Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

Random Forests

Breiman, L. (2001) · Machine Learning · doi:10.1023/a:1010933404324 · Cited by 133,538 · see citing works

KEGG: Kyoto Encyclopedia of Genes and Genomes

Kanehisa, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.27 · Cited by 37,077 · see citing works

KEGG: Kyoto Encyclopedia of Genes and Genomes

Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232 · see citing works

Diet rapidly and reproducibly alters the human gut microbiome

David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works

Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works

Diversity of the Human Intestinal Microbial Flora

Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works

A core gut microbiome in obese and lean twins

Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works

A metagenome-wide association study of gut microbiota in type 2 diabetes

Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works

The gut microbiota as an environmental factor that regulates fat storage

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915 · see citing works

Richness of human gut microbiome correlates with metabolic markers

Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works

Cross-talk between <i>Akkermansia muciniphila</i> and intestinal epithelium controls diet-induced obesity

Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works

FITTING MULTIVARIATE MODELS TO COMMUNITY DATA: A COMMENT ON DISTANCE-BASED REDUNDANCY ANALYSIS

McArdle, B. H., & Anderson, M. J. (2001) · Ecology · doi:10.1890/0012-9658(2001)082[0290:fmmtcd]2.0.co;2 · Cited by 4,001 · see citing works

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works

SOAP2: an improved ultrafast tool for short read alignment

Li, R., Yu, C., Li, Y., Lam, T., Yiu, S., Kristiansen, K., & Wang, J. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp336 · Cited by 3,763 · see citing works

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Vétizou, M., Pitt, J. M., Daillère, R., Lepage, P., Waldschmitt, N., Flament, C., Rusakiewicz, S., Routy, B., Roberti, M. P., Duong, C. P. M., et al. (2015) · Science · doi:10.1126/science.aad1329 · Cited by 3,488 · see citing works

Analysis of Longitudinal Data

Diggle, P. J., Heagerty, P. J., Liang, K., & Zeger, S. L. (2002) · doi:10.1093/oso/9780198524847.001.0001 · Cited by 3,388 · see citing works

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry.

The Human Serum Metabolome (HUSERMET) Consortium, Dunn, W. B., Broadhurst, D., Begley, P., Zelena, E., Francis-McIntyre, S., Anderson, N., Brown, M., Knowles, J. D., Halsall, A., et al. (2011) · Nature Protocols · doi:10.1038/nprot.2011.335 · Cited by 3,294 · see citing works

Metabolite profiles and the risk of developing diabetes

Wang, T. J., Larson, M. G., Vasan, R. S., Cheng, S., Rhee, E. P., McCabe, E., Lewis, G. D., Fox, C. S., Jacques, P. F., Fernandez, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2307 · Cited by 3,143 · see citing works

Gut metagenome in European women with normal, impaired and diabetic glucose control

Karlsson, F. H., Tremaroli, V., Nookaew, I., Bergström, G., Behre, C. J., Fagerberg, B., Nielsen, J., & Bäckhed, F. (2013) · Nature · doi:10.1038/nature12198 · Cited by 3,115 · see citing works

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915 · see citing works

HMDB 3.0—The Human Metabolome Database in 2013

Wishart, D. S., Jewison, T., Guo, A. C., Wilson, M., Knox, C., Liu, Y., Djoumbou-Feunang, Y., Mandal, R., Aziat, F., Dong, E., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1065 · Cited by 2,845 · see citing works

Microbiota and SCFA in lean and overweight healthy subjects

Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D. (2010) · Obesity · doi:10.1038/oby.2009.167 · Cited by 2,457 · see citing works

Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine

Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202 · see citing works

An integrated catalog of reference genes in the human gut microbiome

MetaHIT Consortium, Li, J., Jia, H., Cai, X., Zhong, H., Feng, Q., Sunagawa, S., Arumugam, M., Kultima, J. R., Prifti, E., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2942 · Cited by 2,164 · see citing works

Human gut microbes impact host serum metabolome and insulin sensitivity

Pedersen, H. K., Gudmundsdottir, V., Nielsen, H. B., Hyotylainen, T., Nielsen, T., Jensen, B. A. H., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., et al. (2016) · Nature · doi:10.1038/nature18646 · Cited by 2,116 · see citing works

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

Olney, J. (1969) · Science · doi:10.1126/science.164.3880.719 · Cited by 1,885 · see citing works

