The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
Functional neurological disorder: new subtypes and shared mechanisms
Open accessAbstract
Functional neurological disorder is common in neurological practice. A new approach to the positive diagnosis of this disorder focuses on recognisable patterns of genuinely experienced symptoms and signs that show variability within the same task and between different tasks over time. Psychological stressors are common risk factors for functional neurological disorder, but are often absent. Four entities-functional seizures, functional movement disorders, persistent perceptual postural dizziness, and functional cognitive disorder-show similarities in aetiology and pathophysiology and are variants of a disorder at the interface between neurology and psychiatry. All four entities have distinctive features and can be diagnosed with the support of clinical neurophysiological studies and other biomarkers. The pathophysiology of functional neurological disorder includes overactivity of the limbic system, the development of an internal symptom model as part of a predictive coding framework, and dysfunction of brain networks that gives movement the sense of voluntariness. Evidence supports tailored multidisciplinary treatment that can involve physical and psychological therapy approaches.
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“Early adverse life experiences, negative affectivity, neuroticism, depression, and anxiety have been identified as psycho logical predisposing conditions for persistent physical symptoms”
From Persistent physical symptoms: definition, genesis, and management (2024) · cites this paper as [69]
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“Common biomedical factors, such as persistent inflammation and dysregulation of the immune, autonomic, metabolic, and microbiome systems, as well as genetic and epigenetic factors, can cause somatic symptoms to persist or intensify”
From Persistent physical symptoms: definition, genesis, and management (2024) · cites this paper as [69]
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Cites
LaFrance, W. C., Baker, G. A., Duncan, R., Goldstein, L. H., & Reuber, M. (2013) · Epilepsia · doi:10.1111/epi.12356 · Cited by 856
Staab, J. P., Eckhardt-Henn, A., Horii, A., Jacob, R., Strupp, M., Brandt, T., & Bronstein, A. (2017) · Journal of Vestibular Research · doi:10.3233/ves-170622 · Cited by 840
Self-citationCurrent Concepts in Diagnosis and Treatment of Functional Neurological Disorders
Espay, A. J., Aybek, S., Carson, A., Edwards, M. J., Goldstein, L. H., Hallett, M., LaFaver, K., LaFrance, W. C., Lang, A. E., Nicholson, T., et al. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.1264 · Cited by 786
Self-citationHobbs, R. F., Bankhead, C. R., Mukhtar, T. K., Stevens, S., Perera, R., Holt, T., & Salisbury, C. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00620-6 · Cited by 609
Symptoms and the body: taking the inferential leap
Van den Bergh, O., Witthöft, M., Petersen, S., & Brown, R. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.015 · Cited by 543
Ludwig, L., Pasman, J. A., Nicholson, T., Aybek, S., David, A. S., Tuck, S., Kanaan, R. A., Roelofs, K., Carson, A., & Stone, J. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30051-8 · Cited by 495
Self-citationPsychogenic movement disorders
Gupta, A., & Lang, A. E. (2009) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32832dc169 · Cited by 440
The involuntary nature of conversion disorder
Voon, V., Gallea, C., Hattori, N., Bruno, M., Ekanayake, V., & Hallett, M. (2010) · Neurology · doi:10.1212/wnl.0b013e3181ca00e9 · Cited by 335
Self-citationGoldstein, L. H., Robinson, E. J., Mellers, J. D. C., Stone, J., Carson, A., Reuber, M., Medford, N., McCrone, P., Murray, J., Richardson, M. P., et al. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30128-0 · Cited by 287
Self-citationTowards an integrative theory of psychogenic non-epileptic seizures (PNES)
Brown, R. J., & Reuber, M. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.06.003 · Cited by 279
Research works printed but not linked: 2
- Sundararajan, 2016, Biomarkers in the diagnosis and study of psychogenic nonepileptic seizures: a systematic review, Seizure, 35, 11, 10.1016/j.seizure.2015.12.011 · DOI
- Gilmour, 2021, Inpatient treatment of functional neurological disorder: a scoping review, Can J Neurol Sci, 48, 204, 10.1017/cjn.2020.159 · DOI
Cited by
Sorted by citations
Persistent physical symptoms: definition, genesis, and management
Löwe, B., Toussaint, A., Rosmalen, J. G. M., Huang, W.-L., Burton, C., Weigel, A., Levenson, J. L., & Henningsen, P. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00623-8 · Cited by 280
Vucic, S., Chen, K.-H. S., Kiernan, M. C., Hallett, M., Benninger, D. H., Lazzaro, V. D., Rossini, P. M., Benussi, A., Berardelli, A., Currà, A., et al. (2023) · Clinical Neurophysiology · doi:10.1016/j.clinph.2023.03.010 · Cited by 238
Self-citationIncidence and prevalence of functional neurological disorder: a systematic review
Finkelstein, S. A., Diamond, C., Carson, A. J., & Stone, J. (2024) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2024-334767 · Cited by 113
Self-citationWhy functional neurological disorder is not feigning or malingering
Edwards, M. J., Yogarajah, M., & Stone, J. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-022-00765-z · Cited by 96
Self-citationUnderstanding Functional Neurological Disorder: Recent Insights and Diagnostic Challenges
Mavroudis, I. A., Kazis, D. A., Kamal, F. Z., Gurzu, I. L., Ciobica, A. S., Pădurariu, M., Novac, B., & Iordache, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084470 · Cited by 88
Metadata
- Authors
- Hallett, M., Aybek, S., Dworetzky, B. A., McWhirter, L., Staab, J. P., & Stone, J.
- Affiliations
- National Institutes of Health (US)
- University Hospital of Bern (CH)
- Brigham and Women's Hospital (US)
- University of Edinburgh (GB)
- Mayo Clinic (US)
- Corresponding author
- Hallett, Mark
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 21
- Issue
- 6
- Pages
- 537-550
- ISSN
- 1474-4422 (ISSN-L)
- PMC
- PMC9107510
- OpenAlex
- W4223971211
- Cited by
- 538
- References
- 128
- Citations by year
- 2026: 154 · 2025: 159 · 2024: 126 · 2023: 81 · 2022: 17
- FWCI
- 16.48
- Type
- journal article
- Language
- en
- Update notices
- erratum (2022-06-01)
- Open access
- bronze
- doi.org
- Licence
- Locations
- The Lancet Neurology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
- Funders
- National Institute of Neurological Disorders and Stroke
- U.S. Army Medical Research and Development Command
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PP00P3_176985)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Keywords
- conversion disorder, psychogenic non-epileptic seizures, functional movement disorders, functional cognitive disorder, psychological stress, predictive coding, brain network dysfunction, neurophysiological markers, multidisciplinary treatment
- MeSH terms
- Brain, Conversion Disorder, Humans, Seizures
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