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Cited by 164Birth, Development, and HealthPregnancy and preeclampsia studiesPrenatal Substance Exposure Effects

Compensatory placental growth after restricted maternal nutrition in early pregnancy

Open access
Lunney, L.H.·1998·Placenta
DOI 10.1016/s0143-4004(98)90105-9
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Abstract

This study examined the effects of undernutrition in pregnancy on fetal and placental growth among infants born in 1944-1946 in The Netherlands, including infants born during the war-induced Dutch famine of 1944-1945. There was an increase in placental weight, but not in birthweight, in infants whose mothers' nutrition was compromised around conception or in the first trimester of pregnancy. Therefore, the placental index was also increased. Compared to pre-famine controls, the relative increase after first trimester exposure to undernutrition was larger in the northern part of the country (5.2 per cent, 95 per cent confidence interval 1.4, 9.0) where nutritional deprivation was presumably moderate compared to the west (3.5 per cent, 95 per cent confidence interval 0.2, 7.2) where nutritional deprivation was severe. The increase in placental weight is interpreted as compensatory for the reduction in maternal caloric intake. Whereas this suggests that pregnancy undernutrition can stimulate compensatory placental growth, the latter was only seen after first trimester undernutrition, which does not affect infant size at birth. For these infants, therefore, birthweight is not an appropriate proxy measure of undernutrition in pregnancy. These factors need to be considered in future studies relating pregnancy nutrition to adult health outcomes.

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Crossref · 10.1016/s0143-4004(98)90105-9

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37 of 37 references verified0 citation errors · 0 not checkable

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  • In Dutch hunger winter populations, placental weight at term was increased when the famine occurred in the 1st trimester but was reduced, along with infant birth weight, in women who were in their 3rd trimester at the time of the famine.

    “In the Dutch hunger winter populations, placental weight at term was increased when the famine occurred in the 1 st trimester but was reduced, along with infant birth weight, in women who were in their 3 rd trimester at the time of the famine (350, 471).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [350]

  • Placental efficiency measured as the fetal to placental weight ratio was greater in response to undernutrition in late pregnancy than in control pregnancies before the famine.

    “However, despite this, placental efficiency measured as the fetal to placental weight ratio was greater in response to the undernutrition in late pregnancy than seen in control pregnancies before the famine (350,”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [350]

  • The size of the human placenta at term is affected by calorie intake and dietary composition during pregnancy.

    “The size of the human placenta at term is known to be affected by the calorie intake and dietary composition during the pregnancy (216, 350, 471).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [350]

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Authors
Lunney, L. H.
Affiliations
Institute for Cancer Prevention (US)
Corresponding author
Lunney, L.H.
Venue
Placenta
Publisher
Elsevier BV
Published
1998-01
Volume
19
Issue
1
Pages
105-111
ISSN
0143-4004 (ISSN-L)
DOI
10.1016/s0143-4004(98)90105-9
OpenAlex
W2024706817
Cited by
164
References
38
Citations by year
2026: 4 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 9 · 2016: 4 · 2015: 14 · 2014: 5 · 2013: 3 · 2012: 16
FWCI
4.37
Type
journal article
Language
en
Open access
Licence
Locations
  • Placenta (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hd026492-02)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (1RO1-HD26492-02)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
placental development, maternal undernutrition, early pregnancy, Dutch famine, fetal growth, birth weight, fetal programming, adult health outcomes
MeSH terms
Adult, Birth Weight, Female, Humans, Netherlands, Nutrition Disorders, Organ Size, Placentation, Pregnancy, Pregnancy Complications, Pregnancy Trimester, First, Starvation, History, 20th Century

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