The Obesity-Cancer Link: Lessons Learned from a Fatless Mouse
Abstract
Current dogma suggests that the positive correlation between obesity and cancer is driven by white adipose tissue that accompanies obesity, possibly through excess secretion of adipokines. Recent studies in fatless A-Zip/F1 mice, which have undetectable adipokine levels but display accelerated tumor formation, suggest that adipokines are not required for the enhanced tumor development. The A-Zip/F-1 mice are also diabetic and display elevated circulating levels of other factors frequently associated with obesity (insulin, insulin-like growth factor-1, and proinflammatory cytokines) and activation of several signaling pathways associated with carcinogenesis. In view of this information, the risk factors underlying the obesity-cancer link need to be revisited. We postulate that the pathways associated with insulin resistance and inflammation, rather than adipocyte-derived factors, may represent key prevention and therapeutic targets for disrupting the obesity-cancer link. [Cancer Res 2007;67(6):2391–3]
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Elevated inflammatory proteins in obese individuals suggest that inflammation may play a determinant role in connecting obesity to metabolic, hepatic and cardiovascular diseases, and to some cancers.
“Elevated inflammatory proteins in obese individuals [1] suggest that inflammation may play a determinant role in connecting obesity to metabolic, hepatic and cardiovascular diseases [2], and to some cancers [3].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [3]
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- Authors
- Hursting, S. D., Nunez, N. P., Varticovski, L., & Vinson, C.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- 1Division of Nutritional Sciences, University of Texas, Austin, Texas;
- 3Laboratory of Human Carcinogenesis and
- National Institutes of Health (US)
- Venue
- Cancer Research
- Published
- 2007-03-15
- Volume
- 67
- Issue
- 6
- Pages
- 2391-2393
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2155243001
- Cited by
- 110
- References
- 20
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 10 · 2015: 9 · 2014: 4 · 2013: 8 · 2012: 15
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01co12400-79-0-22)
- National Cancer Institute (N01CO12400)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- obesity, cancer, adipokines, white adipose tissue, tumor formation, insulin resistance, inflammation, insulin-like growth factor I, inflammatory cytokines
- MeSH terms
- Animals, Disease Models, Animal, Humans, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Mammary Neoplasms, Experimental, Neoplasms, Obesity, Signal Transduction, Mice
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