Cited by 317Retinal Diseases and TreatmentsRetinal Development and DisordersRetinal Imaging and Analysis

The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.

Photoreceptor degeneration and dysfunction in aging and age-related maculopathy

Jackson, Gregory R, Owsley, Cynthia, Curcio, Christine A·2002·Ageing Research Reviews

Open this paper in CoChat — free account

Abstract

The relative rate of rod and cone degeneration is a fundamental characteristic of any disorder affecting photoreceptors, including aging and age-related maculopathy (ARM). The human macula consists of a small cone-dominated fovea surrounded by a rod-dominated parafovea. In aging and early ARM, rods degenerate before cones, a decline in scotopic (rod-mediated) sensitivity is more prominent than a decline in photopic (cone-mediated) sensitivity, and the time course of dark adaptation of rods slows dramatically. The topography of rod dysfunction and loss in early ARM matches the location of pathology in the retinal pigment epithelium (RPE)/Bruch's membrane complex visible in the ocular fundus. Rod dysfunction and loss in aging and ARM may be due to retinoid deficiency at the level of the photoreceptors cause by impaired retinoid translocation across the RPE/Bruch's membrane complex, a hypothesis deserving of further investigation.

Integrity signals

Registry

Crossref · 10.1016/s1568-1637(02)00007-7

Cites

91 of 91 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Handbook of Sensory Physiology
Sanders, M. D. (1975) · British Journal of Ophthalmology · doi:10.1136/bjo.59.2.111-c · Cited by 7,166
A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss: AREDS Report No. 8
(2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1417 · Cited by 3,285
Human photoreceptor topography
Curcio, C. A., Sloan, K. R., Kalina, R. E., & Hendrickson, A. E. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902920402 · Cited by 2,894
Self-citation
An international classification and grading system for age-related maculopathy and age-related macular degeneration
Bird, A. C., Bressler, N. M., Bressler, S. B., Chisholm, I. H., Coscas, G., Davis, M. D., de Jong, P. T. V. M., Klaver, C. C. W., Klein, B. E. K., Klein, R., et al. (1995) · Survey of Ophthalmology · doi:10.1016/s0039-6257(05)80092-x · Cited by 1,926
Prevalence of age-related maculopathy
Klein, R., Klein, B. E. K., & Linton, K. L. P. (1992) · Ophthalmology · doi:10.1016/s0161-6420(92)31871-8 · Cited by 1,845
An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration
Hageman, G. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(01)00010-6 · Cited by 1,265
The Wisconsin Age-related Maculopathy Grading System
Klein, R., Davis, M. D., Magli, Y. L., Segał, P., Klein, R., & Hubbard, L. D. (1991) · Ophthalmology · doi:10.1016/s0161-6420(91)32186-9 · Cited by 1,188
The Five-year Incidence and Progression of Age-related Maculopathy
Klein, R., Klein, R., Jensen, S. C., & Meuer, S. M. (1997) · Ophthalmology · doi:10.1016/s0161-6420(97)30368-6 · Cited by 1,154
Risk factors for age-related macular degeneration
Smith, W., Assink, J., Klein, R., Mitchell, P., Klaver, C. C. W., Klein, B. E. K., Hofman, A., Jensen, S., Wang, J. J., & de Jong, P. T. V. M. (2001) · Ophthalmology · doi:10.1016/s0161-6420(00)00580-7 · Cited by 1,071
Prevalence of age-related maculopathy in Australia
Mitchell, P., Smith, W., Attebo, K., & Wang, J. J. (1995) · Ophthalmology · doi:10.1016/s0161-6420(95)30846-9 · Cited by 1,062

Show all 91 references

Research works printed but not linked: 2

Lamb, 1998, Towards a molecular description of human dark adaptation, J. Physiol., 506, 88
Marshall, J., Hussain, A.A., Starita, C., Moore, D.J., Patmore, A.L., 1998. Aging and Bruch’s membrane. In: Marmor, M.F., Wolfensberger, T.J. (Eds.), The Retinal Pigment Epithelium: Function and Disease. Oxford University Press, New York, pp. 669–692.

