Cited by 458Diabetes Management and ResearchDiabetes Treatment and ManagementDiabetes Management and Education

Continuous glucose monitoring: a review of recent studies demonstrating improved glycemic outcomes

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Rodbard, David·2017·Diabetes Technology & Therapeutics

Abstract

Continuous Glucose Monitoring (CGM) has been demonstrated to be clinically valuable, reducing risks of hypoglycemia and hyperglycemia, glycemic variability (GV), and improving patient quality of life for a wide range of patient populations and clinical indications. Use of CGM can help reduce HbA1c and mean glucose. One CGM device, with accuracy (%MARD) of approximately 10%, has recently been approved for self-adjustment of insulin dosages (nonadjuvant use) and approved for reimbursement for therapeutic use in the United States. CGM had previously been used off-label for that purpose. CGM has been demonstrated to be clinically useful in both type 1 and type 2 diabetes for patients receiving a wide variety of treatment regimens. CGM is beneficial for people using either multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII). CGM is used both in retrospective (professional, masked) and real-time (personal, unmasked) modes: both approaches can be beneficial. When CGM is used to suspend insulin infusion when hypoglycemia is detected until glucose returns to a safe level (low-glucose suspend), there are benefits beyond sensor-augmented pump (SAP), with greater reduction in the risk of hypoglycemia. Predictive low-glucose suspend provides greater benefits in this regard. Closed-loop control with insulin provides further improvement in quality of glycemic control. A hybrid closed-loop system has recently been approved by the U.S. FDA. Closed-loop control using both insulin and glucagon can reduce risk of hypoglycemia even more. CGM facilitates rigorous evaluation of new forms of therapy, characterizing pharmacodynamics, assessing frequency and severity of hypo- and hyperglycemia, and characterizing several aspects of GV.

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Research works printed but not linked: 2

  1. Lewis D, Leibrand S; #OpenAPS Community: Real- World Use of Open Source Artificial Pancreas Systems. J Diabetes Sci Technol 2016;10:1411.
  2. Weiss R, Garg SK, Bode BW, et al.: Hypoglycemia Re- duction and Changes in HemoglobinHbA1c in the ASPIRE In-Home Study. Diabetes Technol Ther 2015;17:542-547.

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Authors
Rodbard, D.
Affiliations
Biomedical Informatics Consultants LLC
Corresponding author
Rodbard, David
Venue
Diabetes Technology & Therapeutics
Published
2017-06
Volume
19
Issue
3_suppl
Pages
S25-S37
ISSN
  • 1520-9156 (ISSN-L)
  • 1557-8593
OpenAlex
W2624348061
Cited by
458
References
131
Citations by year
2026: 27 · 2025: 45 · 2024: 56 · 2023: 41 · 2022: 63 · 2021: 58 · 2020: 58 · 2019: 56 · 2018: 45 · 2017: 8 · 2016: 1
FWCI
36.08
Type
journal article
Language
en
Open access
Locations
  • Diabetes Technology & Therapeutics (publishedVersion, other-oa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
International Society for Pediatric and Adolescent Diabetes
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Keywords
continuous glucose monitoring, glycemic control, hypoglycemia, hyperglycemia, glycemic variability, HbA1c, type 1 diabetes, type 2 diabetes, sensor-augmented pump, predictive low glucose suspend, hybrid closed-loop system, multiple daily insulin injections, insulin pump therapy, quality of life
MeSH terms
Blood Glucose, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Insulin, Blood Glucose Self-Monitoring

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