Cited by 128Animal Nutrition and PhysiologyMuscle metabolism and nutritionFood Nutrient Composition and Product Development

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Ileal digestibility of dietary protein in the growing pig and adult human

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Deglaire, Amélie, Bos, Cécile, Tomé, Daniel, Moughan, Paul J.·2009·British Journal of Nutrition

DOI 10.1017/s0007114509991267

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Abstract

The suitability of the pig as an animal model for predicting protein digestibility in man was evaluated. Healthy adult human subjects (mean body weight 67 kg; n 11) and growing pigs (mean body weight 40 kg; n 15) were fed semi-synthetic mixed meals containing, as a sole source of N, casein (C), hydrolysed casein (HC) or rapeseed isolate (R). There was no prior adaptation to the test meal. Ileal digesta were sampled through a naso-ileal tube (human subjects) or a post-valve T-caecum cannula (pigs) after ingestion of a bolus meal. The protein sources were 15 N-labelled. Amino acid (AA) digestibilities were not determined for R. Ileal apparent N digestibility was markedly lower (14–16 %; P < 0·001) in human subjects than in pigs (C, HC, R). Similarly, most apparent ileal AA digestibilities were lower (8 % on average; P < 0·05) in human subjects (C, HC). Ileal true N digestibility was slightly lower (3–5 %; P < 0·001) in human subjects than in pigs (C, HC, R) and most true ileal AA digestibilities were similar ( P >0·05) between the species (C, HC). Exceptions were for phenylalanine, tyrosine, lysine, histidine and aspartic acid for which digestibilities were lower (3 % on average; P < 0·001) in human subjects. A similar ranking of the diets was observed for true ileal N digestibility between species. The inter-species correlation for true ileal digestibility was high for N ( r 0·98 over 3 × 2 data; P = 0·11) and AA ( r 0·87 over 26 × 2 data; P < 0·0001). Overall, this supports the use of the pig as a model for predicting differences among dietary protein digestibility, especially regarding true ileal N digestibility, in man.

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Authors: Deglaire, A., Bos, C., Tomé, D., & Moughan, P. J.
Affiliations: AgroParisTech (FR)
Riddet Institute (NZ)
Corresponding author: Moughan, Paul J.
ORCID: Deglaire, Amélie
Tomé, Daniel
Moughan, Paul J.
Venue: British Journal of Nutrition
Publisher: Cambridge University Press (CUP)
Published: 2009-08-26
Volume: 102
Issue: 12
Pages: 1752-1759
ISSN: 0007-1145 (ISSN-L)
1475-2662
DOI: 10.1017/s0007114509991267
OpenAlex: W2099169189
Cited by: 128
References: 44
Citations by year: 2026: 7 · 2025: 11 · 2024: 11 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 13 · 2019: 10 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 6 · 2012: 12
FWCI: 12.33
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified)
Locations: British Journal Of Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: AgroParisTech
Institut National de la Recherche Agronomique
Riddet Institute
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Life Sciences › Agricultural and Biological Sciences › Food Science › Food Nutrient Composition and Product Development
Keywords: ileal protein digestibility, dietary protein, apparent nitrogen digestibility, amino acid digestibility, casein, 15N labeling, mixed meal
MeSH terms: Adult, Amino Acids, Animals, Caseins, Dietary Proteins, Digestion, Female, Humans, Ileum, Male, Nitrogen, Nitrogen Isotopes, Swine, Linear Models, Models, Animal

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Ileal digestibility of dietary protein in the growing pig and adult human

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