Sorted by citations

Items 101–200 of 317

Genome-wide Profiling Identifies DNA Methylation Signatures of Aging in Rod Photoreceptors Associated with Alterations in Energy Metabolism
Corso‐Díaz, X., Gentry, J., Rebernick, R. J., Jaeger, C., Brooks, M. J., van Asten, F., Kooragayala, K., Gieser, L. M., Nellissery, J. K., Covián, R., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107525 · Cited by 46
Proper control of R‐loop homeostasis is required for maintenance of gene expression and neuronal function during aging
Jauregui-Lozano, J. P. P., Escobedo, S. E., Easton, A., Lanman, N. A., Weake, V. M., & Hall, H. (2022) · Aging Cell · doi:10.1111/acel.13554 · Cited by 43
Monitoring retinal function in early age-related maculopathy: visual performance after 1 year
Feigl, B., Brown, B. H., Lovie-kitchin, J. E., & Swann, P. (2004) · Eye · doi:10.1038/sj.eye.6701711 · Cited by 45
Potential of melatonin to treat or prevent age-related macular degeneration through stimulation of telomerase activity
Rastmanesh, R. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.08.036 · Cited by 44
Functional optical coherence tomography enables in vivo optoretinography of photoreceptor dysfunction due to retinal degeneration
Kim, T.-H., Wang, B., Lu, Y., Son, T., & Yao, X. (2020) · Biomedical Optics Express · doi:10.1364/boe.399334 · Cited by 43
Müller Glial Cells in the Macula: Their Activation and Cell-Cell Interactions in Age-Related Macular Degeneration
Navneet, S., Wilson, K., & Rohrer, B. (2024) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.65.2.42 · Cited by 42
STRUCTURAL AND FUNCTIONAL CHANGES OVER TIME IN MacTel PATIENTS
Schmitz-Valckenberg, S., Ong, E. L., Rubin, G. S., Pető, T., Tufail, A., Egan, C. A., Bird, A. C., & Fitzke, F. W. (2009) · Retina · doi:10.1097/iae.0b013e3181a4d2f1 · Cited by 41
Age-Related Decline in VIP-Positive Parasympathetic Nerve Fibers in the Human Submacular Choroid
Jablonski, M. M., Iannaccone, A., Reynolds, D., Gallaher, P., Allen, S., Wang, X., & Reiner, A. J. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0972 · Cited by 42
Death by color: differential cone loss in the aging mouse retina.
Cunea, A., Powner, M. B., & Jeffery, G. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.05.012 · Cited by 44
Photoreceptor organisation and phenotypic characterization in retinas of two diurnal rodent species: Potential use as experimental animal models for human vision research
Bobu, C., Lahmam, M., Vuillez, P., Ouarour, A., & Hicks, D. (2007) · Vision Research · doi:10.1016/j.visres.2007.08.011 · Cited by 40
The ARMS2 A69S Polymorphism Is Associated with Delayed Rod-Mediated Dark Adaptation in Eyes at Risk for Incident Age-Related Macular Degeneration
Mullins, R. F., McGwin, G., Searcey, K., Clark, M. E., Kennedy, E. L., Curcio, C. A., Stone, E. M., & Owsley, C. J. (2018) · Ophthalmology · doi:10.1016/j.ophtha.2018.10.037 · Cited by 40
Self-citation
Is the Retina a Mirror of the Aging Brain? Aging of Neural Retina Layers and Primary Visual Cortex Across the Lifespan
Jorge, L., Canário, N., Quental, H., Bernardes, R., & Castelo-Branco, M. S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00360 · Cited by 39
Restoring Color Perception to the Blind
Lan, Y., Castillo, J., Gonzalez-Calle, A., Neitz, J., & Humayun, M. S. (2020) · Ophthalmology · doi:10.1016/j.ophtha.2020.08.019 · Cited by 39
Fucoidan protects ARPE-19 cells from oxidative stress via normalization of reactive oxygen species generation through the Ca2+-dependent ERK signaling pathway
Li, X., Zhao, H., WANG, Q., Liang, H., & Jiang, X. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3224 · Cited by 40