Dietary intervention impact on gut microbial gene richness

Cotillard, A., Kennedy, S. P., Kong, L. C., Prifti, E., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Levenez, F., Galleron, N., et al. (2013) · Nature · doi:10.1038/nature12480 · Cited by 1,832 · see citing works

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

Claesson, M. J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E., Marchesi, J. R., Falush, D., Dinan, T., Fitzgerald, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000097107 · Cited by 1,754 · see citing works

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

Zhang, X., Zhang, D., Jia, H., Feng, Q., Wang, D., Liang, D., Wu, X., Li, J., Tang, L., Li, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3914 · Cited by 1,690 · see citing works

Gut microbiome development along the colorectal adenoma-carcinoma sequence

Feng, Q., Liang, S., Jia, H., Stadlmayr, A., Tang, L., Lan, Z., Zhang, D., Xia, H., Xu, X., Jie, Z., et al. (2015) · Nature Communications · doi:10.1038/ncomms7528 · Cited by 1,506 · see citing works

A Genomic View of the Human- <i>Bacteroides thetaiotaomicron</i> Symbiosis

Xu, J., Bjursell, M. K., Himrod, J., Deng, S., Carmichael, L. K., Chiang, H. C., Hooper, L. V., & Gordon, J. I. (2003) · Science · doi:10.1126/science.1080029 · Cited by 1,353 · see citing works

Persistent gut microbiota immaturity in malnourished Bangladeshi children

Subramanian, S., Huq, S., Yatsunenko, T., Haque, R., Mahfuz, M., Alam, M. A., Benezra, A., DeStefano, J., Meier, M. F., Muegge, B. D., et al. (2014) · Nature · doi:10.1038/nature13421 · Cited by 1,270 · see citing works

Faecalibacterium prausnitzii and human intestinal health

Miquel, S., Martín, R., Rossi, O., Bermúdez‐Humarán, L. G., Chatel, J., Sokol, H., Thomas, M., Wells, J. M., & Langella, P. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.003 · Cited by 1,239 · see citing works

Human colonic microbiota associated with diet, obesity and weight loss

Duncan, S. H., Lobley, G. E., Holtrop, G., Ince, J., Johnstone, A. M., Louis, P., & Flint, H. J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.155 · Cited by 1,222 · see citing works

Gut Microbiota and Metabolic Endotoxemia in Young Obese Mexican Subjects

Radilla-Vázquez, R. B., Parra‐Rojas, I., Martínez-Hernández, N. E., Márquez‐Sandoval, F., Illades‐Aguiar, B., & Castro-Alarcón, N. (2016) · Obesity Facts · doi:10.1159/000442479 · Cited by 1,200 · see citing works

Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss

Furet, J.-P., Kong, L.-C., Tap, J., Poitou, C., Basdevant, A., Bouillot, J.-L., Mariat, D., Corthier, G., Doré, J., Henegar, C., et al. (2010) · Diabetes · doi:10.2337/db10-0253 · Cited by 1,173 · see citing works

Differences in Fecal Microbiota in Different European Study Populations in Relation to Age, Gender, and Country: a Cross-Sectional Study

Mueller, S., Saunier, K., Hanisch, C., Norin, E., Alm, L., Midtvedt, T., Cresci, A., Silvi, S., Orpianesi, C., Verdenelli, M. C., et al. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.2.1027-1033.2006 · Cited by 1,006 · see citing works

Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations

Rubino, F., Nathan, D. M., Eckel, R. H., Schauer, P. R., Alberti, K. G. M. M., Zimmet, P., Prato, S. D., Ji, L., SADIKOT, S. M., Herman, W. H., et al. (2016) · Diabetes Care · doi:10.2337/dc16-0236 · Cited by 991 · see citing works

Obesity, inflammation, and the gut microbiota

Cox, A. J., West, N. P., & Cripps, A. W. (2015) · The Lancet Diabetes &amp; Endocrinology · doi:10.1016/s2213-8587(14)70134-2 · Cited by 869 · see citing works

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

Tremaroli, V., Karlsson, F., Werling, M., Ståhlman, M., Kovatcheva-Datchary, P., Olbers, T., Fändriks, L., le Roux, C. W., Nielsen, J., & Bäckhed, F. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.009 · Cited by 757 · see citing works

Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism

Cuskin, F., Lowe, E. C., Temple, M. J., Zhu, Y., Cameron, E. A., Pudlo, N. A., Porter, N. T., Urs, K., Thompson, A. J., Cartmell, A., et al. (2015) · Nature · doi:10.1038/nature13995 · Cited by 550 · see citing works

