SARS-CoV-2 spike E484K mutation reduces antibody neutralisation
Open accessAbstract
It is concerning that emerging variants of SARS-CoV-2 can evade neutralising antibodies induced by previous infection or vaccination through mutations in the spike protein, including the receptor-binding domain (RBD). The asparagine (N) to tyrosine (Y) substitution at position 501 (N501Y), present in variants of concern belonging to the B.1.1.7, B.1.351, and P.1 lineages, does not seem to affect in-vitro neutralisation of human convalescent or post-vaccination sera. However, additional substitutions, such as E484K present in B.1.351 and P.1 lineages, might allow evasion from neutralising antibodies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Eta showed reduced neutralization by bamlanivimab and etesevimab monoclonal antibodies and convalescent sera.
“This variant showed reduced neutralization by bamlanivimab and etesevimab monoclonal antibodies and convalescent sera [43, 44].”
From Waves and variants of SARS-CoV-2: understanding the causes and effect of the COVID-19 catastrophe (2022) · cites this paper as [44]
In the paper’s main text (page not provided), convalescent sera neutralised a recombinant virus carrying E484K less efficiently than the comparison virus. The study did not test Eta as a variant or report results for bamlanivimab or etesevimab, so those parts of the claim are not supported by this source. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
(2021) · doi:10.1101/2021.01.15.426911 · Cited by 1,354 · see citing works
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
Wang, Z., Schmidt, F., Weisblum, Y., Muecksch, F., Barnes, C. O., Finkin, S., Schaefer-Babajew, D., Cipolla, M., Gaebler, C., Lieberman, J. A., et al. (2021) · Nature · doi:10.1038/s41586-021-03324-6 · Cited by 1,343 · see citing works
Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants
Weisblum, Y., Schmidt, F., Zhang, F., DaSilva, J., Poston, D., Lorenzi, J. C., Muecksch, F., Rutkowska, M., Hoffmann, H.-H., Michailidis, E., et al. (2020) · eLife · doi:10.7554/elife.61312 · Cited by 1,308 · see citing works
Greaney, A. J., Loes, A. N., Crawford, K. H. D., Starr, T. N., Malone, K. D., Chu, H. Y., & Bloom, J. D. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.02.003 · Cited by 1,178 · see citing works
Greaney, A. J., Loes, A. N., Crawford, K. H. D., Starr, T. N., Malone, K. D., Chu, H. Y., & Bloom, J. D. (2021) · doi:10.1101/2020.12.31.425021 · Cited by 1,178 · see citing works
Wu, K., Werner, A. P., Moliva, J. I., Koch, M., Choi, A., Stewart-Jones, G. B. E., Bennett, H., Boyoglu-Barnum, S., Shi, W., Graham, B. S., et al. (2021) · doi:10.1101/2021.01.25.427948 · Cited by 419 · see citing works
Rathnasinghe, R., Jangra, S., Čupić, A., Martínez‐Romero, C., Mulder, L. C. F., Kehrer, T., Yildiz, S., Choi, A., Mena, I., Vrieze, J. D., et al. (2021) · medRxiv · doi:10.1101/2021.01.19.21249592 · Cited by 118 · see citing works
Self-citation
Flagged first, then by citations
1 of the 8 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The biological and clinical significance of emerging SARS-CoV-2 variants
Tao, K., Tzou, P. L., Nouhin, J., Gupta, R. K., de Oliveira, T., Kosakovsky Pond, S. L., Fera, D., & Shafer, R. W. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-021-00408-x · Cited by 1,009 · see citing works
Ranzani, O., Hitchings, M. D. T., Dorión, M., D’Agostini, T. L., de Paula, R. C., de Paula, O. F. P., Villela, E. F. D. M., Torres, M. S. S., de Oliveira, S. B., Schulz, W. L., et al. (2021) · BMJ · doi:10.1136/bmj.n2015 · Cited by 348 · see citing works
SARS-CoV-2 Variants of Concern
Choi, J. Y., & Smith, D. M. (2021) · Yonsei Medical Journal · doi:10.3349/ymj.2021.62.11.961 · Cited by 297 · see citing works
Nucleocapsid mutations R203K/G204R increase the infectivity, fitness, and virulence of SARS-CoV-2
Wu, H., Xing, N., Meng, K., Fu, B., Xue, W., Dong, P., Tang, W., Xiao, Y., Liu, G., Luo, H., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.11.005 · Cited by 224 · see citing works
Chi, W.-Y., Li, Y.-D., Huang, H., Chan, T. E. H., Chow, S.-Y., Su, J.-H., Ferrall, L., Hung, C., & Wu, T. ‐. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00853-8 · Cited by 216 · see citing works
Waves and variants of SARS-CoV-2: understanding the causes and effect of the COVID-19 catastrophe
Thakur, V., Bhola, S., Thakur, P., Patel, S. K. S., Kulshrestha, S., Ratho, R. K., & Kumar, P. (2022) · Infection · doi:10.1007/s15010-021-01734-2 · Cited by 210 · see citing works
“This variant showed reduced neutralization by bamlanivimab and etesevimab monoclonal antibodies and convalescent sera [43, 44].”