The retinal pigmented epithelium – from basic developmental biology research to translational approaches
Amram, B., Cohen‐Tayar, Y., David, A., & Ashery‐Padan, R. (2017) · The International Journal of Developmental Biology · doi:10.1387/ijdb.160393ra · Cited by 39
Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model
Ramirez, A. I., Fernández‐Albarral, J. A., de Hoz, R., López‐Cuenca, I., Salobrar‐García, E., Rojas, P., Valiente‐Soriano, F. J., Avilés‐Trigueros, M., Villegas‐Pérez, M. P., Vidal‐Sanz, M., et al. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2020.05.024 · Cited by 37
Photo-damage, photo-protection and age-related macular degeneration
Marquioni‐Ramella, M. D., & Suburo, Á. M. (2015) · Photochemical & Photobiological Sciences · doi:10.1039/c5pp00188a · Cited by 38
Impact of aging and age-related maculopathy on inactivation of the a-wave of the rod-mediated electroretinogram
Jackson, G. R., McGwin, G., Phillips, J. M., Klein, R., & Owsley, C. J. (2005) · Vision Research · doi:10.1016/j.visres.2005.09.003 · Cited by 37
Self-citation
Therapeutic Margins in a Novel Preclinical Model of Retinitis Pigmentosa
Davis, R. J., Hsu, C.-W., Tsai, Y., Wert, K. J., Sancho-Pellúz, J., Lin, C., & Tsang, S. H. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0419-13.2013 · Cited by 37
Mid-stage intervention achieves similar efficacy as conventional early-stage treatment using gene therapy in a pre-clinical model of retinitis pigmentosa
Wert, K. J., Sancho-Pellúz, J., & Tsang, S. H. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt452 · Cited by 37
Dark Adaptation and Its Role in Age-Related Macular Degeneration
Nigalye, A. K., Pfau, K., Pundlik, S. J., Jeffrey, B. G., Cukras, C. A., & Husain, D. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11051358 · Cited by 37
Functional validation of a human CAPN5 exome variant by lentiviral transduction into mouse retina
Wert, K. J., Skeie, J. M., Bassuk, A. G., Olivier, A. K., Tsang, S. H., & Mahajan, V. B. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt661 · Cited by 35
Mesopic and Dark-Adapted Two-Color Fundus-Controlled Perimetry in Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
von der Emde, L. A., Pfau, M., Thiele, S., Möller, P. T., Hassenrik, R., Fleckenstein, M., Holz, F. G., & Schmitz-Valckenberg, S. (2019) · Translational Vision Science & Technology · doi:10.1167/tvst.8.1.7 · Cited by 33
Effect of Ambient Light and Age‐Related Macular Degeneration on Precision Walking
Alexander, M. S., Lajoie, K., Neima, D. R., Strath, R. A., Robinovitch, S. N., & Marigold, D. S. (2014) · Optometry and Vision Science · doi:10.1097/opx.0000000000000316 · Cited by 33
In Vivo Confocal Intrinsic Optical Signal Identification of Localized Retinal Dysfunction
Zhang, Q.-X., Lu, R., Curcio, C. A., & Yao, X.-C. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10732 · Cited by 33
Self-citation
Omega-3 fatty acids supplementation protects the retina from age-associated degeneration in aged C57BL/6J mice
Prokopiou, E., Kolovos, P., Georgiou, C., Kalogerou, M., Potamiti, L., Sokratous, K., Kyriacou, K. C., & Georgiou, T. (2019) · BMJ Open Ophthalmology · doi:10.1136/bmjophth-2019-000326 · Cited by 33
Retinal Prosthetic Approaches to Enhance Visual Perception for Blind Patients
Shim, S., Eom, K., Jeong, J., & Kim, S. J. (2020) · Micromachines · doi:10.3390/mi11050535 · Cited by 35
Role of retinal pigment epithelium in age-related macular disease: a systematic review
Bird, A. C. (2020) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2020-317447 · Cited by 33
Spatial Dissociation of Subretinal Drusenoid Deposits and Impaired Scotopic and Mesopic Sensitivity in AMD