PCR detection and quantitation of predominant anaerobic bacteria in human and animal fecal samples

Wang, R. F., Cao, W. W., & Cerniglia, C. E. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.4.1242-1247.1996 · Cited by 502 · see citing works

Bacteroides uniformis CECT 7771 Ameliorates Metabolic and Immunological Dysfunction in Mice with High-Fat-Diet Induced Obesity

Gauffin-Cano, P., Santacruz, A., Moya-Pérez, Á., & Sanz, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041079 · Cited by 438 · see citing works

Major phenylpropanoid‐derived metabolites in the human gut can arise from microbial fermentation of protein

Russell, W. R., Duncan, S. H., Scobbie, L., Duncan, G., Cantlay, L., Calder, A. G., Anderson, S. E., & Flint, H. J. (2013) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.201200594 · Cited by 417 · see citing works

Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome

Shoaie, S., Ghaffari, P., Kovatcheva‐Datchary, P., Mardinoğlu, A., Sen, P., Pujos‐Guillot, E., de Wouters, T., Juste, C., Rizkalla, S. W., Chilloux, J., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.001 · Cited by 417 · see citing works

Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children

Zhang, C., Yin, A., Li, H., Wang, R., Wu, G. G., Shen, J., Zhang, M. H., Wang, L., Hou, Y., OuYang, H., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.07.007 · Cited by 416 · see citing works

Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue genes

Kong, L.-C., Tap, J., Aron-Wisnewsky, J., Pelloux, V., Basdevant, A., Bouillot, J.-L., Zucker, J.-D., Doré, J., & Clément, K. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.058743 · Cited by 416 · see citing works

Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota

Peterson, C. T., Sharma, V., Elmén, L., & Peterson, S. N. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12474 · Cited by 318 · see citing works

BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis

Qian, S., Tang, Y., Li, X., Liu, Y., Zhang, Y.-Y., Huang, H.-Y., Xue, R.-D., Yu, H.-Y., Guo, L., Gao, H.-D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215236110 · Cited by 311 · see citing works

Multivariate regression analysis of distance matrices for testing associations between gene expression patterns and related variables

Zapala, M. A., & Schork, N. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609333103 · Cited by 292 · see citing works

Obesity changes the human gut mycobiome

Rodríguez, M. M., Pérez, D., Chaves, F. J., Esteve, E., Marín-García, P., Xifra, G., Vendrell, J. J., Jové, M., Pamplona, R., Ricart, W., et al. (2015) · Scientific Reports · doi:10.1038/srep14600 · Cited by 270 · see citing works

A diabetes-predictive amino acid score and future cardiovascular disease

Magnusson, M., Lewis, G. D., Ericson, U., Orho‐Melander, M., Hedblad, B., Engström, G., Östling, G., Clish, C. B., Wang, T. J., Gerszten, R. E., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs424 · Cited by 264 · see citing works

Consumption of monosodium glutamate in relation to incidence of overweight in Chinese adults: China Health and Nutrition Survey (CHNS).

He, K., Du, S., Xun, P., Sharma, S., Wang, H.-J., Zhai, F., & Popkin, B. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.008870 · Cited by 220 · see citing works

Regulation of Toll‐like receptor signaling pathways in innate immune responses

Qian, C., & Cao, X. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06786.x · Cited by 168 · see citing works

The induction of obesity in rodents by means of monosodium glutamate

Bunyan, J., Murrell, E. A., & Shah, P. (1976) · British Journal Of Nutrition · doi:10.1079/bjn19760005 · Cited by 154 · see citing works

Development of a Quantitative Metabolomic Approach to Study Clinical Human Fecal Water Metabolome Based on Trimethylsilylation Derivatization and GC/MS Analysis

Gao, X., Pujos‐Guillot, E., & Sébédio, J. (2010) · Analytical Chemistry · doi:10.1021/ac1006552 · Cited by 141 · see citing works

Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch

Wang, J., Liu, R., Wang, F., Hong, J., Li, X., Chen, M., Ke, Y., Zhang, X., Ma, Q., Wang, R., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2867 · Cited by 136 · see citing works

Obesity, voracity, and short stature: the impact of glutamate on the regulation of appetite

