Cited by 110Adipokines, Inflammation, and Metabolic DiseasesCancer Risks and FactorsCancer, Lipids, and Metabolism

The Obesity-Cancer Link: Lessons Learned from a Fatless Mouse

Hursting, Stephen D., Nunez, Nomeli P., Varticovski, Lyuba, Vinson, Charles·2007·Cancer Research

Abstract

Current dogma suggests that the positive correlation between obesity and cancer is driven by white adipose tissue that accompanies obesity, possibly through excess secretion of adipokines. Recent studies in fatless A-Zip/F1 mice, which have undetectable adipokine levels but display accelerated tumor formation, suggest that adipokines are not required for the enhanced tumor development. The A-Zip/F-1 mice are also diabetic and display elevated circulating levels of other factors frequently associated with obesity (insulin, insulin-like growth factor-1, and proinflammatory cytokines) and activation of several signaling pathways associated with carcinogenesis. In view of this information, the risk factors underlying the obesity-cancer link need to be revisited. We postulate that the pathways associated with insulin resistance and inflammation, rather than adipocyte-derived factors, may represent key prevention and therapeutic targets for disrupting the obesity-cancer link. [Cancer Res 2007;67(6):2391–3]

Integrity signals

Registry

Crossref · 10.1158/0008-5472.can-06-4237

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20 of 20 references verified0 citation errors · 0 not checkable

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Authors
Hursting, S. D., Nunez, N. P., Varticovski, L., & Vinson, C.
Affiliations
  • The University of Texas MD Anderson Cancer Center (US)
  • 1Division of Nutritional Sciences, University of Texas, Austin, Texas;
  • 3Laboratory of Human Carcinogenesis and
  • National Institutes of Health (US)
Venue
Cancer Research
Published
2007-03-15
Volume
67
Issue
6
Pages
2391-2393
ISSN
  • 0008-5472 (ISSN-L)
  • 1538-7445
OpenAlex
W2155243001
Cited by
110
References
20
Citations by year
2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 10 · 2015: 9 · 2014: 4 · 2013: 8 · 2012: 15
FWCI
7.34
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01co12400-79-0-22)
  • National Cancer Institute (N01CO12400)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
obesity, cancer, adipokines, white adipose tissue, tumor formation, insulin resistance, inflammation, insulin-like growth factor I, inflammatory cytokines
MeSH terms
Animals, Disease Models, Animal, Humans, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Mammary Neoplasms, Experimental, Neoplasms, Obesity, Signal Transduction, Mice

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