Cited by 120Gut microbiota and healthTryptophan and brain disordersAmino Acid Enzymes and Metabolism

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Gut microbiota of mice putatively modifies amino acid metabolism in the host brain

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Kawase, Takahiro, Nagasawa, Mao, Ikeda, Hiromi, Yasuo, Shinobu, Koga, Yasuhiro, Furuse, Mitsuhiro·2017·British Journal of Nutrition

DOI 10.1017/s0007114517000678

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Abstract

Recently, it has been found that the gut microbiota influences functions of the host brain by affecting monoamine metabolism. The present study focused on the relationship between the gut microbiota and the brain amino acids. Specific pathogen-free (SPF) and germ-free (GF) mice were used as experimental models. Plasma and brain regions were sampled from mice at 7 and 16 weeks of age, and analysed for free d- and l-amino acids, which are believed to affect many physiological functions. At 7 weeks of age, plasma concentrations of d-aspartic acid (d-Asp),l-alanine (l-Ala),l-glutamine (l-Gln) and taurine were higher in SPF mice than in GF mice, but no differences were found at 16 weeks of age. Similar patterns were observed for the concentrations of l-Asp in striatum, cerebral cortex and hippocampus, and l-arginine (l-Arg),l-Ala and l-valine (l-Val) in striatum. In addition, the concentrations of l-Asp,d-Ala,l-histidine,l-isoleucine (l-Ile),l-leucine (l-Leu),l-phenylalanine and l-Val were significantly higher in plasma of SPF mice when compared with those of GF mice. The concentrations of l-Arg,l-Gln,l-Ile and l-Leu were significantly higher in SPF than in GF mice, but those of d-Asp,d-serine and l-serine were higher in some brain regions of GF mice than in those of SPF mice. In conclusion, the concentration of amino acids in the host brain seems to be dependent on presence of the gut microbiota. Amino acid metabolism in the host brain may be modified by manipulating microbiota communities.

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Authors: Kawase, T., Nagasawa, M., Ikeda, H., Yasuo, S., Koga, Y., & Furuse, M.
Affiliations: Kyushu University (JP)
Tokai University (JP)
Corresponding author: Furuse, Mitsuhiro
ORCID: Ikeda, Hiromi
Yasuo, Shinobu
Koga, Yasuhiro
Furuse, Mitsuhiro
Venue: British Journal of Nutrition
Publisher: Cambridge University Press (CUP)
Published: 2017-03-28
Volume: 117
Issue: 6
Pages: 775-783
ISSN: 0007-1145 (ISSN-L)
1475-2662
DOI: 10.1017/s0007114517000678
OpenAlex: W2607231229
Cited by: 119
References: 53
Citations by year: 2026: 5 · 2025: 15 · 2024: 14 · 2023: 15 · 2022: 24 · 2021: 19 · 2020: 9 · 2019: 13 · 2018: 5
FWCI: 3.02
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 13 d)
Locations: British Journal Of Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: Dongguan University of Technology
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords: gut microbiota, brain amino acids, amino acid metabolism, germ-free mice, specific pathogen-free mice, D-aspartic acid, L-alanine, glutamine, taurine, L-arginine, brain regions, plasma amino acids, monoamine metabolism, microbiome manipulation
MeSH terms: Gastrointestinal Microbiome, Amino Acids, Animals, Bacteria, Brain, Mice, Inbred BALB C, Neurotransmitter Agents

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Gut microbiota of mice putatively modifies amino acid metabolism in the host brain

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