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Glycaemic variability in diabetes: clinical and therapeutic implications

Ceriello, Antonio, Monnier, Louis, Owens, David·2019·The Lancet Diabetes & Endocrinology

DOI 10.1016/s2213-8587(18)30136-0

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Abstract

Glycaemic variability is an integral component of glucose homoeostasis. Although it has not yet been definitively confirmed as an independent risk factor for diabetes complications, glycaemic variability can represent the presence of excess glycaemic excursions and, consequently, the risk of hyperglycaemia or hypoglycaemia. Glycaemic variability is currently defined by a large and increasing number of metrics, representing either short-term (within-day and between-day variability) or long-term glycaemic variability, which is usually based on serial measurements of HbA 1c or other measures of glycaemia over a longer period of time. In this Review, we discuss recent evidence examining the association between glycaemic variability and diabetes-related complications, as well as non-pharmacological and pharmacological strategies currently available to address this challenging aspect of diabetes management.

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See all 588

Authors: Ceriello, A., Monnier, L., & Owens, D.
Affiliations: Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
Université de Montpellier (FR)
Swansea University (GB)
Corresponding author: Ceriello, Antonio
ORCID: Ceriello, Antonio
Monnier, Louis
Owens, David
Venue: The Lancet Diabetes & Endocrinology
Publisher: Elsevier BV
Published: 2019-03
Volume: 7
Issue: 3
Pages: 221-230
ISSN: 2213-8587 (ISSN-L)
DOI: 10.1016/s2213-8587(18)30136-0
OpenAlex: W2886853964
Cited by: 588
References: 107
Citations by year: 2026: 58 · 2025: 71 · 2024: 78 · 2023: 81 · 2022: 81 · 2021: 96 · 2020: 87 · 2019: 36
FWCI: 8.42
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Diabetes & Endocrinology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
Keywords: glycemic variability, diabetes mellitus, glucose homeostasis, glycaemic excursions, hyperglycemia, hypoglycemia, diabetes complications, HbA1c, diabetes management, glycemic control
MeSH terms: Blood Glucose, Diabetes Mellitus, Glycated Hemoglobin, Humans, Hyperglycemia, Hypoglycemia, Hypoglycemic Agents, Blood Glucose Self-Monitoring, Monitoring, Ambulatory, Diabetes Complications

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Glycaemic variability in diabetes: clinical and therapeutic implications

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