The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Ileal digestibility of dietary protein in the growing pig and adult human
Open accessAbstract
The suitability of the pig as an animal model for predicting protein digestibility in man was evaluated. Healthy adult human subjects (mean body weight 67 kg; n 11) and growing pigs (mean body weight 40 kg; n 15) were fed semi-synthetic mixed meals containing, as a sole source of N, casein (C), hydrolysed casein (HC) or rapeseed isolate (R). There was no prior adaptation to the test meal. Ileal digesta were sampled through a naso-ileal tube (human subjects) or a post-valve T-caecum cannula (pigs) after ingestion of a bolus meal. The protein sources were 15 N-labelled. Amino acid (AA) digestibilities were not determined for R. Ileal apparent N digestibility was markedly lower (14–16 %; P < 0·001) in human subjects than in pigs (C, HC, R). Similarly, most apparent ileal AA digestibilities were lower (8 % on average; P < 0·05) in human subjects (C, HC). Ileal true N digestibility was slightly lower (3–5 %; P < 0·001) in human subjects than in pigs (C, HC, R) and most true ileal AA digestibilities were similar ( P >0·05) between the species (C, HC). Exceptions were for phenylalanine, tyrosine, lysine, histidine and aspartic acid for which digestibilities were lower (3 % on average; P < 0·001) in human subjects. A similar ranking of the diets was observed for true ileal N digestibility between species. The inter-species correlation for true ileal digestibility was high for N ( r 0·98 over 3 × 2 data; P = 0·11) and AA ( r 0·87 over 26 × 2 data; P < 0·0001). Overall, this supports the use of the pig as a model for predicting differences among dietary protein digestibility, especially regarding true ileal N digestibility, in man.
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“as a consequence, PDCAAS values do not give credit for extra indispensable AA that a protein may add to a diet (26,28)”
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“in a later report from WHO/FAO, scoring patterns for several age groups of children, teenagers and adults were suggested (28)”
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Adhikari, S., Schop, M., de Boer, I. J. M., & Huppertz, T. (2022) · Nutrients · doi:10.3390/nu14050947 · Cited by 265
Validation of a new in vitro dynamic system to simulate infant digestion
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Self-citationProteins of Brassicaceae Oilseeds and their Potential as a Plant Protein Source
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Metadata
- Authors
- Deglaire, A., Bos, C., Tomé, D., & Moughan, P. J.
- Affiliations
- AgroParisTech (FR)
- Riddet Institute (NZ)
- Corresponding author
- Moughan, Paul J.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-08-26
- Volume
- 102
- Issue
- 12
- Pages
- 1752-1759
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2099169189
- Cited by
- 128
- References
- 44
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 11 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 13 · 2019: 10 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 6 · 2012: 12
- FWCI
- 12.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- AgroParisTech
- Institut National de la Recherche Agronomique
- Riddet Institute
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Life Sciences › Agricultural and Biological Sciences › Food Science › Food Nutrient Composition and Product Development
- Keywords
- ileal protein digestibility, dietary protein, apparent nitrogen digestibility, amino acid digestibility, casein, 15N labeling, mixed meal
- MeSH terms
- Adult, Amino Acids, Animals, Caseins, Dietary Proteins, Digestion, Female, Humans, Ileum, Male, Nitrogen, Nitrogen Isotopes, Swine, Linear Models, Models, Animal
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