Cited by 154Adipose Tissue and MetabolismThyroid Disorders and TreatmentsAdipokines, Inflammation, and Metabolic Diseases

The role of thyroid hormone and brown adipose tissue in energy homoeostasis

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Bianco, Antonio C, McAninch, Elizabeth A·2013·The Lancet Diabetes & Endocrinology

Abstract

The presence of brown adipose tissue (BAT) in adults has become increasingly well defined as a result of functional imaging studies of thermogenically active BAT. Findings from these studies have created a surge of scientific interest in BAT, because it represents a potential therapeutic target for obesity--a condition with profound health consequences and few successful therapies. BAT contributes to overall energy expenditure in small mammals and neonates through adaptive thermogenesis. Thyroid-hormone signalling, particularly through induction of type II deiodinase, has a central role in brown adipogenesis in vitro and BAT development in mouse embryos. Additionally, because of high intracellular expression of type II deiodinase, adult BAT has enhanced thyroid-hormone signalling with several thyroid-hormone-dependent thermogenic pathways, including expression of the genes Ppargc1a and Ucp1. BAT thermogenesis explains the essential part played by thyroid hormone in energy homoeostasis and adaptation to cold. Stimulation of BAT in adults, specifically through thyroid-hormone-mediated pathways, is a promising therapeutic target for obesity.

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  • In brown adipocytes, T4 can be converted to its active form T3 via DIO2, thus compensating for low levels of thyroid gland-secreted T3.

    “In brown adipocytes, T4 can be converted to its active form T3 via type 2 iodothyronine deiodinase (DIO2) thus compensating for the low levels of thyroid gland‐secreted T3 88.”

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  1. [46]Bianco AC Silva JE Nuclear 3,5,3′-triiodothyronine (T3) in brown adipose tissue: receptor occupancy and sources of T3 as determined by in vivo techniques Endocrinology 1987 120 55 62 3780570

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Authors
Bianco, A. C., & McAninch, E. A.
Affiliations
University of Miami (US)
Venue
The Lancet Diabetes & Endocrinology
Publisher
Elsevier BV
Published
2013-11
Volume
1
Issue
3
Pages
250-258
ISSN
2213-8587 (ISSN-L)
OpenAlex
W2097615700
Cited by
154
References
96
Citations by year
2026: 8 · 2025: 17 · 2024: 11 · 2023: 13 · 2022: 11 · 2021: 16 · 2020: 12 · 2019: 20 · 2018: 12 · 2017: 7 · 2016: 8 · 2015: 9 · 2014: 10
FWCI
0.99
Type
journal article
Language
en
Open access
Locations
  • The Lancet Diabetes & Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK065055, R01DK077148)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
brown adipose tissue, thyroid hormones, energy homeostasis, adaptive thermogenesis, type 2 deiodinase, brown adipogenesis, PGC-1α, UCP1, obesity, cold adaptation, energy expenditure
MeSH terms
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Uncoupling Protein 1, Adult, Animals, Adipose Tissue, Brown, Energy Metabolism, Homeostasis, Humans, Iodide Peroxidase, Ion Channels, Models, Biological, Obesity, Thyroid Hormones, Transcription Factors, Signal Transduction, Thermogenesis, Mitochondrial Proteins, Mice

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