Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications

Münzel, Thomas; Gori, Tommaso; Keaney, John F.; Maack, Christoph; Daiber, Andreas

doi:10.1093/eurheartj/ehv305

Cited by 394Nitric Oxide and Endothelin EffectsCardiovascular Function and Risk FactorsHeart Failure Treatment and Management

Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications

Open access

Münzel, Thomas, Gori, Tommaso, Keaney, John F., Maack, Christoph, Daiber, Andreas·2015·European Heart Journal

DOI 10.1093/eurheartj/ehv305PMC PMC7959410

Open this paper in CoChat — free account Open PDF

Abstract

Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with an activation of the circulating and local renin–angiotensin–aldosterone system (RAAS), and with a subsequent inappropriately increased production of reactive oxygen species (ROS). While, at low concentrations, ROS modulate important physiological functions through changes in cellular signalling and gene expression, overproduction of ROS may adversely alter cardiac mechanics, leading to further worsening of systolic and diastolic function. In addition, vascular endothelial dysfunction due to uncoupling of the nitric oxide synthase, activation of vascular and phagocytic membrane oxidases or mitochondrial oxidative stress may lead to increased vascular stiffness, further compromising cardiac performance in afterload-dependent hearts. In the present review, we address the potential role of ROS in the pathophysiology of myocardial and vascular dysfunction in heart failure (HF) and their therapeutic targeting. We discuss possible mechanisms underlying the failure of antioxidant vitamins in improving patients’ prognosis, the impact of angiotensin-converting enzyme inhibitors or AT1 receptor blockers on oxidative stress, and the mechanism of the benefit of combination of hydralazine/isosorbide dinitrate. Further, we provide evidence supporting the existence of differences in the pathophysiology of HF with preserved vs. reduced ejection fraction and whether targeting mitochondrial ROS might be a particularly interesting therapeutic option for patients with preserved ejection fraction.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/eurheartj/ehv305

Cites

127 of 127 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Experiments using laboratory animals revealed that heart failure is accompanied by increased superoxide radical formation by NOs in vessels leading to cardiomyopathy.
“Experiments using laboratory animals revealed that heart failure is also accompanied by increased superoxide radical formation by NOs in vessels leading to cardiomyopathy (Umar and Laarse 2010; Munzel et al. 2015).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Munzel et al. 2015

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Part of this paper’s reference list could not be split into single entries.