Zhang, Y., Sadda, S. R., Sarraf, D., Swain, T. A., Clark, M. E., Sloan, K. R., Warriner, W. E., Owsley, C. J., & Curcio, C. A. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.2.32 · Cited by 33
Self-citation
Foveal Sparing of Reticular Drusen in Eyes With Early and Intermediate Age-Related Macular Degeneration
Steinberg, J. S., Fleckenstein, M., Holz, F. G., & Schmitz-Valckenberg, S. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-16657 · Cited by 33
Protein profile of aging and its retardation by caloric restriction in neural retina
Li, D., Sun, F. Y., & Wang, K. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.04.022 · Cited by 33
Pathogenic mechanisms contributing to the vulnerability of aging human photoreceptor cells
Nag, T. C. (2021) · Eye · doi:10.1038/s41433-021-01602-1 · Cited by 34
Quantitative Analysis of Cone Photoreceptor Distribution and Its Relationship with Axial Length, Age, and Early Age-Related Macular Degeneration
Obata, R., & Yanagi, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091873 · Cited by 32
NATURAL COURSE AND CLASSIFICATION OF EXTENSIVE MACULAR ATROPHY WITH PSEUDODRUSEN-LIKE APPEARANCE
Romano, F., Cozzi, M., Monteduro, D., Oldani, M., Boon, C. J. F., Staurenghi, G., & Salvetti, A. P. (2023) · Retina · doi:10.1097/iae.0000000000003683 · Cited by 31
Regulation of a novel isoform of Receptor Expression Enhancing Protein REEP6 in rod photoreceptors by bZIP transcription factor NRL
Hao, H., Veleri, S., Sun, B., Kim, D. S., Keeley, P. W., Kim, J.-W., Yang, H., Yadav, S. P., Manjunath, S. H., Sood, R. B., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu143 · Cited by 31
The Rod-Mediated Multifocal Electroretinogram in Aging and in Early Age-Related Maculopathy
Feigl, B., Brown, B. H., Lovie‐Kitchin, J. E., & Swann, P. (2006) · Current Eye Research · doi:10.1080/02713680600762739 · Cited by 33
Foveal Cone-Photoreceptor Integrity in Aging Macula Disorder
Kanis, M. J., Wisse, R. P. L., Berendschot, T. T. J. M., van de Kraats, J., & Norren, D. V. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1181 · Cited by 31
Decreased Visual Function Scores on a Low Luminance Questionnaire Is Associated with Impaired Dark Adaptation
Yazdanie, M., Alvarez, J. A., Agrón, E., Wong, W. T., Wiley, H. E., Ferris, F. L., Chew, E. Y., & Cukras, C. A. (2017) · Ophthalmology · doi:10.1016/j.ophtha.2017.05.005 · Cited by 31
THE NATURAL HISTORY OF FULL-FIELD STIMULUS THRESHOLD DECLINE IN CHOROIDEREMIA
Dimopoulos, I. S., Freund, P. R., Knowles, J. A., & MacDonald, I. M. (2017) · Retina · doi:10.1097/iae.0000000000001764 · Cited by 30
A Pilot Study Evaluating the Effects of 670 nm Photobiomodulation in Healthy Ageing and Age-Related Macular Degeneration
Grewal, M. K., Sivapathasuntharam, C., Chandra, S., Gurudas, S., Chong, V. N., Bird, A. C., Jeffery, G., & Sivaprasad, S. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041001 · Cited by 29
Local Progression Kinetics of Geographic Atrophy Depends Upon the Border Location
Shen, L. L., Sun, M., Ahluwalia, A., Park, M. M., Young, B. K., & Priore, L. V. D. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.13.28 · Cited by 29
Early degeneration of photoreceptor synapse inCcl2/Cx3cr1-deficient mice onCrb1rd8background
Zhang, J., Tuo, J., Cao, X., Shen, D., Li, W., & Chan, C. (2013) · Synapse · doi:10.1002/syn.21674 · Cited by 31
The occurrence of cone inclusions in the ageing human retina and their possible effect upon vision: An electron microscope study
Nag, T. C., Wadhwa, S., & Chaudhury, S. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.09.007 · Cited by 29
Beyond AREDS Formulations, What Is Next for Intermediate Age-Related Macular Degeneration (iAMD) Treatment? Potential Benefits of Antioxidant and Anti-inflammatory Apocarotenoids as Neuroprotectors
