Influence of n -3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with polycystic ovary syndrome: a systematic review and meta-analysis
Open accessAbstract
Polycystic ovary syndrome (PCOS) is defined as a reproductive endocrine disease that results in a low-grade inflammatory and pro-oxidant state. Dietary factors, including n -3 fatty acids, may have a key role in improving metabolic disorders in PCOS patients. The present study aimed to investigate the influence of n -3 fatty acid supplementation on inflammatory and oxidative stress (OS) markers in patients with PCOS. A systematic literature search of Medline/PubMed, Cochrane Central Register of Controlled Trials, Scopus and Lilacs, until November 2019, was conducted. Randomised clinical trials that reported inflammatory and OS markers as endpoints in women with PCOS receiving n -3 fatty acid supplementation were included. The pooled estimates of the weighted mean differences (WMD) and the standard mean differences (SMD) were calculated. Random effects models were adopted to measure the pooled outcomes. Among the 323 studies retrieved, ten fulfilled the inclusion criteria for a meta-analysis. We founded a significant decrease in high-sensitivity C-reactive protein (hs-CRP) (SMD –0·29 (95 % CI –0·56, –0·02) mg/l) and an increase in adiponectin (WMD 1·42 (95 % CI 1·09, 1·76) ng/ml) concentrations in the intervention group when compared with the placebo group. No statistically significant results were found in the meta-analysis for visfatin, nitric oxide, GSH or malondialdehyde levels or total antioxidant capacity. The data suggest that supplementation of n -3 fatty acids could reduce the inflammatory state in women with PCOS, through a decrease in hs-CRP and an increase in adiponectin levels.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Clinical studies suggest that omega-3 supplementation has beneficial effects on CRP, lipid profiles, and insulin resistance in PCOS patients.
“Clinical studies have suggested that omega-3 supplementation has a beneficial effect on various health factors, such as remission of C-reactive protein (CRP) and improvements in lipid profiles, as well as the insulin resistance in PCOS patients has been lessened [195].”
From Nutritional and herbal interventions for polycystic ovary syndrome (PCOS): a comprehensive review of dietary approaches, macronutrient impact, and herbal medicine in management (2025) · cites this paper as [195]
The Inflammatory markers—high-sensitivity C-reactive protein section (page unavailable) reports a significant reduction in hs-CRP with n-3 supplementation versus placebo in women with PCOS. The paper discusses possible effects on insulin sensitivity and reports reduced triglycerides in adults generally, but it does not establish improved lipid profiles or reduced insulin resistance in PCOS patients. (LLM, conf=0.88)
Experimental — accuracy not yet measuredA meta-analysis of 10 randomized clinical trials showed that n-3 PUFA supplementation decreased serum hs-CRP and increased serum adiponectin levels.
“A meta-analysis of 10 randomized clinical trials showed that n-3 PUFA supplementation decreased serum hs-CRP and increased serum adiponectin levels [90]”
From Role of Omega-3 Fatty Acids in Improving Metabolic Dysfunctions in Polycystic Ovary Syndrome (2024) · cites this paper as [90]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Amini, M., Bahmani, F., Foroozanfard, F., Vahedpoor, Z., Ghaderi, A., Taghizadeh, M., Karbassizadeh, H., & Asemi, Z. (2018) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.1080/0167482x.2018.1508282 · Cited by 31 · see citing works
RetractedMeta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
RoB 2: a revised tool for assessing risk of bias in randomised trials
Sterne, J. A. C., Savović, J., Page, M. J., Elbers, R. G., Blencowe, N. S., Boutron, I., Cates, C. J., Cheng, H.-Y., Corbett, M. S., Eldridge, S. M., et al. (2019) · BMJ · doi:10.1136/bmj.l4898 · Cited by 33,583 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions
(2019) · doi:10.1002/9781119536604 · Cited by 14,828 · see citing works
GRADE guidelines: 3. Rating the quality of evidence
Balshem, H., Helfand, M., Schünemann, H. J., Oxman, A. D., Kunz, R., Brozek, J., Vist, G. E., Falck-Ytter, Y., Meerpohl, J., & Norris, S. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.07.015 · Cited by 8,285 · see citing works
Assessing risk of bias in a randomized trial
Higgins, J. P., Savović, J., Page, M. J., Elbers, R. G., & Sterne, J. A. (2019) · Cochrane Handbook for Systematic Reviews of Interventions · doi:10.1002/9781119536604.ch8 · Cited by 1,765 · see citing works
Teede, H., Deeks, A., & Moran, L. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-41 · Cited by 1,565 · see citing works
Omega-3 fatty acids and inflammatory processes: from molecules to man
Calder, P. C. (2017) · Biochemical Society Transactions · doi:10.1042/bst20160474 · Cited by 1,456 · see citing works
Variance imputation for overviews of clinical trials with continuous response
Follmann, D. A., Elliott, P., Suh, I., & Cutler, J. A. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90054-q · Cited by 1,391 · see citing works
Low-grade inflammation, diet composition and health: current research evidence and its translation
Minihane, A. M., Vinoy, S., Russell, W. R., Baka, A., Roche, H. M., Tuohy, K. M., Teeling, J. L., Blaak, E. E., Fenech, M. F., Vauzour, D., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002093 · Cited by 919 · see citing works
Reciprocal Association of C-Reactive Protein With Adiponectin in Blood Stream and Adipose Tissue
Ouchi, N., Kihara, S., Funahashi, T., Nakamura, T., Nishida, M., Kumada, M., Okamoto, Y., Ohashi, K., Nagaretani, H., Kishida, K., et al. (2003) · Circulation · doi:10.1161/01.cir.0000055188.83694.b3 · Cited by 850 · see citing works
Russo, G. L. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.10.020 · Cited by 843 · see citing works
Association between dietary inflammatory index and inflammatory markers in the HELENA study
Shivappa, N., Hébert, J. R., Marcos, A., Díaz, L. E., Gómez‐Martínez, S., Nova, E., Michels, N., Arouca, A. B., González‐Gil, E. M., Gottrand, F., et al. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600707 · Cited by 543 · see citing works
Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis
Escobar-Morreale, H. F., Luque‐Ramírez, M., & González, F. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.11.036 · Cited by 522 · see citing works
NF-κB inhibition by ω-3 fatty acids modulates LPS-stimulated macrophage TNF-α transcription
Novak, T. E., Babcock, T. A., Jho, D. H., Helton, W. S., & Espat, N. J. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00077.2002 · Cited by 410 · see citing works
The role of low-grade inflammation in the polycystic ovary syndrome
Repaci, A., Gambineri, A., & Pasquali, R. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.08.002 · Cited by 300 · see citing works
Yang, J., Fernández‐Galilea, M., Martínez‐Fernández, L., González‐Muniesa, P., Pérez-Chávez, A., Martínez, J. A., & Moreno-Aliaga, M. J. (2019) · Nutrients · doi:10.3390/nu11040872 · Cited by 294 · see citing works
The pathogenesis and treatment of polycystic ovary syndrome: What’s new?
Bednarska, S., & Siejka, A. (2017) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/59380 · Cited by 284 · see citing works
n−3 Fatty acids and the metabolic syndrome
Carpentier, Y., Portois, L., & Malaisse, W. J. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1499s · Cited by 283 · see citing works
Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review
Chittenden, B., Fullerton, G. M., Maheshwari, A., & Bhattacharya, S. (2009) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60175-7 · Cited by 277 · see citing works
Moshage, H. J., Roelofs, H. M. J., van Pelt, J. F., Hazenberg, B. P. C., Leeuwen, M. A. V., Limburg, P. C., Aarden, L. A., & Yap, S. H. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81056-8 · Cited by 267 · see citing works