BackgroundPan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors
Tan, C. W., Chia, W., Young, B. E., Zhu, F., Lim, B. L., Sia, W. R., Thein, T.-L., Chen, M. I.-C., Leo, Y., Lye, D. C., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2108453 · Cited by 196 · see citing works
Hitchings, M. D. T., Ranzani, O., Torres, M. S. S., de Oliveira, S. B., Almirón, M., Said, R., Borg, R., Schulz, W. L., de Oliveira, R. D., da Silva, P. V., et al. (2021) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2021.100025 · Cited by 200 · see citing works
The Impact of Evolving SARS-CoV-2 Mutations and Variants on COVID-19 Vaccines
McLean, G. R., Kamil, J. P., Lee, B., Moore, P. L., Schulz, T. F., Muik, A., Şahin, U., Türeci, Ö., & Pather, S. (2022) · mBio · doi:10.1128/mbio.02979-21 · Cited by 190 · see citing works
The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and Syncytia Formation
Rajah, M. M., Bernier, A., Buchrieser, J., & Schwartz, O. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167280 · Cited by 176 · see citing works
SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines
Thakur, S., Sasi, S., Pillai, S. G., Nag, A., Shukla, D., Singhal, R., Phalke, S., & Velu, G. S. K. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.815389 · Cited by 158 · see citing works
Chakraborty, C., Sharma, A. R., Bhattacharya, M., & Lee, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.801522 · Cited by 150 · see citing works
Nanotechnology-based strategies against SARS-CoV-2 variants
Huang, X., Kon, E., Han, X., Zhang, X., Kong, N., Mitchell, M. J., Peer, D., & Tao, W. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01174-5 · Cited by 143 · see citing works
Applications of Molecular Dynamics Simulation in Protein Study
Sinha, S., Tam, B., & Wang, S. M. (2022) · Membranes · doi:10.3390/membranes12090844 · Cited by 144 · see citing works
SARS‐CoV‐2 variants and vulnerability at the global level
Chavda, V. P., Patel, A., & Vaghasiya, D. D. (2022) · Journal of Medical Virology · doi:10.1002/jmv.27717 · Cited by 132 · see citing works
Lusvarghi, S., Pollett, S. D., Neerukonda, S. N., Wang, W., Wang, R., Vassell, R. A., Epsi, N. J., Fries, A. C., Agan, B. K., Lindholm, D. A., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abn8543 · Cited by 130 · see citing works
Accelerated SARS-CoV-2 intrahost evolution leading to distinct genotypes during chronic infection
Chaguza, C., Hahn, A. M., Petrone, M. E., Zhou, S., Ferguson, D. J. P., Breban, M. I., Pham, K., Peña-Hernández, M. A., Castaldi, C., Hill, V., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.100943 · Cited by 121 · see citing works
Chakraborty, C., Bhattacharya, M., & Sharma, A. R. (2022) · Reviews in Medical Virology · doi:10.1002/rmv.2270 · Cited by 111 · see citing works
Sun, W., Liu, Y., Amanat, F., González‐Domínguez, I., McCroskery, S., Slamanig, S., Coughlan, L., Rosado, V. C., Lemus, N., Jangra, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26499-y · Cited by 112 · see citing works
Self-citationReinfection in patients with COVID-19: a systematic review
Ren, X., Zhou, J., Guo, J., Hao, C., Zheng, M., Zhang, R., Huang, Q. Y., Yao, X., Li, R., & Jin, Y. (2022) · Global Health Research and Policy · doi:10.1186/s41256-022-00245-3 · Cited by 104 · see citing works
COVID-19 Pandemic and Vaccines Update on Challenges and Resolutions
Khan, W. H., Hashmi, Z., Goel, A., Ahmad, R., Gupta, K., Khan, N., Alam, I., Ahmed, F., & Ansari, M. A. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.690621 · Cited by 101 · see citing works
Geng, J., Chen, L., Yuan, Y., Wang, K., Wang, Y., Qin, C., Wu, G., Chen, R., Zhang, Z., Wei, D., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00760-8 · Cited by 98 · see citing works
SARS-CoV-2 Evolution and Immune Escape in Immunocompromised Patients
Scherer, E., Babiker, A., Adelman, M., Allman, B., Key, A., Kleinhenz, J., Langsjoen, R. M., Nguyen, P.-V., Onyechi, I., Sherman, J. D., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmc2202861 · Cited by 78 · see citing works
The success of SARS-CoV-2 vaccines and challenges ahead
Subbarao, K. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.06.016 · Cited by 90 · see citing works
Yang, Z., Han, Y., Ding, S., Shi, W., Zhou, T., Finzi, A., Kwong, P. D., Mothes, W., & Lu, M. (2022) · mBio · doi:10.1128/mbio.03227-21 · Cited by 77 · see citing works
Immunity to SARS-CoV-2 up to 15 months after infection
Marcotte, H., Piralla, A., Zuo, F., Du, L., Cassaniti, I., Wan, H., Kumagai‐Braesch, M., Andréll, J., Percivalle, E., Sammartino, J. C., et al. (2022) · iScience · doi:10.1016/j.isci.2022.103743 · Cited by 79 · see citing works
Emerging Vaccine-Breakthrough SARS-CoV-2 Variants
Wang, R., Chen, J., Hozumi, Y., Yin, C., & Wei, G. (2022) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.1c00557 · Cited by 81 · see citing works
Hitchings, M. D. T., Ranzani, O., Dorión, M., D’Agostini, T. L., de Paula, R. C., de Paula, O. F. P., Villela, E. F. D. M., Torres, M. S. S., de Oliveira, S. B., Schulz, W. L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26459-6 · Cited by 78 · see citing works
Ramzi, Z. S. (2021) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2021.10.059 · Cited by 77 · see citing works
Ferrareze, P. A. G., Franceschi, V. B., Mayer, A. D. M., Caldana, G. D., Zimerman, R. A., & Thompson, C. E. (2021) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2021.104941 · Cited by 82 · see citing works
Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape
Mast, F. D., Fridy, P. C., Ketaren, N. E., Wang, J., Jacobs, E. Y., Olivier, J. P., Sanyal, T., Molloy, K. R., Schmidt, F., Rutkowska, M., et al. (2021) · eLife · doi:10.7554/elife.73027 · Cited by 67 · see citing works
SARS-CoV-2 variants and COVID-19 vaccines: Current challenges and future strategies
