The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Role of Toll-like receptors in the development of immunotolerance mediated by probiotics
Open accessAbstract
Commensal bacteria are important in intestinal homeostasis and appear to play a role in early tolerance to foreign antigens. The requirement for homeostatic balance between tolerance and immunity poses a unique regulatory challenge to mucosal immune systems. Dysregulation of this balance can contribute to the pathogenesis of numerous inflammatory conditions such as inflammatory bowel diseases. The primary response to these bacteria is triggered by pattern recognition receptors (PRR), which bind pathogen-associated molecular patterns (PAMP). PRR comprise Toll-like receptors (TLR), nucleotide-binding oligomerization domains, adhesion molecules and lectins. Probiotics are living commensal micro-organisms of the intestinal tract with clinically documented health effects in human subjects. They are known to affect the gastrointestinal tract and the associated immune system and to have numerous effects on intestinal function and immune responses, including immunotolerance. This last effect appears to be mediated via regulatory T-cell activation by intestinal dendritic cells and the low activation of T-helper 1 and 2 (Th1 and Th2) cell inflammatory responses. However, the precise mechanisms of probiotic activity remain poorly understood. The aim of the present work was to review the function of TLR in the development of immunotolerance and examine the specific role of probiotics in the regulation of tolerance to antigens.
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Cites
A Toll-like receptor recognizes bacterial DNA
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Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis
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Cited by
Mechanisms of action of probiotics
Plaza-Diaz, J., Ruiz-Ojeda, F. J., Gil-Campos, M., & Gil, A. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy063 · Cited by 1,423
Self-citationPlaza-Díaz, J., Ruiz-Ojeda, F., Vilchez-Padial, L., & Gil, A. (2017) · Nutrients · doi:10.3390/nu9060555 · Cited by 423
Self-citationThe Role of Probiotics in Cancer Prevention
Śliżewska, K., Markowiak-Kopeć, P., & Śliżewska, W. (2020) · Cancers · doi:10.3390/cancers13010020 · Cited by 282
International Society of Sports Nutrition Position Stand: Probiotics
Jäger, R., Mohr, A. E., Carpenter, K. C., Kerksick, C. M., Purpura, M., Moussa, A., Townsend, J. R., Lamprecht, M., West, N. P., Black, K., et al. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0329-0 · Cited by 277
Unveiling The Therapeutic Potential of Probiotics: A Review
Tukaram, K. S., Sopanrao, S. R., & Kacharu, L. O. (2025) · Journal of Future Foods · doi:10.1016/j.jfutfo.2025.09.011 · Cited by 19
Metadata
- Authors
- Gómez-Llorente, C., Muñoz, S., & Gil, A.
- Venue
- Proceedings of the Nutrition Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-04-23
- Volume
- 69
- Issue
- 3
- Pages
- 381-389
- ISSN
- 0029-6651 (ISSN-L)
- 1475-2719
- OpenAlex
- W2044551431
- Cited by
- 160
- References
- 8
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
