Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

The chemokine system in diverse forms of macrophage activation and polarization

MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534

Astrocytes: Biology and pathology

Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676

Mechanisms underlying inflammation in neurodegeneration

Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

Epstein, F. H., Lipton, S. A., & Rosenberg, P. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403033300907 · Cited by 2,676

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. V. (2007) · Nature Neuroscience · doi:10.1038/nn2014 · Cited by 1,643

Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia

Boillée, S., Yamanaka, K., Lobsiger, C. S., Copeland, N. G., Jenkins, N. A., Kassiotis, G., Kollias, G., & Cleveland, D. W. (2006) · Science · doi:10.1126/science.1123511 · Cited by 1,623

β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression

Rothstein, J. D., Patel, S., Regan, M. R., Haenggeli, C., Huang, Y. H., Bergles, D. E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D. S., et al. (2005) · Nature · doi:10.1038/nature03180 · Cited by 1,518

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

Rothstein, J. D., Van Kammen, M., Levey, A. I., Martin, L. J., & Kuncl, R. W. (1995) · Annals of Neurology · doi:10.1002/ana.410380114 · Cited by 1,471

ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

Bruijn, L. I., Becher, M. W., Lee, M. K., Anderson, K. L., Jenkins, N. A., Copeland, N. G., Sisodia, S. S., Rothstein, J. D., Borchelt, D. R., Price, D. L., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80272-x · Cited by 1,341

Links between Electrophysiological and Molecular Pathology of Amyotrophic Lateral Sclerosis

Quinlan, K. A. (2011) · Integrative and Comparative Biology · doi:10.1093/icb/icr116 · Cited by 29

Ca2+-activated K+ channels modulate microglia affecting motor neuron survival in hSOD1G93A mice

Cocozza, G., Castro, M. A. D., Carbonari, L., Grimaldi, A., Antonangeli, F., Garofalo, S., Porzia, A., Madonna, M., Mainiero, F., Santoni, A., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.002 · Cited by 29

Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Lee, J. D., Liu, N., Levin, S. C., Ottosson, L., Andersson, U., Harris, H. E., & Woodruff, T. M. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1435-2 · Cited by 28

The role of gut microbiota, butyrate and proton pump inhibitors in amyotrophic lateral sclerosis: a systematic review

Erber, A. C., Çetin, H., Berry, D., & Schernhammer, E. S. (2019) · International Journal of Neuroscience · doi:10.1080/00207454.2019.1702549 · Cited by 28

Translatomic analysis of regenerating and degenerating spinal motor neurons in injury and ALS

Shadrach, J. L., Stansberry, W. M., Milen, A. M., Ives, R. E., Fogarty, E. A., Antonellis, A., & Pierchala, B. A. (2021) · iScience · doi:10.1016/j.isci.2021.102700 · Cited by 25

Endothelin-1 is over-expressed in amyotrophic lateral sclerosis and induces motor neuron cell death

Ranno, E., D’Antoni, S., Spatuzza, M., Berretta, A., Laureanti, F., Bonaccorso, C. M., Pellitteri, R., Longone, P., Spalloni, A., Iyer, A. M., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.01.002 · Cited by 28

Non-steroidal anti-inflammatory drugs and amyotrophic lateral sclerosis: Results from five prospective cohort studies

Fondell, E., O’Reilly, É. J., Fitzgerald, K. C., Falcone, G. J., McCullough, M. L., Thun, M. J., Park, Y., Kolonel, L. N., & Ascherio, A. (2012) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482968.2012.703209 · Cited by 27

Novel Molecular Biomarkers at the Blood-Brain Barrier in ALS

Bataveljić, D., Milosevic, M. M., Radenović, L., & Anđjus, P. R. (2014) · BioMed Research International · doi:10.1155/2014/907545 · Cited by 28

CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis

Evans, M. C., Gaillard, P. J., de Boer, M., Appeldoorn, C. C. M., Dorland, R., Sibson, N. R., Turner, M. R., Anthony, D. C., & Stolp, H. B. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-66 · Cited by 28

Synthesis and docking study of diaryl-isothiazole and 1,2,3-thiadiazole derivatives as potential neuroprotective agents

