The influence of maternal nutrient restriction in early to mid-pregnancy on placental and fetal development in sheep
Open accessAbstract
Placental weight is a primary factor determining size at birth in many species. In sheep, placental weight peaks at approximately mid-gestation, with structural remodelling occurring over the second half of pregnancy to meet the increasing nutritional demands of the growing fetus. Numerous factors influence placental growth and development in sheep, and many workers (see Kelly, 1992) have investigated the role of maternal nutrition as a regulator of placental and fetal size. We have studied the effects of feeding ewes approximately 50 % of their recommended energy requirements during early to mid-pregnancy on fetal and placental indices measured at mid-gestation (i.e. 80 d) and close to term (i.e. 145 d). Maternal nutrient restriction is associated with a reduction in placental weight at 80 d, but an increase in placental weight at 145 d of gestation, compared with ewes fed adequately in early pregnancy. No significant effect on fetal weight was observed at either 80 or 145 d gestation, although differences in body dimensions and the insulin-like growth factor-1 axis were found in lambs from nutrient-restricted ewes delivered close to term. Maternal nutrition during pregnancy plays a pivotal role in the regulation of fetal and placental development in sheep, and therefore has the potential to influence both short- and longer-term health outcomes.
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Similar changes in placental morphology are also seen in response to overnutrition in juvenile and adult sheep.
“Similar changes in placental morphology are also seen in response to overnutrition in juvenile and adult sheep (250, 354, 454).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [250]
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Research works printed but not linked: 2
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Placental Origins of Chronic Disease
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- Authors
- Heasman, L., Clarke, L., Stephenson, T. J., & Symonds, M. E.
- Affiliations
- Queen's Medical Centre (GB)
- Corresponding author
- Heasman, L.
- Venue
- Proceedings of the Nutrition Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 1999-05
- Volume
- 58
- Issue
- 2
- Pages
- 283-288
- ISSN
- 0029-6651 (ISSN-L)
- 1475-2719
- OpenAlex
- W2170714658
- Cited by
- 84
- References
- 37
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 7 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of The Nutrition Society (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- maternal nutrient restriction, placental weight, fetal development, sheep pregnancy, fetal weight, insulin-like growth factor I, maternal energy intake, placental development
- MeSH terms
- Animals, Energy Intake, Female, Embryonic and Fetal Development, Food Deprivation, Gestational Age, Nutritional Requirements, Organ Size, Placenta, Pregnancy, Sheep
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