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663 · see citing works
Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism
MITCHELL, P. (1961) · Nature · doi:10.1038/191144a0 · Cited by 4,704 · see citing works
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
Paulus, W. J., & Tschöpe, C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.092 · Cited by 3,564 · see citing works
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886 · see citing works
A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure
Cohn, J. N., Johnson, G., Ziesche, S., Cobb, F., Francis, G., Tristani, F., Smith, R., Dunkman, W. B., Loeb, H., Wong, M., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199108013250502 · Cited by 2,833 · see citing works
Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure
Cohn, J. N., Archibald, D. G., Ziesche, S., Franciosa, J. A., Harston, W. E., Tristani, F. E., Dunkman, W. B., Jacobs, W., Francis, G. S., Flohr, K. H., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198606123142404 · Cited by 2,400 · see citing works
Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace
Förstermann, U., & Münzel, T. (2006) · Circulation · doi:10.1161/circulationaha.105.602532 · Cited by 1,957 · see citing works
Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure
Taylor, A. L., Ziesche, S., Yancy, C., Carson, P., D'Agostino, R., Ferdinand, K., Taylor, M., Adams, K., Sabolinski, M., Worcel, M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa042934 · Cited by 1,773 · see citing works
Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
Guzik, T. J., Hoch, N. E., Brown, K. A., McCann, L. A., Rahman, A., Dikalov, S., Goronzy, J., Weyand, C., & Harrison, D. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070657 · Cited by 1,736 · see citing works
Antioxidants prevent health-promoting effects of physical exercise in humans
Ristow, M., Zarse, K., Oberbach, A., Klöting, N., Birringer, M., Kiehntopf, M., Stumvoll, M., Kahn, C. R., & Blüher, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903485106 · Cited by 1,582 · see citing works
NAD + /NADH and NADP + /NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences
Ying, W. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1672 · Cited by 1,494 · see citing works
Oxygen, oxidative stress, hypoxia, and heart failure
Giordano, F. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24408 · Cited by 1,494 · see citing works
Reactive Oxygen Species (Ros-Induced) Ros Release
Zorov, D. B., Filburn, C. R., Klotz, L.-O., Zweier, J. L., & Sollott, S. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1001 · Cited by 1,412 · see citing works
Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer: A Randomized Controlled Trial
(2005) · JAMA · doi:10.1001/jama.293.11.1338 · Cited by 1,209 · see citing works
Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction
Redfield, M. M., Chen, H. H., Borlaug, B. A., Semigran, M. J., Lee, K. L., Lewis, G. D., LeWinter, M. M., Rouleau, J. L., Bull, D. A., Mann, D. L., et al. (2013) · JAMA · doi:10.1001/jama.2013.2024 · Cited by 1,156 · see citing works
A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation
Erickson, J. R., Joiner, M.-L. A., Guan, X., Kutschke, W., Yang, J., Oddis, C. V., Bartlett, R. K., Lowe, J. S., O'Donnell, S. E., Aykin-Burns, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.048 · Cited by 1,122 · see citing works
Mitochondrial ROS-induced ROS release: An update and review
Zorov, D. B., Juhaszova, M., & Sollott, S. J. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.04.029 · Cited by 1,081 · see citing works
The annual global economic burden of heart failure
Cook, C., Cole, G., Asaria, P., Jabbour, R. J., & Francis, D. P. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.12.028 · Cited by 912 · see citing works
Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury
Zhao, K., Zhao, G.-M., Wu, D., Soong, Y., Birk, A. V., Schiller, P. W., & Szeto, H. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402999200 · Cited by 782 · see citing works
NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart
Kuroda, J., Ago, T., Matsushima, S., Zhai, P., Schneider, M. D., & Sadoshima, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002178107 · Cited by 772 · see citing works
Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.
MacMillan-Crow, L.-A., Crow, J. P., Kerby, J. D., Beckman, J. S., & Thompson, J. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11853 · Cited by 768 · see citing works
Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System
Lassegue, B. P., Martín, A. S., & Griendling, K. K. (2012) · Circulation Research · doi:10.1161/circresaha.111.243972 · Cited by 768 · see citing works
A mechanistic role for cardiac myocyte apoptosis in heart failure
Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C., & Kitsis, R. N. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17664 · Cited by 765 · see citing works
The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis
Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr254 · Cited by 760 · see citing works
Exercise Training in Heart Failure: From Theory to Practice. A Consensus Document of the Heart Failure Association and the European Association for Cardiovascular Prevention and Rehabilitation