Amirhamzeh, A., Vosoughi, M., Shafiee, A., & Amini, M. (2012) · Medicinal Chemistry Research · doi:10.1007/s00044-012-0124-9 · Cited by 27

Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS

Yue, W., Deng, X., Wang, Z., Jiang, M., Hu, R., Duan, Y., Wang, Q., Cui, J., & Fang, Y. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00354-8 · Cited by 26

PACAP signaling exerts opposing effects on neuroprotection and neuroinflammation during disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

Ringer, C., Büning, L.-S., Schäfer, M. K.-H., Eiden, L. E., Weihe, E., & Schütz, B. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.02.010 · Cited by 27

The use of non-steroidal anti-inflammatory drugs in neurological diseases

Terzi, M., Altun, G., Şen, S., Kocaman, A., Kaplan, A. A., Yurt, K. K., & Kaplan, S. (2017) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.03.003 · Cited by 26

Myasthenia gravis and amyotrophic lateral sclerosis: A pathogenic overlap

Gotaas, H. T., SKEIE, G. O., & Gilhus, N. E. (2016) · Neuromuscular Disorders · doi:10.1016/j.nmd.2016.03.003 · Cited by 26

Reduction of cytosolic phospholipase A2α upregulation delays the onset of symptoms in SOD1G93A mouse model of amyotrophic lateral sclerosis

Solomonov, Y., Hadad, N., & Lévy, R. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0602-y · Cited by 27

MG53 Protects hUC-MSCs against Inflammatory Damage and Synergistically Enhances Their Efficacy in Neuroinflammation Injured Brain through Inhibiting NLRP3/Caspase-1/IL-1β Axis

Ma, S., Wang, Y., Zhou, X., Li, Z., Zhang, Z., Wang, Y., Huang, T., Zhang, Y., Shi, J., & Guan, F. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00268 · Cited by 28

Gastrodin as a multi-target protective compound reverses learning memory deficits and AD-like pathology in APP/PS1 transgenic mice

Yue-Qin, Z., Gu, J.-H., Chen, L., Zhang, T., & Zhou, X. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104324 · Cited by 26

C‐reactive protein levels in patients with amyotrophic lateral sclerosis: A systematic review

Kharel, S., Ojha, R., Preethish‐Kumar, V., & Bhagat, R. (2022) · Brain and Behavior · doi:10.1002/brb3.2532 · Cited by 26

Pathogenic Extracellular Vesicle (EV) Signaling in Amyotrophic Lateral Sclerosis (ALS)

Kim, G., Chen, X., & Yang, Y. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01232-9 · Cited by 26

Accumulation of misfolded SOD1 outlines distinct patterns of motor neuron pathology and death during disease progression in a SOD1G93A mouse model of amyotrophic lateral sclerosis

Salvany, S., Casanovas, A., Piedrafita, L., Gras, S., Calderó, J., & Esquerda, J. E. (2022) · Brain Pathology · doi:10.1111/bpa.13078 · Cited by 26

Safety and efficacy of edaravone in patients with amyotrophic lateral sclerosis: a systematic review and meta-analysis

Nourelden, A. Z., Kamal, I., Hagrass, A. I., Tawfik, A. G., Elhady, M. M., Fathallah, A. H., Eshag, M. M. E., & Zaazouee, M. S. (2023) · Neurological Sciences · doi:10.1007/s10072-023-06869-8 · Cited by 26

Intrathecal granulocyte colony-stimulating factor modulate glial cell line-derived neurotrophic factor and vascular endothelial growth factor A expression in glial cells after experimental spinal cord ischemia

Chen, C., Huang, S., Chen, N.-F., Feng, C., Hung, H.-C., Sung, C.-S., Jean, Y., Wen, Z., & Chen, W.-F. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.017 · Cited by 24

Fundamental roles of the Optineurin gene in the molecular pathology of Amyotrophic Lateral Sclerosis

Zhao, S., Chen, R., Gao, Y., Lu, Y., Bai, X., & Zhang, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1319706 · Cited by 27

Current therapy in amyotrophic lateral sclerosis (ALS): A review on past and future therapeutic strategies

