Cited by 876Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesOral microbiology and periodontitis research

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Obesity, inflammation, and the gut microbiota

Cox, Amanda J, West, Nicholas P, Cripps, Allan W·2015·The Lancet Diabetes & Endocrinology

DOI 10.1016/s2213-8587(14)70134-2

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Abstract

As the prevalence of obesity and associated disease continues to rise and concerns for the spiralling economic and social costs also escalate, innovative management strategies beyond primary prevention and traditional lifestyle interventions are urgently needed. The biological basis of disease is one avenue for further exploration in this context. Several key inflammatory markers have been consistently associated with both obesity and risk of adverse outcomes in obesity-associated diseases, which suggests that a persistent, low-grade, inflammatory response is a potentially modifiable risk factor. In this Review, we provide evidence supporting perturbation of the intestinal microbiota and changes in intestinal permeability as potential triggers of inflammation in obesity. Further characterisation of the mechanisms underpinning the triggers of such inflammatory responses in overweight and obese individuals could offer unique opportunities for intervention strategies to help ameliorate the risk of obesity-associated disease.

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1 retracted

Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance
Tsukumo, D. M. L., Carvalho-Filho, M. A., Carvalheira, J. B. C., Prada, P. O., Hirabara, S. M., Schenka, A. A., Araújo, E. P., Vassallo, J., Curi, R., Velloso, L. A., et al. (2007) · Diabetes · doi:10.2337/db06-1595 · Cited by 826
Retracted
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511
Gut flora in health and disease
Guarner, F., & Malagelada, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,480
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241
Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides
Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091
Review article: the role of butyrate on colonic function
HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03562.x · Cited by 2,721
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518
Microbiota and SCFA in lean and overweight healthy subjects
Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D. (2010) · Obesity · doi:10.1038/oby.2009.167 · Cited by 2,457
Health: United States
Lee, J. A. H. (1986) · JAMA · doi:10.1001/jama.1986.03370120114036 · Cited by 2,252
The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
Donohoe, D. R., Garge, N., Zhang, X., Sun, W., O'Connell, T. M., Bunger, M. K., & Bultman, S. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.018 · Cited by 2,003
Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
Cani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R., Tuohy, K. M., Gibson, G. R., & Delzenne, N. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0791-0 · Cited by 1,770
Regulation of inflammation by short chain fatty acids
Vinolo, M. A. R., Rodrigues, H. G., Nachbar, R. T., & Curi, R. (2011) · Nutrients · doi:10.3390/nu3100858 · Cited by 1,724
Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation
Le Poul, E., Loison, C., Struyf, S., Springael, J.-Y., Lannoy, V., Decobecq, M.-E., Brezillon, S., Dupriez, V., Vassart, G., Van Damme, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301403200 · Cited by 1,651
The medical care costs of obesity: An instrumental variables approach
Cawley, J., & Meyerhoefer, C. D. (2011) · Journal of Health Economics · doi:10.1016/j.jhealeco.2011.10.003 · Cited by 1,517
Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes
Spranger, J., Kroke, A., Möhlig, M., Hoffmann, K., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · Diabetes · doi:10.2337/diabetes.52.3.812 · Cited by 1,493
Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans
Jumpertz, R., Le, D. S., Turnbaugh, P. J., Trinidad, C., Bogardus, C., Gordon, J. I., & Krakoff, J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.010132 · Cited by 1,232
Human colonic microbiota associated with diet, obesity and weight loss
Duncan, S. H., Lobley, G. E., Holtrop, G., Ince, J., Johnstone, A. M., Louis, P., & Flint, H. J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.155 · Cited by 1,222
C-reactive protein, fibrinogen, and cardiovascular disease prediction
The Emerging Risk Factors Collaboration (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1107477 · Cited by 1,150
Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice
Kim, M. H., Kang, S. G., Park, J. H., Yanagisawa, M., & Kim, C. H. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.056 · Cited by 1,127
Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes
Creely, S. J., McTernan, P. G., Kusminski, C. M., Fisher, F. M., Da Silva, N. F., Khanolkar, M., Evans, M., Harte, A. L., & Kumar, S. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00302.2006 · Cited by 1,043
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E
Michelsen, K. S., Wong, M. H., Shah, P. K., Zhang, W., Yano, J., Doherty, T. M., Akira, S., Rajavashisth, T. B., & Arditi, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403249101 · Cited by 1,019
A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation.
Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776
High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health
Russell, W. R., Gratz, S. W., Duncan, S. H., Holtrop, G., Ince, J., Scobbie, L., Duncan, G., Johnstone, A. M., Lobley, G. E., Wallace, R. J., et al. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002188 · Cited by 775
High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse
Ding, S., Chi, M. M., Scull, B. P., Rigby, R., Schwerbrock, N. M. J., Magness, S., Jobin, C., & Lund, P. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012191 · Cited by 713
Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier
Karczewski, J., Troost, F. J., Konings, I., Dekker, J., Kleerebezem, M., Brummer, R.-J. M., & Wells, J. M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00327.2009 · Cited by 676
Chylomicrons promote intestinal absorption of lipopolysaccharides
Ghoshal, S., Witta, J., Zhong, J., de Villiers, W., & Eckhardt, E. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800156-jlr200 · Cited by 662
Obesity and C ‐reactive protein in various populations: a systematic review and meta‐analysis
Choi, J., Joseph, L., & Pilote, L. (2012) · Obesity Reviews · doi:10.1111/obr.12003 · Cited by 657
Energy intake is associated with endotoxemia in apparently healthy men
Amar, J., Burcelin, R., Ruidavets, J. B., Cani, P. D., Fauvel, J., Alessi, M., Chamontin, B., & Ferrières, J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1219 · Cited by 610
Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function
Ewaschuk, J. B., Diaz, H., Meddings, L., Diederichs, B., Dmytrash, A., Backer, J., Looijer-van Langen, M., & Madsen, K. L. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90227.2008 · Cited by 590
A high-fat diet is associated with endotoxemia that originates from the gut
Pendyala, S., Walker, J. M., & Holt, P. R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.01.034 · Cited by 546
Effects of butyrate on intestinal barrier function in a Caco-2 cell monolayer model of intestinal barrier
Peng, L., He, Z., Chen, W., Holzman, I. R., & Lin, J. (2007) · Pediatric Research · doi:10.1203/01.pdr.0000250014.92242.f3 · Cited by 518
Association of endotoxemia with carotid atherosclerosis and cardiovascular disease
Wiedermann, C. J., Kiechl, S., Dunzendorfer, S., Schratzberger, P., Egger, G., Oberhollenzer, F., & Willeit, J. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00448-9 · Cited by 505
Increase in Plasma Endotoxin Concentrations and the Expression of Toll-Like Receptors and Suppressor of Cytokine Signaling-3 in Mononuclear Cells After a High-Fat, High-Carbohydrate Meal
Ghanim, H., Abuaysheh, S., Sia, C. L., Korzeniewski, K., Chaudhuri, A., Fernandez-Real, J. M., & Dandona, P. (2009) · Diabetes Care · doi:10.2337/dc09-0979 · Cited by 494
Gut Microbiota, Lipopolysaccharides, and Innate Immunity in the Pathogenesis of Obesity and Cardiovascular Risk
Manco, M., Putignani, L., & Bottazzo, G. F. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0030 · Cited by 489
Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity
Ukena, S. N., Singh, A., Dringenberg, U., Engelhardt, R., Seidler, U., Hansen, W., Bleich, A., Bruder, D., Franzke, A., Rogler, G., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001308 · Cited by 482
Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
Song, M. J., Kim, K. H., Yoon, J. M., & Kim, J. B. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.170 · Cited by 454
Endotoxemia Is Associated With an Increased Risk of Incident Diabetes
Pussinen, P. J., Havulinna, A. S., Lehto, M. J., Sundvall, J., & Salomaa, V. V. (2011) · Diabetes Care · doi:10.2337/dc10-1676 · Cited by 416
G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation
Sina, C., Gavrilova, O., Förster, M., Till, A., Derer, S., Hildebrand, F., Rabe, B., Chalaris, A., Scheller, J., Rehmann, A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900063 · Cited by 385
A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome
Xiao, S., Fei, N., Pang, X., Shen, J., Wang, L., Zhang, B., Zhang, M. H., Zhang, X., Zhang, C., Li, M., et al. (2013) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12228 · Cited by 376
Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability
Suzuki, T., Yoshida, S., & Hara, H. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508888733 · Cited by 370
The Intestinal Metabolome: An Intersection Between Microbiota and Host
Ursell, L. K., Haiser, H. J., Treuren, W. V., Garg, N., Reddivari, L., Vanamala, J., Dorrestein, P. C., Turnbaugh, P. J., & Knight, R. D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.03.001 · Cited by 365
Circulating Zonulin, a Marker of Intestinal Permeability, Is Increased in Association with Obesity-Associated Insulin Resistance
Moreno‐Navarrete, J. M., Sabater, M., Ortega, F. J., Ricart, W., & Fernández‐Real, J. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037160 · Cited by 317
Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation
Laugerette, F., Vors, C., Géloën, A., Chauvin, M., Soulage, C. O., Lambert-Porcheron, S., Peretti, N., Alligier, M., Burcelin, R., Laville, M., et al. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.11.011 · Cited by 304
Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression
Ghanim, H., Sia, C. L., Upadhyay, M., Korzeniewski, K., Viswanathan, P., Abuaysheh, S., Mohanty, P., & Dandona, P. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28584 · Cited by 299
Is the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders?
Harris, K. A., Kassis, A. N., Major, G. C., & Chou, C. J. (2012) · Journal of Obesity · doi:10.1155/2012/879151 · Cited by 289
Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells
Konieczna, P., Groeger, D., Ziegler, M., Frei, R., Ferstl, R., Shanahan, F., Quigley, E. M. M., Kiely, B., Akdiş, C. A., & O’Mahony, L. (2011) · Gut · doi:10.1136/gutjnl-2011-300936 · Cited by 284
Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: a randomised, placebo controlled trial.
Breuer, R. I., Soergel, K. H., Lashner, B. A., Christ, M. L., Hanauer, S. B., Vanagunas, A., Harig, J. M., Keshavarzian, A., ROBINSON, M. G., Sellin, J. H., et al. (1997) · Gut · doi:10.1136/gut.40.4.485 · Cited by 282
Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression
Siavoshian, S., Segain, J.-P., Kornprobst, M., Bonnet, C., Cherbut, C., Galmiche, J.-P., & Blottière, H. M. (2000) · Gut · doi:10.1136/gut.46.4.507 · Cited by 277
The correlation between adiposity and adiponectin, tumor necrosis factor α, interleukin-6 and high sensitivity C-reactive protein levels. Is adipocyte size associated with inflammation in adults?
Bahçeci, M., Gökalp, D., Bahçeci, S., Tuzcu, A. K., Atmaca, S., & Arikan, S. (2007) · Journal of Endocrinological Investigation · doi:10.1007/bf03347427 · Cited by 266
Endotoxemia, Immune Response to Periodontal Pathogens, and Systemic Inflammation Associate With Incident Cardiovascular Disease Events
Pussinen, P. J., Tuomisto, K., Jousilahti, P., Havulinna, A. S., Sundvall, J., & Salomaa, V. V. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.106.138743 · Cited by 265
TLR4 and Insulin Resistance
Kim, J. J., & Sears, D. D. (2010) · Gastroenterology Research and Practice · doi:10.1155/2010/212563 · Cited by 260
Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; a randomized, double-blinded, placebo-controlled trial
Lamprecht, M., Bogner, S., Schippinger, G., Steinbauer, K., Fankhauser, F., Hallstroem, S., Schuetz, B., & Greilberger, J. F. (2012) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-9-45 · Cited by 257
Short chain fatty acids
Binder, H. J., Cummings, J. H., & Soergel, K. H. (1994) · Kluwer Academic Publishers eBooks · Cited by 236
High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes
Zweigner, J., Gramm, H.-J., Singer, O. C., Wegscheider, K., & Schumann, R. R. (2001) · Blood · doi:10.1182/blood.v98.13.3800 · Cited by 236
Distribution and Kinetics of Lipoprotein-Bound Endotoxin
Levels, J. H. M., Abraham, P. R., van den Ende, A., & van Deventer, S. J. H. (2001) · Infection and Immunity · doi:10.1128/iai.69.5.2821-2828.2001 · Cited by 234
Obesity and the Microbiota
Tilg, H., Moschen, A. R., & Kaser, A. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.03.030 · Cited by 233
Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance
Moreno-Navarrete, J. M., Ortega, F., Serino, M., Luche, E., Waget, A., Pardo, G., Salvador, J., Ricart, W., Frühbeck, G., Burcelin, R., et al. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.256 · Cited by 223
Determinants of Serum Concentrations of Lipopolysaccharide-Binding Protein (LBP) in the Adult Population: The Role of Obesity
González‐Quintela, A., Alonso‐Sampedro, M., Franco, J. C., Vizcaíno, L., Loidi, L., & Gudé, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054600 · Cited by 221
Beneficial effect of oral administration of Lactobacillus casei strain Shirota on insulin resistance in diet-induced obesity mice
Naito, E., Yoshida, Y., Makino, K., KOUNOSHI, Y., Kunihiro, S., Takahashi, R., Matsuzaki, T., Miyazaki, K., & Ishikawa, F. (2010) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2010.04922.x · Cited by 213
Metabolic endotoxemia: a molecular link between obesity and cardiovascular risk
Neves, A. L., Coelho, J., Couto, L., Leite-Moreira, A., & Roncon-Albuquerque, R. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0079 · Cited by 211
Short-chain fatty acids induced autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death
Tang, Y., Chen, Y., Jiang, H., & Nie, D. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.117 · Cited by 207
Inflammation and the Incidence of Type 2 Diabetes
Bertoni, A. G., Burke, G. L., Owusu, J. A., Carnethon, M. R., Vaidya, D. M., Barr, R. G., Jenny, N. S., Ouyang, P., & Rotter, J. I. (2010) · Diabetes Care · doi:10.2337/dc09-1679 · Cited by 207
Lactobacillus plantarum DSM 2648 is a potential probiotic that enhances intestinal barrier function
Anderson, R. C., Cookson, A. L., McNabb, W. C., Kelly, W. J., & Roy, N. C. (2010) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2010.02038.x · Cited by 194
Regulatory T Cells and Human Disease
Cools, N., Ponsaerts, P., Tendeloo, V. F. V., & Berneman, Z. N. (2007) · Clinical and Developmental Immunology · doi:10.1155/2007/89195 · Cited by 194
Probiotics in the management of irritable bowel syndrome and inflammatory bowel disease
Whelan, K., & Quigley, E. M. M. (2013) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32835d7bba · Cited by 190
The role of lipopolysaccharide-binding protein in modulating the innate immune response
Zweigner, J., Schumann, R. R., & Weber, J. R. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2005.10.006 · Cited by 182
Regulation of Toll‐like receptor signaling pathways in innate immune responses
Qian, C., & Cao, X. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06786.x · Cited by 167
The G-protein-coupled receptor 40 family (GPR40–GPR43) and its role in nutrient sensing
Covington, D. K., Briscoe, C. A., Brown, A. J., & Jayawickreme, C. K. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340770 · Cited by 154
Short-chain fatty acids alter tight junction permeability in intestinal monolayer cells via lipoxygenase activation
Ohata, A., Usami, M., & Miyoshi, M. (2005) · Nutrition · doi:10.1016/j.nut.2004.12.004 · Cited by 150
Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies
Al-Attas, O. S., Al‐Daghri, N. M., Al-Rubeaan, K. A., da Silva, N. F., Sabico, S., Kumar, S., McTernan, P. G., & Harte, A. L. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-20 · Cited by 145
SYSTEMIC INFLAMMATION INCREASES INTESTINAL PERMEABILITY DURING EXPERIMENTAL HUMAN ENDOTOXEMIA
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Walton, G., Lu, C., Trogh, I., Arnaut, F., & Gibson, G. R. (2012) · Nutrition Journal · doi:10.1186/1475-2891-11-36 · Cited by 119
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Authors: Cox, A. J., West, N. P., & Cripps, A. W.
Affiliations: Griffith University (AU)
Corresponding author: Cox, Amanda J
ORCID: Cox, Amanda J
West, Nicholas P
Cripps, Allan W
Venue: The Lancet Diabetes & Endocrinology
Publisher: Elsevier BV
Published: 2015-03
Volume: 3
Issue: 3
Pages: 207-215
ISSN: 2213-8587 (ISSN-L)
DOI: 10.1016/s2213-8587(14)70134-2
OpenAlex: W1996175687
Cited by: 869
References: 106
Citations by year: 2026: 41 · 2025: 77 · 2024: 115 · 2023: 105 · 2022: 103 · 2021: 99 · 2020: 96 · 2019: 77 · 2018: 50 · 2017: 37 · 2016: 31 · 2015: 33
FWCI: 3.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Diabetes & Endocrinology (publishedVersion)
PubMed (publishedVersion)
Griffith Research Online (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: obesity, inflammation, gut microbiota, intestinal permeability, low-grade inflammation, obesity-related comorbidities, overweight, inflammatory markers
MeSH terms: Humans, Inflammation, Models, Biological, Obesity, Permeability, Biomarkers, Prevalence, Gastrointestinal Tract, Microbiota

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Obesity, inflammation, and the gut microbiota

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