Green tea, anti-diabetic or diabetogenic: a dose response study
Abstract
Present study was conducted to clarify whether lower or higher dietary dose of green tea is beneficial for the reduction of risk of type 2 diabetes. Five weeks old male SD rats were fed high fat diet for 2 weeks then divided into 4 groups of 8 animals as Normal Control (NC), Diabetic Control (DBC), Green Tea Low (GTL, 0.5%, Green Tea High (GTH, 2.0%) groups. Diabetes was induced by intra-peritoneal (i.p) injection of STZ (40 mg/kg BW) in all animals except NC group. After 4 weeks feeding of experimental diets, serum fasting blood glucose was not decreased but relatively increased in both green tea fed groups compared to DBC group. Serum insulin concentration was significantly (p< 0.05) increased in GTL group but not in GTH group when compared with DBC group. Serum lipids were significantly decreased in GTH group but not in GTL group compared to DBC group. Intra-peritoneal glucose tolerance test, blood HbA1c, liver weight, and liver glycogen level were not influenced by the feeding of green tea containing diets. Data of this study suggest that lower dose of green tea is insulinotropic when higher dose is hyperglycemic but hypolipidemic at least in this experimental condition.
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The anabolic modulatory activities of phytoecdysteroids suggest their potential use in diabetic conditions for blood glucose-lowering through direct stimulation of pancreatic β-cells.
“The anabolic modulatory activities of PEs suggest their potential use in diabetic conditions for their blood glucose-lowering properties through the direct stimulation of pancreatic β-cells165.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [165]
PEs have anabolic modulatory activities used to treat diabetes, as they have blood-glucose-lowering properties by stimulating β-cells of the pancreas.
“PEs have anabolic modulatory activities that are used to treat diabetes, as they have blood-glucose-lowering properties by stimulating β-cells of the pancreas [156].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [156]
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- Authors
- Islam, M. S., & Choi, H.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Islam, Md.Shahidul
- ORCID
- Islam, Md.Shahidul
- Venue
- BioFactors
- Publisher
- Wiley
- Published
- 2007-01
- Volume
- 29
- Issue
- 1
- Pages
- 45-53
- ISSN
- 0951-6433 (ISSN-L)
- 1872-8081
- OpenAlex
- W2078608247
- Cited by
- 44
- References
- 27
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2020: 6 · 2019: 5 · 2017: 4 · 2016: 6 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 3
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BioFactors (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Prevent Cancer Foundation
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- green tea, type 2 diabetes, dose-response relationship, streptozotocin-induced diabetes, insulinotropic effect, hyperglycemia, hypolipidemic effect, serum lipids, high-fat diet, fasting blood glucose, HbA1c, liver glycogen
- MeSH terms
- Animals, Blood Glucose, Body Weight, Cholesterol, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Dietary Fats, Dose-Response Relationship, Drug, Glucose Tolerance Test, Cholesterol, HDL, Cholesterol, LDL, Liver, Male, Organ Size, Plant Extracts, Tea, Triglycerides, Rats, Sprague-Dawley, Rats
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