Genetic variation in thyroid hormone pathway genes; polymorphisms in the TSH receptor and the iodothyronine deiodinases

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220 · see citing works

Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases

Bianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853 · see citing works

Small Differences in Thyroid Function May Be Important for Body Mass Index and the Occurrence of Obesity in the Population

Knudsen, N., Laurberg, P., Rasmussen, L. B., Bülow, I., Perrild, H., Ovesen, L., & Jørgensen, T. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2225 · Cited by 753 · see citing works

TSH Is a Negative Regulator of Skeletal Remodeling

Abe, E., Marians, R. C., Yu, W., Wu, X.-B., Ando, T., Li, Y., Iqbal, J., Eldeiry, L., Rajendren, G., Blair, H. C., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00771-2 · Cited by 691 · see citing works

Narrow Individual Variations in Serum T₄and T₃in Normal Subjects: A Clue to the Understanding of Subclinical Thyroid Disease

Andersen, S., Pedersen, K. M., Bruun, N. H., & Laurberg, P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8165 · Cited by 686 · see citing works

Subclinical Hypothyroidism

Cooper, D. S. (2001) · New England Journal of Medicine · doi:10.1056/nejm200107263450406 · Cited by 524 · see citing works

Reduced Activation and Increased Inactivation of Thyroid Hormone in Tissues of Critically Ill Patients

Peeters, R. P., Wouters, P. J., Kaptein, E., van Toor, H., Visser, T. J., & Van den Berghe, G. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-022013 · Cited by 452 · see citing works

Targeted Disruption of the Type 2 Selenodeiodinase Gene (<i>DIO</i>2) Results in a Phenotype of Pituitary Resistance to T₄

Schneider, M. J., Fiering, S. N., Pallud, S. E., Parlow, A. F., St. Germain, D. L., & Galton, V. A. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.12.0740 · Cited by 376 · see citing works

Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans

Luiza Maia, A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25083 · Cited by 360 · see citing works

Resistance to Thyrotropin Caused by Mutations in the Thyrotropin-Receptor Gene

Sunthornthepvarakul, T., Gottschalk, M. E., Hayashi, Y., & Refetoff, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199501193320305 · Cited by 340 · see citing works

Iodothyronine Levels in the Human Developing Brain: Major Regulatory Roles of Iodothyronine Deiodinases in Different Areas

Kester, M. H. A., de Mena, R. M., Obregón, M.-J., Marinkovic, D., Howatson, A. G., Visser, T. J., Hume, R., & de Escobar, G. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031832 · Cited by 330 · see citing works

Genetic associations: false or true?

Ioannidis, J. P. A. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00030-3 · Cited by 289 · see citing works

Major Genetic Influence on the Regulation of the Pituitary-Thyroid Axis: A Study of Healthy Danish Twins

Hansen, P. S., Brix, T. H., Sørensen, T. I. A., Kyvik, K. O., & Hegedüs, L. (2004) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2003-031641 · Cited by 257 · see citing works

Polymorphisms in Thyroid Hormone Pathway Genes Are Associated with Plasma TSH and Iodothyronine Levels in Healthy Subjects

Peeters, R. P., van Toor, H., Klootwijk, W., de Rijke, Y. B., Kuiper, G. G. J. M., Uitterlinden, A. G., & Visser, T. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021592 · Cited by 242 · see citing works

Subclinical Hyperthyroidism

Toft, A. D. (2001) · New England Journal of Medicine · doi:10.1056/nejmcp010145 · Cited by 231 · see citing works

Thyrotropin Receptor Expression in Graves’ Orbital Adipose/Connective Tissues: Potential Autoantigen in Graves’ Ophthalmopathy1

Bahn, R. S., Dutton, C. M., Natt, N., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4676 · Cited by 228 · see citing works

Association Between a Novel Variant of the Human Type 2 Deiodinase Gene Thr92Ala and Insulin Resistance

Mentuccia, D., Proietti-Pannunzi, L., Tanner, K., Bacci, V., Pollin, T. I., Poehlman, E. T., Shuldiner, A. R., & Celi, F. S. (2002) · Diabetes · doi:10.2337/diabetes.51.3.880 · Cited by 205 · see citing works