Tortosa-Caparrós, E., Navas-Carrillo, D., Marín, F. R., & Orenes‐Piñero, E. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1126549 · Cited by 265 · see citing works
González, F., Rote, N. S., Minium, J., & Kirwan, J. P. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2327 · Cited by 228 · see citing works
Fish Oil Decreases Macrophage Tumor Necrosis Factor Gene Transcription by Altering the NFκB Activity
Lo, C.-J., Chiu, K. C., Fu, M., Lo, R., & Helton, S. W. (1999) · Journal of Surgical Research · doi:10.1006/jsre.1998.5524 · Cited by 227 · see citing works
Heshmati, J., Morvaridzadeh, M., Maroufizadeh, S., Akbari, A., Yavari, M., Amirinejad, A., Maleki‐Hajiagha, A., & Sepidarkish, M. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104462 · Cited by 211 · see citing works
Modulation of Inflammatory Cytokines by Omega-3 Fatty Acids
Kang, J. X., & Weylandt, K. H. (2008) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-8831-5_5 · Cited by 209 · see citing works
Omega‐3 fatty acids in wild plants, nuts and seeds
Simopoulos, A. P. (2002) · Asia Pacific Journal of Clinical Nutrition · doi:10.1046/j.1440-6047.11.s.6.5.x · Cited by 190 · see citing works
Cussons, A. J., Watts, G. F., Mori, T. A., & Stuckey, B. G. A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0870 · Cited by 181 · see citing works
Barrea, L., Marzullo, P., Muscogiuri, G., Di Somma, C., Scacchi, M., Orio, F., Aimaretti, G., Colao, A., & Savastano, S. (2018) · Nutrition Research Reviews · doi:10.1017/s0954422418000136 · Cited by 171 · see citing works
Plasma adiponectin and insulin resistance in women with polycystic ovary syndrome
Ardawi, M. S. M., & Rouzi, A. A. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.11.077 · Cited by 165 · see citing works
Fang, F., Ni, K., Cai, Y., Shang, J., Zhang, X., & Xiong, C. (2016) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2016.11.008 · Cited by 132 · see citing works
Mori, T. A., Puddey, I. B., Burke, V., Croft, K. D., Dunstan, D. W., Rivera, J. H., & Beilin, L. J. (2000) · Redox Report · doi:10.1179/rer.2000.5.1.45 · Cited by 124 · see citing works
Barbe, A., Bongrani, A., Mellouk, N., Estienne, A., Kurowska, P., Grandhaye, J., Elfassy, Y., Lévy, R., Rak, A., Froment, P., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071526 · Cited by 124 · see citing works
Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis
Blay, S. L., de Aguiar, J. V. N. M., & Passos, I. C. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s91700 · Cited by 111 · see citing works
Regulation of adipokine secretion by n -3 fatty acids
Moreno-Aliaga, M. J., Lorente‐Cebrián, S., & Martínez, J. A. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110001801 · Cited by 105 · see citing works
Mediators of Inflammation in Polycystic Ovary Syndrome in Relation to Adiposity
Sathyapalan, T., & Atkin, S. L. (2010) · Mediators of Inflammation · doi:10.1155/2010/758656 · Cited by 104 · see citing works
Chattopadhayay, R., Ganesh, A., Samanta, J., Jana, S. K., Chakravarty, B. N., & Chaudhury, K. (2009) · Gynecologic and Obstetric Investigation · doi:10.1159/000270900 · Cited by 103 · see citing works
Yang, K., Zeng, L., Bao, T., & Ge, J. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0346-x · Cited by 103 · see citing works
Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome
Kelley, C. E. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14172 · Cited by 101 · see citing works
Babcock, T. A., Novak, T. E., Ong, E., Jho, D. H., Helton, W. S., & Espat, N. J. (2002) · Journal of Surgical Research · doi:10.1006/jsre.2002.6498 · Cited by 101 · see citing works
Mas, E., Woodman, R. J., Burke, V., Puddey, I. B., Beilin, L. J., Durand, T., & Mori, T. A. (2010) · Free Radical Research · doi:10.3109/10715762.2010.492830 · Cited by 95 · see citing works
Susceptibility to chronic inflammation: an update
Nasef, N. A., Mehta, S. Y., & Ferguson, L. R. (2017) · Archives of Toxicology · doi:10.1007/s00204-016-1914-5 · Cited by 95 · see citing works