Piepoli, M. F., Conraads, V. M., Corrà, U., Dickstein, K., Francis, D. P., Jaarsma, T., McMurray, J. J. V., Pieske, B. M., Piotrowicz, E., Schmid, J., et al. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfr017 · Cited by 748 · see citing works
Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?
Ischiropoulos, H., & Beckman, J. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317638 · Cited by 748 · see citing works
Mitochondrial DNA Damage and Dysfunction Associated With Oxidative Stress in Failing Hearts After Myocardial Infarction
Ide, T., Tsutsui, H., Hayashidani, S., Kang, D., Suematsu, N., Nakamura, K., Utsumi, H., Hamasaki, N., & Takeshita, A. (2001) · Circulation Research · doi:10.1161/01.res.88.5.529 · Cited by 733 · see citing works
Mitochondrial Electron Transport Complex I Is a Potential Source of Oxygen Free Radicals in the Failing Myocardium
Ide, T., Tsutsui, H., Kinugawa, S., Utsumi, H., Kang, D., Hattori, N., Uchida, K., Arimura, K., Egashira, K., & Takeshita, A. (1999) · Circulation Research · doi:10.1161/01.res.85.4.357 · Cited by 702 · see citing works
Redox signaling: hydrogen peroxide as intracellular messenger
Rhee, S. G. (1999) · Experimental & Molecular Medicine · doi:10.1038/emm.1999.9 · Cited by 701 · see citing works
Exercise Training Improves Exercise Capacity and Diastolic Function in Patients With Heart Failure With Preserved Ejection Fraction
Edelmann, F., Gelbrich, G., Düngen, H., Fröhling, S., Wachter, R., Stahrenberg, R., Binder, L., Töpper, A., Lashki, D. J., Schwarz, S., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.054 · Cited by 677 · see citing works
Nox family NADPH oxidases: Molecular mechanisms of activation.
Brandes, R., Weissmann, N., & Schröder, K. (2014) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2014.07.046 · Cited by 660 · see citing works
Uric Acid and Survival in Chronic Heart Failure: Validation and Application in Metabolic, Functional, and Hemodynamic Staging
Anker, S. D., Doehner, W., Rauchhaus, M., Sharma, R., Francis, D., Knosalla, C., Davos, C. H., Cicoira, M., Shamim, W., Kemp, M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000065637.10517.a0 · Cited by 593 · see citing works
NADPH Oxidases: Functions and Pathologies in the Vasculature
Lassègue, B., & Griendling, K. K. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.181610 · Cited by 592 · see citing works
Increased myocardial NADPH oxidase activity in human heart failure
Heymes, C., Bendall, J. K., Ratajczak, P., Cave, A. C., Samuel, J., Hasenfuss, G. P., & Shah, A. M. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00471-6 · Cited by 582 · see citing works
X-ROS Signaling: Rapid Mechano-Chemo Transduction in Heart
Prosser, B. L., Ward, C. W., & Lederer, W. J. (2011) · Science · doi:10.1126/science.1202768 · Cited by 564 · see citing works
First‐in‐class cardiolipin‐protective compound as a therapeutic agent to restore mitochondrial bioenergetics
Szeto, H. H. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12461 · Cited by 550 · see citing works
Endothelial function in chronic congestive heart failure
Drexler, H., Hayoz, D., Münzel, T. F., Hornig, B., Just, H., Brunner, H. R., & ZELIS, R. F. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90710-g · Cited by 549 · see citing works
Self-citation
Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure
Dai, D.-F., Johnson, S. C., Villarin, J. J., Chin, M. T., Nieves-Cintrón, M., Chen, T., Marcinek, D. J., Dorn, G. W., Kang, Y. J., Prolla, T. A., et al. (2011) · Circulation Research · doi:10.1161/circresaha.110.232306 · Cited by 527 · see citing works
Synchronized Whole Cell Oscillations in Mitochondrial Metabolism Triggered by a Local Release of Reactive Oxygen Species in Cardiac Myocytes
Aon, M. A., Cortassa, S., Marbán, E., & O'Rourke, B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302673200 · Cited by 521 · see citing works
Vascular Oxidative Stress and Endothelial Dysfunction in Patients With Chronic Heart Failure
Landmesser, U., Spiekermann, S., Dikalov, S., Tatge, H., Wilke, R., Kohler, C., Harrison, D. G., Hornig, B., & Drexler, H. (2002) · Circulation · doi:10.1161/01.cir.0000041431.57222.af · Cited by 517 · see citing works
Activation of NADPH Oxidase During Progression of Cardiac Hypertrophy to Failure
Li, J., Gall, N. P., Grieve, D., Chen, M., & Shah, A. M. (2002) · Hypertension · doi:10.1161/01.hyp.0000032031.30374.32 · Cited by 517 · see citing works
Peroxynitrite-Mediated Inactivation of Manganese Superoxide Dismutase Involves Nitration and Oxidation of Critical Tyrosine Residues
MacMillan-Crow, L. A., Crow, J. P., & Thompson, J. A. (1998) · Biochemistry · doi:10.1021/bi971894b · Cited by 508 · see citing works
Lysozyme M–Positive Monocytes Mediate Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction
Wenzel, P., Knorr, M., Kossmann, S., Stratmann, J., Hausding, M., Schuhmacher, S., Karbach, S. H., Schwenk, M., Yogev, N., Schulz, E., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.034470 · Cited by 505 · see citing works
Self-citation
Mitochondrial pharmacology
Smith, R. A. J., Hartley, R. C., Cochemé, H. M., & Murphy, M. P. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.03.010 · Cited by 501 · see citing works
The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin
Birk, A. V., Liu, S., Soong, Y., Mills, W., Singh, P. K., Warren, J. D., Seshan, S. V., Pardee, J. D., & Szeto, H. H. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012121216 · Cited by 486 · see citing works
Redox Signaling in Cardiac Physiology and Pathology
Burgoyne, J. R., Mongue‐Din, H., Eaton, P., & Shah, A. M. (2012) · Circulation Research · doi:10.1161/circresaha.111.255216 · Cited by 483 · see citing works
Subcellular localization of Nox4 and regulation in diabetes
Block, K. L., Gorin, Y. C., & Abboud, H. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906805106 · Cited by 476 · see citing works
Direct Evidence for Increased Hydroxyl Radicals Originating From Superoxide in the Failing Myocardium
Ide, T., Tsutsui, H., Kinugawa, S., Suematsu, N., Hayashidani, S., Ichikawa, K., Utsumi, H., Machida, Y., Egashira, K., & Takeshita, A. (2000) · Circulation Research · doi:10.1161/01.res.86.2.152 · Cited by 427 · see citing works
Oxygen Free Radical Release in Human Failing Myocardium Is Associated With Increased Activity of Rac1-GTPase and Represents a Target for Statin Treatment
Maack, C., Kartes, T., Kilter, H., Schäfers, H., Nickenig, G., Böhm, M., & Laufs, U. (2003) · Circulation · doi:10.1161/01.cir.0000091084.46500.bb · Cited by 424 · see citing works
Self-citation
Impact of Oxypurinol in Patients With Symptomatic Heart Failure
Hare, J. M., Mangal, B., Brown, J., Fisher, C., Freudenberger, R., Colucci, W. S., Mann, D. L., Liu, P., Givertz, M. M., & Schwarz, R. P. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.01.068 · Cited by 392 · see citing works
Vitamin C Improves Endothelial Function of Conduit Arteries in Patients With Chronic Heart Failure
Hornig, B., Arakawa, N., Kohler, C., & Drexler, H. (1998) · Circulation · doi:10.1161/01.cir.97.4.363 · Cited by 389 · see citing works
Protein Nitration in Cardiovascular Diseases
Turko, I. V., & Murad, F. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.4.619 · Cited by 372 · see citing works
Elevated Cytosolic Na + Decreases Mitochondrial Ca 2+ Uptake During Excitation-Contraction Coupling and Impairs Energetic Adaptation in Cardiac Myocytes
Maack, C., Cortassa, S. C., Aon, M. A., Ganesan, A. N., Liu, T., & O'Rourke, B. P. (2006) · Circulation Research · doi:10.1161/01.res.0000232546.92777.05 · Cited by 369 · see citing works
Self-citation
Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy
Dai, D., Chen, T., Szeto, H. H., Nieves‐Cintrón, M., Kutyavin, V. I., Santana, L. F., & Rabinovitch, P. S. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.12.044 · Cited by 363 · see citing works
A Redox-Dependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy
Ago, T., Liu, T., Zhai, P., Chen, W., Hong Li, A., Molkentin, J. D., Vatner, S. F., & Sadoshima, J. (2008) · Cell · doi:10.1016/j.cell.2008.04.041 · Cited by 362 · see citing works
Cardiac Energy Metabolism Homeostasis: Role of Cytosolic Calcium
Balaban, R. S. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2002.2082 · Cited by 357 · see citing works
Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species
Daiber, A. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.032 · Cited by 347 · see citing works
Self-citation
Elevated Cytosolic Na + Increases Mitochondrial Formation of Reactive Oxygen Species in Failing Cardiac Myocytes
Kohlhaas, M., Liu, T., Knopp, A., Zeller, T., Ong, M. F., Böhm, M., O'Rourke, B. P., & Maack, C. (2010) · Circulation · doi:10.1161/circulationaha.109.914911 · Cited by 330 · see citing works
Self-citation
Mitochondrial reactive oxygen species production and elimination
Nickel, A. G., Kohlhaas, M., & Maack, C. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.03.011 · Cited by 318 · see citing works
Self-citation
Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug.
Münzel, T. F., Kurz, S. D., Rajagopalan, S., Thoenes, M., Berrington, W. R., Thompson, J. A., Freeman, B. Α., & Harrison, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118935 · Cited by 313 · see citing works
Self-citation
Redox signaling in cardiac myocytes
Santos, C. X. C., Anilkumar, N. P., Zhang, M., Brewer, A. C., & Shah, A. M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.01.003 · Cited by 312 · see citing works
Oxidants and aging
Beckman, K. B., & Ames, B. N. (2000) · Elsevier eBooks · doi:10.1016/b978-044482650-3/50027-4 · Cited by 307 · see citing works
Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study
Givertz, M. M., Anstrom, K. J., Redfield, M. M., Deswal, A., Haddad, H., Butler, J., Tang, W. H. W., Dunlap, M. E., LeWinter, M. M., Mann, D. L., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.014536 · Cited by 296 · see citing works
NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation
Craige, S. M., Chen, K., Pei, Y., Li, C., Huang, X., Chen;, C., Shibata, R., Sato, K., Walsh, K., & Keaney, J. F. (2011) · Circulation · doi:10.1161/circulationaha.111.030775 · Cited by 283 · see citing works
Self-citation
Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction
Silberman, G. A., Fan, T. M., Liu, H., Jiao, Z., Xiao, H., Lovelock, J. D., Boulden, B. M., Widder, J. D., Fredd, S., Bernstein, K. E., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.883777 · Cited by 254 · see citing works
Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling
Ghouleh, I. A., Khoo, N. K. H., Knaus, U. G., Griendling, K. K., Touyz, R. M., Thannickal, V. J., Barchowsky, A., Nauseef, W. M., Kelley, E. E., Bauer, P. M., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.011 · Cited by 249 · see citing works
Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species—Studies in White Blood Cells and in Animal Models
Kröller‐Schön, S., Steven, S., Kossmann, S., Scholz, A., Daub, S., Oelze, M. W., Xia, N., Hausding, M., Mikhed, Y., Zinßius, E., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4953 · Cited by 246 · see citing works
Self-citation
A pore way to die
Halestrap, A. P. (2005) · Nature · doi:10.1038/434578a · Cited by 240 · see citing works
Release of nitric oxide by angiotensin‐(1–7) from porcine coronary endothelium: implications for a novel angiotensin receptor
Pörsti, I. H., Bara, A. T., Busse, R., et al. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb14787.x · Cited by 239 · see citing works
Extensive tyrosine nitration in human myocardial inflammation
Kooy, N. W., Lewis, S. J., Royall, J. A., Ye, Y. Z., Kelly, D. R., & Beckman, J. S. (1997) · Critical Care Medicine · doi:10.1097/00003246-199705000-00017 · Cited by 235 · see citing works
Enhancing Mitochondrial Ca 2+ Uptake in Myocytes From Failing Hearts Restores Energy Supply and Demand Matching
Liu, T., & O'Rourke, B. P. (2008) · Circulation Research · doi:10.1161/circresaha.108.175919 · Cited by 226 · see citing works
Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits.
Keaney, J. F., Gaziano, J. M., Xu, A., Frei, B. B., Curran-Celentano, J., Shwaery, G. T., Loscalzo, J., & Vita, J. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117039 · Cited by 225 · see citing works
Self-citation
Monoamine Oxidase A–Mediated Enhanced Catabolism of Norepinephrine Contributes to Adverse Remodeling and Pump Failure in Hearts With Pressure Overload
Kaludercic, N., Takimoto, E., Nagayama, T., Feng, N., Lai, E. W., Bedja, D., Chen, K., Gabrielson, K. L., Blakely, R., Shih, J. C., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.198366 · Cited by 222 · see citing works
Incidence of early tolerance to hemodynamic effects of continuous infusion of nitroglycerin in patients with coronary artery disease and heart failure.
Elkayam, U., Kulick, D., McIntosh, N. A., Roth, A., Hsueh, W. A., & Rahimtoola, S. H. (1987) · Circulation · doi:10.1161/01.cir.76.3.577 · Cited by 210 · see citing works
Critical Role of the NAD(P)H Oxidase Subunit p47 phox for Left Ventricular Remodeling/Dysfunction and Survival After Myocardial Infarction
Doerries, C., Grote, K., Hilfiker-Kleiner, D., Luchtefeld, M., Schaefer, A., Holland, S. M., Sorrentino, S., Manes, C., Schieffer, B., Drexler, H., et al. (2007) · Circulation Research · doi:10.1161/01.res.0000261657.76299.ff · Cited by 206 · see citing works
S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding
Alegre‐Cebollada, J., Kosuri, P., Giganti, D. O., Eckels, E. C., Rivas‐Pardo, J. A., Hamdani, N., Warren, C. M., Solaro, R. J., Linke, W. A., & Fernández, J. M. (2014) · Cell · doi:10.1016/j.cell.2014.01.056 · Cited by 205 · see citing works
Role of Sodium-Calcium Exchanger in Modulating the Action Potential of Ventricular Myocytes From Normal and Failing Hearts
Armoundas, A. A., Hobai, I. A., Tomaselli, G. F., Winslow, R. L., & O'Rourke, B. P. (2003) · Circulation Research · doi:10.1161/01.res.0000080932.98903.d8 · Cited by 190 · see citing works
Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species
Redout, E. M., WAGNER, M., Zuidwijk, M. J., Boer, C., Musters, R. J. P., VANHARDEVELD, C., Paulus, W. J., & Simonides, W. S. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.05.012 · Cited by 188 · see citing works
Regulation of myocardial growth and death by NADPH oxidase
Maejima, Y., Kuroda, J., Matsushima, S., Ago, T., & Sadoshima, J. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.12.018 · Cited by 185 · see citing works
Inhibiting Mitochondrial Na + /Ca 2+ Exchange Prevents Sudden Death in a Guinea Pig Model of Heart Failure
Liu, T., Takimoto, E., Dimaano, V. L. J., DeMazumder, D., Kettlewell, S., Smith, G. L., Sidor, A., Abraham, T. P., & O'Rourke, B. P. (2014) · Circulation Research · doi:10.1161/circresaha.115.303062 · Cited by 183 · see citing works
Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress
Dai, D.-F., Hsieh, E. J., Liu, Y., Chen, T., Beyer, R. P., Chin, M. T., MacCoss, M. J., & Rabinovitch, P. S. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvr274 · Cited by 178 · see citing works
Nox4 is a Novel Inducible Source of Reactive Oxygen Species in Monocytes and Macrophages and Mediates Oxidized Low Density Lipoprotein–Induced Macrophage Death
Lee, C. F., Qiao, M., Schröder, K., Zhao, Q. D., & Asmis, R. (2010) · Circulation Research · doi:10.1161/circresaha.109.215392 · Cited by 167 · see citing works
Enhanced Ca 2+ -Activated Na + -Ca 2+ Exchange Activity in Canine Pacing-Induced Heart Failure
Hobai, I. A., & O'Rourke, B. P. (2000) · Circulation Research · doi:10.1161/01.res.87.8.690 · Cited by 166 · see citing works
Dynamic Regulation of Sodium/Calcium Exchange Function in Human Heart Failure
Weber, C. R., Piacentino, V., Houser, S. R., & Bers, D. M. (2003) · Circulation · doi:10.1161/01.cir.0000095274.72486.94 · Cited by 162 · see citing works
Nitroso–Redox Balance in the Cardiovascular System
Hare, J. M. (2004) · New England Journal of Medicine · doi:10.1056/nejme048269 · Cited by 160 · see citing works
Redox Regulation of Sodium and Calcium Handling
Wagner, S., Rokita, A. G., Anderson, M. E., & Maier, L. S. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4818 · Cited by 157 · see citing works
Broad Suppression of NADPH Oxidase Activity Exacerbates Ischemia/Reperfusion Injury Through Inadvertent Downregulation of Hypoxia-inducible Factor-1α and Upregulation of Peroxisome Proliferator–activated Receptor-α
Matsushima, S., Kuroda, J., Ago, T., Zhai, P., Ikeda, Y., Oka, S., Fong, G., Tian, R., & Sadoshima, J. (2013) · Circulation Research · doi:10.1161/circresaha.111.300171 · Cited by 157 · see citing works
CaMKII oxidative activation and the pathogenesis of cardiac disease
Luczak, E. D., & Anderson, M. E. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.02.004 · Cited by 153 · see citing works
Free radical biology of the cardiovascular system
Chen, A. F., Chen, D., Daiber, A., Faraci, F. M., Li, H., Rembold, C. M., & Laher, I. (2012) · Clinical Science · doi:10.1042/cs20110562 · Cited by 153 · see citing works
Self-citation
Selective Effects of Oxygen Free Radicals on Excitation-Contraction Coupling in Ventricular Muscle
Gao, W. D., Liu, Y., & Marbán, E. (1996) · Circulation · doi:10.1161/01.cir.94.10.2597 · Cited by 152 · see citing works
Na+ transport in the normal and failing heart — Remember the balance
Despa, S. I., & Bers, D. M. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.04.011 · Cited by 146 · see citing works
Myocardial energetics in heart failure
Nickel, A. G., Löffler, J., & Maack, C. (2013) · Basic Research in Cardiology · doi:10.1007/s00395-013-0358-9 · Cited by 143 · see citing works
Self-citation
Mechanochemotransduction During Cardiomyocyte Contraction Is Mediated by Localized Nitric Oxide Signaling
Jian, Z., Han, H., Zhang, T., Puglisi, J. L., Izu, L. T., Shaw, J. A., Onofiok, E., Erickson, J. R., Chen, Y., Horváth, B., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2005046 · Cited by 139 · see citing works
Maximum oxidative phosphorylation capacity of the mammalian heart
Mootha, V. K., Arai, A. E., & Balaban, R. S. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.272.2.h769 · Cited by 130 · see citing works
Intracellular Ca 2+ Increases the Mitochondrial NADH Concentration During Elevated Work in Intact Cardiac Muscle
Brandes, R., & Bers, D. M. (1997) · Circulation Research · doi:10.1161/01.res.80.1.82 · Cited by 130 · see citing works
The ambivalence of vitamin E in atherogenesis
Stocker, R., & Stocker, R. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01404-8 · Cited by 130 · see citing works
Delivery of Nox2-NADPH oxidase siRNA with polyketal nanoparticles for improving cardiac function following myocardial infarction
Somasuntharam, I., Boopathy, A. V., Khan, R. S., Martinez, M. D., Brown, M. E., Murthy, N., & Davis, M. E. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.06.051 · Cited by 125 · see citing works
Oxidative stress and endothelial dysfunction: Therapeutic implications
Gori, T., & Münzel, T. F. (2011) · Annals of Medicine · doi:10.3109/07853890.2010.543920 · Cited by 124 · see citing works
Self-citation
Reduced Phospholamban Phosphorylation Is Associated With Impaired Relaxation in Left Ventricular Myocytes From Neuronal NO Synthase–Deficient Mice
Zhang, Y. H., Zhang, Y. H., Sears, C. E., Emanuel, K., Redwood, C. S., El‐Armouche, A., Kranias, E. G., & Casadei, B. (2007) · Circulation Research · doi:10.1161/circresaha.107.164798 · Cited by 117 · see citing works
Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure
Daiber, A., Oelze, M. W., Coldewey, M., Kaiser, K., Huth, C., Schildknecht, S., Bachschmid, M. M., Nazirisadeh, Y., Ullrich, V., Mülsch, A., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.106 · Cited by 112 · see citing works
Self-citation
Calcium release microdomains and mitochondria
Kohlhaas, M., & Maack, C. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt032 · Cited by 112 · see citing works
Self-citation
Calcium entry via Na/Ca exchange during the action potential directly contributes to contraction of failing human ventricular myocytes
Weisser-Thomas, J. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00732-0 · Cited by 105 · see citing works
The effect of peroxynitrite on the catalytic activity of soluble guanylyl cyclase
Weber, M., Lauer, N., Mülsch, A., & Kojda, G. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00706-7 · Cited by 102 · see citing works
Oxypurinol improves coronary and peripheral endothelial function in patients with coronary artery disease
Baldus, S. E., Köster, R., Chumley, P. H., Heitzer, T. A., Rudolph, V., Ostad, M. A., Warnholtz, A., Staude, H.-J., Thuneke, F., Koss, K., et al. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.06.004 · Cited by 100 · see citing works
Self-citation
The Conversion from the Dehydrogenase Type to the Oxidase Type of Rat Liver Xanthine Dehydrogenase by Modification of Cysteine Residues with Fluorodinitrobenzene
Nishino, T., & Nishino, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.47.29859 · Cited by 93 · see citing works
Clinical outcomes and cardiovascular responses to exercise training in heart failure patients with preserved ejection fraction: a systematic review and meta-analysis
Dieberg, G., Ismail, H., Giallauria, F., & Smart, N. A. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00904.2014 · Cited by 92 · see citing works
Targeting Mitochondrial Oxidative Stress in Heart Failure
Maack, C., & Böhm, M. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.01.032 · Cited by 89 · see citing works
Self-citation
Elimination of NADPH Oxidase Activity Promotes Reductive Stress and Sensitizes the Heart to Ischemic Injury
Yu, Q., Lee, C. F., Wang, W., Karamanlidis, G., Kuroda, J., Matsushima, S., Sadoshima, J., & Tian, R. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000555 · Cited by 84 · see citing works
Circulating white blood cells and platelets amplify oxidative stress in heart failure
Ijsselmuiden, A. J. J., Musters, R. J. P., de Ruiter, G., et al. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1364 · Cited by 82 · see citing works
Rationale and design of the EMBRACE STEMI Study: A phase 2a, randomized, double-blind, placebo-controlled trial to evaluate the safety, tolerability and efficacy of intravenous Bendavia on reperfusion injury in patients treated with standard therapy including primary percutaneous coronary intervention and stenting for ST-segment elevation myocardial infarction
Chakrabarti, A. K., Kostka, K., Abueg, C., Brown, D. A., Czyz, E., Tendera, M., Jánosi, A., Giugliano, R. P., Kloner, R. A., Weaver, W. D., et al. (2013) · American Heart Journal · doi:10.1016/j.ahj.2012.12.008 · Cited by 80 · see citing works
Hypoxia–Reoxygenation Triggers Coronary Vasospasm in Isolated Bovine Coronary Arteries via Tyrosine Nitration of Prostacyclin Synthase
Zou, M.-H., & Bachschmid, M. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.1.135 · Cited by 80 · see citing works
Oxidative Post-Translational Modifications Develop LONP1 Dysfunction in Pressure Overload Heart Failure
Hoshino, A., Okawa, Y., Ariyoshi, M., Kaimoto, S., Uchihashi, M., Fukai, K., Iwai‐Kanai, E., & Matoba, S. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.001062 · Cited by 67 · see citing works
Mechanisms of Increased Vascular Superoxide Production in an Experimental Model of Idiopathic Dilated Cardiomyopathy
Mollnau, H., Oelze, M. W., August, M., Wendt, M., Daiber, A., Schulz, E., Baldus, S. E., Kleschyov, A. L., Materne, A., Wenzel, P., et al. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000190673.41925.9b · Cited by 66 · see citing works
Self-citation
Intracellular Na+ and cardiac metabolism
Bay, J., Kohlhaas, M., & Maack, C. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.05.010 · Cited by 64 · see citing works
Self-citation
Inhibition of xanthine oxidase improves myocardial contractility in patients with ischemic cardiomyopathy
Baldus, S., Müllerleile, K., Chumley, P., Steven, D., Rudolph, V., Lund, G. K., Staude, H.-J., Stork, A., Köster, R., Kähler, J., et al. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.07.010 · Cited by 63 · see citing works
Self-citation
PDE5 inhibitor sildenafil in the treatment of heart failure: A meta-analysis of randomized controlled trials
Zhuang, X., Long, M., Li, F., Hu, X., Liao, X., & Du, Z. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.01.102 · Cited by 55 · see citing works
Novel insights into interactions between mitochondria and xanthine oxidase in acute cardiac volume overload
Gladden, J. D., Zelickson, B. R., Wei, C.-C., Ulasova, E., Zheng, J., Ahmed, M. I., Chen, Y., Bamman, M., Ballinger, S., Darley-Usmar, V., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.08.022 · Cited by 54 · see citing works
Modulation of angiotensin II signaling following exercise training in heart failure
Zucker, I. H., Schultz, H. D., Patel, K. P., & Wang, H. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00026.2015 · Cited by 49 · see citing works
Allopurinol, Xanthine Oxidase, and Cardiac Ischemia
Lee, B. E., Toledo, A. H., Anaya-Prado, R., Roach, R. R., & Toledo-Pereyra, L. H. (2009) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e3181bca50c · Cited by 46 · see citing works
ACE Inhibition Lowers Angiotensin-II-Induced Monocyte Adhesion to HUVEC by Reduction of p65 Translocation and AT1 Expression
Soehnlein, O., Schmeißer, A., Cicha, I., Reiss, C., Ulbrich, H. K., Lindbom, L., Daniel, W. G., & Garlichs, C. D. (2005) · Journal of Vascular Research · doi:10.1159/000087340 · Cited by 43 · see citing works
Endothelial Dysfunction in Congestive Heart Failure: ACE Inhibition Vs. Angiotensin II Antagonism
Schäfer, A., Fraccarollo, D., Tas, P. W. L., Schmidt, I., Ertl, G., & Bauersachs, J. K. (2004) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2003.10.009 · Cited by 42 · see citing works
Hydralazine and Organic Nitrates Restore Impaired Excitation-Contraction Coupling by Reducing Calcium Leak Associated with Nitroso-Redox Imbalance*
Dulce, R. A., Yiğiner, Ö., González, D. R., Goss, G. M., Feng, N., Zheng, M., & Hare, J. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.412130 · Cited by 42 · see citing works
Randomized study to evaluate the relation between oral isosorbide dinitrate dosing interval and the development of early tolerance to its effect on left ventricular filling pressure in patients with chronic heart failure.
Elkayam, U., Roth, A., Mehra, A., Ostrzega, E., Shotan, A., Kulick, D., Jamison, M., Johnston, J., & Rahimtoola, S. H. (1991) · Circulation · doi:10.1161/01.cir.84.5.2040 · Cited by 41 · see citing works
Influence of the new angiotensin converting enzyme inhibitor ramipril on several models of acute inflammation and the adjuvant arthritis in the rat.
Caspritz, G., Alpermann, H. G., & Schleyerbach, R. (1986) · PubMed · Cited by 24 · see citing works
Time to Energize Coenzyme Q 10 for Patients With Heart Failure? ∗
Ezekowitz, J. A. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2014.07.007 · Cited by 14 · see citing works
Coenzyme Q 10
Mortensen, S. A. (2015) · JACC Heart Failure · doi:10.1016/j.jchf.2014.12.006 · Cited by 9 · see citing works

Flagged first, then by citations

Sorted by citations

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
Heart failure and kidney dysfunction: epidemiology, mechanisms and management
Schefold, J. C., Filippatos, G., Hasenfuss, G., Anker, S. D., & von Haehling, S. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.113 · Cited by 671 · see citing works
Lifestyle modifications for preventing and treating heart failure
Aggarwal, M., Bozkurt, B., Panjrath, G., Aggarwal, B., Ostfeld, R. J., Barnard, N. D., Gaggin, H., Freeman, A. M., Allen, K., Madan, S., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2160 · Cited by 162 · see citing works
Acute ingestion of citrulline stimulates nitric oxide synthesis but does not increase blood flow in healthy young and older adults with heart failure
Kim, I.-Y., Schutzler, S. E., Schrader, A., Spencer, H. J., Azhar, G., Deutz, N. E. P., & Wolfe, R. R. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00339.2015 · Cited by 67 · see citing works
Dietary nitrate-induced increases in human muscle power: High versus low responders
Coggan, A. R., Broadstreet, S. R., Mikhalkova, D., Bole, I., Leibowitz, J. L., Kadkhodayan, A., Park, S., Thomas, D. P., Thies, D., & Peterson, L. R. (2018) · Physiological Reports · doi:10.14814/phy2.13575 · Cited by 66 · see citing works
Adverse Outcome Pathway for the Neurotoxicity of Per- and Polyfluoroalkyl Substances: A Systematic Review
Li, S., Qin, S., Zeng, H., Chou, W., Oudin, A., Kanninen, K. M., Jalava, P., Dong, G., & Zeng, X. (2024) · Eco-Environment & Health · doi:10.1016/j.eehl.2024.08.002 · Cited by 54 · see citing works
Associations of the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay diet with cardiac remodelling in the community: the Framingham Heart Study
Walker, M. E., O’Donnell, A. A., Himali, J. J., Rajendran, I., Melo van Lent, D., Ataklte, F., Jacques, P. F., Beiser, A. S., Seshadri, S., Vasan, R. S., et al. (2021) · British Journal of Nutrition · doi:10.1017/s0007114521000660 · Cited by 22 · see citing works
Molecular Perspectives of Mitochondrial Adaptations and Their Role in Cardiac Proteostasis
Alam, S., Abdullah, C. S., Aishwarya, R., Morshed, M., & Bhuiyan, M. S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.01054 · Cited by 12 · see citing works
Untitled work
Chen (2016) · doi:10.1016/j.amjmed.2016.02.048 · Cited by 6 · see citing works

The Effect of Nebivolol on Endothelial Function in Newly Diagnosed Hypertensive Patients with and without Diastolic Dysfunction
Şahı̇n, T., Kahraman, G., Yilmaz, C. T., Kılıç, T., Ural, D., Kozdağ, G., Komşuoğlu, B., & Fıcı, F. (2007) · High Blood Pressure & Cardiovascular Prevention · doi:10.2165/00151642-200714040-00006 · Cited by 1 · see citing works
Effect of nebivolol on endothelial dysfunction in patients with Behçet’s disease; a prospective single-arm controlled study
Akkaya, H., Şahin, Ö., Borlu, M., et al. (2012) · The Anatolian Journal of Cardiology · doi:10.5152/akd.2013.034 · Cited by 1 · see citing works
Does the AT2-receptor mediate anti-atherosclerotic actions?
Kintscher, U., & Unger, T. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000174611.49274.1e · Cited by 2 · see citing works
The hyperglycemia induced by angiotensin II in rats is mediated by AT1 receptors
Machado, L. J. C., Marubayashi, U., dos Reis, A. M., & Coimbra, C. C. (1998) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1998001000018 · Cited by 11 · see citing works
New perspectives in angiotensin system control.
Timmermans, P. B. M. W. M., Wong, P. C., Chiu, A. T., et al. (1993) · PubMed · Cited by 28 · see citing works

Authors: Münzel, T., Gori, T., Keaney, J. F., Maack, C., & Daiber, A.
Affiliations: Johannes Gutenberg University Mainz (DE)
University of Massachusetts Chan Medical School (US)
Universitätsklinikum des Saarlandes (DE)
Corresponding author: Münzel, Thomas
ORCID: Münzel, Thomas
Gori, Tommaso
Keaney, John F.
Maack, Christoph
Daiber, Andreas
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 2015-07-04
Volume: 36
Issue: 38
Pages: 2555-2564
ISSN: 0195-668X (ISSN-L)
1522-9645
DOI: 10.1093/eurheartj/ehv305
PMC: PMC7959410
OpenAlex: W2119221698
Cited by: 394
References: 127
Citations by year: 2026: 18 · 2025: 28 · 2024: 27 · 2023: 37 · 2022: 39 · 2021: 35 · 2020: 45 · 2019: 44 · 2018: 39 · 2017: 39 · 2016: 31 · 2015: 12
FWCI: 4.93
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: European Heart Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: NIH
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Keywords: oxidative stress, heart failure, systolic dysfunction, diastolic dysfunction, reactive oxygen species, renin-angiotensin-aldosterone system, endothelial dysfunction, nitric oxide synthase uncoupling, mitochondrial reactive oxygen species, vascular stiffness, antioxidant vitamins, ACE inhibitors, angiotensin receptor blockers, preserved ejection fraction, reduced ejection fraction
MeSH terms: Angiotensin-Converting Enzyme Inhibitors, Antioxidants, Cardiovascular System, Drug Therapy, Combination, Exercise Therapy, Humans, Hydralazine, Mitochondria, Nitrates, Nitric Oxide, Phosphodiesterase Inhibitors, Stroke Volume, Vitamins, Xanthine Oxidase, Reactive Oxygen Species, Oxidative Stress, Nitric Oxide Synthase, NADPH Oxidases, Heart Failure, Systolic, Heart Failure, Diastolic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks