The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination
Open accessAbstract
Narcolepsy is a sleep disorder characterised by loss of hypothalamic hypocretin (orexin) neurons. The prevalence of narcolepsy is about 30 per 100 000 people, and typical age at onset is 12-16 years. Narcolepsy is strongly associated with the HLA-DQB1*06:02 genotype, and has been thought of as an immune-mediated disease. Other risk genes, such as T-cell-receptor α chain and purinergic receptor subtype 2Y11, are also implicated. Interest in narcolepsy has increased since the epidemiological observations that H1N1 infection and vaccination are potential triggering factors, and an increase in the incidence of narcolepsy after the pandemic AS03 adjuvanted H1N1 vaccination in 2010 from Sweden and Finland supports the immune-mediated pathogenesis. Epidemiological observations from studies in China also suggest a role for H1N1 virus infections as a trigger for narcolepsy. Although the pathological mechanisms are unknown, an H1N1 virus-derived antigen might be the trigger.
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1 retracted
la Herrán-Arita, A. K. D., Kornum, B. R., Mahlios, J., Jiang, W., Lin, L., Hou, T., Macaubas, C., Einen, M. A., Plazzi, G., Crowe, C., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007762 · Cited by 95
Self-citationRetractedSakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613
Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R., et al. (2000) · Nature Medicine · doi:10.1038/79690 · Cited by 2,118
Reduced Number of Hypocretin Neurons in Human Narcolepsy
Thannickal, T. C., Moore, R. Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M., & Siegel, J. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00058-1 · Cited by 2,089
Hypocretin (orexin) deficiency in human narcolepsy
Nishino, S., Ripley, B., Overeem, S., Lammers, G. J., & Mignot, E. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05582-8 · Cited by 1,776
Immune cell regulation by autocrine purinergic signalling
Junger, W. G. (2011) · Nature Reviews Immunology · doi:10.1038/nri2938 · Cited by 810
Cited by
Molecular mimicry and autoimmunity
Rojas, M., Restrepo-Jiménez, P., Monsalve, D. M., Pacheco, Y., Acosta-Ampudia, Y., Ramírez-Santana, C., Leung, P. S. C., Ansari, A. A., Gershwin, M. E., & Anaya, J.-M. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.10.012 · Cited by 627
Vojdani, A., Vojdani, E., & Kharrazian, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.617089 · Cited by 322
The Neurobiology of Sleep and Wakefulness
Schwartz, M. D., & Kilduff, T. S. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.07.002 · Cited by 207
Kępińska, A. P., Iyegbe, C. O., Vernon, A. C., Yolken, R., Murray, R. M., & Pollak, T. A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00072 · Cited by 193
Morbidity and mortality of middle-aged and elderly narcoleptics
Jennum, P., Thorstensen, E. W., Pickering, L., Ibsen, R., & Kjellberg, J. (2017) · Sleep Medicine · doi:10.1016/j.sleep.2017.03.029 · Cited by 41
Self-citation
Metadata
- Authors
- Partinen, M., Kornum, B. R., Plazzi, G., Jennum, P., Julkunen, I., & Vaarala, O.
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 13
- Issue
- 6
- Pages
- 600-613
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W1913166529
- Cited by
- 275
- References
- 121
- FWCI
- 20.43
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination. https://app.cochat.ai/papers/10.1016/s1474-4422(14)70075-4
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- Partinen, M., Kornum, B. R., Plazzi, G., Jennum, P., Julkunen, I., & Vaarala, O. (2014). Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination. The Lancet Neurology. https://doi.org/10.1016/s1474-4422(14)70075-4
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
