The DOI matches its Crossref record; 46 of the 47 references it cites were found in a registry or an index.
Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men
Open accessAbstract
Leucine has been suggested to have the potential to modulate muscle protein metabolism by increasing muscle protein synthesis. The objective of this study was to investigate the surplus value of the co-ingestion of free leucine with protein hydrolysate and carbohydrate following physical activity in elderly men. Eight elderly men (mean age 73 +/- 1 years) were randomly assigned to two cross-over treatments consuming either carbohydrate and protein hydrolysate (CHO+PRO) or carbohydrate, protein hydrolysate with additional leucine (CHO+PRO+leu) after performing 30 min of standardized physical activity. Primed, continuous infusions with L-[ring-(13)C(6)]phenylalanine and L-[ring-(2)H(2)]tyrosine were applied, and blood and muscle samples were collected to assess whole-body protein turnover as well as protein fractional synthetic rate in the vastus lateralis muscle over a 6 h period. Whole-body protein breakdown and synthesis rates were not different between treatments. Phenylalanine oxidation rates were significantly lower in the CHO+PRO+leu v. CHO+PRO treatment. As a result, whole-body protein balance was significantly greater in the CHO+PRO+leu compared to the CHO+PRO treatment (23.8 (SEM 0.3) v. 23.2 (SEM 0.3) micromol/kg per h, respectively; P < 0.05). Mixed muscle fractional synthetic rate averaged 0.081 (SEM 0.003) and 0.082 (SEM 0.006) %/h in the CHO+PRO+leu and CHO+PRO treatment, respectively (NS). Co-ingestion of leucine with carbohydrate and protein following physical activity does not further elevate muscle protein fractional synthetic rate in elderly men when ample protein is ingested.
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“In line, leucine fortification has been shown [70,97,98], though not always [99], to augment the MPS response to suboptimal doses of animal protein.”
From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [99]
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Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
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Leucine. A possible regulator of protein turnover in muscle.
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Use of Whey and Leucine on Muscle
Lollo, P. C. B., Amaya‐Farfán, J., Moura, C. S., & Morato, P. N. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1914-7_3
Chuxin, S., Zhang, S., Ma, H. F., Wu, R., & Liao, Y. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1772577
Metadata
- Authors
- Koopman, R., Verdijk, L. B., Beelen, M., Gorselink, M., Kruseman, A. N., Wagenmakers, A. J. M., Kuipers, H., & van Loon, L. J. C.
- Affiliations
- Maastricht University (NL)
- University of Birmingham (GB)
- Corresponding author
- Koopman, René
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2008-03
- Volume
- 99
- Issue
- 3
- Pages
- 571-580
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2020049342
- Cited by
- 104
- References
- 47
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 11 · 2015: 5 · 2014: 10 · 2013: 6 · 2012: 11
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- leucine supplementation, muscle protein synthesis, older men, protein hydrolysates, carbohydrate intake, phenylalanine oxidation, vastus lateralis, protein turnover, aging
- MeSH terms
- Whey Proteins, Aged, Aging, Amino Acids, Blood Glucose, Diet, Dietary Carbohydrates, Dietary Proteins, Humans, Insulin, Leucine, Male, Milk Proteins, Muscle Proteins, Proteins, Exercise, Muscle, Skeletal, Cross-Over Studies, Dietary Supplements
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