An overview on antidiabetic medicinal plants having insulin mimetic property
Open accessAbstract
Diabetes mellitus is one of the common metabolic disorders acquiring around 2.8% of the world's population and is anticipated to cross 5.4% by the year 2025. Since long back herbal medicines have been the highly esteemed source of medicine therefore, they have become a growing part of modern, high-tech medicine. In view of the above aspects the present review provides profiles of plants (65 species) with hypoglycaemic properties, available through literature source from various database with proper categorization according to the parts used, mode of reduction in blood glucose (insulinomimetic or insulin secretagogues activity) and active phytoconstituents having insulin mimetics activity. From the review it was suggested that, plant showing hypoglycemic potential mainly belongs to the family Leguminoseae, Lamiaceae, Liliaceae, Cucurbitaceae, Asteraceae, Moraceae, Rosaceae and Araliaceae. The most active plants are Allium sativum, Gymnema sylvestre, Citrullus colocynthis, Trigonella foenum greacum, Momordica charantia and Ficus bengalensis. The review describes some new bioactive drugs and isolated compounds from plants such as roseoside, epigallocatechin gallate, beta-pyrazol-1-ylalanine, cinchonain Ib, leucocyandin 3-O-beta-d-galactosyl cellobioside, leucopelargonidin-3- O-alpha-L rhamnoside, glycyrrhetinic acid, dehydrotrametenolic acid, strictinin, isostrictinin, pedunculagin, epicatechin and christinin-A showing significant insulinomimetic and antidiabetic activity with more efficacy than conventional hypoglycaemic agents. Thus, from the review majorly, the antidiabetic activity of medicinal plants is attributed to the presence of polyphenols, flavonoids, terpenoids, coumarins and other constituents which show reduction in blood glucose levels. The review also discusses the management aspect of diabetes mellitus using these plants and their active principles.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Phytomedicine is a cost-effective alternative to synthetic medications for treating DM, offering fewer side effects, longer-lasting benefits, and improved patient compliance.
“Phytomedicine is a cost-effective alternative to synthetic medications for treating DM, offering fewer side effects, longer-lasting benefits, and improved patient compliance.”
From A critical review on diabetes mellitus type 1 and type 2 management approaches: from lifestyle modification to current and novel targets and therapeutic agents. (2024) · cites this paper as [129]
The Introduction describes medicinal plants as potential alternative antidiabetic treatments with effects it calls safe, and the Discussion reports hypoglycaemic activity. The copy does not establish that phytomedicine costs less than synthetic medication, has longer-lasting benefits, or improves patient compliance. The Discussion also cautions that some plant materials are unsafe and require toxicity studies. (LLM, conf=0.88)
Experimental — accuracy not yet measuredHerbals/botanicals have demonstrated potent anti-diabetic effects via a variety of mechanisms, such as enhancing insulin sensitivity, stimulating insulin secretion, blocking carbohydrate absorption, and reducing oxidative stress.
“Herbals/botanicals have demonstrated potent anti-diabetic effects via a variety of mechanisms, such as enhancing insulin sensitivity, stimulating insulin secretion, blocking the absorption of carbohydrates, and reducing OS; the inhibition of α-glucosidase enzyme and the generation of advanced glycation products, the transcription of GLUT-4 and PPAR, and the presence of antioxidants.”
From A critical review on diabetes mellitus type 1 and type 2 management approaches: from lifestyle modification to current and novel targets and therapeutic agents. (2024) · cites this paper as [129]
Ethanolic garlic extracts exhibited an antidiabetic effect against streptozotocin- and alloxan-induced diabetic mice and rabbits by activating insulin secretion from parietal cells of the pancreas.
“Ethanolic garlic extracts exhibited an antidiabetic effect against streptozotocin- and alloxan-induced diabetic mice and rabbits by activating the insulin secretion from parietal cells of the pancreas [113].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [113]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Medicinal plants of India with anti-diabetic potential
Grover, J. K., Yadav, S., & Vats, V. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(02)00059-4 · Cited by 1,798 · see citing works
Indian herbs and herbal drugs used for the treatment of diabetes
Modak, M., Dixit, P., Londhe, J., Ghaskadbi, S., & Devasagayam, T. P. A. (2007) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.40.163 · Cited by 989 · see citing works
Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus
Li, W., Zheng, H. C., Bukuru, J., & KIMPE, N. D. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2003.12.031 · Cited by 970 · see citing works
Antidiabetic Agents from Medicinal Plants
Jung, M., Park, M., Lee, H., et al. (2006) · Current Medicinal Chemistry · doi:10.2174/092986706776360860 · Cited by 573 · see citing works
Bnouham, M., Ziyyat, A., Mekhfi, H., et al. (2019) · International Journal of Diabetes and Metabolism · doi:10.1159/000497588 · Cited by 355 · see citing works
Antidiabetic potential of medicinal plants.
Malviya, N., Jain, S., & Malviya, S. (2010) · PubMed · Cited by 332 · see citing works
Role of Selected Indian Plants in Management of Type 2 Diabetes: A Review
Saxena, A., & Vikram, N. K. (2004) · The Journal of Alternative and Complementary Medicine · doi:10.1089/107555304323062365 · Cited by 316 · see citing works
Jeppesen, P. B., Gregersen, S., Alstrup, K., & Hermansen, K. (2002) · Phytomedicine · doi:10.1078/0944-7113-00081 · Cited by 292 · see citing works
Jeppesen, P. B., Gregersen, S., Poulsen, C., et al. (2000) · Metabolism · doi:10.1016/s0026-0495(00)91325-8 · Cited by 286 · see citing works
Liu, D., Wei, Z. C., Yang, Z., Carter, J. D., Si, H., & Reynolds, K. A. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1089 · Cited by 236 · see citing works
Hypoglycaemic effect of Teucrium polium: studies with rat pancreatic islets
Esmaeili, M. A., & Yazdanparast, R. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.06.023 · Cited by 216 · see citing works
Antidiabetic activity and toxicity of Zizyphus spina-christi leaves.
Abdel-Zaher, A. O., Salim, S. Y., Assaf, M., & Abdel-Hady, R. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.04.007 · Cited by 208 · see citing works
Anand, P., Murali, K. Y., Tandon, V., Murthy, P. S., & Chandra, R. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.03.044 · Cited by 196 · see citing works
Herbal medicines for diabetes mellitus: a review.
Rao, M. U., Sreenivasulu, M., Chengaiah, B., et al. (2010) · International Journal of PharmTech Research · Cited by 193 · see citing works
Patel, D. K., Kumar, R., Prasad, S., et al. (2011) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(11)60051-8 · Cited by 183 · see citing works
Self-citationInsulin Sensitizing and Insulinotropic Action of Berberine from Cortidis Rhizoma
Ko, B., Choi, S. B., Park, S. K., Jang, J. S., Kim, Y. E., & Park, S. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.1431 · Cited by 181 · see citing works
4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties
Broca, C., Gross, R., Petit, P., Sauvaire, Y. D., Manteghetti, M., Tournier, M., Masiello, P., Gomis, R., & Ribes, G. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.4.e617 · Cited by 168 · see citing works
Ponnusamy, S., Ravindran, R., Zinjarde, S. S., et al. (2010) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2011/515647 · Cited by 163 · see citing works
Isulinotropic properties of Nigella sativa oil in Streptozotocin plus Nicotinamide diabetic hamster
Fararh, K., Atoji, Y., Shimizu, Y., & Takewaki, T. (2002) · Research in Veterinary Science · doi:10.1016/s0034-5288(02)00108-x · Cited by 158 · see citing works
Jarald, E. E., Joshi, S. B., & D.Ch., J. (2008) · Cited by 152 · see citing works
Maroo, J., Vasu, V. T., Aalinkeel, R., & Gupta, S. S. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(02)00095-8 · Cited by 144 · see citing works
Plants Having Potential Antidiabetic Activity: A Review
Chauhan, A., Sharma, P. K., Srivastava, P., et al. (2010) · Der pharmacia lettre · Cited by 111 · see citing works
Traditional medicinal plants of Manipur as anti-diabetics
Singh, L. W. (2011) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9001265 · Cited by 101 · see citing works
Hannan, J. M. A., Marenah, L., Ali, L., Rokeya, B., Flatt, P., & Abdel-Wahab, Y. (2007) · Journal of Endocrinology · doi:10.1677/joe.1.07084 · Cited by 90 · see citing works
Sy, G. Y., Cissé, A., Nongonierma, R., Sarr, M., Mbodj, N. A., & Faye, B. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.01.024 · Cited by 84 · see citing works
Kwon, D. Y., Jang, J. S., Hong, S. M., Lee, J. E., Sung, S. R., Park, H. R., & Park, S. (2007) · European Journal of Nutrition · doi:10.1007/s00394-006-0630-y · Cited by 84 · see citing works
Mishra, S. B., Rao, C. V., Ojha, S. K., et al. (2010) · International Journal of Pharmaceutical Sciences and Research · Cited by 81 · see citing works
Korean red ginseng stimulates insulin release from isolated rat pancreatic islets
Kim, K., & Kim, H. Y. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.08.006 · Cited by 79 · see citing works
Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract
Noor, H., & Ashcroft, S. J. H. (1998) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(98)00008-7 · Cited by 75 · see citing works
Cinchonain Ib isolated from Eriobotrya japonica induces insulin secretion in vitro and in vivo
Qadan, F., Verspohl, E. J., Nahrstedt, A., et al. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.04.023 · Cited by 72 · see citing works
Chen, C., Hsu, C., Chen, C., & Liu, H. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.02.032 · Cited by 70 · see citing works
Islam, M., & Choi, H. (2008) · Phytotherapy Research · doi:10.1002/ptr.2417 · Cited by 68 · see citing works
Patel, D. K., Kumar, R., Prasad, S., & Hemalatha, S. (2011) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(11)60087-7 · Cited by 67 · see citing works
Self-citationPatel, D. K., Kumar, R., Laloo, D., et al. (2011) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(11)60110-7 · Cited by 67 · see citing works
Self-citationLee, H. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020674o · Cited by 65 · see citing works
Puri, D. (2001) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(01)00306-3 · Cited by 65 · see citing works
Hypoglycaemic activity of different extracts of various herbal plants.
Singh, A., Singh, K., & Saxena, A. (2010) · International Journal of Research in Ayurveda and Pharmacy · Cited by 64 · see citing works
Haeri, M. R., Izaddoost, M., Ardekani, M. R. S., et al. (2008) · Phytotherapy Research · doi:10.1002/ptr.2557 · Cited by 62 · see citing works
Wang, Z., Lu, F., Leng, S.-H., Fang, X., Chen, G., Wang, Z.-S., Dong, L., & Yan, Z.-Q. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6004 · Cited by 61 · see citing works
Park, S., Jang, J. S., & Hong, S. M. (2007) · Metabolism · doi:10.1016/j.metabol.2006.12.004 · Cited by 60 · see citing works
Ko, B., Jang, J. S., Hong, S. M., Sung, S. R., Lee, J. E., Lee, M. Y., Jeon, W. K., & Park, S. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.60533 · Cited by 57 · see citing works
Frankish, N., Boylan, F., Mills, C., et al. (2010) · Planta Medica · doi:10.1055/s-0029-1240868 · Cited by 56 · see citing works
Yazdanparast, R., Esmaeili, M. A., & Helan, J. A. (2005) · Cited by 50 · see citing works
Green tea, anti-diabetic or diabetogenic: a dose response study
Islam, M. S., & Choi, H. (2007) · BioFactors · doi:10.1002/biof.5520290105 · Cited by 44 · cited 1× · see citing works
“Lower dose of Camellia sinensis on SD rats fed with high fat diet for 2 weeks showed insulinotropic effect in experimental condition[27].”