Camelo, S., Latil, M., Veillet, S., Dilda, P. J., & Lafont, R. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4984927 · Cited by 30
Functional optoretinography: concurrent OCT monitoring of intrinsic signal amplitude and phase dynamics in human photoreceptors
Ma, G., Son, T., Kim, T.-H., & Yao, X. (2021) · Biomedical Optics Express · doi:10.1364/boe.423733 · Cited by 28
Visual function and performance with blue‐light blocking filters in age‐related macular degeneration
Bittner, A. K., Deschler, E. K., & Dagnelie, G. (2008) · Clinical and Experimental Ophthalmology · doi:10.1111/j.1442-9071.2008.01824.x · Cited by 28
Caloric restriction retards age-related changes in rat retina
Li, D., Sun, F. Y., & Wang, K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.020 · Cited by 28
Functional intrinsic optical signal imaging for objective optoretinography of human photoreceptors
Son, T., Kim, T.-H., Ma, G., Kim, H., & Yao, X. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220978898 · Cited by 28
A Novel Polysaccharide Compound Derived from Algae Extracts Protects Retinal Pigment Epithelial Cells from High Glucose-Induced Oxidative Damage in Vitro
Xie, P., Fujii, I., Zhao, J.-E., Shinohara, M., & Matsukura, M. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b110706 · Cited by 29
Development of the Vision Impairment in Low Luminance Questionnaire
Pondorfer, S. G., Terheyden, J. H., Overhoff, H., Stasch-Bouws, J., Holz, F. G., & Finger, R. P. (2021) · Translational Vision Science & Technology · doi:10.1167/tvst.10.1.5 · Cited by 27
The role of dark adaptation in understanding early AMD
Murray, I. J., Rodrigo-Diaz, E., Kelly, J., Aslam, T. M., Tahir, H. J., Carden, D. E., Patryas, L., & Parry, N. R. A. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.101015 · Cited by 26
Relationship Between Presumptive Inner Nuclear Layer Thickness and Geographic Atrophy Progression in Age-Related Macular Degeneration
Ebneter, A., Jaggi, D., Abegg, M. H., Wolf, S., & Zinkernagel, M. S. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-18865 · Cited by 27
Objective functional assessment of age‐related maculopathy: a special application for the multifocal electroretinogram
Feigl, B., Lovie‐Kitchin, J. E., & Brown, B. H. (2005) · Clinical and Experimental Optometry · doi:10.1111/j.1444-0938.2005.tb06714.x · Cited by 27
Light-Induced Length Shrinkage of Rod Photoreceptor Outer Segments
Lu, Y., Benedetti, J., & Yao, X. (2018) · Translational Vision Science & Technology · doi:10.1167/tvst.7.6.29 · Cited by 26
Electroretinogram measures in a septuagenarian population
Neveu, M. M., Dangour, A. D., Allen, E., Robson, A. G., Bird, A. C., Uauy, R. D., & Holder, G. E. (2011) · Documenta Ophthalmologica · doi:10.1007/s10633-011-9282-1 · Cited by 26
The Silk-protein Sericin Induces Rapid Melanization of Cultured Primary Human Retinal Pigment Epithelial Cells by Activating the NF-κB Pathway
Eidet, J. R., Reppe, S., Pasovic, L., Olstad, O. K., Lyberg, T., Khan, A. Z., Fostad, I. G., Chen, D. F., & Utheim, T. P. (2016) · Scientific Reports · doi:10.1038/srep22671 · Cited by 26
Slowed Dark Adaptation in Early AMD: Dual Stimulus Reveals Scotopic and Photopic Abnormalities
Tahir, H. J., Rodrigo-Diaz, E., Parry, N. R. A., Kelly, J., Carden, D. E., Aslam, T. M., & Murray, I. J. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24227 · Cited by 25
Declines in Arrestin and Rhodopsin in the Macula with Progression of Age-Related Macular Degeneration
Ethen, C. M., Feng, X., Olsen, T. W., & Ferrington, D. A. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0810 · Cited by 25
Cervical sympathectomy causes photoreceptor-specific cell death in the rat retina
Steinle, J. J., Lindsay, N. L., & Lashbrook, B. L. (2005) · Autonomic Neuroscience · doi:10.1016/j.autneu.2005.03.004 · Cited by 25
Foveal phase retardation changes associated with normal aging
VanNasdale, D. A., Elsner, A. E., Hobbs, T. R., & Burns, S. A. (2011) · Vision Research · doi:10.1016/j.visres.2011.08.017 · Cited by 24
Subjects With Unilateral Neovascular AMD Have Bilateral Delays in Rod-Mediated Phototransduction Activation Kinetics and in Dark Adaptation Recovery
Dimopoulos, I. S., TENNANT, M. T. S., Johnson, A., Fisher, S., Freund, P. R., & Sauvé, Y. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12194 · Cited by 23
Polarization-Sensitive Optical Coherence Tomography and Conventional Retinal Imaging Strategies in Assessing Foveal Integrity in Geographic Atrophy
Sayegh, R. G., Zotter, S., Roberts, P. K., Kańduła, M. M., Sacu, S., Kreil, D. P., Baumann, B., Pircher, M., Hitzenberger, C. K. F., & Schmidt-Erfurth, U. M. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-15114 · Cited by 23
Localization of nitro-tyrosine immunoreactivity in human retina
Nag, T. C., Kathpalia, P., Gorla, S., & Wadhwa, S. (2019) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2019.01.006 · Cited by 23
Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice
Diéguez, H. H., Romeo, H. E., Fleitas, M. F. G., Aranda, M. L., Milne, G. A., Rosenstein, R. E., & Dorfman, D. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.031641 · Cited by 25
Sensory Transduction in Photoreceptors and Olfactory Sensory Neurons: Common Features and Distinct Characteristics
Genovese, F., Reisert, J., & Kefalov, V. J. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.761416 · Cited by 26
Macula-less rat and macula-bearing monkey retinas exhibit common lifelong proteomic changes
Böhm, M. R. R., Mertsch, S., König, S., Spieker, T., & Thanos, S. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.04.020 · Cited by 22
What Does Genetics Tell Us About Age-Related Macular Degeneration?
Graßmann, F., Ach, T., Brandl, C., Heid, I. M., & Weber, B. H. F. (2015) · Annual Review of Vision Science · doi:10.1146/annurev-vision-082114-035609 · Cited by 21
Visual quality assessment in patients with orange-tinted blue light–filtering and clear ultraviolet light–filtering intraocular lenses
Schmack, I., Schimpf, M., Stolzenberg, A., Conrad-Hengerer, I., Hengerer, F. H., & Dick, H. B. (2012) · Journal of Cataract & Refractive Surgery · doi:10.1016/j.jcrs.2011.12.028 · Cited by 21
Possible therapy for age-related macular degeneration using human telomerase
Rowe-Rendleman, C. L., & Glickman, R. D. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00072-8 · Cited by 21
In Vivo Longitudinal Measurement of Cone Photoreceptor Density in Intermediate Age-Related Macular Degeneration
Wang, X., Sadda, S. R., Ip, M. S., Sarraf, D., & Zhang, Y. (2022) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2022.11.020 · Cited by 20
PROGRESS TOWARD THE MAINTENANCE AND REPAIR OF DEGENERATING RETINAL CIRCUITRY
Vugler, A. (2010) · Retina · doi:10.1097/iae.0b013e3181e2a680 · Cited by 21
Fast intrinsic optical signal correlates with activation phase of phototransduction in retinal photoreceptors
Yao, X., & Kim, T.-H. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220935406 · Cited by 20
Assessment of age changes and repeatability for computer-based rod dark adaptation
Patryas, L., Parry, N. R. A., Carden, D. E., Baker, D. H., Kelly, J., Aslam, T. M., & Murray, I. J. (2013) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-013-2324-5 · Cited by 18
Immunolocalisation pattern of complex I–V in ageing human retina: Correlation with mitochondrial ultrastructure
Nag, T. C., & Wadhwa, S. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.08.016 · Cited by 19
Changes in Retinal Structure and Ultrastructure in the Aged Mice Correlate With Differences in the Expression of Selected Retinal miRNAs
Hermenean, A. O., Trotta, M. C., Gharbia, S., Hermenean, A. G., Peteu, V. E., Baltă, C., Cotoraci, C. A., Gesualdo, C., Rossi, S., Gherghiceanu, M., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.593514 · Cited by 19
Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption.
Perkins, G. A., Scott, R. T., Perez, A. J., Ellisman, M. H., Johnson, J. E., & Fox, D. A. (2012) · Europe PMC (PubMed Central) · Cited by 19
Intraocular lens short wavelength light filtering
Edwards, K. H., & Gibson, G. A. (2010) · Clinical and Experimental Optometry · doi:10.1111/j.1444-0938.2010.00538.x · Cited by 19
Photopic and scotopic multifocal pupillographic responses in age-related macular degeneration
Rosli, Y., Bedford, S., James, A. C., & Maddess, T. (2012) · Vision Research · doi:10.1016/j.visres.2012.07.019 · Cited by 19
Age-Related Changes in Retinal Functional Topography
Langrová, H., Zrenner, E., Kurtenbach, A., & Seeliger, M. W. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1309 · Cited by 19
Age related distribution of 4-hydroxy 2-nonenal immunoreactivity in human retina
Nag, T. C., Kumar, P., & Wadhwa, S. (2017) · Experimental Eye Research · doi:10.1016/j.exer.2017.09.014 · Cited by 19
Aging of the Retinal Pigment Epithelium
Boulton, M. E. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-374-5_19 · Cited by 19
Remote Ischemic Preconditioning Protects Retinal Photoreceptors: Evidence From a Rat Model of Light-Induced Photoreceptor Degeneration
Brandli, A. A., Johnstone, D. M., & Stone, J. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19361 · Cited by 18
Two-photon excited autofluorescence imaging of freshly isolated frog retinas
Lu, R., Li, Y.-C., Ye, T., Strang, C. E., Keyser, K. T., Curcio, C. A., & Yao, X.-C. (2011) · Biomedical Optics Express · doi:10.1364/boe.2.001494 · Cited by 18
Self-citation
The contribution of central and peripheral vision in scene categorization: A study on people with central vision loss
Thibaut, M., Tran, T. H. C., Szaffarczyk, S., & Boucart, M. (2014) · Vision Research · doi:10.1016/j.visres.2014.03.004 · Cited by 18
Microtubule alterations may destabilize photoreceptor integrity: Age-related microtubule changes and pattern of expression of MAP-2, Tau and hyperphosphorylated Tau in aging human photoreceptor cells
Nag, T. C., Kathpalia, P., & Wadhwa, S. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108153 · Cited by 18
Outer Retinal Layers’ Thickness Changes in relation to Age and Choroidal Thickness in Normal Eyes
Abdellatif, M. K., Zankalony, Y. A. E., Ebeid, A. A. A., & Ebeid, W. M. (2019) · Journal of Ophthalmology · doi:10.1155/2019/1698967 · Cited by 18
The association between dark adaptation and macular pigment optical density in healthy subjects
Patryas, L., Parry, N. R. A., Carden, D., Aslam, T. M., & Murray, I. J. (2014) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-014-2564-z · Cited by 17
Slowed dark adaptation in older eyes; effect of location
Tahir, H. J., Rodrigo-Diaz, E., Parry, N. R. A., Kelly, J., Carden, D. E., & Murray, I. J. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.11.016 · Cited by 17
Prolactin mitigates deficiencies of retinal function associated with aging
Arnold, E., Thébault, S. C., Aroña, R. M., de la Escalera, G. M., & Clapp, C. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.10.002 · Cited by 17
Aging and mfERG topography
Tam, W.-K., Chan, H. H., Brown, B. H., Leung, K.-W., Woo, V. C. P., & Yap, M. K. H. (2004) · Eye · doi:10.1038/sj.eye.6701777 · Cited by 17