Hermanussen, M., García, A. P., Sunder, M., Voigt, M., Salazar, V., & Tresguerres, J. A. F. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602263 · Cited by 132 · see citing works

Metabolomic fingerprint of severe obesity is dynamically affected by bariatric surgery in a procedure-dependent manner

Gralka, E., Luchinat, C., Tenori, L., Ernst, B., Thurnheer, M., & Schultes, B. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.110536 · Cited by 128 · see citing works

Metabolite Profiling Identifies Candidate Markers Reflecting the Clinical Adaptations Associated with Roux-en-Y Gastric Bypass Surgery

Mutch, D. M., Fuhrmann, J. C., Rein, D., Wiemer, J. C., Bouillot, J., Poitou, C., & Clément, K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007905 · Cited by 118 · see citing works

Bacteroides thetaiotaomicron: a dynamic, niche‐adapted human symbiont

Comstock, L. E., & Coyne, M. J. (2003) · BioEssays · doi:10.1002/bies.10350 · Cited by 116 · see citing works

Decreased lipolysis and enhanced glycerol and glucose utilization by adipose tissue prior to development of obesity in monosodium glutamate (MSG) treated-rats

Dolnikoff, M. S., Martín‐Hidalgo, A., Machado, U. F., Lima, F. B., & Herrera, E. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801517 · Cited by 109 · see citing works

Characterization of Glycosaminoglycan (GAG) Sulfatases from the Human Gut Symbiont Bacteroides thetaiotaomicron Reveals the First GAG-specific Bacterial Endosulfatase

Ulmer, J. E., Vilén, E. M., Namburi, R. B., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.573303 · Cited by 105 · see citing works

Analyzing the molecular foundations of commensalism in the mouse intestine

Hooper, L. V. (2000) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)00055-7 · Cited by 99 · see citing works

Roux-en-Y Gastric Bypass Surgery, but Not Calorie Restriction, Reduces Plasma Branched-Chain Amino Acids in Obese Women Independent of Weight Loss or the Presence of Type 2 Diabetes

Lips, M. A., van Klinken, J. B., van Harmelen, V., Dharuri, H. K., Hoen, P. A. C. ’., Laros, J. F. J., van Ommen, G. B., Janssen, I. M. C., van Ramshorst, B., van Wagensveld, B. A., et al. (2014) · Diabetes Care · doi:10.2337/dc14-0195 · Cited by 94 · see citing works

Rare Loss-of-Function Variants in NPC1 Predispose to Human Obesity

Liu, R., Zou, Y., Hong, J., Cao, M., Cui, B., Zhang, H., Chen, M., Shi, J., Ning, T., Zhao, S., et al. (2017) · Diabetes · doi:10.2337/db16-0877 · Cited by 42 · see citing works

Serum metabolomics reveals lipid metabolism variation between coronary artery disease and congestive heart failure: a pilot study

Luan, H., Chen, X., Zhong, S., Yuan, X., Meng, N., Zhang, J., Fu, J., Xu, R., Lee, C., Song, S., et al. (2013) · Biomarkers · doi:10.3109/1354750x.2013.781222 · Cited by 19 · see citing works

Gut microbiota in human metabolic health and disease

Fan, Y., & Pedersen, O. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0433-9 · Cited by 4,724 · see citing works

Mechanisms of NAFLD development and therapeutic strategies

Friedman, S. L., Neuschwander-Tetri, B. A., Rinella, M., & Sanyal, A. J. (2018) · Nature Medicine · doi:10.1038/s41591-018-0104-9 · Cited by 4,354 · see citing works

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study

Depommier, C., Everard, A., Druart, C., Plovier, H., Van Hul, M., Vieira-Silva, S., Falony, G., Raes, J., Maiter, D., Delzenne, N. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0495-2 · Cited by 2,357 · see citing works

You are what you eat: Diet, health and the gut microbiota

Zmora, N., Suez, J., & Elinav, E. (2019) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-018-0061-2 · Cited by 1,792 · see citing works

The gut microbiome in atherosclerotic cardiovascular disease

Jie, Z., Xia, H., Zhong, S.-L., Feng, Q., Li, S., Liang, S., Zhong, H., Liu, Z., Gao, Y., Zhao, H., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00900-1 · Cited by 1,638 · see citing works

Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529 · see citing works

Gut microbial metabolites in obesity, NAFLD and T2DM

Canfora, E. E., Meex, R. C. R., Venema, K., & Blaak, E. E. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0156-z · Cited by 1,493 · see citing works