Wei, Y., Zhong, S., Yang, H., Wang, X., Lv, B., Bian, Y., Pei, Y., Xu, C., Zhao, Q., Yulan, W., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116496 · Cited by 28

Inflammatory Cytokine Levels in Patients with Sporadic Amyotrophic Lateral Sclerosis

Sun, Q., Huo, Y., Bai, J., Wang, H., Wang, H., Yang, F., Cui, F., Song, H., & Huang, X. (2021) · Neurodegenerative Diseases · doi:10.1159/000522078 · Cited by 25

Peripheral inflammation and neurodegeneration; a potential for therapeutic intervention in Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS)

Hanna, L., Poluyi, E., Ikwuegbuenyi, C. A., Morgan, E., & Imaguezegie, G. (2022) · The Egyptian Journal of Neurosurgery : the official publication of the Egyptian Society of Neurological Surgeons/Egyptian journal of neurosurgery · doi:10.1186/s41984-022-00150-4 · Cited by 30

Medications on hypertension, hyperlipidemia, diabetes, and risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis

Hu, N., & Ji, H. (2022) · Neurological Sciences · doi:10.1007/s10072-022-06131-7 · Cited by 27

Neuroprotective Effects of Direct Intrathecal Administration of Granulocyte Colony‐Stimulating Factor in Rats with Spinal Cord Injury

Chen, W.-F., Chen, C., Chen, N., Sung, C., & Wen, Z. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12429 · Cited by 25

Profilin-1 Haploinsufficiency Protects Against Obesity-Associated Glucose Intolerance and Preserves Adipose Tissue Immune Homeostasis

Romeo, G. R., Pae, M., Eberlé, D., Lee, J., & Shoelson, S. E. (2013) · Diabetes · doi:10.2337/db13-0050 · Cited by 25

Astrocyte elevated gene-1 is a novel regulator of astrogliosis and excitatory amino acid transporter-2 via interplaying with nuclear factor-κB signaling in astrocytes from amyotrophic lateral sclerosis mouse model with hSOD1 G93A mutation

Yin, X. L., Wang, S., Qi, Y., Wang, X., Jiang, H., Wang, T., Yang, Y., Wang, Y., Zhang, C., & Feng, H. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.05.004 · Cited by 25

In-vivo evaluation of neuronal and glial changes in amyotrophic lateral sclerosis with diffusion tensor spectroscopy

Reischauer, C., Gutzeit, A., Neuwirth, C., Fuchs, A., Sartoretti‐Schefer, S., Weber, M., & Czell, D. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.10.001 · Cited by 25

Imaging Neurochemistry and Brain Structure Tracks Clinical Decline and Mechanisms of ALS in Patients

Andronesi, O. C., Nicholson, K. A., Jafari‐Khouzani, K., Bogner, W., Wang, J., Chan, J. G. M., Macklin, E. A., Levine, M., Breen, C. T., Schwarzschild, M. A., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.590573 · Cited by 23

Exploring the properties and potential of the neural extracellular matrix for next‐generation regenerative therapies

Ortega, J. A., de Aguiar, G. P. S., Chandravanshi, P., Levy, N., Engel, E., & Álvarez, Z. (2024) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1962 · Cited by 27

The role of macrophage plasticity in neurodegenerative diseases

Ma, H., Zhu, M., Chen, M., Li, X., & Feng, X. (2024) · Biomarker Research · doi:10.1186/s40364-024-00624-7 · Cited by 24

Diffusion tensor imaging identifies presymptomatic axonal degeneration in the spinal cord of ALS mice

Gatto, R. G., Li, W., & Magin, R. L. (2017) · Brain Research · doi:10.1016/j.brainres.2017.11.017 · Cited by 24

Burn-Induced Microglia Activation is Associated With Motor Neuron Degeneration and Muscle Wasting in Mice

Ma, L., Zhou, Y., Khan, M. A. S., Yasuhara, S., & Martyn, J. A. J. (2019) · Shock · doi:10.1097/shk.0000000000001300 · Cited by 24

