White matter changes in mild cognitive impairment and AD: a diffusion tensor imaging study
Abstract
Diffusion tensor imaging (DTI) can detect, in vivo, the directionality of molecular diffusion and estimate the microstructural integrity of white matter (WM) tracts. In this study, we examined WM changes in patients with Alzheimer's disease (AD) and in subjects with amnestic mild cognitive impairment (MCI) who are at greater risk for developing AD. A DTI index of WM integrity, fractional anisotropy (FA), was calculated in 14 patients with probable mild AD, 14 participants with MCI and 21 elderly healthy controls (NC). Voxel-by-voxel comparisons showed significant regional reductions of FA in participants with MCI and AD compared to controls in multiple posterior white matter regions. Moreover, there was substantial overlap of locations of regional decrease in FA in the MCI and AD groups. These data demonstrate that white matter changes occur in MCI, prior to the development of dementia.
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Results from DTI show that fibre tract alterations are widespread in the brain at the stage of mild cognitive impairment and Alzheimer's disease dementia.
“Results from DTI showed that fibre tract alterations are widespread in the brain at the stage of mild cognitive impairment and Alzheimer’s disease dementia (Bozzali et al., 2002; Medina et al., 2006; Acosta-Cabronero et al., 2010, 2012; Sexton et al., 2011; Bosch et al., 2012; for reviews see Acosta-Cabronero and Nestor, 2014; Teipel et al., 2015).”
From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Medina et al., 2006
We controlled for the influence of white matter hyperintensities, i.e. macrostructural white matter changes that can significantly alter DTI measures such as mean diffusivity.
“We controlled for the influence of white matter hyperintensities, i.e. macrostructural white matter changes that can significantly alter DTI measures such as mean diffusivity (Medina et al., 2006).”
From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Medina et al., 2006
White matter abnormalities emerge as early findings in the aging brain and sporadic Alzheimer's disease.
“White matter (WM) abnormalities emerge as early findings in the aging brain and sporadic Alzheimer's disease (AD) (Amlien & Fjell 2014;Bartzokis 2004;Medina et al. 2006).”
From Apolipoprotein E ε4 disrupts oligodendrocyte differentiation by interfering with astrocyte‐derived lipid transport (2023) · cites this paper as Medina et al. 2006
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- Authors
- Medina, D., deToledo-Morrell, L., Urresta, F., Gabrieli, J. D. E., Moseley, M., Fleischman, D., Bennett, D. A., Leurgans, S., Turner, D. A., & Stebbins, G. T.
- Affiliations
- Rush University Medical Center (US)
- Stanford University (US)
- Corresponding author
- Stebbins, Glenn T.
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 27
- Issue
- 5
- Pages
- 663-672
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2123261378
- Cited by
- 492
- References
- 77
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 7 · 2020: 10 · 2019: 16 · 2018: 20 · 2017: 26 · 2016: 16 · 2015: 26 · 2014: 25 · 2013: 38 · 2012: 40
- FWCI
- 15.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG017917, AG 10161, AG-17917, AG09466, P30AG010161, P01AG009466)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- white matter integrity, mild cognitive impairment, Alzheimer's disease, fractional anisotropy, diffusion tensor imaging, amnestic MCI, dementia risk, white matter microstructure
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cognition Disorders, Data Interpretation, Statistical, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Psychiatric Status Rating Scales, Anisotropy, Infarction, Middle Cerebral Artery, Diffusion Magnetic Resonance Imaging
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