Bañuls, C., Rovira‐Llopis, S., Marañón, A., Veses, S., Jover, A., Gomez, M., Rocha, M., Hernández‐Mijares, A., & Víctor, V. M. (2017) · Metabolism · doi:10.1016/j.metabol.2017.02.012 · Cited by 90 · see citing works
Jamilian, M., Samimi, M., Mirhosseini, N. Z., Ebrahimi, F. A., Aghadavod, E., Talaee, R., Jafarnejad, S., Dizaji, S. H., & Asemi, Z. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.05.027 · Cited by 89 · see citing works
The role of cytokines in polycystic ovarian syndrome
Ebejer, K., & Calleja‐Agius, J. (2013) · Gynecological Endocrinology · doi:10.3109/09513590.2012.760195 · Cited by 88 · see citing works
Vargas, M. L., Almario, R. U., Buchan, W., Kim, K., & Karakas, S. E. (2011) · Metabolism · doi:10.1016/j.metabol.2011.04.007 · Cited by 86 · see citing works
Mohammadi, E., Rafraf, M., Farzadi, L., Jafarabadi, M. A., & Sabour, S. (2012) · PubMed · Cited by 84 · see citing works
Rahmani, E., Samimi, M., Ebrahimi, F. A., Foroozanfard, F., Ahmadi, S., Rahimi, M., Jamilian, M., Aghadavod, E., Bahmani, F., Taghizadeh, M., et al. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.09.008 · Cited by 83 · see citing works
Altieri, P., Cavazza, C., Pasqui, F., Morselli, A. M., Gambineri, A., & Pasquali, R. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04355.x · Cited by 75 · see citing works
Rafraf, M., Mohammadi, E., Jafarabadi, M. A., & Farzadi, L. (2012) · Journal of the American College of Nutrition · doi:10.1080/07315724.2012.10720443 · Cited by 70 · see citing works
Pundir, J., Charles, D., Sabatini, L., Hiam, D., Jitpiriyaroj, S., Teede, H. J., Coomarasamy, A., Moran, L., & Thangaratinam, S. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy045 · Cited by 66 · see citing works
Mirmasoumi, G., Fazilati, M., Foroozanfard, F., Vahedpoor, Z., Mahmoodi, S., Taghizadeh, M., Esfeh, N. K., Mohseni, M., Karbassizadeh, H., & Asemi, Z. (2017) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0043-119751 · Cited by 64 · see citing works
Amini, L., Tehranian, N., Movahedin, M., Tehrani, F. R., & Ziaee, S. (2015) · Europe PMC (PubMed Central) · Cited by 61 · see citing works
Enechukwu, C. I., Onuegbu, A. J., Olisekodiaka, J. M., Eleje, G. U., Ikechebelu, J. I., Ugboaja, J., Amah, U. K., Okwara, J. E., & Igwegbe, A. O. (2019) · Obstetrics & Gynecology Science · doi:10.5468/ogs.2019.62.5.335 · Cited by 55 · see citing works
High-visfatin levels in women with polycystic ovary syndrome: evidence from a meta-analysis
Sun, Y., Wu, Z., Wei, L. S., Liu, C., Zhu, S., & Tang, S. (2015) · Gynecological Endocrinology · doi:10.3109/09513590.2015.1056140 · Cited by 47 · see citing works
Targets to treat metabolic syndrome in polycystic ovary syndrome
Mahalingaiah, S., & Diamanti‐Kandarakis, E. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1101067 · Cited by 44 · see citing works
N-3 fatty acids as preventive and therapeutic agents in attenuating PCOS complications
Salek, M., Clark, C. C. T., Taghizadeh, M., & Jafarnejad, S. (2019) · EXCLI journal · doi:10.17179/excli2019-1534 · Cited by 40 · see citing works
Nadjarzadeh, A., Firouzabadi, R. D., Daneshbodi, H., Lotfi, M. H., Vaziri, N., & Mozaffari–Khosravi, H. (2015) · Europe PMC (PubMed Central) · Cited by 37 · see citing works
Biomarkers of Endothelial Dysfunction in Women With Polycystic Ovary Syndrome
Dambala, K., Paschou, S. Α., Michopoulos, A., Siasos, G., Goulis, D. G., Vavilis, D., & Tarlatzis, B. C. (2019) · Angiology · doi:10.1177/0003319719840091 · Cited by 34 · see citing works
Clinical, biochemical and ultrasonographic characteristics of Scandinavian women with PCOS
Vanky, E., Kjøtrød, S., Salvesen, K. Å., Romundstad, P., Moen, M. H., & Carlsen, S. M. (2004) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1111/j.0001-6349.2004.00373.x · Cited by 26 · see citing works
Talari, H. R., Poladchang, S., Hamidian, Y., Samimi, M., Gilasi, H. R., Ebrahimi, F. A., & Asemi, Z. (2018) · Oman Medical Journal · doi:10.5001/omj.2018.88 · Cited by 26 · see citing works
