The DOI matches its Crossref record; 103 of the 106 references it cites were found in a registry or an index.
Obesity, inflammation, and the gut microbiota
Abstract
As the prevalence of obesity and associated disease continues to rise and concerns for the spiralling economic and social costs also escalate, innovative management strategies beyond primary prevention and traditional lifestyle interventions are urgently needed. The biological basis of disease is one avenue for further exploration in this context. Several key inflammatory markers have been consistently associated with both obesity and risk of adverse outcomes in obesity-associated diseases, which suggests that a persistent, low-grade, inflammatory response is a potentially modifiable risk factor. In this Review, we provide evidence supporting perturbation of the intestinal microbiota and changes in intestinal permeability as potential triggers of inflammation in obesity. Further characterisation of the mechanisms underpinning the triggers of such inflammatory responses in overweight and obese individuals could offer unique opportunities for intervention strategies to help ameliorate the risk of obesity-associated disease.
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“This body of work suggests that increased intestinal permeability from high-fat / high sugar diets allows bacterial lipopolysaccharide (LPS), an outer membrane component of gram-negative bacteria linked with induction of inflammation, from the gut microbiota to translocate into the systemic circulation, resulting in systemic endotoxemia.”
From The athletic gut microbiota (2020) · cites this paper as [68]
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“One leading theory on the pathogenesis of obesity emphasizes a close link between the metabolic and immune systems via the gut microbiota [68].”
From The athletic gut microbiota (2020) · cites this paper as [68]
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Cites
1 retracted
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RetractedAn obesity-associated gut microbiome with increased capacity for energy harvest
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Diet rapidly and reproducibly alters the human gut microbiome
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Human gut microbes associated with obesity
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Diversity of the Human Intestinal Microbial Flora
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Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
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Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
Liu, R., Hong, J., Xu, X., Feng, Q., Zhang, D., Gu, Y., Shi, J., Zhao, S., Liu, W., Wang, X., et al. (2017) · Nature Medicine · doi:10.1038/nm.4358 · Cited by 1,501
Akdiş, C. A. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00538-7 · Cited by 1,066
Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body
Cristofori, F., Dargenio, V. N., Dargenio, C., Miniello, V. L., Barone, M., & Francavilla, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.578386 · Cited by 991
Actinobacteria: A relevant minority for the maintenance of gut homeostasis
Binda, C., Lopetuso, L. R., Rizzatti, G., Gibiino, G., Cennamo, V., & Gasbarrini, A. (2018) · Digestive and Liver Disease · doi:10.1016/j.dld.2018.02.012 · Cited by 828
Metadata
- Authors
- Cox, A. J., West, N. P., & Cripps, A. W.
- Affiliations
- Griffith University (AU)
- Corresponding author
- Cox, Amanda J
- Venue
- The Lancet Diabetes & Endocrinology
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 3
- Issue
- 3
- Pages
- 207-215
- ISSN
- 2213-8587 (ISSN-L)
- OpenAlex
- W1996175687
- Cited by
- 869
- References
- 106
- Citations by year
- 2026: 41 · 2025: 77 · 2024: 115 · 2023: 105 · 2022: 103 · 2021: 99 · 2020: 96 · 2019: 77 · 2018: 50 · 2017: 37 · 2016: 31 · 2015: 33
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Diabetes & Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Griffith Research Online (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- obesity, inflammation, gut microbiota, intestinal permeability, low-grade inflammation, obesity-related comorbidities, overweight, inflammatory markers
- MeSH terms
- Humans, Inflammation, Models, Biological, Obesity, Permeability, Biomarkers, Prevalence, Gastrointestinal Tract, Microbiota
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