Convergent Molecular Pathways in Type 2 Diabetes Mellitus and Parkinson’s Disease: Insights into Mechanisms and Pathological Consequences

Sandeep, X. X. X. X., Ahmad, M. H., Rani, L., & Mondal, A. C. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02867-7 · Cited by 24

Advances in Cellular Models to Explore the Pathophysiology of Amyotrophic Lateral Sclerosis

Veyrat‐Durebex, C., Corcia, P., Dangoumau, A., Laumonnier, F., Piver, É., Gordon, P. H., Andres, C. R., Vourc’h, P., & Blasco, H. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8573-9 · Cited by 28

Infection of the Central Nervous System, Sepsis and Amyotrophic Lateral Sclerosis

Fang, F., Chen, H., Wirdefeldt, K., Ronnevi, L., Al‐Chalabi, A., Peters, T. L., Kamel, F., & Ye, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029749 · Cited by 25

Phosphorylation of p53 by LRRK2 induces microglial tumor necrosis factor α-mediated neurotoxicity

Ho, D. H., Seol, W., Eun, J. H., & Son, I. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.163 · Cited by 25

Circulating Cytokines Could Not Be Good Prognostic Biomarkers in a Mouse Model of Amyotrophic Lateral Sclerosis

Moreno‐Martínez, L., de la Torre, M., Toivonen, J. M., Zaragoza, P., García‐Redondo, A., Calvo, A. C., & Osta, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00801 · Cited by 26

Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis

Neel, D. V., Basu, H., Gunner, G., & Chiu, I. M. (2022) · Immunological Reviews · doi:10.1111/imr.13083 · Cited by 22

Unlike Physical Exercise, Modified Environment Increases the Lifespan of SOD1G93A Mice However Both Conditions Induce Cellular Changes

Gerber, Y. N., Sabourin, J.-C., Hugnot, J., & Perrin, F. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045503 · Cited by 26

Myelosuppressive Conditioning Using Busulfan Enables Bone Marrow Cell Accumulation in the Spinal Cord of a Mouse Model of Amyotrophic Lateral Sclerosis

Lewis, C. B., Manning, J., Barr, C., Peake, K., Humphries, R. K., Rossi, F. M. V., & Krieger, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060661 · Cited by 23

Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy

Morsch, M., Radford, R. A. W., Don, E. K., Lee, A., Hortle, E., Cole, N. J., & Chung, R. S. (2017) · Journal of Visualized Experiments · doi:10.3791/54983 · Cited by 25

Silencing of FUS in the common marmoset (Callithrix jacchus) brain via stereotaxic injection of an adeno-associated virus encoding shRNA

Endo, K., Ishigaki, S., Masamizu, Y., Fujioka, Y., Watakabe, A., Yamamori, T., Hatanaka, N., Nambu, A., Okado, H., Katsuno, M., et al. (2017) · Neuroscience Research · doi:10.1016/j.neures.2017.08.006 · Cited by 23

Optineurin Insufficiency Disbalances Proinflammatory and Anti-inflammatory Factors by Reducing Microglial IFN-β Responses

Markovinović, A., Ljutić, T., Béland, L., & Munitić, I. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.07.007 · Cited by 25

Multimodal tract-based analysis in ALS patients at 7T: A specific white matter profile?

Verstraete, E., Polders, D., Mandl, R. C. W., van den Heuvel, M. P., Veldink, J. H., Luijten, P. R., van den Berg, L. H., & Hoogduin, J. M. (2013) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2013.844168 · Cited by 22

CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis

Zaccai, S., Nemirovsky, A., Lerner, L., Alfahel, L., Eremenko, E., Israelson, A., & Monsonego, A. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-023-03007-1 · Cited by 23

Calcium in the pathomechanism of amyotrophic lateral sclerosis – Taking center stage?

Patai, R., Nógrádi, B., Engelhardt, J. I., & Siklós, L. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.089 · Cited by 24

Alterations of GABA B receptors in the APP/PS1 mouse model of Alzheimer's disease

Salazar, A., Osse, A. M. L., Ortiz, A. A., Murtishaw, A. S., & Kinney, J. W. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.10.013 · Cited by 26

Rosmarinic Acid Alleviates Neurological Symptoms in the G93A-SOD1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Seo, J., Choi, J., Leem, Y., & Han, P. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.341 · Cited by 22

Neuron-Microglia Interactions in Motor Neuron Degeneration. The Inflammatory Hypothesis in Amyotrophic Lateral Sclerosis Revisited

Rodríguez, M. J., & Mahy, N. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867324666161123091314 · Cited by 22

A Cystine-Rich Whey Supplement (Immunocal®) Delays Disease Onset and Prevents Spinal Cord Glutathione Depletion in the hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

Ross, E., Winter, A. N., Wilkins, H., Sumner, W., Duval, N., Patterson, D., & Linseman, D. A. (2014) · Antioxidants · doi:10.3390/antiox3040843 · Cited by 21

Impact of Pharmacological Inhibition of Hydrogen Sulphide Production in the SOD1G93A-ALS Mouse Model

Spalloni, A., Greco, V., Ciriminna, G., Carregari, V. C., Marini, F., Pieroni, L., Mercuri, N. B., Urbani, A., & Longone, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102550 · Cited by 22

Oligomerization of Cu,Zn-Superoxide Dismutase (SOD1) by Docosahexaenoic Acid and Its Hydroperoxides In Vitro: Aggregation Dependence on Fatty Acid Unsaturation and Thiols

Appolinário, P. P., Medinas, D. B., Chaves‐Filho, A. B., Genaro‐Mattos, T. C., Cussiol, J. R. R., Netto, L. E. S., Augusto, O., & Miyamoto, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125146 · Cited by 20

A Crucial Role for the Protein Quality Control System in Motor Neuron Diseases

Cristofani, R., Crippa, V., Cicardi, M. E., Tedesco, B., Ferrari, V., Chierichetti, M., Casarotto, E., Piccolella, M., Messi, E., Galbiati, M., et al. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00191 · Cited by 24

Pharmacological inhibition of ALCAT1 mitigates amyotrophic lateral sclerosis by attenuating SOD1 protein aggregation

Liu, X., Zhang, J., Li, J., Song, C., & Shi, Y. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101536 · Cited by 20

Mechanisms of NLRP3 activation and pathology during neurodegeneration

Jose, S., Groves, N. J., Roper, K. E., & Gordon, R. (2022) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2022.106273 · Cited by 22

The non-cell-autonomous component of ALS: new in vitro models and future challenges

Ferraiuolo, L. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140168 · Cited by 21

Scolopendra subspinipes mutilans attenuates neuroinflammation in symptomatic hSOD1G93Amice

Cai, M., Choi, S., Song, B. K., Son, I., Kim, S., & Yang, E. J. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-131 · Cited by 20

Disruption of calcitonin gene-related peptide signaling accelerates muscle denervation and dampens cytotoxic neuroinflammation in SOD1 mutant mice

Ringer, C., Tune, S., Bertoune, M., Schwarzbach, H., Tsujikawa, K., Weihe, E., & Schütz, B. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2337-4 · Cited by 20

Altered CSF cytokine network in amyotrophic lateral sclerosis patients: A pathway-based statistical analysis

Martínez, H. R., Escamilla-Ocañas, C. E., Tenorio-Pedraza, J. M., Gómez‐Almaguer, D., Jaime‐Pérez, J. C., Olguín-Ramírez, L. A., Salazar‐Marioni, S. A., & González‐Garza, M. T. (2016) · Cytokine · doi:10.1016/j.cyto.2016.09.022 · Cited by 20

Hyperexcitability in Cultured Cortical Neuron Networks from the G93A-SOD1 Amyotrophic Lateral Sclerosis Model Mouse and its Molecular Correlates

Marcuzzo, S., Terragni, B., Bonanno, S., Isaia, D., Cavalcante, P., Cappelletti, C., Ciusani, E., Rizzo, A., Regalia, G., Yoshimura, N., et al. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.07.041 · Cited by 19

Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice

Bertin, É., Martínez, A., Fayoux, A., Carvalho, K., Carracedo, S., Fernagut, P., Koch‐Nolte, F., Blum, D. L., Bertrand, S. S., & Boué‐Grabot, É. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04461-5 · Cited by 19