Serum visfatin and adiponectin – markers in women with polycystic ovarian syndrome
Bannigida, D. M., Nayak, S. B., & Vijayaragavan, R. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1518987 · Cited by 23 · see citing works
Sóter, M. O., Ferreira, C. N., Sales, M. F., Cândido, A. L., dos Reis, F. M., Milagres, K. S., Ronda, C. R. S. C., Silva, I. D. F. O., Sousa, M. O., & Gomes, K. B. (2015) · Cytokine · doi:10.1016/j.cyto.2015.06.008 · Cited by 21 · see citing works
Self-citationDezfouli, M., Moeinzadeh, F., Taheri, S., & Feizi, A. (2019) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2019.06.007 · Cited by 21 · see citing works
Hajishafiee, M., Askari, G., Iranj, B., Ghiasvand, R., Bellissimo, N., de Zepetnek, J. O. T., & Salehi-abargouei, A. (2016) · Hormone and Metabolic Research · doi:10.1055/s-0042-105288 · Cited by 20 · see citing works
Shahrokhi, S. A., & Naeini, A. A. (2019) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2019.1603215 · Cited by 19 · see citing works
Mejía-Montilla, J., Reyna‐Villasmil, E., Domínguez-Brito, L., Naranjo-Rodríguez, C., Verdugo, D. D. N., Samaniego, M. V. P., & Vargas-Olalla, V. (2018) · Endocrinología Diabetes y Nutrición (English ed ) · doi:10.1016/j.endien.2018.04.006 · Cited by 16 · see citing works
Mejía-Montilla, J., Reyna‐Villasmil, E., Domínguez-Brito, L., Naranjo-Rodríguez, C., Verdugo, D. D. N., Samaniego, M. V. P., & Vargas-Olalla, V. (2018) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2017.12.010 · Cited by 14 · see citing works
Mayyas, F., alsaheb, A. F. A., & Alzoubi, K. H. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02976 · Cited by 11 · see citing works
Session 3: Fatty acids and the immune system Regulation of adipokine secretion by n-3 fatty acids
Moreno-Aliaga, M. J., Lorente‐Cebrián, S., & Martínez, J. A. (2010) · Cited by 7 · see citing works
Flagged first, then by citations
4 of the 76 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- JPT Higgins, J Thomas, J Chandler, et al., editors]. Oxford, UK: The Cochrane Collaboration.
Cited by
Sorted by citations
Kavyani, Z., Musazadeh, V., Fathi, S., Faghfouri, A. H., Dehghan, P., & Sarmadi, B. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109104 · Cited by 145 · see citing works
Duică, F., Dănilă, C. A., Boboc, A. E., Antoniadis, P., Condrat, C. E., Onciul, S., Suciu, N., Creţoiu, S. M., Varlas, V. N., & Crețoiu, D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.614679 · Cited by 106 · see citing works
Natural Molecules in the Management of Polycystic Ovary Syndrome (PCOS): An Analytical Review
Iervolino, M., Lepore, E., Forte, G., Laganà, A. S., Buzzaccarini, G., & Unfer, V. (2021) · Nutrients · doi:10.3390/nu13051677 · Cited by 98 · see citing works
Awonuga, A. O., Camp, O. G., & Abu‐Soud, H. M. (2023) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-023-01159-6 · Cited by 79 · see citing works
The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis
Schüler‐Toprak, S., Ortmann, O., Buechler, C., & Treeck, O. (2022) · Biomedicines · doi:10.3390/biomedicines10102503 · Cited by 61 · see citing works
Cheshmeh, S., Ghayyem, M., Khamooshi, F., Heidarzadeh‐Esfahani, N., Rahmani, N., Hojati, N., Mosaieby, E., Moradi, S., & Pasdar, Y. (2021) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-021-01223-3 · Cited by 30 · see citing works
Moslehi, N., Zeraattalab-Motlagh, S., Rahimi Sakak, F., Shab-Bidar, S., Tehrani, F. R., & Mirmiran, P. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuac075 · Cited by 28 · see citing works
Muhammed Saeed, A. A., Noreen, S., Awlqadr, F. H., Farooq, M. I., Qadeer, M., Rai, N., Farag, H. A., & Saeed, M. N. (2025) · Journal of Health, Population and Nutrition · doi:10.1186/s41043-025-00899-y · Cited by 29 · see citing works
“Clinical studies have suggested that omega-3 supplementation has a beneficial effect on various health factors, such as remission of C-reactive protein (CRP) and improvements in lipid profiles, as well as the insulin resistance in PCOS patients has been lessened [195].”
The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome
Wu, M., Zhang, J., Gu, R., Dai, F., Yang, D., Zheng, Y., Tan, W., Jia, Y., Li, B., & Cheng, Y. (2022) · European journal of medical research · doi:10.1186/s40001-022-00746-4 · Cited by 23 · see citing works
Dietary supplements in polycystic ovary syndrome–current evidence
Han, Y., Hou, Y., Han, Q., Yuan, X., & Chen, L. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1456571 · Cited by 19 · see citing works
Mazloomi, S., Sheikh, N., Farimani, M. S., & Pilehvari, S. (2021) · International Journal of Endocrinology · doi:10.1155/2021/9949753 · Cited by 18 · see citing works
Role of Omega-3 Fatty Acids in Improving Metabolic Dysfunctions in Polycystic Ovary Syndrome
Albardan, L., Platat, C., & Kalupahana, N. S. (2024) · Nutrients · doi:10.3390/nu16172961 · Cited by 18 · see citing works
“A meta-analysis of 10 randomized clinical trials showed that n -3 PUFA supplementation decreased serum hs-CRP and increased serum adiponectin levels [90], confirming the benefit of n -3 PUFAs in reducing systemic inflammation in women with PCOS.”
MethodZhao, G., Fan, Y., Li, R., Huang, Y. S., Li, W., Zhao, Y., Zhou, M., & He, J. (2025) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-025-01409-9 · Cited by 12 · see citing works
Bodnaruc, A. M., Roberge, M., Giroux, I., & Aguer, C. (2024) · Endocrines · doi:10.3390/endocrines5040035 · Cited by 12 · see citing works
Evaluation of angiopoietin-like protein 3 (ANGPTL3) levels in polycystic ovary syndrome
Vatannejad, A., Salimi, F., Moradi, N., Fouani, F. Z., Zandieh, Z., Ansaripour, S., Sadeghi, A., & Fadaei, R. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118595 · Cited by 11 · see citing works
Wang, R., Huang, K., Wang, M., Zou, W., Huang, Y., Jiang, W., Feng, Y., Shen, H., & Lei, X. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1705284 · Cited by 6 · see citing works
Emamat, H., Boushehri, S. N., Eslami, M. A., Totmaj, A. S., & Ghalandari, H. (2022) · Phytotherapy Research · doi:10.1002/ptr.7698 · Cited by 5 · see citing works
Role of Seed Cycling in Polycystic Ovaries Syndrome
Irfan, T., Seher, K., Rizwan, B., Fatima, S., & Sani, A. (2021) · Pakistan BioMedical Journal · doi:10.54393/pbmj.v4i2.122 · Cited by 5 · see citing works
Zhang, Y., Shi, B., Tian, Y., XU, S., & Chang, H. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1697275 · Cited by 4 · see citing works
Liu, S., Wang, R., Yu, W., Shi, C., Wang, X., Liu, A., & Zhang, L. (2026) · Nutrients · doi:10.3390/nu18060964 · Cited by 4 · see citing works
Nowosad, K., Ostrowska, M., Glibowski, P., Iłowiecka, K., & Koch, W. (2025) · Nutrients · doi:10.3390/nu17142377 · Cited by 4 · see citing works
Role of complementary and alternative medicine in polycystic ovary syndrome
Siddique, R., & Mehmood, M. H. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-87932-3.00031-1 · Cited by 4 · see citing works
Beneficial effects of long-chain n-3 fatty acids on insulin-resistance: basic and clinical aspects
Delarue, J. (2025) · Biochimie · doi:10.1016/j.biochi.2025.09.014 · Cited by 3 · see citing works
Onyegbule, O. A., Meludu, S., Dioka, C. E., Okwara, J. E., Obi-Ezeani, C. N., Njoku, C. M., & Onah, E. C. (2022) · Journal of Applied Sciences and Clinical Practice · doi:10.4103/jascp.jascp_8_22 · Cited by 2 · see citing works
Lipidomic biomarkers in polycystic ovary syndrome: An overview
Ilie, I. R. P., Herdean, A. M., Herdean, A. I., & Georgescu, C. E. (2022) · Annales d Endocrinologie · doi:10.1016/j.ando.2022.07.675 · Cited by 2 · see citing works
Paco-Chipana, M., Mena‐Ulecia, K., Hidalgo‐Rosa, Y., Valdivida, M. I. H., Goyzueta-Mamani, L. D., Cárdenas-Pillco, B., Chávez‐Fumagalli, M. Á., & Barazorda-Ccahuana, H. L. (2024) · F1000Research · doi:10.12688/f1000research.146070.1 · Cited by 1 · see citing works
Cinar, R., Günday, Ö. K., Kahraman, A., & Yılmazer, M. (2025) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.61622/rbgo/2025rbgo86 · Cited by 1 · see citing works
Singh, S., Rana, M., Rajput, S. K., Mishra, R. K., Mishra, S., & Arya, V. (2026) · Journal of Nutrition · doi:10.1016/j.tjnut.2026.101371 · Cited by 1 · see citing works
Zarezadeh, R., Fattahi, A., Hamdi, K., Nouri, M., & Darabi, M. (2026) · Journal of Ovarian Research · doi:10.1186/s13048-026-02151-5 · Cited by 1 · see citing works
Nutritional Management of Polycystic Ovary Syndrome: Insights into Diet and Nutrition Strategies
Jan, B., Ahmad, S., Ibrahim, M., & Choudhary, B. (2024) · Natural Resources for Human Health · doi:10.53365/nrfhh/183616 · Cited by 1 · see citing works
Cheshmeh, S., Ghayyem, M., Khamooshi, F., Heydarzadeh, N., Hojati, N., Mosaieby, E., Moradi, S., & Pasdar, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-245937/v1
Therapeutic role of Omega-3 fatty acids in improving PCOS and PCOS related complications
Irfan, T., Rizwan, B., Seher, K., Aslam, M., & Bashir, S. (2020) · DIET FACTOR (Journal of Nutritional & Food Sciences) · doi:10.54393/df.v1i02.16
Macronutrients and Disease: Polycystic Ovary Syndrome
Tehrani, F. R., & Naz, M. S. G. (2025) · Springer eBooks · doi:10.1007/978-3-031-32047-7_28-1
Victorino, K. G. G., Ariza‐Ortega, J. A., & Delgado‐Olivares, L. (2025) · South Florida Journal of Development · doi:10.46932/sfjdv6n3-028
FROM SYMPTOMS TO SOLUTIONS: THE BIOCHEMICAL POWER OF LIFESTYLE IN PCOS
Maciejczyk, A., Krupa, K., Kraciuk, N., Bury, A., Bartecki, K., Błoniecka, J., Piekarska, M., & Daniel, A. (2025) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.3(47).2025.3525
Dietary prevention and diet therapy for selected reproductive healthdisorders in women
Szymkowiak, A., & Pisarski, R. K. (2025) · Zeszyty Naukowe Collegium Witelona · doi:10.5604/01.3001.0055.5686
Chemali, R., & Grech, G. (2026) · Advances in predictive, preventive and personalised medicine · doi:10.1007/978-3-032-32838-0_7
- Authors
- Tosatti, J. A. G., Alves, M. T., Cândido, A. L., Reis, F. M., Araújo, V. E., & Gomes, K. B.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Pontifícia Universidade Católica de Minas Gerais (BR)
- Corresponding author
- Gomes, Karina B.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2020-08-17
- Volume
- 125
- Issue
- 6
- Pages
- 657-668
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W3071515262
- Cited by
- 38
- References
- 76
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 2
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (2017-6)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- polycystic ovary syndrome, omega-3 fatty acids, omega-3 supplementation, inflammation, oxidative stress, high-sensitivity C-reactive protein, adiponectin, visfatin, nitric oxide, malondialdehyde, glutathione, total antioxidant capacity
- MeSH terms
- Antioxidants, C-Reactive Protein, Female, Glutathione, Humans, Inflammation, Malondialdehyde, Nitric Oxide, Polycystic Ovary Syndrome, Fatty Acids, Omega-3, Oxidative Stress, Dietary Supplements, Adiponectin, Nicotinamide Phosphoribosyltransferase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