Gong, W., Parkkila, S., Wu, X., & Aspatwar, A. (2022) · International Reviews of Immunology · doi:10.1080/08830185.2022.2079642 · Cited by 74 · see citing works
COVID-19 and SARS-CoV-2 Variants: Current Challenges and Health Concern
Zeyaullah, M., AlShahrani, A. M., Muzammil, K., Ahmad, I., Alam, S., Khan, W. H., & Ahmad, R. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.693916 · Cited by 72 · see citing works
Noori, M., Nejadghaderi, S. A., Arshi, S., Carson‐Chahhoud, K., Ansarin, K., Kolahi, A., & Safiri, S. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2277 · Cited by 64 · see citing works
Predicting the antigenic evolution of SARS-COV-2 with deep learning
Han, W., Chen, N., Xu, X., Sahil, A., Zhou, J., Li, Z., Zhong, H., Gao, E., Zhang, R., Wang, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39199-6 · Cited by 64 · see citing works
A review on evolution of emerging SARS-CoV-2 variants based on spike glycoprotein
Ghosh, N., Nandi, S., & Saha, I. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108565 · Cited by 64 · see citing works
Jhun, H., Park, H., Hisham, Y., Song, C., & Kim, S. (2021) · Immune Network · doi:10.4110/in.2021.21.e32 · Cited by 62 · see citing works
Carreño, J. M., Alshammary, H., Singh, G., Raskin, A. J., Amanat, F., Amoako, A. A., Gonzalez-Reiche, A. S., van de Guchte, A., PARIS study group, Awawda, M. H., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103626 · Cited by 61 · see citing works
Self-citationPhilomina J, B., Jolly, B., John, N., Bhoyar, R. C., Majeed, N., Senthivel, V., CP, F., Rophina, M., Vasudevan, B., Imran, M., et al. (2021) · Journal of Infection · doi:10.1016/j.jinf.2021.05.018 · Cited by 62 · see citing works
Mohammad, T., Choudhury, A., Habib, I., Asrani, P., Mathur, Y., Umair, M., Anjum, F., Shafie, A., Yadav, D. K., & Hassan, M. I. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.765039 · Cited by 60 · see citing works
Evaluation of SARS-CoV-2 Main Protease Inhibitors Using a Novel Cell-Based Assay
Cao, W., Cho, C.-C. D., Geng, Z. Z., Shaabani, N., Ma, X. R., Vatansever, E. C., Alugubelli, Y. R., Ma, Y., Chaki, S. P., Ellenburg, W. H., et al. (2022) · ACS Central Science · doi:10.1021/acscentsci.1c00910 · Cited by 62 · see citing works
Toledo-Romaní, M. E., Carmenate, M. G., Valenzuela‐Silva, C., Rodríguez, W. B., Martínez-Pérez, M., Rodríguez-González, M., Paredes-Moreno, B., Mendoza-Hernández, I., González-Mugica, R., Samón-Tabío, O., et al. (2022) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2022.100423 · Cited by 61 · see citing works
Clinical grade ACE2 as a universal agent to block SARS‐CoV‐2 variants
Monteil, V., Eaton, B., Postnikova, E. N., Murphy, M. J., Braunsfeld, B., Crozier, I., Kricek, F., Niederhöfer, J., Schwarzböck, A., Breid, H., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202115230 · Cited by 58 · see citing works
Could live attenuated vaccines better control COVID-19?
Okamura, S., & Ebina, H. (2021) · Vaccine · doi:10.1016/j.vaccine.2021.08.018 · Cited by 59 · see citing works
Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil
Clemens, S. A. C., Folegatti, P. M., Emary, K. R. W., Weckx, L. Y., Ratcliff, J., Bibi, S., Mendes, A. V. A., Milan, E. P., Pittella, A. M., Schwarzbold, A. V., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25982-w · Cited by 57 · see citing works
Rapid and Sensitive Genotyping of SARS-CoV-2 Key Mutation L452R with an RPA-PfAgo Method
Zhao, C., Yang, L., Zhang, X., Tang, Y., Wang, Y., Shao, X., Gao, S., Liu, X., & Wang, P. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c03563 · Cited by 55 · see citing works
Lu, M., Chamblee, M., Zhang, Y., Ye, C., Dravid, P., Park, J., Mahesh, K., Trivedi, S., Murthy, S. S., Sharma, H., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2110105119 · Cited by 54 · see citing works
Self-citationLou, E. G., Sapoval, N., McCall, C., Bauhs, L., Carlson‐Stadler, R., Kalvapalle, P. B., Lai, Y., Palmer, K., Penn, R., Rich, W., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155059 · Cited by 51 · see citing works
The challenges of COVID‐19 Delta variant: Prevention and vaccine development
He, X., He, C., Hong, W., Zhang, K., & Wei, X. (2021) · MedComm · doi:10.1002/mco2.95 · Cited by 49 · see citing works
SARS-CoV-2: phenotype, genotype, and characterization of different variants
Saberiyan, M., Karimi, E., Khademi, Z., Movahhed, P., Safi, A., & Ghahfarrokhi, A. M. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00352-6 · Cited by 52 · see citing works
Laurini, E., Marson, D., Aulić, S., Fermeglia, A., & Pricl, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-99827-3 · Cited by 47 · see citing works
Lives saved and hospitalizations averted by COVID-19 vaccination in New York City: a modeling study
Shoukat, A., VILCHES, T. N., Moghadas, S. M., Sah, P., Schneider, E. C., Shaff, J., Zucker, J. R., Quinn, C., Chokshi, D. A., & Galvani, A. P. (2021) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2021.100085 · Cited by 49 · see citing works
Variations within the Glycan Shield of SARS-CoV-2 Impact Viral Spike Dynamics
Newby, M. L., Fogarty, C. A., Allen, J. D., Butler, J., Fadda, E., & Crispin, M. (2022) · Journal of Molecular Biology · doi:10.1016/j.jmb.2022.167928 · Cited by 46 · see citing works
Nissinen, R., Leirisalo-Repo, M., Peltomaa, R., Palosuo, T., & Vaarala, O. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.008599 · Cited by 49 · see citing works
He, C., Yang, H. J., He, X., Hong, W., Hong, L., Chen, Z., Shen, G., Yang, L., Li, J., Wang, Z., et al. (2021) · MedComm · doi:10.1002/mco2.72 · Cited by 43 · see citing works
Chakraborty, S. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108424 · Cited by 46 · see citing works
Yang, W.-T., Huang, W.-H., Liao, T.-L., Hsiao, T.-H., Chuang, H.-N., & Liu, P.-Y. (2022) · Infection and Drug Resistance · doi:10.2147/idr.s344099 · Cited by 45 · see citing works
Furukawa, K., Tjan, L. H., Kurahashi, Y., Sutandhio, S., Nishimura, M., Arii, J., & Mori, Y. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.10780 · Cited by 45 · see citing works
Structure and Mutations of SARS-CoV-2 Spike Protein: A Focused Overview
Mehra, R., & Kepp, K. P. (2021) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.1c00433 · Cited by 45 · see citing works
The Development of SARS-CoV-2 Variants: The Gene Makes the Disease
Pérez-Gómez, R. (2021) · Journal of Developmental Biology · doi:10.3390/jdb9040058 · Cited by 45 · see citing works
Yang, Z. L., Zhang, S., Tang, Y., Zhang, S., Xu, D.-Q., Yue, S., & Liu, Q. (2022) · Aging and Disease · doi:10.14336/ad.2021.1210 · Cited by 44 · see citing works
Jangra, S., Landers, J. J., Rathnasinghe, R., O’Konek, J. J., Janczak, K. W., Cascalho, M., Kennedy, A. A., Tai, A. W., Baker, J. R., Schotsaert, M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.729189 · Cited by 44 · see citing works
Self-citationHassler, L., Wysocki, J. A., Gelarden, I. A., Sharma, I., Τοματσίδου, Α., Ye, M., Gula, H., Nicoleascu, V., Randall, G. C., Pshenychnyi, S., et al. (2022) · Journal of the American Society of Nephrology · doi:10.1681/asn.2021091209 · Cited by 44 · see citing works
Salleh, M. Z., Norazmi, M. N., & Deris, Z. Z. (2022) · PeerJ · doi:10.7717/peerj.13083 · Cited by 43 · see citing works
Alveolar macrophages: Achilles’ heel of SARS-CoV-2 infection
Wang, Z., Li, S., & Huang, B. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01106-8 · Cited by 47 · see citing works
Saha, A., Roy, S. G., Dwivedi, R., Tripathi, P., Kumar, K., Nambiar, S. M., & Pathak, R. (2025) · Vaccines · doi:10.3390/vaccines13040424 · Cited by 44 · see citing works
Durability of SARS-CoV-2–Specific T-Cell Responses at 12 Months Postinfection
Lu, Z., Laing, E. D., DaMata, J. P., Pohida, K., Tso, M. S., Samuels, E. C., Epsi, N. J., Dorjbal, B., Lake, C. M., Richard, S. A., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab543 · Cited by 41 · see citing works
Evolution of the SARS-CoV-2 genome and emergence of variants of concern
Safari, I., & Elahi, E. (2021) · Archives of Virology · doi:10.1007/s00705-021-05295-5 · Cited by 41 · see citing works
Klingler, J., Lambert, G. S., Itri, V., Liu, S. T. H., Bandrés, J. C., Enyindah-Asonye, G. M., Liu, X., Simon, V. R., Gleason, C., Kleiner, G., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.759688 · Cited by 42 · see citing works
Self-citationCOVID-19: From emerging variants to vaccination
Senevirathne, T. H., Wekking, D., Swain, J. W. R., Solinas, C., & Silva, P. D. (2023) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2023.11.005 · Cited by 42 · see citing works
Rathnasinghe, R., Jangra, S., Ye, C., Čupić, A., Singh, G., Martínez‐Romero, C., Mulder, L. C. F., Kehrer, T., Yildiz, S., Choi, A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30763-0 · Cited by 41 · see citing works
Self-citationAllosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike protein
Tan, Z. W., Tee, W.-V., Samsudin, F., Guarnera, E., Bond, P. J., & Berezovsky, I. N. (2022) · Structure · doi:10.1016/j.str.2021.12.011 · Cited by 37 · see citing works
Tarke, A., Ramezani-Rad, P., Neto, T. A. P., Lee, Y., Silva‐Moraes, V., Goodwin, B., Bloom, N. I., Siddiqui, L., Avalos, L., Frazier, A., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101583 · Cited by 37 · see citing works
Gopinath, S., Ishak, A., Dhawan, N., Poudel, S., Shrestha, P. S., Singh, P., Xie, E., Tahir, P., Marzaban, S., Michel, J., et al. (2022) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed7050081 · Cited by 38 · see citing works
Xiao, H., Hu, J., Huang, C., Feng, W., Liu, Y., Kumblathan, T., Tao, J., Xu, J., Le, X. C., & Zhang, H. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117000 · Cited by 38 · see citing works
The variants of SARS‐CoV‐2 and the challenges of vaccines
Han, X., & Ye, Q. (2021) · Journal of Medical Virology · doi:10.1002/jmv.27513 · Cited by 35 · see citing works
Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1
Nchioua, R., Schundner, A., Klute, S., Koepke, L., Hirschenberger, M., Noettger, S., Fois, G., Zech, F., Graf, A., Krebs, S., et al. (2023) · Life Science Alliance · doi:10.26508/lsa.202201745 · Cited by 37 · see citing works
Liu, X., Liu, X., Zhou, J., Dong, Y., Jiang, W., & Jiang, W. (2022) · RNA · doi:10.1261/rna.079160.122 · Cited by 37 · see citing works
Puenpa, J., Rattanakomol, P., Saengdao, N., Chansaenroj, J., Yorsaeng, R., Suwannakarn, K., Thanasitthichai, S., Vongpunsawad, S., & Poovorawan, Y. (2023) · Archives of Virology · doi:10.1007/s00705-022-05666-6 · Cited by 37 · see citing works
Molecular Evolution of SARS-CoV-2 during the COVID-19 Pandemic
González-Vázquez, L. D., & Arenas, M. (2023) · Genes · doi:10.3390/genes14020407 · Cited by 40 · see citing works
SARS-CoV-2 mRNA vaccine BNT162b2 triggers a consistent cross-variant humoral and cellular response
Mileto, D., Fenizia, C., Cutrera, M., Gagliardi, G., Gigantiello, A., Silvestri, A. D., Rizzo, A., Mancon, A., Bianchi, M., Poli, F., et al. (2021) · Emerging Microbes & Infections · doi:10.1080/22221751.2021.2004866 · Cited by 36 · see citing works
Lusvarghi, S., Wang, W., Herrup, R., Neerukonda, S. N., Vassell, R. A., Bentley, L., Eakin, A. E., Erlandson, K. J., & Weiss, C. D. (2021) · Journal of Virology · doi:10.1128/jvi.01110-21 · Cited by 33 · see citing works
Piepenbrink, M. S., Park, J., Deshpande, A. A., Loos, A., Ye, C., Basu, M., Sarkar, S., Khalil, A. M., Chauvin, D., Woo, J. C., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010691 · Cited by 40 · see citing works
Self-citationCancela, F., Ramos, N., Smyth, D., Etchebehere, C., Berois, M., Rodríguez, J., Rufo, C., Alemán, A., Borzacconi, L., López, J., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0284483 · Cited by 29 · see citing works
Knabl, L., Lee, H., Wieser, M., Mur, A., Zabernigg, A. F., Knabl, L., Rauch, S., Böck, M., Schumacher, J., Kaiser, N., et al. (2022) · Communications Medicine · doi:10.1038/s43856-022-00083-x · Cited by 34 · see citing works
Molecular Basis of Mink ACE2 Binding to SARS-CoV-2 and Its Mink-Derived Variants
Su, C., He, J., Han, P., Bai, B., Li, D., Cao, J. X., Tian, M., Hu, Y., Zheng, A., Niu, S., et al. (2022) · Journal of Virology · doi:10.1128/jvi.00814-22 · Cited by 34 · see citing works
Halfmann, P., Minor, N. R., Haddock, L. A., Maddox, R., Moreno, G. K., Braun, K. M., Baker, D. A., Riemersa, K. K., Prasad, A., Alman, K. J., et al. (2022) · Virus Evolution · doi:10.1093/ve/veac104 · Cited by 34 · see citing works
SARS-CoV-2 variants: Impact on biological and clinical outcome
Mahilkar, S., Agrawal, S. R., Chaudhary, S., Parikh, S., Sonkar, S. C., Verma, D. K., Chitalia, V., Mehta, D., Koner, B. C., Vijay, N., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.995960 · Cited by 35 · see citing works
Current state of, prospects for, and obstacles to mRNA vaccine development
Aljabali, A. A. A., Bashatwah, R. M., Obeid, M. A., Mishra, V., Mishra, Y., Serrano‐Aroca, Á., Lundstrom, K. H., & Tambuwala, M. M. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.103458 · Cited by 34 · see citing works
The consequences of SARS-CoV-2 within-host persistence
Sigal, A., Neher, R. A., & Lessells, R. J. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01125-y · Cited by 36 · see citing works
Chadha, J., Khullar, L., & Mittal, N. (2021) · Environmental Microbiology · doi:10.1111/1462-2920.15687 · Cited by 32 · see citing works
PARIS and SPARTA: Finding the Achilles’ Heel of SARS-CoV-2
Simon, V. R., Kota, V. K., Bloomquist, R. F., Hanley, H. B., Forgacs, D., Pahwa, S. G., Pallikkuth, S., Miller, L. G., Schaenman, J. M. D., Yeaman, M. R., et al. (2022) · mSphere · doi:10.1128/msphere.00179-22 · Cited by 28 · see citing works
Self-citationFang, Y., Sun, P., Xie, X., Du, M., Du, F., Ye, J., Kalveram, B., Plante, J. A., Plante, K. S., Li, B., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abp9962 · Cited by 30 · see citing works
