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Cited by 128Animal Nutrition and PhysiologyMuscle metabolism and nutritionFood Nutrient Composition and Product Development

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Ileal digestibility of dietary protein in the growing pig and adult human

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Deglaire, Amélie, Bos, Cécile, Tomé, Daniel, Moughan, Paul J.·2009·British Journal of Nutrition
DOI 10.1017/s0007114509991267
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Abstract

The suitability of the pig as an animal model for predicting protein digestibility in man was evaluated. Healthy adult human subjects (mean body weight 67 kg; n 11) and growing pigs (mean body weight 40 kg; n 15) were fed semi-synthetic mixed meals containing, as a sole source of N, casein (C), hydrolysed casein (HC) or rapeseed isolate (R). There was no prior adaptation to the test meal. Ileal digesta were sampled through a naso-ileal tube (human subjects) or a post-valve T-caecum cannula (pigs) after ingestion of a bolus meal. The protein sources were 15 N-labelled. Amino acid (AA) digestibilities were not determined for R. Ileal apparent N digestibility was markedly lower (14–16 %; P < 0·001) in human subjects than in pigs (C, HC, R). Similarly, most apparent ileal AA digestibilities were lower (8 % on average; P < 0·05) in human subjects (C, HC). Ileal true N digestibility was slightly lower (3–5 %; P < 0·001) in human subjects than in pigs (C, HC, R) and most true ileal AA digestibilities were similar ( P >0·05) between the species (C, HC). Exceptions were for phenylalanine, tyrosine, lysine, histidine and aspartic acid for which digestibilities were lower (3 % on average; P < 0·001) in human subjects. A similar ranking of the diets was observed for true ileal N digestibility between species. The inter-species correlation for true ileal digestibility was high for N ( r 0·98 over 3 × 2 data; P = 0·11) and AA ( r 0·87 over 26 × 2 data; P < 0·0001). Overall, this supports the use of the pig as a model for predicting differences among dietary protein digestibility, especially regarding true ileal N digestibility, in man.

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Research works printed but not linked: 5

  1. 1991, Protein Quality Evaluation in Human Diets. Report of a Joint FAO/WHO Expert Consultation. FAO Food Nutrition Paper, no. 51
  2. Pond, 1978, The Biology of the Pig
  3. 2003, Official Methods of Analysis of AOAC International
  4. Moughan, 1994, Proceedings of the VIth International Symposium on Digestive Physiology in Pigs, 80, 389
  5. Moughan, 1989, The pig as a model animal for human nutrition research, Proc Nutr Soc N Z, 14, 116

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Metadata

Authors
Deglaire, A., Bos, C., Tomé, D., & Moughan, P. J.
Affiliations
  • AgroParisTech (FR)
  • Riddet Institute (NZ)
Corresponding author
Moughan, Paul J.
ORCID
Venue
British Journal of Nutrition
Publisher
Cambridge University Press (CUP)
Published
2009-08-26
Volume
102
Issue
12
Pages
1752-1759
ISSN
  • 0007-1145 (ISSN-L)
  • 1475-2662
DOI
10.1017/s0007114509991267
OpenAlex
W2099169189
Cited by
128
References
44
Citations by year
2026: 7 · 2025: 11 · 2024: 11 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 13 · 2019: 10 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 6 · 2012: 12
FWCI
12.33
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified)
Locations
  • British Journal Of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • AgroParisTech
  • Institut National de la Recherche Agronomique
  • Riddet Institute
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Food Nutrient Composition and Product Development
Keywords
ileal protein digestibility, dietary protein, apparent nitrogen digestibility, amino acid digestibility, casein, 15N labeling, mixed meal
MeSH terms
Adult, Amino Acids, Animals, Caseins, Dietary Proteins, Digestion, Female, Humans, Ileum, Male, Nitrogen, Nitrogen Isotopes, Swine, Linear Models, Models, Animal

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