Cited by 81

Authors: Zhang, Z. G., & Chopp, M.
Affiliations: Henry Ford Health (US)
Oakland University (US)
Corresponding author: Chopp, Michael
ORCID: Zhang, Zheng Gang
Chopp, Michael
Venue: The Lancet Neurology
Publisher: Elsevier BV
Published: 2009-05
Volume: 8
Issue: 5
Pages: 491-500
ISSN: 1474-4422 (ISSN-L)
DOI: 10.1016/s1474-4422(09)70061-4
PMC: PMC2727708
OpenAlex: W2121567769
Cited by: 596
References: 152
Citations by year: 2026: 8 · 2025: 16 · 2024: 19 · 2023: 26 · 2022: 20 · 2021: 26 · 2020: 35 · 2019: 32 · 2018: 43 · 2017: 34 · 2016: 41 · 2015: 49 · 2014: 50 · 2013: 63 · 2012: 53
FWCI: 5.86
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL064766, R01HL64766)
National Institute of Neurological Disorders and Stroke (P01 NS23392, P01NS42345, P50NS023393, P01NS042345)
Topics: Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords: stroke, cell therapy, pharmacotherapy, neurogenesis, angiogenesis, axonal sprouting, synaptogenesis, neuroplasticity, functional recovery, neural stem cells, brain endothelial cells, astrocytes, oligodendrocytes, neuroprotection
MeSH terms: Animals, Astrocytes, Axons, Brain, Clinical Trials as Topic, Humans, Neuronal Plasticity, Oligodendroglia, Neuroprotective Agents, Neovascularization, Physiologic, Recovery of Function, Stroke, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks