Associations of the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay diet with cardiac remodelling in the community: the Framingham Heart Study
Open accessAbstract
Normal cardiac function is directly associated with the maintenance of cerebrovascular health. Whether the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet, designed for the maintenance of neurocognitive health, is associated with cardiac remodelling is unknown. We evaluated 2512 Framingham Offspring Cohort participants who attended the eighth examination cycle and had available dietary and echocardiographic data (mean age 66 years; 55 % women). Using multivariable regression, we related the cumulative MIND diet score (independent variable) to left ventricular (LV) ejection fraction, left atrial emptying fraction, LV mass (LVM), E/e’ ratio (dependent variables; primary), global longitudinal strain, global circumferential strain (GCS), mitral annular plane systolic excursion, longitudinal segmental synchrony, LV hypertrophy and aortic root diameter (secondary). Adjusting for age, sex and energy intake, higher cumulative MIND diet scores were associated with lower values of indices of LV diastolic (E/e’ ratio: log β = −0·03) and systolic function (GCS: β = −0·04) and with higher values of LVM (log β = 0·02), all P ≤ 0·01. We observed effect modification by age in the association between the cumulative MIND diet score and GCS. When we further adjusted for clinical risk factors, the associations of the cumulative MIND diet score with GCS in participants ≥66 years (β = −0·06, P = 0·005) and LVM remained significant. In our community-based sample, relations between the cumulative MIND diet score and cardiac remodelling differ among indices of LV structure and function. Our results suggest that favourable associations between a higher cumulative MIND diet score and indices of LV function may be influenced by cardiometabolic and lifestyle risk factors.
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Examples of heart-healthy diets are the Mediterranean, DASH, and MIND diets.
“Examples of heart-healthy diets are the Mediterranean, DASH (Dietary Approaches to Stop Hypertension) and MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diets.135-137”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [137]
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- [1]Mozaffarian D, Benjamin EJ, Go AS, (2016) Heart disease and stroke statistics – 2016 update: a report from the American Heart Association. Circulation 133, e38– e360. 26673558
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(2023) · Alzheimer's & Dementia · doi:10.1002/alz.13016 · Cited by 3,212 · see citing works
2024 Alzheimer's disease facts and figures
(2024) · Alzheimer's & Dementia · doi:10.1002/alz.13809 · Cited by 2,536 · see citing works
- Authors
- Walker, M. E., O’Donnell, A. A., Himali, J. J., Rajendran, I., Melo van Lent, D., Ataklte, F., Jacques, P. F., Beiser, A. S., Seshadri, S., Vasan, R. S., & Xanthakis, V.
- Affiliations
- Boston University (US)
- Tufts University (US)
- Corresponding author
- Xanthakis, Vanessa
- ORCID
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2021-02-23
- Volume
- 126
- Issue
- 12
- Pages
- 1888-1896
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- PMC
- PMC8380746
- OpenAlex
- W3132743364
- Cited by
- 22
- References
- 43
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 1
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DZNE Pub (submittedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (HHSN268201500001I, HHSN268201500001C, 75N92019D00031, N01-HC-025195, P20HL113444, R38HL143584, T32HL125232)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK020579)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- MIND diet, cardiac remodeling, left ventricular function, left ventricular mass, diastolic function, left atrial ejection fraction, global longitudinal strain, global circumferential strain, left ventricular hypertrophy, aortic root diameter, dietary adherence, Framingham Offspring cohort, age effect modification, cardiometabolic risk factors
- MeSH terms
- Dietary Approaches To Stop Hypertension, Aged, Female, Humans, Longitudinal Studies, Male, Stroke Volume, Ventricular Function, Left, Ventricular Remodeling
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