The DOI matches its Crossref record, with a small difference in title or year; 259 of the 259 references it cites were found in a registry or an index.
Chapter 2 Hypothalamic Neural Systems Controlling the Female Reproductive Life Cycle
Open accessAbstract
The hypothalamic-pituitary-gonadal (HPG) axis undergoes a number of changes throughout the reproductive life cycle that are responsible for the development, puberty, adulthood, and senescence of reproductive systems. This natural progression is dictated by the neural network controlling the hypothalamus including the cells that synthesize and release gonadotropin-releasing hormone (GnRH) and their regulatory neurotransmitters. Glutamate and GABA are the primary excitatory and inhibitory neurotransmitters in the central nervous system, and as such contribute a great deal to modulating this axis throughout the lifetime via their actions on receptors in the hypothalamus, both directly on GnRH neurons as well as indirectly through other hypothalamic neural networks. Interactions among GnRH neurons, glutamate, and GABA, including the regulation of GnRH gene and protein expression, hormone release, and modulation by estrogen, are critical to age-appropriate changes in reproductive function. Here, we present evidence for the modulation of GnRH neurosecretory cells by the balance of glutamate and GABA in the hypothalamus, and the functional consequences of these interactions on reproductive physiology across the life cycle.
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“and that its occurrence is coincident with a decline of GABAergic transmission to both POA kisspeptin neurons and GnRH neurons [106,107].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [107]
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Cites
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“…the attainment of reproductive competence involves not only molecular modifications of gene and protein expression of GnRH (Ebling and Cronin, 2000; Sisk and Foster, 2004), but also, a maturation of the hypothalamic neural circuitry that regulates the GnRH cells (Ebling and Cronin, 2000; Gore,…”
BackgroundEstradiol and the Developing Brain
McCARTHY, M. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00010.2007 · Cited by 885 · cited 2×
“During late prenatal/early postnatal life, the HPG axis is hyperactive in a sexually dimorphic manner, contributing to sexual differentiation of the brain (Gore, 2008; McCarthy, 2008).”
BackgroundThe Tetrameric Structure of a Glutamate Receptor Channel
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Functional and Pharmacological Differences Between Recombinant N -Methyl- d -Aspartate Receptors
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Cited by
Sorted by citations
Wei, X., Lee, C., Yeung, W. S. B., Giesy, J. P., Wong, M. H., Zhang, X., Hecker, M., & Wong, C. K. C. (2010) · Reproductive Toxicology · doi:10.1016/j.reprotox.2010.12.002 · Cited by 231
Lee, H., Jeung, E., Cho, M., Kim, T., Leung, P. C. K., & Choi, K. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2012.01649.x · Cited by 171
Gore, A. C., Walker, D. M., Zama, A. M., Armenti, A. E., & Uzumcu, M. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1210 · Cited by 141
Self-citationNeuroendocrine Control of the Ovarian Cycle of the Rat
Levine, J. E. (2015) · Knobil and Neill's Physiology of Reproduction · doi:10.1016/b978-0-12-397175-3.00026-0 · Cited by 140
Kokay, I. C., Petersen, S. L., & Grattan, D. R. (2011) · Endocrinology · doi:10.1210/en.2010-0668 · Cited by 131
Metadata
- Authors
- Maffucci, J. A., & Gore, A. C.
- Affiliations
- The University of Texas at Austin (US)
- ORCID
- Andrea C. Gore
- Venue
- International Review of Cell and Molecular Biology
- Publisher
- Elsevier
- Published
- 2009
- Volume
- 274
- Pages
- 69-127
- ISSN
- 0074-7696 (ISSN-L)
- 1937-6448
- PMC
- PMC2821833
- OpenAlex
- W1496951129
- Cited by
- 93
- References
- 259
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 9 · 2019: 9 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 3
- FWCI
- 23.91
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International review of cytology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG-16765, AG028051, R01AG028051, P01AG016765)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- hypothalamic-pituitary-gonadal axis, gonadotropin-releasing hormone, GnRH neurons, glutamate, GABA, neurotransmitter modulation, puberty, reproductive aging, estrogen modulation, GnRH gene expression
- MeSH terms
- Animals, Female, gamma-Aminobutyric Acid, Glutamates, Humans, Hypothalamo-Hypophyseal System, Gonadotropin-Releasing Hormone, Nervous System, Reproduction
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