The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Markers of cardiovascular risk are not changed by increased whole-grain intake: the WHOLEheart study, a randomised, controlled dietary intervention
Open accessAbstract
Recommendations for whole-grain (WG) intake are based on observational studies showing that higher WG consumption is associated with reduced CVD risk. No large-scale, randomised, controlled dietary intervention studies have investigated the effects on CVD risk markers of substituting WG in place of refined grains in the diets of non-WG consumers. A total of 316 participants (aged 18–65 years; BMI>25 kg/m 2) consuming < 30 g WG/d were randomly assigned to three groups: control (no dietary change), intervention 1 (60 g WG/d for 16 weeks) and intervention 2 (60 g WG/d for 8 weeks followed by 120 g WG/d for 8 weeks). Markers of CVD risk, measured at 0 (baseline), 8 and 16 weeks, were: BMI, percentage body fat, waist circumference; fasting plasma lipid profile, glucose and insulin; and indicators of inflammatory, coagulation, and endothelial function. Differences between study groups were compared using a random intercepts model with time and WG intake as factors. Although reported WG intake was significantly increased among intervention groups, and demonstrated good participant compliance, there were no significant differences in any markers of CVD risk between groups. A period of 4 months may be insufficient to change the lifelong disease trajectory associated with CVD. The lack of impact of increasing WG consumption on CVD risk markers implies that public health messages may need to be clarified to consider the source of WG and/or other diet and lifestyle factors linked to the benefits of whole-grain consumption seen in observational studies.
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MethodWhole-grain consumption and risk of coronary heart disease: results from the Nurses' Health Study
Liu, S., Stampfer, M. J., Hu, F. B., Giovannucci, E., Rimm, E., Manson, J. E., Hennekens, C. H., & Willett, W. C. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.3.412 · Cited by 774
McKeown, N. M., Meigs, J. B., Liu, S., Wilson, P. W., & Jacques, P. F. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.2.390 · Cited by 574
Katcher, H. I., Legro, R. S., Kunselman, A. R., Gillies, P. J., Demers, L. M., Bagshaw, D. M., & Kris-Etherton, P. M. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.79 · Cited by 317
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Cited by
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
The Mediterranean Diet, its Components, and Cardiovascular Disease
Widmer, R. J., Flammer, A. J., Lerman, L. O., & Lerman, A. (2015) · The American Journal of Medicine · doi:10.1016/j.amjmed.2014.10.014 · Cited by 963
“No significant differences in cardiovascular disease surrogate markers were observed after 4 months, although the study might have been underpowered to detect them in such a short period of time, despite a similar design to the positive trials involving whole grains and cardiovascular disease.(82) A single meta-analys…”
Result(2013) · The Journal of Nutrition · doi:10.3945/jn.111.155325 · Cited by 634
Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation
Bach Knudsen, K. E., Lærke, H. N., Hedemann, M. S., Nielsen, T. S., Ingerslev, A. K., Gundelund Nielsen, D. S., Theil, P. K., Purup, S., Hald, S., Schioldan, A. G., et al. (2018) · Nutrients · doi:10.3390/nu10101499 · Cited by 572
Bread Affects Clinical Parameters and Induces Gut Microbiome-Associated Personal Glycemic Responses
Korem, T., Zeevi, D., Zmora, N., Weissbrod, O., Bar, N., Lotan-Pompan, M., Avnit-Sagi, T., Kosower, N., Malka, G., Rein, M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.002 · Cited by 318
Metadata
- Authors
- Brownlee, I. A., Moore, C., Chatfield, M., Richardson, D. P., Ashby, P., Kuznesof, S. A., Jebb, S. A., & Seal, C. J.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-03-23
- Volume
- 104
- Issue
- 1
- Pages
- 125-134
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2070995512
- Cited by
- 232
- References
- 6
- FWCI
- 19.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Markers of cardiovascular risk are not changed by increased whole-grain intake: the WHOLEheart study, a randomised, controlled dietary intervention. https://app.cochat.ai/papers/10.1017/s0007114510000644
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- Brownlee, I. A., Moore, C., Chatfield, M., Richardson, D. P., Ashby, P., Kuznesof, S. A., Jebb, S. A., & Seal, C. J. (2010). Markers of cardiovascular risk are not changed by increased whole-grain intake: the WHOLEheart study, a randomised, controlled dietary intervention. British Journal of Nutrition. https://doi.org/10.1017/s0007114510000644
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