The DOI matches its Crossref record; 250 of the 250 references it cites were found in a registry or an index.
Tau pathology and neurodegeneration
Abstract
The pathway leading from soluble and monomeric to hyperphosphorylated, insoluble and filamentous tau protein is at the centre of many human neurodegenerative diseases, collectively referred to as tauopathies. Dominantly inherited mutations in MAPT, the gene that encodes tau, cause forms of frontotemporal dementia and parkinsonism, proving that dysfunction of tau is sufficient to cause neurodegeneration and dementia. However, most cases of tauopathy are not inherited in a dominant manner. The first tau aggregates form in a few nerve cells in discrete brain areas. These become self propagating and spread to distant brain regions in a prion-like manner. The prevention of tau aggregation and propagation is the focus of attempts to develop mechanism-based treatments for tauopathies.
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“Aggregates composed of both 3R and 4R tau are seen in disease states, though curiously several tauopathies including PSP, CBD, FTDP-17, and AGD exclusively feature 4R tau deposits.”
From Glial contributions to neurodegeneration in tauopathies (2017) · cites this paper as [1]
In the citing paper
“Pathological studies have shown the deposition of abnormal proteins in the brain tissues of FTD patients, including TDP-43 (50% of cases), tau (40% of cases), and FUS (5–10% of cases).314,315”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [315]
Citations
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Cited by
Sorted by citations
Ageing as a risk factor for neurodegenerative disease
Hou, Y., Dan, X., Babbar, M., Wei, Y., Hasselbalch, S. G., Croteau, D. L., & Bohr, V. A. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0244-7 · Cited by 3,310
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Pathology of Neurodegenerative Diseases
Dugger, B. N., & Dickson, D. W. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028035 · Cited by 1,665
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Gao, C., Jiang, J., Tan, Y., & Chen, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01588-0 · Cited by 1,616
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
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Metadata
- Authors
- Spillantini, M. G., & Goedert, M.
- Affiliations
- University of Cambridge (GB)
- MRC Laboratory of Molecular Biology (GB)
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 12
- Issue
- 6
- Pages
- 609-622
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2137140827
- Cited by
- 1,133
- References
- 250
- Citations by year
- 2026: 60 · 2025: 89 · 2024: 69 · 2023: 78 · 2022: 97 · 2021: 102 · 2020: 99 · 2019: 113 · 2018: 87 · 2017: 89 · 2016: 80 · 2015: 88 · 2014: 60 · 2013: 19
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Parkinson's UK (K-1012)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- tau pathology, tauopathy, neurodegeneration, tau aggregation, hyperphosphorylated tau, MAPT mutations, frontotemporal dementia, parkinsonism, prion-like propagation, tau-targeted therapy
- MeSH terms
- Animals, Brain, Humans, tau Proteins, Neurodegenerative Diseases, Tauopathies
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