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Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic
Open accessAbstract
Restorative cell-based and pharmacological therapies for experimental stroke substantially improve functional outcome. These therapies target several types of parenchymal cells (including neural stem cells, cerebral endothelial cells, astrocytes, oligodendrocytes, and neurons), leading to enhancement of endogenous neurogenesis, angiogenesis, axonal sprouting, and synaptogenesis in the ischaemic brain. Interaction between these restorative events probably underpins the improvement in functional outcome. This Review provides examples of cell-based and pharmacological restorative treatments for stroke that stimulate brain plasticity and functional recovery. The molecular pathways activated by these therapies, which induce remodelling of the injured brain via angiogenesis, neurogenesis, and axonal and dendritic plasticity, are discussed. The ease of treating intact brain tissue to stimulate functional benefit in restorative therapy compared with treating injured brain tissue in neuroprotective therapy might more readily help with translation of restorative therapy from the laboratory to the clinic.
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“Additionally, brain capillaries sprout, and glial cells are activated to create a favourable cerebral environment for neuronal growth and plasticity.3,4”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [3]
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“The promotion of brain remodelling and plasticity is not limited to a sharp and well defined therapeutic window.1–3”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [3]
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Citations
Cites
Tissue Plasminogen Activator for Acute Ischemic Stroke
(1995) · New England Journal of Medicine · doi:10.1056/nejm199512143332401 · Cited by 11,654
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
Hacke, W., Kaste, M., Bluhmki, E., Brozman, M., Dávalos, A., Guidetti, D., Larrue, V., Lees, K. R., Medeghri, Z., Machnig, T., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0804656 · Cited by 6,684
Risau, W. (1997) · Nature · doi:10.1038/386671a0 · Cited by 5,727
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,628
Mechanism of activation of protein kinase B by insulin and IGF‐1.
Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 3,014
Neuronal replacement from endogenous precursors in the adult brain after stroke
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799
Benardete, E. A., & Nair, A. K. (2015) · Cerebrovascular Diseases Extra · doi:10.1159/000370060 · Cited by 2,559
The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130
Fiber tracking: principles and strategies – a technical review
Mori, S., & van Zijl, P. C. M. (2002) · NMR in Biomedicine · doi:10.1002/nbm.781 · Cited by 2,019
Research works printed but not linked: 1
- Ding, 2008, Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats, J Cereb Blood Flow Metab, 28, 1440, 10.1038/jcbfm.2008.33 · DOI · Paper page
Cited by
Sorted by citations
Items 101–200 of 594
Promoting brain remodeling to aid in stroke recovery
Zhang, Z. G., & Chopp, M. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.07.005 · Cited by 78
Self-citationLi, W., Ling, S., Yang, Y., Hu, Z., Davies, H., & Fang, M. (2014) · PubMed · Cited by 79
Neuro-nanotechnology: diagnostic and therapeutic nano-based strategies in applied neuroscience