A unified catalog of 204,938 reference genomes from the human gut microbiome

Almeida, A., Nayfach, S., Boland, M., Strozzi, F., Beracochea, M., Shi, Z. J., Pollard, K. S., Sakharova, E., Parks, D. H., Hugenholtz, P., et al. (2021) · Nature Biotechnology · doi:10.1038/s41587-020-0603-3 · Cited by 1,367 · see citing works

Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer

Song, M., Chan, A. T., & Sun, J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.06.048 · Cited by 752 · see citing works

Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents

Walter, J., Armet, A. M., Finlay, B. B., & Shanahan, F. (2020) · Cell · doi:10.1016/j.cell.2019.12.025 · Cited by 596 · see citing works

Microbial regulation of organismal energy homeostasis

Cani, P. D., Van Hul, M., Lefort, C., Depommier, C., Rastelli, M., & Everard, A. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0017-4 · Cited by 569 · see citing works

Major microbiota dysbiosis in severe obesity: fate after bariatric surgery

Aron-Wisnewsky, J., Prifti, E., Belda, E., Ichou, F., Kayser, B. D., Dao, M. C., Verger, E. O., Hedjazi, L., Bouillot, J.-L., Chevallier, J.-M., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-316103 · Cited by 418 · see citing works

Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention

Liu, Y., Wang, Y., Ni, Y., Cheung, C. K. Y., Lam, K. S. L., Wang, Y., Xia, Z., Ye, D., Guo, J., Tse, M. A., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.001 · Cited by 405 · see citing works

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)

Zhang, Y., Gu, Y., Ren, H., Wang, S., Zhong, H., Zhao, X., Ma, J., Gu, X., Xue, Y., Huang, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18414-8 · Cited by 380 · see citing works

The Gut Microbiota and Unhealthy Aging: Disentangling Cause from Consequence

DeJong, E. N., Surette, M. G., & Bowdish, D. M. E. (2020) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2020.07.013 · Cited by 370 · see citing works

Fecal SCFAs and SCFA-producing bacteria in gut microbiome of human NAFLD as a putative link to systemic T-cell activation and advanced disease

Rau, M., Rehman, A., Dittrich, M., Groen, A. K., Hermanns, H. M., Seyfried, F., Beyersdorf, N., Dandekar, T., Rosenstiel, P., & Geier, A. (2018) · United European Gastroenterology Journal · doi:10.1177/2050640618804444 · Cited by 334 · see citing works

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

Han, H., Yi, B., Zhong, R., Wang, M., Zhang, S., Ma, J., Yin, Y., Yin, J., Chen, L., & Zhang, H. (2021) · Microbiome · doi:10.1186/s40168-021-01093-y · Cited by 292 · see citing works

Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities

Zhang, X., Zhong, H., Li, Y., Shi, Z., Ren, H., Zhang, Z., Zhou, X., Tang, S., Han, X., Lin, Y., et al. (2021) · Nature Aging · doi:10.1038/s43587-020-00014-2 · Cited by 250 · see citing works

The promise of the gut microbiome as part of individualized treatment strategies

Schupack, D. A., Mars, R. A. T., Voelker, D. H., Abeykoon, J. P., & Kashyap, P. C. (2022) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-021-00499-1 · Cited by 217 · see citing works

Link between gut‐microbiome derived metabolite and shared gene‐effects with hepatic steatosis and fibrosis in NAFLD

Caussy, C., Hsu, C., Lo, M., Liu, A., Bettencourt, R., Ajmera, V. H., Bassirian, S., Hooker, J., Sy, E., Richards, L., et al. (2018) · Hepatology · doi:10.1002/hep.29892 · Cited by 205 · see citing works

Deciphering the Chemical Lexicon of Host–Gut Microbiota Interactions

Nicolas, G. R., & Chang, P. V. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.04.006 · Cited by 195 · see citing works

d-glutamate and Gut Microbiota in Alzheimer’s Disease

Chang, C.-H., Lin, C.-H., & Lane, H.-Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082676 · Cited by 191 · see citing works

Effects of Diet-Modulated Autologous Fecal Microbiota Transplantation on Weight Regain

Rinott, E., Youngster, I., Yaskolka Meir, A., Tsaban, G., Zelicha, H., Kaplan, A., Knights, D., Tuohy, K., Fava, F., Scholz, M. U., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.08.041 · Cited by 192 · see citing works

