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Cited by 107Phytoestrogen effects and researchEffects and risks of endocrine disrupting chemicalsEstrogen and related hormone effects

Endocrine disruption by dietary phyto-oestrogens: impact on dimorphic sexual systems and behaviours

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Patisaul, Heather B.·2017·Proceedings of the Nutrition Society
DOI 10.1017/s0029665116000677PMC PMC5646220
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Abstract

A wide range of health benefits have been ascribed to soya intake including a lowered risk of osteoporosis, heart disease, breast cancer, and menopausal symptoms. Because it is a hormonally active diet, however, soya can also be endocrine disrupting, suggesting that intake has the potential to cause adverse health effects in certain circumstances, particularly when exposure occurs during development. Consequently, the question of whether or not soya phyto-oestrogens are beneficial or harmful to human health is neither straightforward nor universally applicable to all groups. Possible benefits and risks depend on age, health status, and even the presence or absence of specific gut microflora. As global consumption increases, greater awareness and consideration of the endocrine-disrupting properties of soya by nutrition specialists and other health practitioners is needed. Consumption by infants and small children is of particular concern because their hormone-sensitive organs, including the brain and reproductive system, are still undergoing sexual differentiation and maturation. Thus, their susceptibility to the endocrine-disrupting activities of soya phyto-oestrogens may be especially high. As oestrogen receptor partial agonists with molecular and cellular properties similar to anthropogenic endocrine disruptors such as bisphenol A, the soya phyto-oestrogens provide an interesting model for how attitudes about what is ‘synthetic’v. what is ‘natural,’ shapes understanding and perception of what it means for a compound to be endocrine disrupting and/or potentially harmful. This review describes the endocrine-disrupting properties of soya phyto-oestrogens with a focus on neuroendocrine development and behaviour.

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  • Evidence of endocrine disrupting properties of GEN dates back decades, and soy is well recognized as a hormonally active food.

    “Evidence of the endocrine disrupting properties of GEN dates back decades, and soy is so well recognized as a hormonally active food, that it is frequently advertised and promoted as such (15, 111–115).”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [112]

  • There are some data showing endocrine disruption of AVP-related pathways and systems, including behaviors, by GEN.

    “but there are some data showing endocrine disruption of AVP-related pathways and systems, including behaviors (112).”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [112]

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Cited by

Sorted by citations

Authors
Patisaul, H. B.
Affiliations
North Carolina State University (US)
Corresponding author
Patisaul, Heather B.
ORCID
Patisaul, Heather B.
Venue
Proceedings of the Nutrition Society
Publisher
Cambridge University Press (CUP)
Published
2016-07-08
Volume
76
Issue
2
Pages
130-144
ISSN
  • 0029-6651 (ISSN-L)
  • 1475-2719
DOI
10.1017/s0029665116000677
PMC
PMC5646220
OpenAlex
W2463686992
Cited by
107
References
13
Citations by year
2026: 9 · 2025: 10 · 2024: 10 · 2023: 11 · 2022: 14 · 2021: 20 · 2020: 11 · 2019: 12 · 2018: 5 · 2017: 3 · 2016: 2
FWCI
1.15
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified)
Locations
  • Proceedings of The Nutrition Society (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • North Carolina State University
  • National Institute of Environmental Health Sciences (R21ES021233)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
endocrine disruption, phytoestrogens, soybean, sexual differentiation, sexual behavior, neuroendocrine development, gut microbiota, bisphenol A
MeSH terms
Bisphenol A Compounds, Animals, Benzhydryl Compounds, Diet, Disease Models, Animal, Humans, Isoflavones, Neurosecretory Systems, Phenols, Reproduction, Sexual Behavior, Sexual Behavior, Animal, Glycine max, Phytoestrogens, Endocrine Disruptors

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