Shabani, L., Abbasi, M., Azarnew, Z., Amani, A. M., & Vaez, A. (2023) · BioMedical Engineering OnLine · doi:10.1186/s12938-022-01062-y · Cited by 82
Opportunities and Challenges: Stem Cell‐Based Therapy for the Treatment of Ischemic Stroke
Tang, Y., Ma, Y., Zhang, Z., Wang, Y., & Yang, G. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12386 · Cited by 77
Self-citationThe role of astrocytes in mediating exogenous cell‐based restorative therapy for stroke
Li, Y., Liu, Z., Xin, H., & Chopp, M. (2013) · Glia · doi:10.1002/glia.22585 · Cited by 79
Self-citationLi, Y., Zhang, X., Cui, L., Chen, R., Zhang, Y., Zhang, C., Zhu, X., He, T., Shen, Z., Dong, L., et al. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14140 · Cited by 76
Treatment of traumatic brain injury with thymosin β4 in rats
Xiong, Y., Mahmood, A., Meng, Y., Zhang, Y., Zhang, Z. G., Morris, D. C., & Chopp, M. (2010) · Journal of neurosurgery · doi:10.3171/2010.4.jns10118 · Cited by 75
Self-citationTobin, M. K., Stephen, T. K. L., Lopez, K. L., Pergande, M. R., Bartholomew, A. M., Cologna, S. M., & Lazarov, O. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.013583 · Cited by 75
Therapeutic Effects of hMAPC and hMSC Transplantation after Stroke in Mice
Mora-Lee, S., Sirerol-Piquer, M. S., Gutiérrez-Pérez, M., Gómez‐Pinedo, U., Roobrouck, V. D., Lopez, T. V., Casado-Nieto, M., Abizanda, G., Rábena, M. T., Verfaillie, C. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043683 · Cited by 75
Polentes, J., Jendelová, P., Cailleret, M., Braun, H., Romanyuk, N., Tropel, P., Brenot, M., Itier, V., Seminatore, C., Baldauf, K., et al. (2012) · Cell Transplantation · doi:10.3727/096368912x653228 · Cited by 77
Kalra, L. (2010) · Stroke · doi:10.1161/strokeaha.109.572297 · Cited by 74
Mechanisms and Functional Significance of Stroke-Induced Neurogenesis
Marlier, Q., Verteneuil, S., Vandenbosch, R., & Malgrange, B. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00458 · Cited by 77
Cui, H., Yang, A., Zhou, H.-J., Wang, C., Luo, J., Lin, Y., Zong, Y.-X., & Tang, T. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0605-8 · Cited by 73
Xiong, Y., Mahmood, A., Zhang, Y.-L., Meng, Y.-L., Zhang, Z.-G., Qu, C., Sager, T., & Chopp, M. (2010) · Journal of Neurosurgery · doi:10.3171/2010.10.jns10925 · Cited by 67
Self-citationReitmeir, R., Kilic, E., Reinboth, B. S., Guo, Z., ElAli, A., Zechariah, A., Kilic, Ü., & Hermann, D. M. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0914-z · Cited by 69
Stem Cell Mediation of Functional Recovery after Stroke in the Rat
Ramos‐Cabrer, P., Justicia, C., Wiedermann, D., & Hoehn, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012779 · Cited by 71
Franco, E. C. S., Cardoso, M. M., Gouvêia, A., Pereira, A., & Gomes‐Leal, W. (2012) · Neuroscience Research · doi:10.1016/j.neures.2012.03.006 · Cited by 71
Angiopoietin/Tie2 pathway mediates type 2 diabetes induced vascular damage after cerebral stroke
Cui, X., Chopp, M., Zacharek, A., Ye, X., Roberts, C. J., & Chen, J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.04.005 · Cited by 71
Self-citationSildenafil Enhances Neurogenesis and Oligodendrogenesis in Ischemic Brain of Middle-Aged Mouse
Zhang, R. L., Chopp, M., Roberts, C. J., Wei, M., Wang, X., Liu, X., Lü, M., & Zhang, Z. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048141 · Cited by 75
Self-citationVenkat, P., Chen, J., & Chopp, M. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18782789 · Cited by 65
