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Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis

Joyce, Johanna A, Laakkonen, Pirjo, Bernasconi, Michele, Bergers, Gabriele, Ruoslahti, Erkki, Hanahan, Douglas·2003·Cancer Cell
DOI 10.1016/s1535-6108(03)00271-x
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Abstract

The vasculature in the angiogenic stages of a mouse model of pancreatic islet carcinogenesis was profiled in vivo with phage libraries that display short peptides. We characterized seven peptides distinguished by their differential homing to angiogenic progenitors, solid tumors, or both. None homed appreciably to normal pancreatic islets or other organs. Five peptides selectively homed to neoplastic lesions in the pancreas and not to islet beta cell tumors growing subcutaneously, xenotransplant tumors from a human cancer cell line, or an endogenously arising squamous cell tumor of the skin. Three peptides with distinctive homing to angiogenic islets, tumors, or both colocalized with markers that identify endothelial cells or pericytes. One peptide is homologous with pro-PDGF-B, which is expressed in endothelial cells, while its receptor is expressed in pericytes.

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Metadata

Authors
Joyce, J. A., Laakkonen, P., Bernasconi, M., Bergers, G., Ruoslahti, E., & Hanahan, D.
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2003-11
Volume
4
Issue
5
Pages
393-403
ISSN
1535-6108
DOI
10.1016/s1535-6108(03)00271-x
Cited by
211
References
3
Language
en
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