The Type 2 Deiodinase A/G (Thr92Ala) Polymorphism Is Associated with Decreased Enzyme Velocity and Increased Insulin Resistance in Patients with Type 2 Diabetes Mellitus

Canani, L. H. S., Capp, C., Dora, J. M., Meyer, E. L. D. S., Wagner, M. S., Harney, J. W., Larsen, P. R., Gross, J. L., Bianco, A. C., & Maia, A. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1977 · Cited by 204 · see citing works

Association of the TSHR gene with Graves' disease: the first disease specific locus

DeChairo, B. M., Zabaneh, D., Collins, J. E., Brand, O. J., Dawson, G., Green, A., Mackay, I., Franklyn, J. A., Connell, J., Wass, J. A. H., et al. (2005) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201485 · Cited by 176 · see citing works

A Thyroid Hormone Receptor α Gene Mutation (P398H) Is Associated with Visceral Adiposity and Impaired Catecholamine-stimulated Lipolysis in Mice

Liu, Y., Schultz, J. J., & Brent, G. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306120200 · Cited by 165 · see citing works

Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor

Nakabayashi, K., Matsumi, H., Bhalla, A., Bae, J., Mosselman, S., Hsu, S. Y., & Hsueh, A. J. W. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14340 · Cited by 161 · see citing works

Interrelationships between age, thyroid volume, thyroid nodularity, and thyroid function in patients with sporadic nontoxic goiter

Berghout, A., Wiersinga, W. M., Smits, N. J., & TOUBER, J. L. (1990) · The American Journal of Medicine · doi:10.1016/0002-9343(90)90178-g · Cited by 141 · see citing works

Functional TSH receptor in human abdominal preadipocytes and orbital fibroblasts

Bell, A., Gagnon, A., Grunder, L., et al. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.2.c335 · Cited by 138 · see citing works

The GeneLocusEncoding Iodothyronine Deiodinase Type 3 (Dio3) Is Imprinted in the Fetus and Expresses Antisense Transcripts

Hernández, A., Fiering, S., Martinez, E., Galton, V. A., & Germain, D. L. S. (2002) · Endocrinology · doi:10.1210/en.2002-220800 · Cited by 130 · see citing works

The Expression of Thyrotropin Receptor in the Brain

Crisanti, P., Omri, B., Hughes, E. J., Méduri, G., Héry, C., Clauser, É., Jacquemin, C., & Saunier, B. (2001) · Endocrinology · doi:10.1210/endo.142.2.7943 · Cited by 125 · see citing works

Multiple SNPs in Intron 7 of Thyrotropin Receptor Are Associated with Graves’ Disease

Hiratani, H., Bowden, D. W., Ikegami, S., Shirasawa, S., Shimizu, A., Iwatani, Y., & Akamizu, T. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2148 · Cited by 122 · see citing works

Limited Genetic Susceptibility to Severe Graves' Ophthalmopathy: No Role for CTLA-4 But Evidence for an Environmental Etiology

Villanueva, R., Inzerillo, A. M., Tomer, Y., Barbesino, G., Meltzer, M. A., Concepcion, E. S., Greenberg, D. A., Maclaren, N., Sun, Z. S., Zhang, D. M., et al. (2000) · Thyroid · doi:10.1089/thy.2000.10.791 · Cited by 120 · see citing works

Intracellular entrapment of wild-type TSH receptor by oligomerization with mutants linked to dominant TSH resistance

Calebiro, D., de Filippis, T., Lucchi, S., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi329 · Cited by 117 · see citing works

Regulation of Human Adipocyte Gene Expression by Thyroid Hormone

Viguerie, N., Millet, L., Avizou, S., Vidal, H., Larrouy, D., & Langin, D. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8200 · Cited by 116 · see citing works

Substrate-Induced Down-Regulation of Human Type 2 Deiodinase (hD2) Is Mediated through Proteasomal Degradation and Requires Interaction with the Enzyme’s Active Center¹

Steinsapir, J., Bianco, A. C., Buettner, C., Harney, J., & Larsen, P. R. (2000) · Endocrinology · doi:10.1210/endo.141.3.7355 · Cited by 109 · see citing works

A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters

Peeters, R. P., van den Beld, A. W., Attalki, H., Toor, H. V., de Rijke, Y. B., Kuiper, G. G. J. M., Lamberts, S. W. J., Janssen, J. A. M. J. L., Uitterlinden, A. G., & Visser, T. J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00571.2004 · Cited by 108 · see citing works

Mapping of a Major Susceptibility Locus for Graves’ Disease (GD-1) to Chromosome 14q31

Tomer, Y., Barbesino, G., Keddache, M. A., et al. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.4064 · Cited by 104 · see citing works

A Polymorphism in the Extracellular Domain of the Thyrotropin Receptor Is Highly Associated with Autoimmune Thyroid Disease in Females

Cuddihy, R. M., Dutton, C. M., & Bahn, R. S. (1995) · Thyroid · doi:10.1089/thy.1995.5.89 · Cited by 99 · see citing works

Intracellular pathways of iodothyro-nine metabolism

Leonard, J., & Koehrle, J. (1996) · Cited by 93 · see citing works

Positive association of the DIO2 (deiodinase type 2) gene with mental retardation in the iodine-deficient areas of China

Guo, T.-W., Zhang, F.-C., Yang, M.-S., Gao, X.-C., Bian, L., Duan, S.-W., Zheng, Z.-J., Gao, J.-J., Wang, H., Li, R.-L., et al. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2004.019190 · Cited by 91 · see citing works

Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency.

Berry, M. J., Grieco, D., Taylor, B. A., Maia, A. L., Kieffer, J. D., Beamer, W. G., Glover, E. A., Poland, A., & Larsen, P. R. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116730 · Cited by 86 · see citing works

Microsatellites and PCR primers for genetic studies and genomic sequencing of the human ISH receptor gene

de Roux, N., Misrahi, M., Chatelain, N., et al. (1996) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(95)03753-5 · Cited by 79 · see citing works

Sympathetic and parasympathetic innervation of adipose tissue: metabolic implications

Romijn, J. A., & Fliers, E. (2005) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000172586.09762.55 · Cited by 71 · see citing works

Increased glucose transporter (GLUT4) protein expression in hyperthyroidism

Casla, A., Rovira, A., Wells, J. A., & Dohm, G. L. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91374-2 · Cited by 71 · see citing works

Association of Autoimmune Thyroid Disease with Microsatellite Markers for the Thyrotropin Receptor Gene and CTLA-4 in Japanese Patients

Akamizu, T., Sale, M. M., Rich, S. S., Hiratani, H., Noh, J. Y., Kanamoto, N., Saijo, M., Miyamoto, Y., Saito, Y., Nakao, K., et al. (2000) · Thyroid · doi:10.1089/thy.2000.10.851 · Cited by 70 · see citing works

Germline Polymorphism of Codon 727 of Human Thyroid-Stimulating Hormone Receptor Is Associated with Toxic Multinodular Goiter1

Gabriel, E. M., Bergert, E. R., Grant, C. S., van Heerden, J. A., Thompson, G. B., & Morris, J. C. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.9.5966 · Cited by 69 · see citing works

Genetic and Environmental Influences on Thyroid Hormone Variation in Mexican Americans

Samollow, P. B., Perez, G. M., Kammerer, C. M., Finegold, D. N., Zwartjes, P. W., Havill, L. M., Comuzzie, A. G., Mahaney, M. C., Göring, H. H. H., Blangero, J., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031706 · Cited by 69 · see citing works

A Polymorphism in Type I Deiodinase Is Associated with Circulating Free Insulin-Like Growth Factor I Levels and Body Composition in Humans

Peeters, R. P., van den Beld, A. W., van Toor, H., Uitterlinden, A. G., Janssen, J. A. M. J. L., Lamberts, S. W. J., & Visser, T. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1301 · Cited by 60 · see citing works

Aging Alters the Activity of 5′-Deiodinase in the Adenohypophysis, Thyroid Gland, and Liver of the Male Rat*

Donda, A., & Lemarchand-Béraud, T. (1989) · Endocrinology · doi:10.1210/endo-124-3-1305 · Cited by 58 · see citing works

Association of Graves' Disease with Intragenic Polymorphism of the Thyrotropin Receptor Gene in a Cohort of Singapore Patients of Multi-Ethnic Origins

Ho, S.-C., Goh, S.-S., & Khoo, D. H. C. (2003) · Thyroid · doi:10.1089/105072503322238773 · Cited by 56 · see citing works

The mRNA Structure Has Potent Regulatory Effects on Type 2 Iodothyronine Deiodinase Expression

Gereben, B., Kollár, A., Harney, J. W., & Larsen, P. R. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.7.0879 · Cited by 56 · see citing works

Thyrotropin Receptor Mutations in Hyperfunctioning Thyroid Adenomas from Brazil

Nogueira, C. R., Kopp, P. A., Arseven, O. K., Santos, C. L. S., Jameson, J. L., & Medeiros-Neto, G. A. (1999) · Thyroid · doi:10.1089/thy.1999.9.1063 · Cited by 54 · see citing works

Somatic Mutations in Thyroid Nodular Disease

Krohn, K., & Paschke, R. (2002) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2001.3290 · Cited by 52 · see citing works

Thyrotropin Receptor Polymorphisms and Thyroid Diseases

Tonacchera, M., & Pinchera, A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.8.6801 · Cited by 52 · see citing works

A Germline Single Nucleotide Polymorphism at the Intracellular Domain of the Human Thyrotropin Receptor Does Not Have a Major Effect on the Development of Graves' Disease

Ban, Y., Greenberg, D. A., Concepcion, E., et al. (2002) · Thyroid · doi:10.1089/105072502321085171 · Cited by 52 · see citing works

Insulin-like growth factor I alters peripheral thyroid hormone metabolism in humans: comparison with growth hormone

Hussain, M. A., Schmitz, O., Jørgensen, J. O. L., et al. (1996) · European Journal of Endocrinology · doi:10.1530/eje.0.1340563 · Cited by 51 · see citing works

Association of autoimmune thyroid disease with a microsatellite marker for the thyrotropin receptor gene and CTLA-4 in a Japanese population.

Sale, M. M., Akamizu, T., HOWARD, T. D., et al. (1997) · PubMed · Cited by 50 · see citing works

Lack of Association of Nonautoimmune Hyperfunctioning Thyroid Disorders and a Germline Polymorphism of Codon 727 of the Human Thyrotropin Receptor in a European Caucasian Population1

Mühlberg, T., Herrmann, K., Joba, W., et al. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.8.6704 · Cited by 48 · see citing works

Prevalence of subclinical hyperthyroidism and relationship between thyroid hormonal status and thyroid ultrasonographic parameters in patients with non‐toxic nodular goitre

Rieu, M., Bekka, S., Sambor, B., Berrod, J., & Fombeur, J. P. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb01752.x · Cited by 48 · see citing works

Polymorphism of a Variant Human Thyrotropin Receptor (hTSHR) Gene

SUNTHORNTHEPVARAKUL, T., Hayashi, Y., & Refetoff, S. (1994) · Thyroid · doi:10.1089/thy.1994.4.147 · Cited by 44 · see citing works

Thyroid-stimulating hormone receptor and its role in Graves’ disease

Chistiakov, D. A. (2003) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2003.09.001 · Cited by 43 · see citing works

Functional significance of the thyrotropin receptor germline polymorphism D727E

Sykiotis, G. P., Neumann, S., Georgopoulos, N. A., Sgourou, A., Papachatzopoulou, A., Markou, K. B., Kyriazopoulou, V. E., Paschke, R., Vagenakis, A. G., & Papavassiliou, A. G. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00071-8 · Cited by 40 · see citing works

Messenger RNA expression for a TSH receptor variant in the thymus of a two-year-old child

Paschke, R., & Geenen, V. G. (1995) · Journal of Molecular Medicine · doi:10.1007/bf00195143 · Cited by 37 · see citing works

Effects of Thyrotropin on the Proliferation and Differentiation of Cultured Rat Preadipocytes

Haraguchi, K., Shimura, H., KAWAGUCHI, A., et al. (1999) · Thyroid · doi:10.1089/thy.1999.9.613 · Cited by 35 · see citing works

Screening of SNPs at 18 positional candidate genes, located within the GD-1 locus on chromosome 14q23–q32, for susceptibility to Graves’ disease: a TDT study

Chistiakov, D. A., Savostyanov, K. V., & Turakulov, R. I. (2004) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2004.07.011 · Cited by 30 · see citing works

Tri-iodothyronine and cycloheximide enhance insulin-like growth factor-binding protein-1 gene expression in human hepatoma cells

Angervo, M., Leinonen, P. J., Koistinen, R., et al. (1993) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0100007 · Cited by 30 · see citing works

Further studies of genetic susceptibility to Graves' disease in a Russian population.

Chistiakov, D. A., Savost'anov, K. V., Turakulov, R. I., et al. (2002) · PubMed · Cited by 26 · see citing works

Functional analysis of a variant of the thyrotropin receptor gene in a family with Graves' disease

Gustavsson, B. G., Eklöf, C., Westermark, K., et al. (1995) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(95)03562-l · Cited by 23 · see citing works

Enhanced cAMP Accumulation by the Human Thyrotropin Receptor Variant with the Pro52Thr Substitution in the Extracellular Domain

Loos, U., Hagner, S., Bohr, U. R. M., et al. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20781.x · Cited by 23 · see citing works

Normal Function in Vivo of a Homozygotic Polymorphism in the Human Thyrotropin Receptor

Cuddihy, R. M., Bryant, W. P., & Bahn, R. S. (1995) · Thyroid · doi:10.1089/thy.1995.5.255 · Cited by 20 · see citing works

Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement

Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928 · see citing works

Selenium in human health and disease

Fairweather-Tait, S. J., Bao, Y., Broadley, M. R., Collings, R., Ford, D., Hesketh, J. E., & Hurst, R. (2011) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2010.3275 · Cited by 1,330 · see citing works

Hypothyroidism

Chaker, L., Razvi, S., Bensenor, I. M., Azizi, F., Pearce, E. N., & Peeters, R. P. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00357-7 · Cited by 330 · see citing works

Paradigms of dynamic control of thyroid hormone signaling

Bianco, A. C., Dumitrescu, A., Gereben, B., Ribeiro, M. O., Fonseca, T. L., Fernandes, G. W., & Bocco, B. M. L. C. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00275 · Cited by 293 · see citing works

Age- and Race-Based Serum Thyrotropin Reference Limits

Surks, M. I., & Boucai, L. (2010) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2009-1845 · Cited by 258 · see citing works

An approach for development of age-, gender-, and ethnicity-specific thyrotropin reference limits

Boucai, L., Hollowell, J. G., & Surks, M. I. (2011) · Thyroid · doi:10.1089/thy.2010.0092 · Cited by 235 · see citing works

Pituitary Diseases and Bone

Mazziotti, G., Frara, S., & Giustina, A. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00005 · Cited by 181 · see citing works

High-Normal Thyroid Function and Risk of Atrial Fibrillation: The Rotterdam Study

Heeringa, J., Hoogendoorn, E. H., van der Deure, W. M., Hofman, A., Peeters, R. P., Hop, W. C. J., den Heijer, M., Visser, T. J., & Witteman, J. C. M. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.20.2219 · Cited by 161 · see citing works

The role of thyroid hormone and brown adipose tissue in energy homoeostasis

Bianco, A. C., & McAninch, E. A. (2013) · The Lancet Diabetes &amp; Endocrinology · doi:10.1016/s2213-8587(13)70069-x · Cited by 154 · see citing works

Ethnic differences in maternal thyroid parameters during pregnancy: the Generation R study

Korevaar, T. I. M., Medici, M., de Rijke, Y. B., Visser, W., de Muinck Keizer-Schrama, S. M. P. F., Jaddoe, V. W. V., Hofman, A., Ross, H. A., Visser, W. E., Hooijkaas, H., et al. (2013) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2013-2005 · Cited by 150 · see citing works