Modeling the Flexural Rigidity of Rod Photoreceptors
Haeri, M., Knox, B. E., & Ahmadi, A. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2012.11.3835 · Cited by 16
Colour, Face, and Visuospatial Imagery Abilities in Low-Vision Individuals with Visual Field Deficits
Dulin, D., Cavézian, C., Serrière, C., Bachoud‐Lévi, A., Bartolomeo, P., & Sylvie Chokron, A. (2011) · Quarterly Journal of Experimental Psychology · doi:10.1080/17470218.2011.608852 · Cited by 16
Recent advances in the dark adaptation investigations.
Yang, G., Chen, T., Tao, Y., & Zhang, Z. (2015) · Europe PMC (PubMed Central) · doi:10.3980/j.issn.2222-3959.2015.06.31 · Cited by 16
Photoreceptor Stability and Degeneration in Mammalian Retina: Lessons from the Edge
Stone, J., Mervin, K., Walsh, N., Valter, K., Provis, J. M., & Penfold, P. L. (2005) · Springer eBooks · doi:10.1007/3-540-26977-0_9 · Cited by 16
Perception of very small visual stimuli in the fovea: normative data for the Rarebit Foveal Test
Nilsson, M., Wanger, P., & Martin, L. (2006) · Clinical and Experimental Optometry · doi:10.1111/j.1444-0938.2006.00016.x · Cited by 16
Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease
Fontaine, V. K., Monteiro, E., Fournié, M., Brazhnikova, E., Boumedine, T., Vidal, C., Balducci, C., Guibout, L., Latil, M., Dilda, P. J., et al. (2020) · Aging · doi:10.18632/aging.103014 · Cited by 15
Repeatability of Scotopic Sensitivity and Dark Adaptation Using a Medmont Dark-Adapted Chromatic Perimeter in Age-related Macular Degeneration
Uddin, D. Y., Jeffrey, B. G., Flynn, O. J., Wong, W. T., Wiley, H. E., Keenan, T. D. L., Chew, E. Y., & Cukras, C. A. (2020) · Translational Vision Science & Technology · doi:10.1167/tvst.9.7.31 · Cited by 15
Is cataract surgery a risk factor for progression of macular degeneration?
Patel, J. I. (2006) · Current Opinion in Ophthalmology · doi:10.1097/icu.0b013e3280112a0f · Cited by 15
Microdot test of foveal function. A comparison with visual acuity at high and low contrast
Malmer, L., & Martin, L. (2005) · Ophthalmic and Physiological Optics · doi:10.1111/j.1475-1313.2004.00244.x · Cited by 15
The role of microRNAs in the pathophysiology of the aging eye
Tamaddon, M., Fazel, M., Rezaee, D., Khalilzad, M. A., Majidpoor, J., Ahmadieh, H., Fattahi, M.-D., Namakin, K., Suri, F., & Najafi, S. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102805 · Cited by 14

Authors: Jackson, G. R., Owsley, C., & Curcio, C. A.
Affiliations: University of Alabama (US)
Corresponding author: Curcio, Christine A
ORCID: Owsley, Cynthia
Curcio, Christine A
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2002-06
Volume: 1
Issue: 3
Pages: 381-396
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/s1568-1637(02)00007-7
OpenAlex: W1970140546
Cited by: 317
References: 91
Citations by year: 2026: 8 · 2025: 13 · 2024: 7 · 2023: 13 · 2022: 15 · 2021: 17 · 2020: 20 · 2019: 14 · 2018: 14 · 2017: 17 · 2016: 16 · 2015: 9 · 2014: 13 · 2013: 25 · 2012: 16
FWCI: 2.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (R01 AG 04212, R01AG004212)
National Eye Institute (R01EY006109, EY06109)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Keywords: photoreceptor degeneration, rod photoreceptors, cone photoreceptors, age-related maculopathy, retinal aging, scotopic sensitivity, dark adaptation, retinal pigment epithelium, Bruch's membrane, macula
MeSH terms: Aging, Animals, Dark Adaptation, Humans, Macular Degeneration, Photoreceptor Cells, Vertebrate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Photoreceptor degeneration and dysfunction in aging and age-related maculopathy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks