Improvement in Aphasia Scores After Stroke Is Well Predicted by Initial Severity
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Background and Purpose— Most improvement from poststroke aphasia occurs within the first 3 months, but there remains unexplained variability in recovery. Recently, we reported a strong correlation between initial impairment and change scores in motor recovery at 90 days. We wanted to determine whether aphasia recovery (defined as a change from baseline to 90 days) shows a comparably strong correlation and whether the relation was similar to that in motor recovery. Methods— Twenty-one stroke patients had aphasia scores on the Western Aphasia Battery (WAB) obtained on stroke admission (WAB initial ) and at 90 days (WAB 3 mo ). The relation between actual change (Δ) scores (defined as WAB 3 mo − WAB initial ) and WAB initial was calculated in multiple-regression analysis. Results— Regression analysis demonstrated that WAB initial was highly correlated with ΔWAB ( R 2 =0.81, P <0.001) and that, in addition, the relation between WAB initial and ΔWAB was proportional, such that patients recovered 0.73 of maximal potential recovery (WAB maximum −WAB initial ). Conclusions— We show that, like motor recovery, there is a highly predictable relation between aphasia recovery and initial impairment, which is also proportional in nature. The comparability of recovery from motor and language impairment suggests that common mechanisms may govern reduction of poststroke neurologic impairment across different functional domains and that they could be the focus of therapeutic intervention.
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The %MPR represents a percentage score of the maximum potential change allowing for direct meaningful comparison of amount of possible improvement on the WAB-R AQ for people with varied aphasia severity and accounts for ceiling effects.
“The %MPR represents a percentage score of the maximum potential change (i.e. the endpoint score minus the baseline score) allowing for direct meaningful comparison of amount of possible improvement on the WAB-R AQ for people with varied aphasia severity. Using the %MPR also accounts for the ceiling effects of the standardized test.”
From A randomized control trial of intensive aphasia therapy after acute stroke: The Very Early Rehabilitation for SpEech (VERSE) study (2021) · cites this paper as [28]
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- Authors
- Lazar, R. M., Minzer, B., Antoniello, D., Festa, J. R., Krakauer, J. W., & Marshall, R. S.
- Affiliations
- Columbia University Irving Medical Center (US)
- Venue
- Stroke
- Published
- 2010-07
- Volume
- 41
- Issue
- 7
- Pages
- 1485-1488
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- PMC
- PMC2921806
- OpenAlex
- W2113082109
- Cited by
- 291
- References
- 12
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 16 · 2023: 19 · 2022: 25 · 2021: 22 · 2020: 25 · 2019: 29 · 2018: 26 · 2017: 27 · 2016: 14 · 2015: 18 · 2014: 10 · 2013: 13 · 2012: 8
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (K02-048099)
- National Institute of Neurological Disorders and Stroke (P50NS049060, U10NS086728, 1P50-NS049060)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD043249, 5R01-HD43249)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- post-stroke aphasia, aphasia recovery, Western Aphasia Battery, recovery prediction, motor recovery, language recovery
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aphasia, Female, Humans, Language Tests, Male, Middle Aged, Predictive Value of Tests, Severity of Illness Index, Databases, Factual, Treatment Outcome, Recovery of Function, Stroke, Young Adult
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