Genetic Predisposition to Elevated Serum Thyrotropin Is Associated with Exceptional Longevity

Atzmon, G., Barzilai, N., Surks, M. I., & Gabriely, I. (2009) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2009-0808 · Cited by 145 · see citing works

Molecular aspects of thyroid hormone transporters, including MCT8, MCT10, and OATPs, and the effects of genetic variation in these transporters

van der Deure, W. M., Peeters, R. P., & Visser, T. J. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0042 · Cited by 130 · see citing works

Heritability of serum TSH, free T4 and free T3 concentrations: a study of a large UK twin cohort

Panicker, V., Wilson, S. G., Spector, T. D., Brown, S. J., Falchi, M., Richards, J. B., Surdulescu, G. L., Lim, E. M., Fletcher, S. J., & Walsh, J. P. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03079.x · Cited by 128 · see citing works

MECHANISMS IN ENDOCRINOLOGY: Beyond the fixed setpoint of the hypothalamus–pituitary–thyroid axis

Fliers, E., Kalsbeek, A., & Boelen, A. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0285 · Cited by 124 · see citing works

Thyrotropin secretion patterns in health and disease

Roelfsema, F., & Veldhuis, J. D. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1076 · Cited by 113 · see citing works

Thyroid hormones and aging

Peeters, R. P. (2008) · Hormones · doi:10.14310/horm.2002.1111035 · Cited by 98 · see citing works

Genetic determination of the hypothalamic–pituitary–thyroid axis: where do we stand?

Medici, M., Visser, W. E., Visser, T. J., & Peeters, R. P. (2015) · Endocrine Reviews · doi:10.1210/er.2014-1081 · Cited by 92 · see citing works

Moderate weight loss is sufficient to affect thyroid hormone homeostasis and inhibit its peripheral conversion

Agnihothri, R. V., Courville, A. B., Linderman, J. D., Smith, S., Brychta, R., Remaley, A., Chen, K. Y., Simchowitz, L., & Celi, F. S. (2014) · Thyroid · doi:10.1089/thy.2013.0055 · Cited by 94 · see citing works

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

Jansen, S. W., Akintola, A. A., Roelfsema, F., van der Spoel, E., Cobbaert, C. M., Ballieux, B. E., Egri, P., Kvarta-Papp, Z., Gereben, B., Fekete, C., et al. (2015) · Scientific Reports · doi:10.1038/srep11525 · Cited by 82 · see citing works

Fatigue and fatigue-related symptoms in patients treated for different causes of hypothyroidism

Louwerens, M., Appelhof, B. C., Verloop, H., Medici, M., Peeters, R. P., Visser, T. J., Boelen, A., Fliers, E., Smit, J. W. A., & Dekkers, O. M. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0501 · Cited by 50 · see citing works

The Genetic Basis of Thyroid Function: Novel Findings and New Approaches

Kuś, A., Chaker, L., Teumer, A., Peeters, R. P., & Medici, M. (2020) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/clinem/dgz225 · Cited by 44 · see citing works

Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review

Theodorakis, N., Kreouzi, M., Pappas, A., & Nikolaou, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413438 · Cited by 43 · see citing works

Main Factors Involved in Thyroid Hormone Action

Tedeschi, L., Vassalle, C., Iervasi, G., & Sabatino, L. (2021) · Molecules · doi:10.3390/molecules26237337 · Cited by 25 · see citing works

Thyroid Hormone Receptors

Vennström, B., Liu, H., & Forrest, D. (2010) · Springer eBooks · doi:10.1007/978-90-481-3303-1_7 · Cited by 4 · see citing works

Trans-activation by thyroid hormone receptors: functional parallels with steroid hormone receptors.

Thompson, C. C., & Evans, R. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.10.3494 · Cited by 156 · see citing works

Gene regulation by thyroid hormone receptors

Hörlein, A., Heinzel, T., & Rosenfeld, M. G. (1996) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-199610000-00009 · Cited by 20 · see citing works

Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific

Zavacki, A. M., Harney, J. W., Brent, G. A., & Larsen, P. R. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.10.8264663 · Cited by 73 · see citing works