Pain in amyotrophic lateral sclerosis
Open accessAbstract
Pain is a largely neglected symptom in patients with amyotrophic lateral sclerosis (ALS) although it is reported by most of these patients. It occurs at all stages of the disease and can be an onset symptom preceding motor dysfunction. Pain is correlated with a deterioration in patients' quality of life and increased prevalence of depression. In the later stages of ALS, pain can be severe enough to require increased use of sedative and analgesic drugs, and is among the events that predict clinical deterioration and death. The site of pain depends on the pain type or underlying mechanism (eg, painful cramps, nociceptive pain, or neuropathic pain). Given the multifactorial nature of pain in patients with ALS, different treatments have been suggested, ranging from non-steroidal anti-inflammatory drugs, drugs for neuropathic pain, opioids, and cannabinoids, to physical therapy strategies and preventive assistive devices. Further understanding of the pathophysiology is crucial to drive assessment in clinical trials of therapeutic strategies targeted at specific mechanisms and studies of individualised therapies.
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GLP-1RA achieves anti-inflammatory results through various methods.
“GLP-1RA achieves anti-inflammatory results through various methods.”
From Anti-inflammatory role of glucagon-like peptide 1 receptor agonists and its clinical implications (2024) · cites this paper as [26]
The Treatment and Pharmacological treatments (Table 1) passages discuss pain management in ALS, not GLP-1 receptor agonists. Searches for GLP-1RA and anti-inflammatory effects found no passage in our copy addressing the claimed mechanisms. (LLM, conf=0.76)
Experimental — accuracy not yet measuredPain is a poorly understood symptom amongst ALS/MND populations.
“A recent review highlighted pain as a symptom which is poorly understood amongst ALS/MND populations [3].”
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- Authors
- Chiò, A., Mora, G., & Lauria, G.
- Affiliations
- University of Turin (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Corresponding author
- Chiò, Adriano
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 16
- Issue
- 2
- Pages
- 144-157
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2560505659
- Cited by
- 134
- References
- 109
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 20 · 2023: 19 · 2022: 12 · 2021: 26 · 2020: 15 · 2019: 8 · 2018: 10 · 2017: 6
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Funders
- Ministero della Salute
- Economic and Social Research Council (ES/L008238/1)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- amyotrophic lateral sclerosis, pain, neuropathic pain, nociceptive pain, quality of life, depression, analgesic use, opioids, cannabinoids, nonsteroidal anti-inflammatory drugs, pain pathophysiology
- MeSH terms
- Amyotrophic Lateral Sclerosis, Humans, Muscle Cramp, Neuralgia, Nociceptive Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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