BackgroundDallak (2009) · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology · doi:10.3844/ajbbsp.2009.118.125 · Cited by 38 · see citing works
Anand, P., Murali, Y. K., Tandon, V., et al. (2008) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2008-1080917 · Cited by 34 · see citing works
Dallak, M. A., Bashir, N., Abbas, M., et al. (2009) · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology · doi:10.3844/ajbbsp.2009.153.161 · Cited by 32 · see citing works
Mirghazanfari, S. M., Keshavarz, M., Nabavizadeh, F., et al. (2010) · PubMed · Cited by 21 · see citing works
Souza, A., Mbatchi, B., & Herchuelz, A. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.11.028 · Cited by 19 · see citing works
Eid, N. I., & El‐Latif, H. A. A. (2007) · Cited by 12 · see citing works
Effect of Alangium salvifolium (Alangiaceae) on Dexamethasone Induced Insulin Resistance in Rats
Kshirsagar, R. P., Darade, S. S., & Takale, V. V. (2010) · Journal of Pharmacy Research · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [37]Kaczmar T. Herbal support for diabetes management. Clin Nutr Insights. 1998;6(8):1–4. [Google Scholar]
- [40]Mentreddy SR, Mohamed AI, Rimando AM. Medicinal plants with hypoglycemic/anti-hyperglycemic properties: a review. Proc Assoc Adv Ind Crop Conf. 2005;20:341–353. [Google Scholar]
Cited by
Sorted by citations
Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review
El-Saber Batiha, G., Magdy Beshbishy, A., G. Wasef, L., Elewa, Y. H. A., A. Al-Sagan, A., Abd El-Hack, M. E., Taha, A. E., M. Abd-Elhakim, Y., & Prasad Devkota, H. (2020) · Nutrients · doi:10.3390/nu12030872 · Cited by 931 · see citing works
Phytotherapy in diabetes: Review on potential mechanistic perspectives
El-Abhar, H. S., & Schaalan, M. F. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i2.176 · Cited by 145 · see citing works
Tegegne, B. A., Adugna, A., Yenet, A., Yihunie Belay, W., Yibeltal, Y., Dagne, A., Hibstu Teffera, Z., Amare, G. A., Abebaw, D., Tewabe, H., et al. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1440456 · Cited by 61 · see citing works
- Authors
- Patel, D., Prasad, S., Kumar, R., & Hemalatha, S.
- Affiliations
- Indian Institute of Technology BHU (IN)
- ORCID
- Hemalatha, S
- Venue
- Asian Pacific Journal of Tropical Biomedicine
- Published
- 2012-04
- Volume
- 2
- Issue
- 4
- Pages
- 320-330
- ISSN
- 2221-1691 (ISSN-L)
- PMC
- PMC3609288
- OpenAlex
- W2056066400
- Cited by
- 836
- References
- 51
- Citations by year
- 2026: 31 · 2025: 46 · 2024: 69 · 2023: 89 · 2022: 76 · 2021: 76 · 2020: 65 · 2019: 68 · 2018: 62 · 2017: 63 · 2016: 50 · 2015: 54 · 2014: 49 · 2013: 23 · 2012: 13
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Asian Pacific Journal of Tropical Biomedicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Grants Commission
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- antidiabetic plants, insulin-like activity, insulin secretagogues, hypoglycemic activity, diabetes mellitus, phytochemical constituents, polyphenols, flavonoids, terpenoids, coumarins, garlic, Gymnema sylvestre, Momordica charantia, fenugreek, Citrullus colocynthis, Ficus benghalensis, plant families, herbal medicine
- MeSH terms
- Animals, Cells, Cultured, Flavonoids, Humans, Hypoglycemic Agents, Insulin, Islets of Langerhans, Phytotherapy, Plant Extracts, Plants, Medicinal, Mice, Rats, Polyphenols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
