The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
On the evolutionary adjustment of spontaneous mutation rates
Open accessAbstract
Evolutionary factors which tend to decrease the mutation rate through natural selection and those which tend to increase the mutation rate are discussed from the standpoint of population genetics. The author's theory of optimum mutation rate based on the principle of minimum genetic load is re-examined, assuming that mutation rate is adjusted in the course of evolution in such a way that the sum of mutational and substitutional load is minimized. Another hypothesis is also examined that only selection toward lowering the mutation rate is effective and the present mutation rate in each organism represents the physical or physiological limit that may be attained by natural selection. The possibility cannot be excluded that the spontaneous mutation rate is near the minimum that may be attained under the present mode of organization of the genetic material, and at the same time is not very far from the optimum in the sense of minimizing the genetic load.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The genetical theory of natural selection
Fisher, R. A. (1930) · doi:10.5962/bhl.title.27468 · Cited by 17,617
Muller, H. J. (1932) · The American Naturalist · doi:10.1086/280418 · Cited by 1,264
AN ESTIMATE OF THE MUTATIONAL DAMAGE IN MAN FROM DATA ON CONSANGUINEOUS MARRIAGES
Morton, N. E., Crow, J. F., & Muller, H. J. (1956) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.42.11.855 · Cited by 789
Muller, H. J. (1950) · Europe PMC (PubMed Central) · Cited by 753
Haldane, J. B. S. (1957) · Journal of Genetics · doi:10.1007/bf02984069 · Cited by 733
The Effect of Variation of Fitness
Haldane, J. B. S. (1937) · The American Naturalist · doi:10.1086/280722 · Cited by 620
Evolution in Sexual and Asexual Populations
Crow, J. F., & Kimura, M. (1965) · The American Naturalist · doi:10.1086/282389 · Cited by 550
Self-citationMuller, H. J. (1950) · Europe PMC (PubMed Central) · Cited by 357
Report of the United Nations Scientific Committee on the Effects of Atomic Radiation
Meredith, W. J. (1967) · International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine · doi:10.1080/09553006614551441 · Cited by 191
A comparison of the effect of lethal and detrimental chromosomes from Drosophila populations.
Greenberg, R., & Crow, J. F. (1960) · Genetics · doi:10.1093/genetics/45.8.1153 · Cited by 136
Cited by
Drake, J. W., Charlesworth, B., Charlesworth, D., & Crow, J. F. (1998) · Genetics · doi:10.1093/genetics/148.4.1667 · Cited by 1,932
Genetic drift, selection and the evolution of the mutation rate
Lynch, M., Ackerman, M. S., Gout, J.-F., Long, H., Sung, W., Thomas, W. K., & Foster, P. L. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.104 · Cited by 911
Adaptive evolution of highly mutable loci in pathogenic bacteria
Moxon, E. R., Rainey, P. B., Nowak, M. A., & Lenski, R. E. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00005-1 · Cited by 755
Adaptive Value of High Mutation Rates of RNA Viruses: Separating Causes from Consequences
Elena, S. F., & Sanjuán, R. (2005) · Journal of Virology · doi:10.1128/jvi.79.18.11555-11558.2005 · Cited by 323
Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load
Wielgoss, S., Barrick, J. E., Tenaillon, O., Wiser, M. J., Dittmar, W. J., Cruveiller, S., Chane-Woon-Ming, B., Médigue, C., Lenski, R. E., & Schneider, D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219574110 · Cited by 292
Metadata
- Authors
- Kimura, M.
- Venue
- Genetical Research
- Publisher
- Hindawi Limited
- Published
- 1967-02
- Volume
- 9
- Issue
- 1
- Pages
- 23-34
- ISSN
- 0016-6723 (ISSN-L)
- 1469-5073
- OpenAlex
- W1991595275
- Cited by
- 337
- References
- 13
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: On the evolutionary adjustment of spontaneous mutation rates. https://app.cochat.ai/papers/10.1017/s0016672300010284
- The paper
- Kimura, M. (1967). On the evolutionary adjustment of spontaneous mutation rates. Genetical Research. https://doi.org/10.1017/s0016672300010284
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