Rapid detection of multiple SARS-CoV-2 variants of concern by PAM-targeting mutations
Ning, B., Youngquist, B. M., Li, D. D., Lyon, C. J., Zelazny, A. M., Maness, N. J., Tian, D., & Hu, Y. (2022) · Cell Reports Methods · doi:10.1016/j.crmeth.2022.100173 · Cited by 29 · see citing works
Antibody escape and global spread of SARS-CoV-2 lineage A.27
Kaleta, T., Kern, L., Hong, S. L., Hölzer, M., Kochs, G., Beer, J., Schnepf, D., Schwemmle, M., Bollen, N., Kolb, P., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28766-y · Cited by 31 · see citing works
He, Q., Mao, Q., Peng, X., He, Z., Lu, S., Zhang, J., Gao, F., Bian, L., An, C., Yu, W., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00926-y · Cited by 31 · see citing works
Li, X., Zhang, L., Chen, S. E., Ji, W., Li, C., & Ren, L. (2021) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2021.104971 · Cited by 30 · see citing works
Basile, K., Rockett, R. J., McPhie, K. A., Fennell, M., Johnson-Mackinnon, J. C., Agius, J. E., Fong, W., Rahman, H., Ko, D., Donavan, L., et al. (2022) · Viruses · doi:10.3390/v14092023 · Cited by 30 · see citing works
Structural Immunology of SARS ‐ CoV ‐2
Yuan, M., & Wilson, I. A. (2024) · Immunological Reviews · doi:10.1111/imr.13431 · Cited by 28 · see citing works
Auth, J., Fröba, M., Große, M., Rauch, P., Ruétalo, N., Schindler, M., Morokutti-Kurz, M., Graf, P., Dolischka, A., Prieschl‐Grassauer, E., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910205 · Cited by 29 · see citing works
- Authors
- Jangra, S., Ye, C., Rathnasinghe, R., Stadlbauer, D., Alshammary, H., Amoako, A. A., Awawda, M. H., Beach, K. F., Bermúdez-González, M. C., Chernet, R. L., Eaker, L. Q., Ferreri, E. D., Floda, D. L., Gleason, C. R., Kleiner, G., Jurczyszak, D., Matthews, J. C., Mendez, W. A., Mulder, L. C. F., Russo, K. T., Salimbangon, A.-B. T., Saksena, M., Shin, A. S., Sominsky, L. A., Srivastava, K., Krammer, F., Simon, V., Martinez-Sobrido, L., García-Sastre, A., & Schotsaert, M.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Texas Biomedical Research Institute (US)
- Tisch Cancer Institute (US)
- Corresponding author
- Schotsaert, Michael
- ORCID
- Jangra, Sonia
- Ye, Chengjin
- Rathnasinghe, Raveen
- Stadlbauer, Daniel
- Alshammary, Hala
- Amoako, Angela A.
- Beach, Katherine F
- Bermúdez-González, Maria C.
- Chernet, Rachel L.
- Ferreri, Emily D.
- Gleason, Charles R.
- Kleiner, Giulio
- Jurczyszak, Denise
- Mulder, Lubbertus C.F.
- Saksena, Miti
- Sominsky, Levy A.
- Krammer, Florian
- Simon, Viviana
- Schotsaert, Michael
- Venue
- The Lancet Microbe
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 2
- Issue
- 7
- Pages
- e283-e284
- ISSN
- 2666-5247 (ISSN-L)
- PMC
- PMC8026167
- OpenAlex
- W3142966103
- Cited by
- 385
- References
- 8
- Citations by year
- 2026: 7 · 2025: 22 · 2024: 35 · 2023: 55 · 2022: 144 · 2021: 121
- FWCI
- 28.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- The Lancet Microbe (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- ImmPort
- Funders
- JPB Foundation (2020\u2013215611)
- U.S. Department of Health and Human Services (HHSN272201400005C)
- NCI (U54CA260560)
- National Institutes of Health
- Pfizer
- NIAID (75N93019C00051, HHSN272201400005C)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- SARS-CoV-2, spike protein, E484K mutation, antibody neutralization, antibody escape, receptor binding domain, Omicron variant, Beta variant, P.1 lineage, convalescent sera, vaccine-induced antibodies
- MeSH terms
- COVID-19, SARS-CoV-2, Humans, Mutation, Antibodies, Neutralizing, Spike Glycoprotein, Coronavirus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review