Self-citationHayakawa, K., Miyamoto, N., Seo, J. H., Pham, L. D., Kim, K., Lo, E. H., & Arai, K. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12120 · Cited by 68
Sharma, S. K., Yang, B., Strong, R., Xi, X., Brenneman, M. M., Grotta, J. C., Aronowski, J. A., & Savitz, S. I. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22452 · Cited by 69
Zhang, Y., Xiong, Y., Mahmood, A., Meng, Y., Qu, C., Schallert, T. J., & Chopp, M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.077 · Cited by 70
Self-citationIchijo, S., Shindo, T., Eguchi, K., Monma, Y., Nakata, T., Morisue, Y., Kanai, H., Osumi, N., Yasuda, S., & Shimokawa, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-84473-6 · Cited by 68
Inflammation Mediated Epileptogenesis as Possible Mechanism Underlying Ischemic Post-stroke Epilepsy
Tröscher, A. R., Gruber, J., Wagner, J. N., Böhm, V., Wahl, A.-S., & von Oertzen, T. J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.781174 · Cited by 66
Enriched environment induces angiogenesis and improves neural function outcomes in rat stroke model
Yu, K., Wu, Y., Zhang, Q., Xie, H., Liu, G., Guo, Z., Li, F., Jia, J., Kuang, S., & Hu, R. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.10.022 · Cited by 67
Chen, J., Ning, R., Zacharek, A., Cui, C., Cui, X., Yan, T., Venkat, P., Zhang, Y., & Chopp, M. (2016) · Stem Cells · doi:10.1002/stem.2193 · Cited by 58
Self-citationFunction of neural stem cells in ischemic brain repair processes
Zhang, R., Zhang, Z., & Chopp, M. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16674487 · Cited by 68
Self-citationIshrat, T., Pillai, B. A., Soliman, S. M., Fouda, A. Y., Kozak, A., Johnson, M. H., Ergul, A., & Fagan, S. C. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8830-6 · Cited by 67
Chopp, M., & Zhang, Z. G. (2015) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2015.1061993 · Cited by 65
Self-citationLaw, Z. K., Tan, H. J., Chin, S. P., Wong, C. Y., Yahya, W. N. N. W., Muda, A. S., Zakaria, R., Ariff, M. I., Ismail, N. A., Cheong, S. K., et al. (2021) · Cytotherapy · doi:10.1016/j.jcyt.2021.03.005 · Cited by 64
Human Urinary Kallidinogenase Promotes Angiogenesis and Cerebral Perfusion in Experimental Stroke
Han, L., Li, J., Chen, Y., Zhang, M., Qian, L., Chen, Y., 吴政政, Xu, Y., & Li, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134543 · Cited by 63
Tang, C., Russell, P. J., Martiniello‐Wilks, R., Rasko, J. E. J., & Khatri, A. (2010) · Stem Cells · doi:10.1002/stem.473 · Cited by 66
Neurorestorative treatments for traumatic brain injury.
Xiong, Y., Mahmood, A., & Chopp, M. (2010) · PubMed · Cited by 64
Self-citationMogi, M., & Horiuchi, M. (2012) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2012.00900.x · Cited by 66
Santra, M., Zhang, Z. G., Yang, J., Santra, S., Santra, S., Chopp, M., & Morris, D. C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.529966 · Cited by 64
Self-citationIschemic Stroke Brain Sends Indirect Cell Death Signals to the Heart
Ishikawa, H., Tajiri, N., Vasconcellos, J., Kaneko, Y., Mimura, O., Dezawa, M., & Borlongan, C. V. (2013) · Stroke · doi:10.1161/strokeaha.113.001714 · Cited by 63
Herz, J., Reitmeir, R., Hagen, S. I., Reinboth, B. S., Guo, Z., Zechariah, A., ElAli, A., Doeppner, T. R., Bacigaluppi, M., Pluchino, S., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.026 · Cited by 62
Guo, L., Ge, J., Zhou, Y., Wang, S., Zhao, R. C. H., & Wu, Y. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0338 · Cited by 61
Cell Therapy from Bench to Bedside Translation in CNS Neurorestoratology Era
Huang, H., Chen, L., & Sanberg, P. R. (2010) · Cell Medicine · doi:10.3727/215517910x516673 · Cited by 61
Crosstalk of Astrocytes and Other Cells during Ischemic Stroke
He, T., Yang, G., & Zhang, Z. (2022) · Life · doi:10.3390/life12060910 · Cited by 63
Self-citationGarbuzova-Davis, S. N., Haller, E. M., Williams, S. N., Haim, E. D., Tajiri, N., Hernandez‐Ontiveros, D. G., Frisina-Deyo, A. J., Boffeli, S. M., Sanberg, P. R., & Borlongan, C. V. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23582 · Cited by 62
Cerebrolysin improves cognitive performance in rats after mild traumatic brain injury
Zhang, Y., Chopp, M., Meng, Y., Zhang, Z. G., Doppler, E., Winter, S., Schallert, T. J., Mahmood, A., & Xiong, Y. (2015) · Journal of neurosurgery · doi:10.3171/2014.11.jns14271 · Cited by 60
Self-citationKhan, M. M., Wakade, C. G., Sevilla, L. M. D., & Brann, D. W. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.05.001 · Cited by 61
Jiang, Q., Qu, C., Chopp, M., Ding, G., Nejad‐Davarani, S. P., Helpern, J. A., Jensen, J. H., Zhang, Z. G., Li, L., Lü, M., et al. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1667 · Cited by 61
Self-citationYan, T., Chopp, M., & Chen, J. (2015) · Neuroscience Bulletin · doi:10.1007/s12264-015-1567-z · Cited by 61
Self-citationProgesterone Changes VEGF and BDNF Expression and Promotes Neurogenesis After Ischemic Stroke
Jiang, C. Q., Zuo, F., Wang, Y., Lu, H., Yang, Q., & Wang, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9651-y · Cited by 60
Kishimoto, M., Suenaga, J., Takase, H., Araki, K., Yao, T., Fujimura, T., Murayama, K., Okumura, K., Ueno, R., Shimizu, N., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-50073-8 · Cited by 59
Sex steroid hormone-mediated functional regulation of microglia-like BV-2 cells during hypoxia
Habib, P., Dreymueller, D., Ludwig, A., Beyer, C., & Dang, J. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.06.003 · Cited by 67
Neurogenic and non-neurogenic functions of endogenous neural stem cells
Butti, E., Cusimano, M., Bacigaluppi, M., & Martino, G. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00092 · Cited by 58
Chen, M., Zou, W., Chen, M., Cao, L., Ding, J., Xiao, W., & Hu, G. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.06.012 · Cited by 58
Hong, M., Shi, H., Wang, N., Tan, H., Wang, Q., & Feng, Y. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00696 · Cited by 59
Zhang, X., Zhang, Q., Li, W., Nie, D., Chen, W., Xu, C., Yi, X., Shi, J., Tian, M., Qin, J., et al. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23304 · Cited by 57
Neuhaus, A. A., Rabie, T., Sutherland, B. A., Papadakis, M., Hadley, G., Cai, R., & Buchan, A. M. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.6299 · Cited by 57
Iskander, A., Knight, R. A., Zhang, Z. G., Ewing, J. R., Shankar, A., Varma, N. R. S., Bagher‐Ebadian, H., Ali, M. M., Arbab, A. S., & Janic, B. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2013-0066 · Cited by 57
Self-citationMcCann, S., & Roulston, C. L. (2013) · Brain Sciences · doi:10.3390/brainsci3020561 · Cited by 59
Nalamolu, K. R., Venkatesh, I., Mohandass, A., Klopfenstein, J. D., Pinson, D. M., Wang, D. Z., & Veeravalli, K. K. (2019) · Cellular Physiology and Biochemistry · doi:10.33594/000000090 · Cited by 56
Lee, J. Y., Kim, S. H., Ko, A.-R., Lee, J. S., Yu, J. H., Seo, J. H., Cho, B. P., & Cho, S. (2013) · Brain Research · doi:10.1016/j.brainres.2013.08.051 · Cited by 56
Ma, F., Segundo, P. M. S., Barceló, V., Morancho, A., Gabriel-Salazar, M., Giralt, D., Montaner, J., & Rosell, A. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.03.016 · Cited by 56
Zhu, J., Liu, Q., Jiang, Y., Wu, L., Xu, G., & Liu, X. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.038 · Cited by 54
Harnessing the Potential of Biomaterials for Brain Repair after Stroke
Tuladhar, A., Payne, S. L., & Shoichet, M. S. (2018) · Frontiers in Materials · doi:10.3389/fmats.2018.00014 · Cited by 56
Blochet, C., Buscemi, L., Clément, T., Gehri, S., Badaut, J., & Hirt, L. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18806893 · Cited by 55
Stem cell transplantation for ischemic stroke
Boncoraglio, G. B., Ranieri, M., Bersano, A., Parati, E. A., & Giovane, C. D. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007231.pub3 · Cited by 54
Chang, D.-J., Lee, N., Choi, C., Jeon, I., Oh, S.-H., Shin, D. A., Hwang, T.-S., Lee, H. J., Kim, S. U., Moon, H., et al. (2013) · Cell Transplantation · doi:10.3727/096368912x657323 · Cited by 54
Shim, Y. S., Pae, C.-U., Cho, K. J., Kim, S. W., Kim, J. C., & Koh, J. S. (2013) · International Journal of Impotence Research · doi:10.1038/ijir.2013.38 · Cited by 53
van Velthoven, C. T. J., Braccioli, L., Willemen, H. L. D. M., Kavelaars, A., & Heijnen, C. J. (2013) · Molecular Therapy · doi:10.1038/mt.2013.260 · Cited by 54
Weise, G., Lorenz, M., Pösel, C., Riegelsberger, U. M., Störbeck, V., Kamprad, M., Kranz, A., Wagner, D., & Boltze, J. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.185 · Cited by 52
Spaccapelo, L., Galantucci, M., Neri, L., Contri, M. B., Pizzala, R., D’Amico, R., Ottani, A., Sandrini, M., Zaffe, D., Giuliani, D., et al. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.03.030 · Cited by 52
The role of the vagus nerve in stroke
Mravec, B. (2010) · Autonomic Neuroscience · doi:10.1016/j.autneu.2010.08.009 · Cited by 53
Mesenchymal Stromal Cells in Stroke: Improvement of Motor Recovery or Functional Compensation?
Boltze, J., Łukomska, B., & Jolkkonen, J. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.94 · Cited by 52
Xiang, J., Routhe, L. G., Wilkinson, D. A., Hua, Y., Moos, T., Xi, G., & Keep, R. F. (2017) · Fluids and Barriers of the CNS · doi:10.1186/s12987-017-0056-3 · Cited by 51
Chen, C., Hsu, P., Wang, T., Miao, Z., Lin, R., & Juo, S. H. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0625-0 · Cited by 54
Ureña‐Guerrero, M. E., Castañeda‐Cabral, J. L., Rivera-Cervantes, M. C., Vélez, R., Jarero-Basulto, J. J., Gudiño‐Cabrera, G., & Beas‐Zárate, C. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200114104342 · Cited by 52
Brain Protection in Schizophrenia, Mood and Cognitive Disorders
Ritsner, M. S. (2010) · Springer eBooks · doi:10.1007/978-90-481-8553-5 · Cited by 50
N‐myc downstream‐regulated gene 2 protects blood–brain barrier integrity following cerebral ischemia
Takarada‐Iemata, M., Yoshikawa, A., Ta, H. M., Okitani, N., Nishiuchi, T., Aida, Y., Kamide, T., Hattori, T., Ishii, H., Tamatani, T., et al. (2018) · Glia · doi:10.1002/glia.23315 · Cited by 50
Awake chronic mouse model of targeted pial vessel occlusion via photothrombosis
Sunil, S., Erdener, Ş. E., Lee, B. S., Postnov, D. D., Tang, J., Kura, S., Cheng, X., Chen, A., Boas, D. A., & Kılıç, K. (2020) · Neurophotonics · doi:10.1117/1.nph.7.1.015005 · Cited by 48
The Implications of Microglial Regulation in Neuroplasticity-Dependent Stroke Recovery
Qiao, C., Liu, Z., & Qie, S. (2023) · Biomolecules · doi:10.3390/biom13030571 · Cited by 55
Tracking Transplanted Bone Marrow Stem Cells and Their Effects in the Rat MCAO Stroke Model
Goldmacher, G., Nasser, R., Lee, D., Yigit, S., Rosenwasser, R. H., & Iacovitti, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060049 · Cited by 50
Jiang, Q., Zhang, Z. G., & Chopp, M. (2009) · Stroke · doi:10.1161/strokeaha.109.568048 · Cited by 50
Self-citationAbsence of Large-Scale Dendritic Plasticity of Layer 5 Pyramidal Neurons in Peri-Infarct Cortex
Mostany, R., & Portera‐Cailliau, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4386-10.2011 · Cited by 53
Johnston, D. G., Denizet, M., Mostany, R., & Portera‐Cailliau, C. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs092 · Cited by 49
Abeysinghe, H. C. S., Bokhari, L., Quigley, A. F., Choolani, M. A., Chan, J. K. Y., Dusting, G. J., Crook, J. M., Kobayashi, N., & Roulston, C. L. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0175-1 · Cited by 50
Li, Y., Liang, W., Guo, C., Chen, X., Huang, Y., Wang, H., Song, L., Zhang, D., Zhan, W., Lin, Z., et al. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112616 · Cited by 51
Subacute functional connectivity correlates with cognitive recovery six months after stroke
Vicentini, J. E., Weiler, M., Casseb, R. F., Almeida, S. R. M., Valler, L., de Campos, B. M., & Li, L. M. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102538 · Cited by 49
Yılmaz, G., Vital, S. A., Yilmaz, C. E., Stokes, K. Y., Alexander, J. S., & Granger, D. N. (2011) · Stroke · doi:10.1161/strokeaha.110.597088 · Cited by 49
Giuliani, D., Zaffe, D., Ottani, A., Spaccapelo, L., Galantucci, M., Minutoli, L., Bitto, A., Irrera, N., Contri, M. B., Altavilla, D., et al. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0873-4 · Cited by 50
Detante, O., Jaillard, A. S., Moisan, A., Barbieux, M., Favre, I., Garambois, K., Hommel, M., & Rémy, C. (2014) · Revue Neurologique · doi:10.1016/j.neurol.2014.10.005 · Cited by 53
Taylor, S. L., Trudeau, D., Arnold, B. J., Wang, J., Gerrow, K., Summerfeldt, K., Holmes, A. S., Zamani, A., Brocardo, P. S., & Brown, C. E. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.022 · Cited by 48
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Metadata
- Authors
- Zhang, Z. G., & Chopp, M.
- Affiliations
- Henry Ford Health (US)
- Oakland University (US)
- Corresponding author
- Chopp, Michael
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 8
- Issue
- 5
- Pages
- 491-500
- ISSN
- 1474-4422 (ISSN-L)
- PMC
- PMC2727708
- OpenAlex
- W2121567769
- Cited by
- 596
- References
- 152
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 19 · 2023: 26 · 2022: 20 · 2021: 26 · 2020: 35 · 2019: 32 · 2018: 43 · 2017: 34 · 2016: 41 · 2015: 49 · 2014: 50 · 2013: 63 · 2012: 53
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL064766, R01HL64766)
- National Institute of Neurological Disorders and Stroke (P01 NS23392, P01NS42345, P50NS023393, P01NS042345)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- stroke, cell therapy, pharmacotherapy, neurogenesis, angiogenesis, axonal sprouting, synaptogenesis, neuroplasticity, functional recovery, neural stem cells, brain endothelial cells, astrocytes, oligodendrocytes, neuroprotection
- MeSH terms
- Animals, Astrocytes, Axons, Brain, Clinical Trials as Topic, Humans, Neuronal Plasticity, Oligodendroglia, Neuroprotective Agents, Neovascularization, Physiologic, Recovery of Function, Stroke, Neurogenesis
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