Aspirin Use Associated With Amyotrophic Lateral Sclerosis: a Total Population-Based Case-Control Study

Tsai, C., Lin, F.-C., Lee, J. K.-W., & Lee, C. T. (2014) · Journal of Epidemiology · doi:10.2188/jea.je20140070 · Cited by 19

Targeting Neuroinflammation in Central Nervous System Diseases by Oral Delivery of Lipid Nanoparticles

Zou, Y., Zhang, J., Chen, L., Xu, Q., Yao, S., & Chen, H. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17030388 · Cited by 19

PET and SPECT Imaging of ALS: An Educational Review

Jamali, A. M., Kethamreddy, M., Burkett, B. J., Port, J. D., & Pandey, M. K. (2023) · Molecular Imaging · doi:10.1155/2023/5864391 · Cited by 18

Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release

Battilocchio, C., Guetzoyan, L. J., Cervetto, C., Mannelli, L. D. C., Frattaroli, D., Baxendale, I. R., Maura, G., Rossi, A., Sautebin, L., Biava, M., et al. (2013) · ACS Medicinal Chemistry Letters · doi:10.1021/ml400079h · Cited by 18

Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets

Ban, J., Sámano, C., Mladinić, M., & Munitić, I. (2019) · Croatian Medical Journal · doi:10.3325/cmj.2019.60.109 · Cited by 20

Typical and atypical stem cells in the brain, vitamin C effect and neuropathology

Nualart, F., Salazar, K., Oyarce, K., Cisternas, P., Jara, N., Silva-Álvarez, C., Pastor, P., Martínez, F., García, A., García, M. D. L. Á., et al. (2012) · Biological Research · doi:10.4067/s0716-97602012000300006 · Cited by 18

Diazoxide Pretreatment Prevents Aβ1–42 Induced Oxidative Stress in Cholinergic Neurons Via Alleviating NOX2 Expression

Fu, Q., Gao, N., Yu, J., Ma, G., Du, Y., Wang, F., Su, Q., & Che, F. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1313-3 · Cited by 18

Bcl11b: A New Piece to the Complex Puzzle of Amyotrophic Lateral Sclerosis Neuropathogenesis?

Lennon, M. J., Jones, S. P., Lovelace, M. D., Guillemin, G. J., & Brew, B. J. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9573-5 · Cited by 17

TRPC Channels and Alzheimer’s Disease

Lu, R., Qian, H., & Wang, J. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1088-4_7 · Cited by 17

Pacific Ciguatoxin Induces Excitotoxicity and Neurodegeneration in the Motor Cortex Via Caspase 3 Activation: Implication for Irreversible Motor Deficit

Asthana, P., Zhang, N., Kumar, G., Chine, V. B., Singh, K. K., Mak, Y. L., Chan, L. L., Lam, P. K. S., & Ma, C. H. E. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0875-5 · Cited by 18

Ibrutinib Delays ALS Installation and Increases Survival of SOD1G93A Mice by Modulating PI3K/mTOR/Akt Signaling

Zheng, C., Li, W., Ali, T., Peng, Z., Liu, J., Pan, Z., Feng, J., & Li, S. (2023) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-023-10068-9 · Cited by 17

Impaired recruitment of neuroprotective microglia and T cells during acute neuronal injury coincides with increased neuronal vulnerability in an amyotrophic lateral sclerosis model

Kawamura, M., Yamasaki, R., Kawamura, N., Tateishi, T., Nagara, Y., Matsushita, T., Ohyagi, Y., & Kira, J. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.01.015 · Cited by 17

Neuroinflammation as a therapeutic target in neurodegenerative diseases

Gordon, R., & Woodruff, T. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805120-7.00003-8 · Cited by 19

Intrathecal Injection of scAAV9–hIGF1 Prolongs the Survival of ALS Model Mice by Inhibiting the NF-kB Pathway

Hu, H., Lin, H., Duan, W., Cui, C., Li, Z., Liu, Y., Wang, W., Wen, D., Wang, Y., & Li, C. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.004 · Cited by 17