Alterations in Gut Glutamate Metabolism Associated with Changes in Gut Microbiota Composition in Children with Autism Spectrum Disorder

Wang, M., Wan, J., Rong, H., He, F., Wang, H., Zhou, J., Cai, C., Wang, Y., Xu, R., Yin, Z., et al. (2019) · mSystems · doi:10.1128/msystems.00321-18 · Cited by 181 · see citing works

Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial

Heianza, Y., Sun, D., Li, X., DiDonato, J. A., Bray, G. A., Sacks, F. M., & Qi, L. (2019) · Gut · doi:10.1136/gutjnl-2018-316155 · Cited by 177 · see citing works

Association between gut microbiota and bone health: Potential mechanisms and prospective

Chen, Y.-C., Greenbaum, J., Shen, H., & Deng, H.-W. (2017) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2017-00513 · Cited by 165 · see citing works

High-fiber diet ameliorates gut microbiota, serum metabolism and emotional mood in type 2 diabetes patients

Chen, L., Liu, B., Ren, L., Du, H., Fei, C., Qian, C., Li, B., Zhang, R., Liu, H., Li, Z., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1069954 · Cited by 155 · see citing works

Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy

Thomas, A. M., Fidelle, M., Routy, B., Kroemer, G., Wargo, J. A., Segata, N., & Zitvogel, L. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00785-8 · Cited by 141 · see citing works

Sex-specific association between gut microbiome and fat distribution

Min, Y., Ma, X., Sankaran, K., Ru, Y., Chen, L., Baiocchi, M., & Zhu, S. (2019) · Nature Communications · doi:10.1038/s41467-019-10440-5 · Cited by 133 · see citing works

The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation

Ouyang, J., Lin, J., Isnard, S., Fombuena, B., Peng, X., Marette, A., Routy, B., Messaoudene, M., Chen, Y., & Routy, J.-P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00645 · Cited by 124 · see citing works

Links between Dietary Protein Sources, the Gut Microbiota, and Obesity

Madsen, L., Myrmel, L. S., Fjære, E., Liaset, B., & Kristiansen, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01047 · Cited by 110 · see citing works

Current and future perspectives of functional metabolomics in disease studies–A review

Yan, M., & Xu, G. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.04.006 · Cited by 105 · see citing works

Longitudinal changes of microbiome composition and microbial metabolomics after surgical weight loss in individuals with obesity

Shen, N., Caixàs, A., Ahlers, M., Patel, K., Gao, Z., Dutia, R., Blaser, M. J., Clemente, J. C., & Laferrère, B. (2019) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2019.05.038 · Cited by 94 · see citing works

Nicotinamide riboside alleviates alcohol-induced depression-like behaviours in C57BL/6J mice by altering the intestinal microbiota associated with microglial activation and BDNF expression

Jiang, Y., Liu, Y., Gao, M., Xue, M., Wang, Z., & Liang, H. (2020) · Food &amp; Function · doi:10.1039/c9fo01780a · Cited by 88 · see citing works

Effects of meal timing on postprandial glucose metabolism and blood metabolites in healthy adults

Takahashi, M., Ozaki, M., Kang, M.-I., Sasaki, H., Fukazawa, M., Iwakami, T., Lim, P. J., Kim, H.-K., Aoyama, S., & Shibata, S. (2018) · Nutrients · doi:10.3390/nu10111763 · Cited by 81 · see citing works

Microbiota-Derived Short-Chain Fatty Acids Promote LAMTOR2-Mediated Immune Responses in Macrophages

Wu, T., Li, H., Su, C., Xu, F., Yang, G., Sun, K., Xu, M., Lv, N., Meng, B., Liu, Y., et al. (2020) · mSystems · doi:10.1128/msystems.00587-20 · Cited by 78 · see citing works

Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis

Zhang, E., Jin, L., Wang, Y., Tu, J., Zheng, R., Ding, L., Fang, Z., Fan, M., Al-Abdullah, I., Natarajan, R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28743-5 · Cited by 76 · see citing works

Gut Feelings Begin in Childhood: the Gut Metagenome Correlates with Early Environment, Caregiving, and Behavior

Flannery, J. E., Stagaman, K., Burns, A. R., Hickey, R. J., Roos, L. E., Giuliano, R. J., Fisher, P. A., & Sharpton, T. J. (2020) · mBio · doi:10.1128/mbio.02780-19 · Cited by 75 · see citing works

Personalized dietary management of overweight and obesity based on measures of insulin and glucose

Hjorth, M. F., Zohar, Y., Hill, J. O., & Astrup, A. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051606 · Cited by 60 · see citing works

Sarcopenic Obesity in Liver Cirrhosis: Possible Mechanism and Clinical Impact

Nishikawa, H., Enomoto, H., Nishiguchi, S., & Iijima, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041917 · Cited by 56 · see citing works

Incretin Hormones, Obesity and Gut Microbiota

Angelini, G., Russo, S., & Mingrone, G. (2024) · Peptides · doi:10.1016/j.peptides.2024.171216 · Cited by 47 · see citing works

Gut microbiome meta-analysis reveals dysbiosis is independent of body mass index in predicting risk of obesity-associated CRC

Greathouse, K. L., White, J. R., Padgett, R. N., Perrotta, B. G., Jenkins, G. D., Chia, N., & Chen, J. (2019) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2018-000247 · Cited by 35 · see citing works

Modification of fecal microbiota as a mediator of effective weight loss and metabolic benefits following bariatric surgery

Oduro-Donkor, D., Turner, M. C., Farnaud, S., Renshaw, D., Kyrou, I., Hanson, P., Hattersley, J., Weickert, M. O., Menon, V., Randeva, H. S., et al. (2020) · Expert Review of Endocrinology &amp; Metabolism · doi:10.1080/17446651.2020.1801412 · Cited by 33 · see citing works

Zinc homeostasis and redox alterations in obesity

Franco, C., & Canzoniero, L. M. T. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1273177 · Cited by 31 · see citing works

Discrimination exposure impacts unhealthy processing of food cues: Crosstalk between the brain and gut

Zhang, X., Wang, H., Kilpatrick, L. A., Dong, T. S., Gee, G. C., Labus, J. S., Osadchiy, V., Beltran-Sanchez, H., Wang, M. C., Vaughan, A., et al. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00134-9 · Cited by 20 · see citing works

Genomic and functional diversity of the human-derived isolates of Faecalibacterium

Li, W., Lin, X., Liang, H., Wu, Z., Wang, M., Sun, J., Li, X., He, W., Gao, X., Hu, T., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1379500 · Cited by 17 · see citing works

Clostridioides difficile and neurological disorders: new perspectives

Biazzo, M., Allegra, M., & Deidda, G. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.946601 · Cited by 11 · see citing works

Correlation between gut dysbiosis, metabolite alterations and erosive hand osteoarthritis – An observational study within the community-based Xiangya Osteoarthritis (XO) cohort

Xie, D., Wang, Y., Li, J., Yang, T., Zhang, Y., Zhang, W., Doherty, M., Zhu, Y., Yang, Z., Wang, Y., et al. (2025) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2025.07.004 · Cited by 8 · see citing works

Impact of Extreme Obesity and Diet‐Induced Weight Loss on the Fecal Metabolome and Gut Microbiota

Nogacka, A. M., Reyes‐Gavilán, C. G. D. L., Faedo, C. M., Ruas‐Madiedo, P., Suárez, A., Mancabelli, L., Ventura, M., Cifuentes, A., León, C., Gueimonde, M., et al. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000030 · Cited by 29 · see citing works

Effect of gut microbiota on host whole metabolome

Moriya, T., Satomi, Y., Murata, S., Sawada, H., & Kobayashi, H. (2017) · Metabolomics · doi:10.1007/s11306-017-1240-9 · Cited by 15 · see citing works

WED-078 Sex-specific effects of beta-blockers on the gut microbiome and metabolome in liver cirrhosis

Haller, R., Nepel, M., Traub, J., et al. (2025) · Journal of Hepatology · doi:10.1016/s0168-8278(25)00912-2

Linking Clinical Blood Metabogram and Gut Microbiota

Lokhov, P. G., Balashova, E. E., Maslov, D. L., et al. (2023) · Metabolites · doi:10.3390/metabo13101095 · Cited by 6 · see citing works

Longitudinal effects of growth restriction on the murine gut microbiome and metabolome

Quinn, M. A., Pritchard, A., Visker, J. R., McPeek, A. C., Raghuvanshi, R., Christian Martin, H., Wellette‐Hunsucker, A. G., Leszczynski, E. C., McCabe, L. R., Pfeiffer, K. A., et al. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00446.2021 · Cited by 3 · see citing works