In Amyotrophic Lateral Sclerosis Blood Cytokines Are Altered, but Do Not Correlate with Changes in Brain Topology

Polverino, A., Rucco, R., Stillitano, I., Bonavita, S., Grimaldi, M., Minino, R., Pesoli, M., Trojsi, F., D’Ursi, A. M., Sorrentino, G., et al. (2020) · Brain Connectivity · doi:10.1089/brain.2020.0741 · Cited by 18

Identification of Celecoxib-Targeted Proteins Using Label-Free Thermal Proteome Profiling on Rat Hippocampus

Gholizadeh, E., Karbalaei, R., Khaleghian, A., Salimi, M., Gilany, K., Soliymani, R., Tanoli, Z., Rezadoost, H., Baumann, M., Jafari, M., et al. (2021) · Molecular Pharmacology · doi:10.1124/molpharm.120.000210 · Cited by 18

Synaptopathy Mechanisms in ALS Caused by C9orf72 Repeat Expansion

Nishimura, A. L., & Arias, N. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.660693 · Cited by 17

Gene expression changes in spinal motoneurons of the SOD1G93A transgenic model for ALS after treatment with G-CSF

Henriques, A., Kastner, S., Chatzikonstantinou, E., Pitzer, C., Plaas, C., Kirsch, F., Wafzig, O., ger, C. K. ⁄., Spoelgen, R., de Aguilar, J. G., et al. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00464 · Cited by 17

Comparative effects of progesterone and the synthetic progestin norethindrone on neuroprotection in a model of spontaneous motoneuron degeneration

Gargiulo-Monachelli, G. M., Meyer, M., Lara, A., Garay, L. I., Lima, A. E., Roig, P., Nicola, A. F. D., & Deniselle, M. C. G. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105385 · Cited by 18

Human in vivo neuroimaging to detect reprogramming of the cerebral immune response following repeated systemic inflammation

van Ton, A. M. P., Leijte, G. P., Franssen, G. M., Bruse, N., Booij, J., Doorduin, J., Rijpkema, M., Kox, M., Abdo, W. F., & Pickkers, P. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.04.004 · Cited by 16

Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system

Gras, S., Blasco, A., Mòdol‐Caballero, G., Tarabal, O., Casanovas, A., Piedrafita, L., Barranco, A., Das, T., Rueda, R., Pereira, S. L., et al. (2021) · Aging · doi:10.18632/aging.203336 · Cited by 17

Pathophysiological Underpinnings of Extra-Motor Neurodegeneration in Amyotrophic Lateral Sclerosis: New Insights From Biomarker Studies

Reyes‐Leiva, D., Dols‐Icardo, O., Sirisi, S., Cortés‐Vicente, E., Turón‐Sans, J., de Luna, N., Blesa, R., Belbin, O., Montal, V., Alcolea, D. A., et al. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.750543 · Cited by 18

Chronic exposure to l-BMAA cyanotoxin induces cytoplasmic TDP-43 accumulation and glial activation, reproducing an amyotrophic lateral sclerosis-like phenotype in mice

Anzilotti, S., Valente, V., Brancaccio, P., Franco, C., Casamassa, A., Lombardi, G., Palazzi, A., Conte, A., Paladino, S., Canzoniero, L. M. T., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115503 · Cited by 16

Axotomy‐induced target disconnection promotes an additional death mechanism involved in motoneuron degeneration in amyotrophic lateral sclerosis transgenic mice

Haulcomb, M. M., Mesnard, N. A., Batka, R. J., Alexander, T. D., Sanders, V. M., & Jones, K. J. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23538 · Cited by 16

Implications of structural and functional brain changes in amyotrophic lateral sclerosis

Dharmadasa, T., Huynh, W., Tsugawa, J., Shimatani, Y., Ma, Y., & Kiernan, M. C. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1464912 · Cited by 16

Association of serum uric acid to lymphocyte ratio, a novel inflammatory biomarker, with risk of stroke: A prospective cohort study

Tian, X., Wang, P., Chen, S., Zhang, Y., Zhang, X., Xu, Q., Luo, Y., Wu, S., & Wang, A. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14094 · Cited by 15

SOMAscan Proteomics Identifies Novel Plasma Proteins in Amyotrophic Lateral Sclerosis Patients

Berrone, E., Chiorino, G., Guana, F., Benedetti, V., Palmitessa, C., Gallo, M., Calvo, A., Casale, F., Manera, U., Favole, A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031899 · Cited by 16

Angiopoietin-1 and ανβ3 integrin peptide promote the therapeutic effects of L-serine in an amyotrophic lateral sclerosis/Parkinsonism dementia complex model

Cai, H., Tian, K.-W., Zhang, Y., Jiang, H., & Han, S. (2018) · Aging · doi:10.18632/aging.101661 · Cited by 16

Single injection of sustained-release prostacyclin analog ONO-1301-MS ameliorates hypoxic toxicity in the murine model of amyotrophic lateral sclerosis

Tada, S., Okuno, T., Shimizu, M., Sakai, Y., Sumi‐Akamaru, H., Kinoshita, M., Yamashita, K., Sanda, E., Choong, C., Namba, A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41771-4 · Cited by 18

Single-cell analysis reveals expanded CD8+ GZMK high T cells in CSF and shared peripheral clones in sporadic amyotrophic lateral sclerosis

Kim, H. J., Ban, J.-J., Kang, J., Im, H. W., Ko, S. H., Sung, J., Park, S., Park, J.-E., & Choi, S. J. (2024) · Brain Communications · doi:10.1093/braincomms/fcae428 · Cited by 16

LPS-Induced Coagulation and Neuronal Damage in a Mice Model Is Attenuated by Enoxaparin

Berkowitz, S. H., Gofrit, S. G., Aharoni, S. A., Golderman, V., Qassim, L., Goldberg, Z., Dori, A., Maggio, N., Chapman, J., & Stein, E. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810472 · Cited by 15

In FUS[1−359]‐tg mice O,S-dibenzoyl thiamine reduces muscle atrophy, decreases glycogen synthase kinase 3 beta, and normalizes the metabolome

Probert, F., Вячеславовна, Г. А., Deykin, A. V., Bettendorff, L., Veniaminova, E. A., Nedorubov, A. A., Chaprov, K., Ivanova, T. A., Anthony, D. C., & Strekalova, T. V. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113986 · Cited by 15

Cardiovascular Diseases, Medications, and ALS: A Population-Based Case-Control Study

Abdel Magid, H. S., Topol, B., McGuire, V., Hinman, J. A., Kasarskis, E. J., & Nelson, L. M. (2022) · Neuroepidemiology · doi:10.1159/000526982 · Cited by 15

Umbilical cord mesenchymal stem cell-conditioned medium inhibits microglial activation to ameliorate neuroinflammation in amyotrophic lateral sclerosis mice and cell models

Tang, J., Kang, Y., Zhou, Y., Chen, Q., Lan, J., Liu, X., & Peng, Y. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110760 · Cited by 16

Mesenchymal Stem Cells-based Cell-free Therapy Targeting Neuroinflammation

Xu, H., Wang, B., Li, A., Wen, J., Su, H., & Qin, D. (2023) · Aging and Disease · doi:10.14336/ad.2023.0904 · Cited by 15

Neuroinflammation in motor neuron disease

Endo, F., Komine, O., & Yamanaka, K. (2016) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12309 · Cited by 95

Neuron-Microglia Interactions in Motor Neuron Degeneration. The Inflammatory Hypothesis in Amyotrophic Lateral Sclerosis Revisited

Rodríguez, M. J., & Mahy, N. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867324666161123091314 · Cited by 22

Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis

Weydt, P., & ̈ller, T. M. (2005) · Neuroreport · doi:10.1097/00001756-200504250-00001 · Cited by 84

Neuroinflammation in neurodegenerative disease.

Yamanaka, K. (2023) · PubMed Central · doi:10.18999/nagjms.85.1.30 · Cited by 1

The microglial-motoneuron dialogue in ALS.

Appel, S. H., Zhao, W., Beers, D. R., & Henkel-Tigges, J. (2011) · Europe PMC (PubMed Central) · Cited by 179